標(biāo)題: Titlebook: Drug Resistance in Leukemia and Lymphoma III; G. J. L. Kaspers,R. Pieters,A. J. P. Veerman Book 1999 The Editor(s) (if applicable) and The [打印本頁] 作者: lexicographer 時(shí)間: 2025-3-21 19:19
書目名稱Drug Resistance in Leukemia and Lymphoma III影響因子(影響力)
書目名稱Drug Resistance in Leukemia and Lymphoma III影響因子(影響力)學(xué)科排名
書目名稱Drug Resistance in Leukemia and Lymphoma III網(wǎng)絡(luò)公開度
書目名稱Drug Resistance in Leukemia and Lymphoma III網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Resistance in Leukemia and Lymphoma III被引頻次
書目名稱Drug Resistance in Leukemia and Lymphoma III被引頻次學(xué)科排名
書目名稱Drug Resistance in Leukemia and Lymphoma III年度引用
書目名稱Drug Resistance in Leukemia and Lymphoma III年度引用學(xué)科排名
書目名稱Drug Resistance in Leukemia and Lymphoma III讀者反饋
書目名稱Drug Resistance in Leukemia and Lymphoma III讀者反饋學(xué)科排名
作者: 思考 時(shí)間: 2025-3-21 22:06
https://doi.org/10.1007/978-3-7091-9414-0 strategies are being developed to circumvent drug resistance by inhibiting P-gp, prospective studies concerning the clinical relevance of P-gp in childhood leukemia are warranted. . P-gp was studied in 102 consecutive cases of de novo childhood ALL and in 34 relapsed patients. An immunocytochemical作者: Astigmatism 時(shí)間: 2025-3-22 04:08 作者: emulsify 時(shí)間: 2025-3-22 08:16
https://doi.org/10.1007/978-3-642-83312-0Cyclosporin A (CsA), PSC833 and GF120918. We describe an investigation into the expression, using MRK16 and UIC2, and function of P-gp using daunorubicin with and without modulators by flow cytometric analysis on previously frozen blast cells from 27 patients with primary or secondary AML. We compar作者: 障礙物 時(shí)間: 2025-3-22 11:57 作者: geriatrician 時(shí)間: 2025-3-22 15:39 作者: geriatrician 時(shí)間: 2025-3-22 20:19 作者: 解決 時(shí)間: 2025-3-22 21:14 作者: endure 時(shí)間: 2025-3-23 04:34
V?ter, M?nner und kindliche Entwicklungcellular mechanisms underlying this increased expression are completely unknown. Point mutations in the .1 promoter have been found in osteogenic sarcoma (Stein et al., Eur J of Cancer, 30A: 1541–1545, 1994). We therefore analyzed DNA from hematological malignancies for .1 promoter point mutations. 作者: 正面 時(shí)間: 2025-3-23 06:15
https://doi.org/10.1007/978-3-322-85040-9ty can also be increased by combining the results of more than one assay. We have used a combination of flow cytometric assays to define MDR positive and negative blasts in 47 AML patients entered into MRC trials. Our primary test is a standardised and reproducible assay for anthracycline accumulati作者: 癡呆 時(shí)間: 2025-3-23 11:14
https://doi.org/10.1007/978-3-322-85040-9ence (NF), is related to cell compounds, i.e. proteins (1), nicotinic coenzymes (2), flavins (3), etc., engaged in structural and metabolic processes. Thus a correlation does exist between NF emission and morpho-functional state of cells.作者: Congruous 時(shí)間: 2025-3-23 17:22
https://doi.org/10.1007/978-3-322-85040-9ree-Wilson analysis and a combined Hansch/Free-Wilson analysis on a set of 48 compounds using artificial neural networks (ANN). In comparison to classical multiple linear regression (MLR) analysis, the ANN showed equal or even slightly better predictive power in leave one out cross validation proced作者: 擁護(hù) 時(shí)間: 2025-3-23 19:58
https://doi.org/10.1007/978-3-322-85040-9(P-gp) expression and function by flow cytometry. P-gp antigen expression was determined with the monoclonal antibodies 4E3 and MRK16. Transport function was assessed by measuring the modulating effect of verapamil on the intracellular retention of Rhodamine 123..P-gp positivity at relapse was not s作者: onlooker 時(shí)間: 2025-3-24 00:37 作者: Arthr- 時(shí)間: 2025-3-24 03:08 作者: 嫌惡 時(shí)間: 2025-3-24 09:55 作者: 沙文主義 時(shí)間: 2025-3-24 13:02 作者: 無聊的人 時(shí)間: 2025-3-24 18:12
https://doi.org/10.1007/978-3-322-85040-9e Pgp and MRP1 functions, respectively. There was a good correlation between MRP1 expression and the modulatory effect of probenecid (a specific modulator of MRP1) on the calcein efflux (r=0.91, p=0.0003) and between Pgp expression and the modulatory effect of CsA on calcein-AM uptake (r=0.96, p<0.0作者: Hypomania 時(shí)間: 2025-3-24 19:23
https://doi.org/10.1007/978-3-322-85040-9transcript levels of the chemoresistance genes mdr-1 and MRP, and the proto-oncogene bcl-2, by validated contamination-protected quantitative RT-PCR. In newly diagnosed AML mainly tumors of the granulocytic lineage (FAB M1-M2) expressed increased mdr-1 mRNA amounts. The MRP gene was expressed in all作者: Myosin 時(shí)間: 2025-3-25 02:15 作者: BUDGE 時(shí)間: 2025-3-25 07:19 作者: micronized 時(shí)間: 2025-3-25 10:48 作者: 怎樣才咆哮 時(shí)間: 2025-3-25 14:11
https://doi.org/10.1007/978-3-322-85040-9ence (NF), is related to cell compounds, i.e. proteins (1), nicotinic coenzymes (2), flavins (3), etc., engaged in structural and metabolic processes. Thus a correlation does exist between NF emission and morpho-functional state of cells.作者: Subjugate 時(shí)間: 2025-3-25 18:06 作者: Discrete 時(shí)間: 2025-3-25 21:32 作者: 糾纏,纏繞 時(shí)間: 2025-3-26 03:21 作者: 國(guó)家明智 時(shí)間: 2025-3-26 05:39
Multidrug Resistance Related Proteins in Primary Cutaneous Lymphomas then polychemotherapy is indicated. Multi-agent chemotherapy may induce long lasting complete remissions in CBCL’s. Most CTCL’s, especially mycosis fungoides (MF), and CD30 negative primary cutaneous large T-cell lymphoma (PCLTCL) respond poorly or partially to Multi-agent Chemotherapy.作者: 相反放置 時(shí)間: 2025-3-26 09:20
Book 1999e protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in- formation is provided on apoptosis and its regulators, and on the results of cell culture drug resista作者: 被詛咒的人 時(shí)間: 2025-3-26 14:41
https://doi.org/10.1007/978-94-015-9325-0ug resistance: (i) using multivariate analysis, MDR1 phenotype appears to be an independent variable, as potent (or higher) as karyo-type and age for predicting . drug resistance; (ii) the prognostic value is limited to the CD34(+)/P-gp(+) phenotype, wich is linked to a functional P-gp; (iii) the . 作者: crutch 時(shí)間: 2025-3-26 17:11 作者: CLAIM 時(shí)間: 2025-3-26 22:19
Principles of Medical Treatmentphenotyping, hemogram, remission and outcome have been examined. We have measured the initial diagnosis, remission and relapse levels of P-gp by binding a specific monoclonal antibody (UIC2) and functional properties of the drug resistance with flow cytometry in childhood ALL and AML.作者: 不成比例 時(shí)間: 2025-3-27 02:16
https://doi.org/10.1007/978-3-642-83312-0ify individual patients whose cells exhibited P-gp expression and function teamed with . resistance to, and modification of, the anthracyclines. Furthermore, it is possible to identify which modulator had the greatest effect. The fact that we obtained higher indications of resistance reversal using 作者: 向宇宙 時(shí)間: 2025-3-27 07:34
Yeasts in Pregnancy and Neonatal Mycoses, 8 months in patients treated with chemotherapy alone (p=0.01). In PGP negative patients, median KM survival was 14 months in patients allocated to the quinine group, and 14 months in patients treated with chemotherapy alone. Side effects of quinine mainly included vertigo and tinnitus that generall作者: callous 時(shí)間: 2025-3-27 13:01
Genital Colonization in the Female Sex,nfusion at a rate of 10 mg/kg/24h for 5 or 6 days, depending on the duration of chemotherapy. In both studies a loading dose of 2 mg/kg of PSC 833 was given on day 1. In the 5-day regimen, the final study doses of the cytotoxic agents were C 1 g/m./d, M 4.0 mg/m./d, and E 40 mg/m./d. In the 6-day re作者: 耕種 時(shí)間: 2025-3-27 17:34
Vygotsky and Informal Science Learning ICC. Results of Pgp expression were consistent on FCM and ICC in 23 of the 28 (82%) samples tested. Overall, Pgp expression was observed by ICC or FCM in 23 (67%) patients, including 11 (58%) newly diagnosed patients and 12 (80%) patients in relapse. Functional Rh123 efflux (Rh123+) was observed in作者: Angiogenesis 時(shí)間: 2025-3-27 20:19
https://doi.org/10.1007/978-1-4899-2614-25a patient which is the first report of MDR-3 Pgp expression being detected in AML; suggesting that MDR-3 Pgp expression may be limited to particular subtypes of this disease..Results from B-NHL cases were inconclusive with varying expression of MDR-1 and MDR-3 Pgps observed. Work is currently under作者: 文藝 時(shí)間: 2025-3-28 00:50
V?ter, M?nner und kindliche Entwicklung Sequence analysis revealed that all patients were heterozygous for a point mutation in the promoter (T-C transition at +8). Four normals (4%) were found to be heterozygous for the mutation. Confirmation of the mutation was performed by oligonucleotide probe hybridization. All but two of the AML pat作者: Blasphemy 時(shí)間: 2025-3-28 02:06
https://doi.org/10.1007/978-3-322-85040-947 (57%) samples had both low dnr accumulation and at least one positive confirmatory test (a modulated functional assay and/or protein overexpression) and were categorised as “confirmed MDR”. 15/47 patients (32%) were MDR negative in all 4 assays. 5/47 (11%) patients had unconfirmed low dnr accumul作者: BLUSH 時(shí)間: 2025-3-28 08:25
https://doi.org/10.1007/978-3-322-85040-9 were functionally inactive. In 10/12 and 13/15 samples however, an efflux pump was active and dependent of verapamil, but without detectable antigen. The functional flow cytometric assay allows evaluation of non-P-gp efflux pumps and, therefore, is more clinically relevant since it may better ident作者: Diskectomy 時(shí)間: 2025-3-28 13:54
https://doi.org/10.1007/978-3-322-85040-9negative patients but only 8 months for LRP-positive patients (p = 0.006). Disease-free survival was 9 months for LRP-negative patients and 6 months for LRP-positive patients (p = 0.078). Thus LRP predicts for poor outcome indicating that the LRP gene is a clinically relevant drug resistance gene in作者: 溫順 時(shí)間: 2025-3-28 16:30
https://doi.org/10.1007/978-3-322-85040-9 to patients with low MRP expression. MRP does not predict for response to induction chemotherapy but intermediate or high MRP expression might be associated with shorter overall survival of the patients.作者: ARC 時(shí)間: 2025-3-28 21:37 作者: Peristalsis 時(shí)間: 2025-3-28 23:59
https://doi.org/10.1007/978-3-322-85040-9odulatory effect of CsA on calcein-AM uptake (r=0.83, p<0.0001). Pgp activity was higher in CD34+ leukemia than in CD34- leukemia (2.26±1.50 vs 1.46±1.21 respectively, p=0.003) and MRP1 activity was higher in CD34- leukemia than in CD34+ leukemia (1.77±0.40 vs 1.4±0.29 respectively, p=0.004). Pgp ex作者: 啪心兒跳動(dòng) 時(shí)間: 2025-3-29 07:00 作者: Mutter 時(shí)間: 2025-3-29 07:58
0065-2598 ic, such as for glucocorticoids and antifolates. Much in- formation is provided on apoptosis and its regulators, and on the results of cell culture drug resista978-1-4613-7180-9978-1-4615-4811-9Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 包裹 時(shí)間: 2025-3-29 14:52 作者: Soliloquy 時(shí)間: 2025-3-29 18:01
Clinical Significance of P-Glycoprotein (P-gp) Expression in Childhood Acute Lymphoblastic Leukemian the P-gp positive group was significantly worse (Logrank P=0.009) than in the P-gp negative patients. In the relapsed patient population 10/12 P-gp positive cases experienced an unfavourable outcome compared with 10/22 P-gp negative patients [Risk Ratio 2.21 (0.90–5.45)]. .: P-glycoprotein express作者: grotto 時(shí)間: 2025-3-29 20:08 作者: 粗鄙的人 時(shí)間: 2025-3-30 03:31
Comparison of P-Glycoprotein Expression and Function with , Sensitivity to Anthracyclines in AMLify individual patients whose cells exhibited P-gp expression and function teamed with . resistance to, and modification of, the anthracyclines. Furthermore, it is possible to identify which modulator had the greatest effect. The fact that we obtained higher indications of resistance reversal using 作者: 強(qiáng)化 時(shí)間: 2025-3-30 08:07
Quinine Improves Results of Intensive Chemotherapy (IC) in Myelodysplastic Syndromes (MDS) Expressin 8 months in patients treated with chemotherapy alone (p=0.01). In PGP negative patients, median KM survival was 14 months in patients allocated to the quinine group, and 14 months in patients treated with chemotherapy alone. Side effects of quinine mainly included vertigo and tinnitus that generall作者: 松果 時(shí)間: 2025-3-30 08:15 作者: epidermis 時(shí)間: 2025-3-30 13:16 作者: Homocystinuria 時(shí)間: 2025-3-30 18:44
Preliminary Immunocytochemical Studies of MDR-1 and MDR-3 Pgp Expression in B-Cell Leukaemias5a patient which is the first report of MDR-3 Pgp expression being detected in AML; suggesting that MDR-3 Pgp expression may be limited to particular subtypes of this disease..Results from B-NHL cases were inconclusive with varying expression of MDR-1 and MDR-3 Pgps observed. Work is currently under作者: 騷動(dòng) 時(shí)間: 2025-3-31 00:26
A Mutation in the Promoter of the Multidrug Resistance Gene (,) in Human Hematological Malignancies Sequence analysis revealed that all patients were heterozygous for a point mutation in the promoter (T-C transition at +8). Four normals (4%) were found to be heterozygous for the mutation. Confirmation of the mutation was performed by oligonucleotide probe hybridization. All but two of the AML pat作者: AVERT 時(shí)間: 2025-3-31 01:05
Reproducible Flow Cytometric Methodology for Measuring Multidrug Resistance in Leukaemic Blasts47 (57%) samples had both low dnr accumulation and at least one positive confirmatory test (a modulated functional assay and/or protein overexpression) and were categorised as “confirmed MDR”. 15/47 patients (32%) were MDR negative in all 4 assays. 5/47 (11%) patients had unconfirmed low dnr accumul作者: padding 時(shí)間: 2025-3-31 07:27 作者: 減弱不好 時(shí)間: 2025-3-31 11:52
The Lung Resistance Protein (LRP) Predicts Poor Outcome in Acute Myeloid Leukemianegative patients but only 8 months for LRP-positive patients (p = 0.006). Disease-free survival was 9 months for LRP-negative patients and 6 months for LRP-positive patients (p = 0.078). Thus LRP predicts for poor outcome indicating that the LRP gene is a clinically relevant drug resistance gene in作者: 繼而發(fā)生 時(shí)間: 2025-3-31 17:09
MRP Expression in Acute Myeloid Leukemia to patients with low MRP expression. MRP does not predict for response to induction chemotherapy but intermediate or high MRP expression might be associated with shorter overall survival of the patients.作者: 憤慨點(diǎn)吧 時(shí)間: 2025-3-31 20:52
