標(biāo)題: Titlebook: Drug-Induced Hepatotoxicity; Ross G. Cameron,George Feuer,Felix A. Iglesia Book 1996 Springer-Verlag Berlin Heidelberg 1996 Hepatotoxizit? [打印本頁(yè)] 作者: hearken 時(shí)間: 2025-3-21 19:01
書(shū)目名稱(chēng)Drug-Induced Hepatotoxicity影響因子(影響力)
作者: 繼而發(fā)生 時(shí)間: 2025-3-21 20:59
Fabio Claudio Ferracchiati,Emanuele Garofalonts in the quantitative and qualitative design of drug therapy. However, this important role of the liver is a “double-edge sword.” Since the liver often converts original drugs to water-soluble forms for excretion, it must of necessity convert many an “inactive” compound to an “active” one during t作者: remission 時(shí)間: 2025-3-22 01:45
Enjoying Music, Video, and eBooksechanisms of drug toxicity has been carried out in animal models or in vitro systems using cultures of non-hepatocyte cell lines. The limitations and pitfalls of extrapolating from non-human data to the clinical situation are well recognised.作者: biopsy 時(shí)間: 2025-3-22 08:02
Connecting Monitors and Hardwareivery to the liver before the drug is distributed throughout the body and exerts its therapeutic effects, (b) trans cellular pores or fenestrations in the endothelial cells lining the sinusoidal spaces are unique to the liver and are sufficiently large to permit most plasma proteins to diffuse into 作者: epidermis 時(shí)間: 2025-3-22 11:59 作者: CESS 時(shí)間: 2025-3-22 15:11 作者: CESS 時(shí)間: 2025-3-22 21:07
Markup Languages: More Than HTML5tion and imprecise correlations between the observed immune response and the histopathology in affected tissues. In particular, assays in vitro in which lymphocytes are exposed to the culprit drug may be unrevealing, either because the immune response is directed to a drug metabolite present in low 作者: 我的巨大 時(shí)間: 2025-3-22 21:24
Testing Windows Phone Applications,ilure (FHF) has no vascular component. HE associated with FHF shows an acute onset with delirium progressing to deep coma. While delirium and seizures are generally uncommon in HE, they may occur during the rapid evolution of HE due to FHF (. 1986). Although some of the characteristics of HE associa作者: 符合國(guó)情 時(shí)間: 2025-3-23 04:04 作者: 勤勉 時(shí)間: 2025-3-23 07:52 作者: 榨取 時(shí)間: 2025-3-23 10:27 作者: 口訣法 時(shí)間: 2025-3-23 15:57
Molecular Biology of Hepatic Drug Reactions,echanisms of drug toxicity has been carried out in animal models or in vitro systems using cultures of non-hepatocyte cell lines. The limitations and pitfalls of extrapolating from non-human data to the clinical situation are well recognised.作者: 提煉 時(shí)間: 2025-3-23 19:40
Cytochromes P450 and Liver Injury,ivery to the liver before the drug is distributed throughout the body and exerts its therapeutic effects, (b) trans cellular pores or fenestrations in the endothelial cells lining the sinusoidal spaces are unique to the liver and are sufficiently large to permit most plasma proteins to diffuse into 作者: 積極詞匯 時(shí)間: 2025-3-24 01:23
Mechanisms of Drug-Induced Cholestasis, bile pigments in the canaliculi andhepatocytes, dilation of the canalicular space with a reduction of microvilli,feathery degeneration, accumulation of copper, and Mallory body-like cytoplasmicinclusions. Finally, the simplest functional definition of cholestasis is adecrease in bile flow. Cholesta作者: enchant 時(shí)間: 2025-3-24 05:00 作者: 按時(shí)間順序 時(shí)間: 2025-3-24 09:46 作者: 天空 時(shí)間: 2025-3-24 13:50 作者: fatuity 時(shí)間: 2025-3-24 14:51 作者: BLANC 時(shí)間: 2025-3-24 22:49
Liver Reactions to Tacrine,rine administration was shown to produce statistically significant improvements in several measures of cognitive function (. et a1. 1992; . et a1. 1994). As a result of these clinical trials, tacrine has been approved by the United States Food and Drug Administration for the treatment of mild to mod作者: forecast 時(shí)間: 2025-3-24 23:09
0171-2004 ho- sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease.978-3-642-64657-7978-3-642-61013-4Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 啞巴 時(shí)間: 2025-3-25 06:05 作者: Instrumental 時(shí)間: 2025-3-25 10:26
Investing in Sales and Marketing Too Earlylinical situations for various reasons. However, a comprehensive but critical review of the past data in experimental animals may be of help for the proper interpretation of these data and for the future elucidation of this complicated but very important clinical and experimental problem.作者: 搜尋 時(shí)間: 2025-3-25 11:41 作者: sulcus 時(shí)間: 2025-3-25 17:00 作者: FRAX-tool 時(shí)間: 2025-3-25 23:25
0171-2004 life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease proces作者: 野蠻 時(shí)間: 2025-3-26 03:02
Organizing and Sharing Pictures and Videosons in animals have frequently revealed impairment of liver function. This chapter will survey the relevant studies and update the approaches concerning the intrinsic relationship which exists between structural and support tissue or cell components and functional, metabolic or enzymatic parameters of hepatocytes responding to toxic drug effects.作者: 積習(xí)已深 時(shí)間: 2025-3-26 05:16 作者: 指令 時(shí)間: 2025-3-26 09:27 作者: white-matter 時(shí)間: 2025-3-26 15:41 作者: Projection 時(shí)間: 2025-3-26 19:15
Effect of Liver Disease on Drug Metabolism and Pharmacokinetics,sposition, either directly or indirectly, are the kidney and the liver. While most clinical studies carried out early in drug development are conducted in healthy subjects. renal or hepatic impairment may exert a considerable influence on both the disposition and the pharmacodynamic consequences of an administered drug.作者: plasma-cells 時(shí)間: 2025-3-26 23:41
Book 1996ch improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and th作者: 油膏 時(shí)間: 2025-3-27 03:51
Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity,ons in animals have frequently revealed impairment of liver function. This chapter will survey the relevant studies and update the approaches concerning the intrinsic relationship which exists between structural and support tissue or cell components and functional, metabolic or enzymatic parameters of hepatocytes responding to toxic drug effects.作者: 蛙鳴聲 時(shí)間: 2025-3-27 06:51 作者: 吞吞吐吐 時(shí)間: 2025-3-27 12:33
Markup Languages: More Than HTML5incorporate them in membranes, or to incorporate them in lipoproteins, which are “secreted” in the blood, or also, in restricted amounts, to hydrolyze them, usually within secondary lysosomes. The amount of TGs present inside a single hepatocyte therefore represents the balance between synthetic processes and removal.作者: guardianship 時(shí)間: 2025-3-27 15:24 作者: 馬籠頭 時(shí)間: 2025-3-27 18:36
Investing in Sales and Marketing Too Earlysposition, either directly or indirectly, are the kidney and the liver. While most clinical studies carried out early in drug development are conducted in healthy subjects. renal or hepatic impairment may exert a considerable influence on both the disposition and the pharmacodynamic consequences of an administered drug.作者: 不理會(huì) 時(shí)間: 2025-3-27 23:40 作者: TIA742 時(shí)間: 2025-3-28 06:11
Clinical Studies and Role of Necrosis in Hepatotoxicity,is the subject of this short treatise. The critical analysis of the liver biopsies of over 40 patients with acetaminophen overdose has served as the basis of specific hypotheses concerning the responses of the liver to certain forms of injury namely: (1) zone 3 (perivenous) hepatocytes die as a unit作者: 碎石 時(shí)間: 2025-3-28 09:32
Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity,nt of adverse changes manifesting in basic parameters of hepatic activities is important. Clinical observations in humans and experimental investigations in animals have frequently revealed impairment of liver function. This chapter will survey the relevant studies and update the approaches concerni作者: 哀求 時(shí)間: 2025-3-28 12:01
Molecular Biology of Hepatic Drug Reactions,g those relevant to the topics covered in the majority of chapters in this volume. Various aspects of the molecular biology of hepatic drug reactions, particularly those pertaining to cell damage mediated by lipid peroxidation, glutathione depletion and genetic susceptibility, are covered by other a作者: SKIFF 時(shí)間: 2025-3-28 18:28 作者: acrimony 時(shí)間: 2025-3-28 21:04
Cytochromes P450 and Liver Injury,inal tract. Once absorbed, they circulate in blood bound to plasma proteins such as albumin, and are sequestered into fat with relative tissue: blood ratios determined by the degree of lipophilicity. For these reasons, lipophilic drugs are not readily excreted by the kidney into urine; therefore con作者: ASSET 時(shí)間: 2025-3-28 23:09
Mechanisms of Drug-Induced Cholestasis,sult from accumulation in blood of compounds normally excreted in bile, such as bilirubin, bile acids, cholesterol, alkaline phosphatase,5’-nucleotidase,.-glutamyltranspeptidase,leucine amino peptidase, lipoprotein X. and immunoglobulin. The response of these compounds and the time course for elevat作者: 排出 時(shí)間: 2025-3-29 06:00
Fatty Liver and Drugs,of injury. To gain a good understanding of these mechanisms, the general scheme of triglyceride metabolism in the liver must be considered. Triglycerides (TGs), which are present in the hepatocytes, are synthesized locally from glycerol and fatty acids by TG synthetase. The liver uses TGs either to 作者: 絕食 時(shí)間: 2025-3-29 09:16
Choline Deficiency: An Important Model for the Study of Hepatotoxicity,als (rats have been studied very extensively) causes acute and chronic damage, not unlike, in some respects, that seen after the . of toxic drugs, e.g., carbon tetrachloride. Deprivation of no other nutrients from the diet of rats has such a fast action as choline. When rats are given a diet devoid 作者: Classify 時(shí)間: 2025-3-29 14:50
Immune Mechanisms and Liver Toxicity,those that are idiosyncratic, non-dose related and non-reproducible in experimental animals. It is important to note that more idiosyncratic drug reactions are attributable predominantly or entirely to pharmacokinetic variations or enzyme polymorphisms or deficiencies than to abnormal immunological 作者: disrupt 時(shí)間: 2025-3-29 18:46
Hepatic Encephalopathy,a. The association of the syndrome with acute or chronic liver failure implicates a plethora of metabolic abnormalities and gut-derived toxins in its pathogenesis. Thus, it is difficult to ascribe the neurological and psychiatric manifestations of HE to the presence of a single agent or changes in a作者: 徹底明白 時(shí)間: 2025-3-29 22:17
Liver Drug Reactions and Pregnancy,970). The epidemiologic impact of iatrogenic liver injury is considerably more important, however, when the mortality due to liver disease is considered. Specifically, the case-fatality rate for drug-induced hepatic injury ranges from a minimum figure of 10% to a high of 50% of cases, depending upon作者: macular-edema 時(shí)間: 2025-3-30 01:58 作者: hankering 時(shí)間: 2025-3-30 06:52
,Reye’s Syndrome,hy and fatty degeneration of the viscera). Manifestations of the disease included viral prodrome usually characterized by upper respiratory infection followed by severe vomiting after which mental changes and coma eventually occurred. Clinically, biochemically and histologically there was evidence o作者: Abominate 時(shí)間: 2025-3-30 11:39 作者: FUSC 時(shí)間: 2025-3-30 14:36
Effect of Liver Disease on Drug Metabolism and Pharmacokinetics,ncing the degree and time course of drug pharmacologic action in the body. Disease states affecting different organs may have a variety of effects on drug disposition and also on pharmacologic and pharmacodynamic effects. The two organs that are recognized as having the greatest influence on drug di作者: Adulate 時(shí)間: 2025-3-30 19:26 作者: EXPEL 時(shí)間: 2025-3-30 21:46
Diagnostic Tools and Clinical Pathology,vious because of a temporal association of developing liver function abnormalities to beginning use of the drug. This scenario generally leads to discontinuation of the drug and resolution of the dysfunction. In this setting biopsy is rarely indicated. With many drugs there is no long-term consequen作者: engrave 時(shí)間: 2025-3-31 01:11 作者: languid 時(shí)間: 2025-3-31 08:07 作者: chlorosis 時(shí)間: 2025-3-31 12:46 作者: DENT 時(shí)間: 2025-3-31 13:30
https://doi.org/10.1007/978-3-642-61013-4Hepatotoxizit?t; Leber; Reye‘s syndrome; drug; hepatoxicity; liver; toxicity; hepatology; metabolic disease作者: ETHER 時(shí)間: 2025-3-31 18:45
978-3-642-64657-7Springer-Verlag Berlin Heidelberg 1996作者: Arboreal 時(shí)間: 2025-4-1 00:18 作者: intellect 時(shí)間: 2025-4-1 04:21 作者: 南極 時(shí)間: 2025-4-1 08:22
Liver Drug Reactions and Pregnancy,970). The epidemiologic impact of iatrogenic liver injury is considerably more important, however, when the mortality due to liver disease is considered. Specifically, the case-fatality rate for drug-induced hepatic injury ranges from a minimum figure of 10% to a high of 50% of cases, depending upon the specific drug involved (. 1978).
