標(biāo)題: Titlebook: Drug Resistance in Leishmania Parasites; Consequences, Molecu Alicia Ponte-Sucre,Emilia Diaz,Maritza Padrón-Niev Book 20131st edition Sprin [打印本頁(yè)] 作者: incontestable 時(shí)間: 2025-3-21 19:08
書目名稱Drug Resistance in Leishmania Parasites影響因子(影響力)
書目名稱Drug Resistance in Leishmania Parasites影響因子(影響力)學(xué)科排名
書目名稱Drug Resistance in Leishmania Parasites網(wǎng)絡(luò)公開度
書目名稱Drug Resistance in Leishmania Parasites網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Resistance in Leishmania Parasites被引頻次
書目名稱Drug Resistance in Leishmania Parasites被引頻次學(xué)科排名
書目名稱Drug Resistance in Leishmania Parasites年度引用
書目名稱Drug Resistance in Leishmania Parasites年度引用學(xué)科排名
書目名稱Drug Resistance in Leishmania Parasites讀者反饋
書目名稱Drug Resistance in Leishmania Parasites讀者反饋學(xué)科排名
作者: Flinch 時(shí)間: 2025-3-21 22:42
Molecular Evolution and Phylogeny of , e increasingly used intrinsic characters to assign . organisms into different species, they are still heirs of the first classifications based primarily on extrinsic characters. The current classification system, which proposes up to 35 species, is based on multilocus enzyme electrophoresis which is作者: agenda 時(shí)間: 2025-3-22 04:17
The Role of Reservoirs: Canine Leishmaniasisns of dogs in Asia, Europe, North Africa, and South America and is an emergent disease in North America. Domestic dogs (.) are the major hosts for these parasites and the main reservoir hosts for human visceral infection..Recent years have seen important advances on the epidemiology, pathology, and 作者: 值得贊賞 時(shí)間: 2025-3-22 07:27 作者: Buttress 時(shí)間: 2025-3-22 11:58
The Role of the Immune System in Resistance to Infectiontion. The outcome of infection depends on the parasite species as well as host genetic factors and immune competence. In order to develop a successful infection, the . must evade both the innate and adaptive immune responses. Whilst protective immunity has been driven by Th1-type T cell responses, t作者: 妨礙議事 時(shí)間: 2025-3-22 15:00
Vaccination as a Control Measureimmune mechanisms for designing vaccines. The following section deals with the first-generation vaccines against cutaneous and visceral leishmaniasis and the candidates for second-generation vaccines, including live vaccines and vaccines based on purified and recombinant . antigens. Thereafter, the 作者: 妨礙議事 時(shí)間: 2025-3-22 18:32 作者: syring 時(shí)間: 2025-3-22 23:51 作者: COWER 時(shí)間: 2025-3-23 03:25
Visceral Leishmaniasisnt subset of patients with visceral leishmaniasis were not responding to SbV in the State of Bihar, India. Revised recommendations using tenfold more drug provided a transient reprieve; however, a large proportion of patients in India, and to some extent in Nepal, remained unresponsive to SbV. Besid作者: thwart 時(shí)間: 2025-3-23 09:31
American Tegumentary Leishmaniasispecies, and, thus, there are intraspecific parasitological dissimilarities that may generate different pathologies. Furthermore, in America, . spp. has diverse reservoirs (that may change continuously) and can use various vectors to infect humans and mammals. Antimonials are the drugs of choice for 作者: 口味 時(shí)間: 2025-3-23 12:44
Genetic Expression and Drug Resistance, the Role of Proteomicsis. However, since in ., the control of gene expression relies on the stability or processing of the mature mRNA, as well as on the posttranslational modifications of proteins, the genomic sequences alone are insufficient to predict protein expression within the parasites. In this scenario, proteomi作者: 神圣在玷污 時(shí)間: 2025-3-23 14:59
The Role of ABC Transporters in Drug-Resistant ,nt in prokaryotes and eukaryotes and are mainly involved in the transport of a variety of molecules across cellular membranes, whereas others are involved in biological processes unrelated to transport. The recent sequencing of the . species genome confirmed the presence of representatives, also cal作者: 河潭 時(shí)間: 2025-3-23 20:15
Functional Analysis of , Membrane (Non-ABC) Transporters Involved in Drug Resistancese transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potential for development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins作者: lipids 時(shí)間: 2025-3-23 22:57 作者: 廢止 時(shí)間: 2025-3-24 05:39
,Religionswissenschaftliche Hinführung,ues for better treatments may help improve this depressing picture. Experts in the field cover current knowledge and future trends of these and many other aspects of drug resistance in . in the present volume. This part offers a general introduction to the biology of ., a piece of knowledge fundamen作者: MOT 時(shí)間: 2025-3-24 09:39
A.S. Ginevsky,A. I. Zhelannikov and genetically isolated populations in all . species tested so far. A predominantly clonal evolution has been proposed for . with rare sexual recombination events. This hypothesis has repeatedly been challenged by the detection of hybrids, mosaic genotypes, and gene flow between populations, stron作者: 顯微鏡 時(shí)間: 2025-3-24 12:28 作者: 厚顏 時(shí)間: 2025-3-24 16:33
,Die Entwickelung der Zünfte in Deutschland,ented, with a particular emphasis on their relation with parasite drug resistance. The focus of this chapter is on antimonials since we have most experience in the field and in the lab with them. Although these drugs are currently being abandoned as first-line treatment in the Indian subcontinent, w作者: HERTZ 時(shí)間: 2025-3-24 22:52 作者: 橢圓 時(shí)間: 2025-3-25 02:03 作者: lymphoma 時(shí)間: 2025-3-25 05:37 作者: pacifist 時(shí)間: 2025-3-25 09:38
https://doi.org/10.1007/978-1-349-00207-8prognosis, and for control of the disease. The present chapter offers a description of American tegumentary leishmaniasis, a fundamental piece of knowledge for the comprehension of the challenges we face for leishmaniasis in times of drug resistance. As a way to better understand the unique scenario作者: 一瞥 時(shí)間: 2025-3-25 11:50 作者: BIDE 時(shí)間: 2025-3-25 17:22
https://doi.org/10.1007/978-1-349-00207-8ociation of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.作者: Ordnance 時(shí)間: 2025-3-25 20:01
https://doi.org/10.1007/978-1-349-00207-8antioxidant pathways, e.g., nonprotein thiols, protects parasites from antimony-mediated oxidative stress. Indeed, in antimony-resistant strains, the increased biosynthesis of trypanothione (a bis(glutathionyl)spermidine conjugate, T[SH]2), the major intracellular thiol of . parasites, occurs, follo作者: 不能逃避 時(shí)間: 2025-3-26 01:36
,Introduction: Leishmaniasis – The Biology of a Parasite,ues for better treatments may help improve this depressing picture. Experts in the field cover current knowledge and future trends of these and many other aspects of drug resistance in . in the present volume. This part offers a general introduction to the biology of ., a piece of knowledge fundamen作者: Pander 時(shí)間: 2025-3-26 04:23 作者: intolerance 時(shí)間: 2025-3-26 11:47
The Role of Reservoirs: Canine Leishmaniasis develop clinical manifestations. This fact cannot be ignored since asymptomatic dogs are infectious to phlebotomine vectors, although at a lower risk than symptomatic dogs. Moreover, dogs never achieve parasitological cure. This fact and the widespread use of the available anti-. drugs for both can作者: TEN 時(shí)間: 2025-3-26 16:00
Epidemiology of Leishmaniasis in the Time of Drug Resistanceented, with a particular emphasis on their relation with parasite drug resistance. The focus of this chapter is on antimonials since we have most experience in the field and in the lab with them. Although these drugs are currently being abandoned as first-line treatment in the Indian subcontinent, w作者: Arteriography 時(shí)間: 2025-3-26 20:21 作者: 衣服 時(shí)間: 2025-3-26 23:06
Vaccines: Past, Present, and Futuresand fly saliva are evaluated as possible vaccine candidates in laboratories across the world, there has been no success in the clinic. The quest for an effective vaccine candidate continues. Progress in understanding . pathogenesis and host immunity coupled with the completion of . genome sequence 作者: 違法事實(shí) 時(shí)間: 2025-3-27 03:32 作者: Diuretic 時(shí)間: 2025-3-27 06:59
American Tegumentary Leishmaniasisprognosis, and for control of the disease. The present chapter offers a description of American tegumentary leishmaniasis, a fundamental piece of knowledge for the comprehension of the challenges we face for leishmaniasis in times of drug resistance. As a way to better understand the unique scenario作者: acetylcholine 時(shí)間: 2025-3-27 09:58 作者: Assemble 時(shí)間: 2025-3-27 15:25
The Role of ABC Transporters in Drug-Resistant ,ociation of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.作者: 斥責(zé) 時(shí)間: 2025-3-27 20:44
Intracellular Mechanisms of Resistanceantioxidant pathways, e.g., nonprotein thiols, protects parasites from antimony-mediated oxidative stress. Indeed, in antimony-resistant strains, the increased biosynthesis of trypanothione (a bis(glutathionyl)spermidine conjugate, T[SH]2), the major intracellular thiol of . parasites, occurs, follo作者: grudging 時(shí)間: 2025-3-28 01:45
and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.978-3-7091-1125-3作者: 詳細(xì)目錄 時(shí)間: 2025-3-28 05:07
https://doi.org/10.1007/978-3-658-29715-2systems is being discussed. The final section highlights novel vaccination strategies based on the unique immunostimulatory and immunoregulatory functions of dendritic cells and considers future prospects of in situ targeting of dendritic cells.作者: 膽小懦夫 時(shí)間: 2025-3-28 07:08 作者: PIZZA 時(shí)間: 2025-3-28 12:25 作者: glisten 時(shí)間: 2025-3-28 17:30 作者: Heterodoxy 時(shí)間: 2025-3-28 21:02 作者: 燒烤 時(shí)間: 2025-3-29 01:33
ng in the area of infectious disease and vaccine developmentOne of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select 作者: animated 時(shí)間: 2025-3-29 03:30 作者: dragon 時(shí)間: 2025-3-29 11:14
Book 20131st editionScientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.作者: legacy 時(shí)間: 2025-3-29 14:15 作者: 只有 時(shí)間: 2025-3-29 17:00 作者: bioavailability 時(shí)間: 2025-3-29 20:45 作者: 生命層 時(shí)間: 2025-3-30 01:02 作者: 發(fā)炎 時(shí)間: 2025-3-30 05:13 作者: Ingrained 時(shí)間: 2025-3-30 08:22
,Religionswissenschaftliche Hinführung,ally resistant to classical drugs; additionally, current therapies may induce drug resistance. Treatment failure in leishmaniasis therefore has diverse causes. Some are related to drugs, such as pharmacokinetic properties, toxicity, use of suboptimal doses or high cost of treatment. Parasite-related作者: FRAUD 時(shí)間: 2025-3-30 12:21
A.S. Ginevsky,A. I. Zhelannikove increasingly used intrinsic characters to assign . organisms into different species, they are still heirs of the first classifications based primarily on extrinsic characters. The current classification system, which proposes up to 35 species, is based on multilocus enzyme electrophoresis which is作者: Cuisine 時(shí)間: 2025-3-30 18:21 作者: corn732 時(shí)間: 2025-3-30 20:58
,Die Entwickelung der Zünfte in Deutschland,hallenged by three major escalating risk factors: human-made and environmental changes, immune status (essentially because of ./HIV co-infection), and treatment failure and drug resistance. The epidemiology of drug resistance is very much codetermined by other factors that threaten control of the di作者: Dna262 時(shí)間: 2025-3-31 01:20 作者: 拖網(wǎng) 時(shí)間: 2025-3-31 06:33 作者: sinoatrial-node 時(shí)間: 2025-3-31 09:24
Initiativen im Politikfeld Gesundheit,concern and classified as a category I disease by the WHO (emerging and uncontrolled), it is unfortunately neglected by most of the health agencies. The high prevalence and incidence of the disease throughout the world to epidemic proportions, coupled with the increasing incidence of drug resistance
