標題: Titlebook: Drug Resistance; William N. Hait Book 1996 Kluwer Academic Publishers 1996 DNA.Drogen.apoptosis.breast cancer.cancer.chemotherapy.drug.dru [打印本頁] 作者: polysomnography 時間: 2025-3-21 20:04
書目名稱Drug Resistance影響因子(影響力)
書目名稱Drug Resistance影響因子(影響力)學(xué)科排名
書目名稱Drug Resistance網(wǎng)絡(luò)公開度
書目名稱Drug Resistance網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Resistance被引頻次
書目名稱Drug Resistance被引頻次學(xué)科排名
書目名稱Drug Resistance年度引用
書目名稱Drug Resistance年度引用學(xué)科排名
書目名稱Drug Resistance讀者反饋
書目名稱Drug Resistance讀者反饋學(xué)科排名
作者: debble 時間: 2025-3-21 21:12
Multidrug Resistance Associated with Overexpression of MRP of tumors, such as non-small cell lung carcinomas, this resistance is inherent, while in others (e.g., acute myelogenous leukemia) it is acquired during treatment. The problem of drug resistance has been studied in the laboratory primarily by using drug-selected, cultured tumor cell lines as model 作者: Indict 時間: 2025-3-22 01:29
Mechanisms of Resistance to Alkylating Agentse result of the induction of a variety of protective mechanisms or the result of the selection of resistant clones. In some cases, neoplastic cells may also have a high intrinsic level of resistance [2]. Alkylating agents, particularly agents that alkylate preferentially at the O6 position of guanin作者: 提升 時間: 2025-3-22 05:01
Glutathione S-Transferaseschemoprotectant. In the human, levels of GSH range from 30μM in plasma to 3mM in kidney proximal tubules; tumors of various organs can contain up to 10mM GSH [1]. GSH is synthesized via the γ-glutamyl cycle (Figure 4–1). The rate-limiting step is catalyzed by γ-glutamylcysteine synthetase (γ-GCS) to作者: 容易做 時間: 2025-3-22 11:12
Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guaninents includes the methylating agents, temozolomide, procarbazine, dacarbazine (DTIC), and steptozotocin, and the chloroethylating agents, carmustine (1,3 bis-chloroethyl 2-nitrosourea, BCNU), lomustine (3-cyclohexyl-1-chloroethyl-nitrosourea, CCNU), (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarC作者: nerve-sparing 時間: 2025-3-22 12:56 作者: nerve-sparing 時間: 2025-3-22 18:58 作者: 鞭子 時間: 2025-3-23 00:04 作者: CRASS 時間: 2025-3-23 03:26 作者: 顯赫的人 時間: 2025-3-23 05:38
Cellular Resistance to Topoisomerase Poisonstous in nature and are required for the regulation of DNA structure (topology) in the cell. Specifically, DNA topoisomerases regulate the coiling of the DNA double helix, a parameter critical for processes such as replication and transcription. Topoisomerases alter DNA coiling by transiently cleavin作者: 擦掉 時間: 2025-3-23 13:27 作者: 潛伏期 時間: 2025-3-23 16:34
Androgen Receptor Mutations in Prostate Cancerincreased use of prostate-specific antigen (PSA) for screening, aging of the population, declining mortality from other causes such as cardiac disease, and environmental and dietary factors that have contributed to prostate carcinogenesis. In 1995 it was estimated that 244,000 new cases of prostate 作者: Ballad 時間: 2025-3-23 19:13 作者: 一再煩擾 時間: 2025-3-24 01:56 作者: 流逝 時間: 2025-3-24 06:23 作者: LAST 時間: 2025-3-24 09:32 作者: CHARM 時間: 2025-3-24 11:48
Authenticity in Documentary-Makingsteinyl glycine by γ-glutamyltranspeptidase; GSH, as a nucleophile, is utilized as a cofactor in a variety of detoxification reactions. Among the enzymes that employ GSH in this manner are the glutathione S-transferases.作者: 大吃大喝 時間: 2025-3-24 15:35
Guidance Engineer Sergei Khrushchevcancer cells to paclitaxel can result in (1) design of better therapeutic modalities (drug combinations, sequences, schedule of treatment) for the treatment of cancer patients; (2) development of appropriate experimental models that represent as closely as possible the clinical cause of paclitaxel i作者: angiography 時間: 2025-3-24 21:04 作者: 者變 時間: 2025-3-25 00:48 作者: 新奇 時間: 2025-3-25 05:43 作者: Flavouring 時間: 2025-3-25 09:49 作者: 公理 時間: 2025-3-25 14:32
Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapyact that profound biological effects had been observed upon substitution of fluorine for hydrogen in several classes of compounds, it was postulated that fluorine-substituted pyrimidine analogs might display selective antitumor activity.作者: 笨重 時間: 2025-3-25 18:13 作者: 轉(zhuǎn)換 時間: 2025-3-25 22:56 作者: 嚴厲譴責 時間: 2025-3-26 03:50
0927-3042 This comprehensive volumeshould be of value for basic and clinical scientists who wish to delvemore deeply into this intriguing problem in the laboratory anddevastating problem in the clinic.978-1-4612-8540-3978-1-4613-1267-3Series ISSN 0927-3042 Series E-ISSN 2509-8497 作者: 緩解 時間: 2025-3-26 06:43
Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antinatologists care for patients with hemophilia and HIV infection, or patients with HIV-associated hematologic disorders, such as immune thrombocytopenia, antiphospholipid antibodies, chronic cytopenias, and thrombotic thrombocytopenic purpura.作者: FLASK 時間: 2025-3-26 10:07
Acquisition of an Antiestrogen-Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular implicated [2]. Estrogens may function as carcinogens and/or cocarcinogens [2,3], but it is their role as promoters of the growth of estrogen-dependent and estrogen-responsive tumors through activation of their nuclear receptors [2] that has provided a rationale for the design of therapeutic strategies, that is, antiestrogens.作者: Hiatus 時間: 2025-3-26 16:20
Book 1996leading investigators in thefield have reviewed the most basic mechanisms of drug resistance, andhave proposed ways to modulate resistance. This comprehensive volumeshould be of value for basic and clinical scientists who wish to delvemore deeply into this intriguing problem in the laboratory anddevastating problem in the clinic.作者: 招人嫉妒 時間: 2025-3-26 18:43 作者: outer-ear 時間: 2025-3-26 21:16
https://doi.org/10.1057/9781137485335 Following the characterization and synthesis of folic acid in 1946, a number of analogues were synthesized and tested [3]. The first derivative was x-methyl-folic acid, which produced changes in blood counts, particularly granulocytes, and bone marrow in rats [4]. However, this antagonist had no activity in humans.作者: 動機 時間: 2025-3-27 01:18
Victorian Writers and the Stagecancer would be diagnosed in the United States and prostate cancer would account for approximately 40,400 deaths in that year [1]. The magnitude of the prostate cancer problem has focused attention on the need for better therapies and effective prevention.作者: Antecedent 時間: 2025-3-27 06:40 作者: Mast-Cell 時間: 2025-3-27 09:26 作者: NATTY 時間: 2025-3-27 16:48
“Cosmonaut 13”: Vladimir Shatalov-DNA adducts, including O.-methylguanine (O.-mG). In cells with persistent O.-mG adducts, over 6,000 lesions are required to induce cell death [1]. In contrast, chloroethylating agents lead to the formation of DNA-interstrand crosslinks, only a few of which are required for cytotoxicity [2].作者: 樹木心 時間: 2025-3-27 20:41
Mechanisms of Resistance to Alkylating Agentsentally useful mutations. Moreover, since the therapeutic indices of most alkylating agents are low, sublethal drug exposure is frequently encountered, and this produces an ideal selection environment.作者: 樹膠 時間: 2025-3-28 00:37 作者: 得意牛 時間: 2025-3-28 05:33 作者: 可商量 時間: 2025-3-28 08:29 作者: 脊椎動物 時間: 2025-3-28 14:07 作者: 詼諧 時間: 2025-3-28 17:39
https://doi.org/10.1007/978-1-4613-1267-3DNA; Drogen; apoptosis; breast cancer; cancer; chemotherapy; drug; drug resistance; hormones; immunodeficienc作者: Collected 時間: 2025-3-28 22:15
978-1-4612-8540-3Kluwer Academic Publishers 1996作者: Ischemia 時間: 2025-3-28 23:51
https://doi.org/10.1057/9781137477972istance (MDR) is an important mechanism of cellular resistance to the cytotoxic activity of certain chemotherapeutic agents. Tumor cells selected for the MDR phenotype overexpress the .1 gene product, P-glycoprotein (P-gp), a membrane-bound drug efflux pump that confers resistance to a broad range o作者: mitral-valve 時間: 2025-3-29 04:49
M. Ramesh,Xun Wu,Michael Howlett of tumors, such as non-small cell lung carcinomas, this resistance is inherent, while in others (e.g., acute myelogenous leukemia) it is acquired during treatment. The problem of drug resistance has been studied in the laboratory primarily by using drug-selected, cultured tumor cell lines as model 作者: 憂傷 時間: 2025-3-29 08:07 作者: habile 時間: 2025-3-29 14:59 作者: Lineage 時間: 2025-3-29 18:57
“Cosmonaut 13”: Vladimir Shatalovnts includes the methylating agents, temozolomide, procarbazine, dacarbazine (DTIC), and steptozotocin, and the chloroethylating agents, carmustine (1,3 bis-chloroethyl 2-nitrosourea, BCNU), lomustine (3-cyclohexyl-1-chloroethyl-nitrosourea, CCNU), (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarC作者: 音樂學(xué)者 時間: 2025-3-29 21:29 作者: Electrolysis 時間: 2025-3-30 02:16 作者: 四海為家的人 時間: 2025-3-30 05:25
https://doi.org/10.1057/9781137485335oncept of antimetabolite was conceived in 1940 when Woods and Fildes described the activity of sulfonamides on bacteria and suggested that the antimicrobial effect was related to some sort of competition with the normal utilization of p-aminobenzoic acid, a fundamental metabolite for bacteria [1,2].作者: 游行 時間: 2025-3-30 08:38 作者: SNEER 時間: 2025-3-30 14:44 作者: eardrum 時間: 2025-3-30 20:28
https://doi.org/10.1057/9781137504685ated to be one million by the year 2000 [1]. The factors responsible for the genesis of breast cancer remain unclear, but estrogens have been strongly implicated [2]. Estrogens may function as carcinogens and/or cocarcinogens [2,3], but it is their role as promoters of the growth of estrogen-depende作者: KEGEL 時間: 2025-3-31 00:42
