標(biāo)題: Titlebook: Drug Targets in Kinetoplastid Parasites; Hemanta K. Majumder Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive li [打印本頁] 作者: malcontented 時間: 2025-3-21 16:58
書目名稱Drug Targets in Kinetoplastid Parasites影響因子(影響力)
書目名稱Drug Targets in Kinetoplastid Parasites影響因子(影響力)學(xué)科排名
書目名稱Drug Targets in Kinetoplastid Parasites網(wǎng)絡(luò)公開度
書目名稱Drug Targets in Kinetoplastid Parasites網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Targets in Kinetoplastid Parasites被引頻次
書目名稱Drug Targets in Kinetoplastid Parasites被引頻次學(xué)科排名
書目名稱Drug Targets in Kinetoplastid Parasites年度引用
書目名稱Drug Targets in Kinetoplastid Parasites年度引用學(xué)科排名
書目名稱Drug Targets in Kinetoplastid Parasites讀者反饋
書目名稱Drug Targets in Kinetoplastid Parasites讀者反饋學(xué)科排名
作者: 暴露他抗議 時間: 2025-3-21 22:03
Selective Lead Compounds against Kinetoplastid Tubulin,ments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been identified that could represent a starting point for the development of new drug candidates against these parasites.作者: epicardium 時間: 2025-3-22 04:21
Wave Propagation in Infinite Domainsiplinary approach that includes protein structure and function and high throughput screening of random and directed chemical libraries, followed by in vivo testing in animals and humans. We outline the opportunities that are made possible by recent technologies, and potential problems that need to be overcome.作者: Grating 時間: 2025-3-22 05:44 作者: 不斷的變動 時間: 2025-3-22 09:05 作者: curriculum 時間: 2025-3-22 16:30 作者: curriculum 時間: 2025-3-22 18:48 作者: 使入迷 時間: 2025-3-22 22:36
0065-2598 ozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas’ disease is endemic in Latin作者: 嘴唇可修剪 時間: 2025-3-23 03:24
Offshore wind energy conversion systemsments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been identified that could represent a starting point for the development of new drug candidates against these parasites.作者: 談判 時間: 2025-3-23 07:11
Begriff und Ziele des Wettbewerbsrechtscation of free detached minicircles and catenated maxicircles, and the generation of two progeny kDNA networks. It is catalyzed by an enzymatic machinery, consisting of kDNA replication proteins that are located at defined sites flanking the kDNA disk in the mitochondrial matrix (for recent reviews on kDNA see refs. 1-8).作者: GAVEL 時間: 2025-3-23 11:41
gy. Therefore, understanding the biology of kinetoplastid topoisomerases and the components and steps involved in this intricate process provide opportunities for target based drug designing against protozoan parasitic diseases.作者: micronutrients 時間: 2025-3-23 15:36
Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets cation of free detached minicircles and catenated maxicircles, and the generation of two progeny kDNA networks. It is catalyzed by an enzymatic machinery, consisting of kDNA replication proteins that are located at defined sites flanking the kDNA disk in the mitochondrial matrix (for recent reviews on kDNA see refs. 1-8).作者: 哀求 時間: 2025-3-23 19:18 作者: adequate-intake 時間: 2025-3-23 23:31
Fishing for Anti-Leishmania Drugs: Principles and Problems,iplinary approach that includes protein structure and function and high throughput screening of random and directed chemical libraries, followed by in vivo testing in animals and humans. We outline the opportunities that are made possible by recent technologies, and potential problems that need to be overcome.作者: 鼓掌 時間: 2025-3-24 04:15 作者: 緊張過度 時間: 2025-3-24 06:49
Antiparasitic Chemotherapy:,fects is therefore of primary importance. Like most parasitic protozoan, the genus . is an obligate auxotroph of purines and hence for requirement of purine bases depends on its own purine salvage pathways.作者: extrovert 時間: 2025-3-24 11:47 作者: figure 時間: 2025-3-24 16:37 作者: 不能和解 時間: 2025-3-24 21:01 作者: impaction 時間: 2025-3-25 01:45
Purine and Pyrimidine Metabolism in ,, small complement of pyrimidine salvage enzymes. Because the pyrimidine nucleotide biosynthetic pathways of . and humans are similar, pyrimidine metabolism in . has generally been considered less amenable to therapeutic manipulation than the purine salvage pathway. However, evidence garnered from a 作者: arboretum 時間: 2025-3-25 04:29 作者: BRUNT 時間: 2025-3-25 10:17
0065-2598 parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue. .978-1-4419-2656-2978-0-387-77570-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Altitude 時間: 2025-3-25 14:06 作者: 完成 時間: 2025-3-25 18:08
Scaled boundary finite element methodgood reason for optimism that newer compounds with greater potency and improved pharmacokinetic properties might be more efficacious. Data have been published demonstrating synergistic activity of azole drugs with various other compounds, indicating that combination chemotherapy may be an effective 作者: Congregate 時間: 2025-3-25 21:22 作者: Chandelier 時間: 2025-3-26 01:41 作者: 無目標(biāo) 時間: 2025-3-26 04:38
Arsenite Resistance in Leishmania and Possible Drug Targets,malaria (WHO). Visceral leishmaniasis or kala-azar, caused by Leishmania donovani, is the most fatal form of leishmaniasis afflicting millions of people worldwide. No vaccination is available against leishmaniasis and fast spreading drug resistance in these parasitic organisms is posing a major medi作者: 閹割 時間: 2025-3-26 11:24 作者: blithe 時間: 2025-3-26 14:06
Drugs and Transporters in Kinetoplastid Protozoa,es, translocate compounds from one intracellular compartment to another, and take up or export drugs. The combination of molecular cloning, genetic approaches, and the completed genome projects for . have allowed detailed functional analysis of various transporters and predictions about the likely f作者: BUCK 時間: 2025-3-26 18:18 作者: 潔凈 時間: 2025-3-26 22:25
Fishing for Anti-Leishmania Drugs: Principles and Problems,. Current drugs are toxic and expensive, and are losing their effectiveness due to parasite resistance. The availability of the genome sequence of two species of .and ., as well as that of . and . should provide a cornucopia of potential new drug targets. Their exploitation will require a multi-disc作者: NAIVE 時間: 2025-3-27 04:51
Sterol 14-Demethylase Inhibitors for , Infections,dic compounds (benznidazole and nifurtimox) that are suboptimal due to poor curative activity for chronic Chagas disease and high rates of adverse drug reactions. Sterol 14-demethylase inhibitors include azole antifungal drugs such as ketoconazole, fluconazole, itraconazole, and others. The first re作者: 歡呼 時間: 2025-3-27 05:40 作者: 抗原 時間: 2025-3-27 12:57
Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy,nfections more efficiently and effectively. Targeting novel glycoproteins/lipids, which are important disease determinants of kinetoplastid diseases, have helped in the development of this field. Better and refined understanding of all the available data would possibly help us in providing a future 作者: Exposure 時間: 2025-3-27 16:04
DNA Topoisomerases of ,: The Potential Targets for Anti-Leishmanial Therapy,resulting from morbidity, primarily in the tropical and subtropical areas. This ancient eukaryote shows variable genetic diversity in their life cycle, wherein DNA topoisomerases play a key role in cellular processes affecting the topology and organization of intracellular DNA. Kinetoplastid topoiso作者: hangdog 時間: 2025-3-27 18:11 作者: 棲息地 時間: 2025-3-27 22:18
Searching the Tritryp Genomes for Drug Targets, are common to all three genomes, and ushers in a new, post-genomic, era for trypanosomatid drug discovery. This vast amount of new information makes possible more comprehensive and accurate target identification using several new computational approaches, including identification of metabolic “chok作者: 啜泣 時間: 2025-3-28 02:40
Purine and Pyrimidine Metabolism in ,,rgy, cAMP and cGMP are key second messenger molecules, purine and pyrimidine nucleotides are precursors for activated forms of both carbohydrates and lipids, nucleotide derivatives of vitamins are essential cofactors in metabolic processes, and nucleoside triphosphates are the immediate precursors f作者: 確保 時間: 2025-3-28 08:04 作者: CRUC 時間: 2025-3-28 12:55 作者: 有毒 時間: 2025-3-28 16:59
Das Verbot unlauteren Wettbewerbsmalaria (WHO). Visceral leishmaniasis or kala-azar, caused by Leishmania donovani, is the most fatal form of leishmaniasis afflicting millions of people worldwide. No vaccination is available against leishmaniasis and fast spreading drug resistance in these parasitic organisms is posing a major medi作者: blithe 時間: 2025-3-28 20:55
Begriff und Ziele des Wettbewerbsrechtsparasitic species of the family Trypanosomatidae, it consists of 5,000-10,000 duplex DNA minicircles (0.5-10 kb) and 25-50 maxicircles (20-40 kb), which are linked topologically into a two dimensional DNA network. Maxicircles encode for typical mitochondrial proteins and ribosomal RNA, whereas minic作者: Fallibility 時間: 2025-3-28 23:32
Fallgruppen und Beispielskataloges, translocate compounds from one intracellular compartment to another, and take up or export drugs. The combination of molecular cloning, genetic approaches, and the completed genome projects for . have allowed detailed functional analysis of various transporters and predictions about the likely f作者: GLARE 時間: 2025-3-29 06:31
Offshore wind energy conversion systemseatments for these diseases are far from ideal and new compounds are needed as antiparasitic drug candidates. Tubulin is the accepted target for treatments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compou作者: rheumatism 時間: 2025-3-29 09:31 作者: deficiency 時間: 2025-3-29 12:37 作者: 反省 時間: 2025-3-29 18:20
Scaled boundary finite element method pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic p作者: 收集 時間: 2025-3-29 21:34
nfections more efficiently and effectively. Targeting novel glycoproteins/lipids, which are important disease determinants of kinetoplastid diseases, have helped in the development of this field. Better and refined understanding of all the available data would possibly help us in providing a future 作者: 吹氣 時間: 2025-3-30 00:03
