標(biāo)題: Titlebook: Drug Receptors and Their Effectors; Biological Council S Nigel J. M. Birdsall Conference proceedings 1981Latest edition Macmillan Publisher [打印本頁] 作者: 宗派 時(shí)間: 2025-3-21 17:21
書目名稱Drug Receptors and Their Effectors影響因子(影響力)
書目名稱Drug Receptors and Their Effectors影響因子(影響力)學(xué)科排名
書目名稱Drug Receptors and Their Effectors網(wǎng)絡(luò)公開度
書目名稱Drug Receptors and Their Effectors網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Receptors and Their Effectors被引頻次
書目名稱Drug Receptors and Their Effectors被引頻次學(xué)科排名
書目名稱Drug Receptors and Their Effectors年度引用
書目名稱Drug Receptors and Their Effectors年度引用學(xué)科排名
書目名稱Drug Receptors and Their Effectors讀者反饋
書目名稱Drug Receptors and Their Effectors讀者反饋學(xué)科排名
作者: morale 時(shí)間: 2025-3-21 22:37 作者: Triglyceride 時(shí)間: 2025-3-22 04:21
Interactions of muscarinic receptors with guanine nucleotides and adenylate cyclase,detailed knowledge of the properties of the binding site, particularly in the brain (Hulme ., 1978; Birdsall ., 1978, 1980.; Galper ., 1977), and despite the identification and characterisation of a plethora of responses elicited by muscarinic agonists in whole cells and tissues (Birdsall and Hulme,作者: Adenocarcinoma 時(shí)間: 2025-3-22 05:20 作者: cancellous-bone 時(shí)間: 2025-3-22 08:44 作者: FUSC 時(shí)間: 2025-3-22 12:55
Implantation of hormone receptors: fusion of membrane components with cell membranes,elling of the underlying mechanisms at the molecular level has been rather slow. Biochemical characterisation of the components required solubilisation of the membrane molecules in detergents, which resulted almost invariably in the loss of biological activity of the receptor-response system. Recons作者: FUSC 時(shí)間: 2025-3-22 19:52
Hormonal control of ion permeability of the pancreatic acinar cell membrane mediated by intracellulrmeability responses are mediated by changes in cytosolic ionised calcium concentration (Petersen, 1976, 1980; Bülbring and Tomita, 1977; Putney, 1979). The pancreatic acini would appear to provide a good model for the study of the mechanisms underlying hormonal control of plasma membrane permeabili作者: infarct 時(shí)間: 2025-3-22 22:06
Phosphatidylinositol metabolism and calcium gating in a 5-HT receptor system,onsible for generating intracellular signals such as cyclic AMP or calcium. These two second messengers seem to be associated with the action of a wide range of agonists. The generation of these messengers is mediated through two different types of receptor. The adrenergic system is a good example i作者: 裂隙 時(shí)間: 2025-3-23 01:28
Interaction of fluorescent analogues of acetylcholine with nicotinic acetylcholine receptors and acs in which the events at the neuromuscular junction may be simulated .. Since this time range is of the order of milliseconds, rapid kinetic techniques have to be employed. Suitable ligands for such studies require the following combination of properties: (1) they must have suitable spectroscopic pr作者: 整頓 時(shí)間: 2025-3-23 08:03 作者: ANA 時(shí)間: 2025-3-23 10:29 作者: antedate 時(shí)間: 2025-3-23 14:58
Adrenocorticotrophin-(1-24)-tetrakosipeptide spans lipid membranes: experiments with liposomes,-(1-24)-tetrakosipeptide (ACTH.) and artificial planar lipid-bilayer membranes was revealed. After addition of ACTH. to one side of the pure lipid membrane, the hormone molecules are adsorbed in a rapid, reversible reaction, whereupon, in a slow reaction, parts of the individual molecules, presumabl作者: Heart-Attack 時(shí)間: 2025-3-23 20:22 作者: 上下倒置 時(shí)間: 2025-3-23 23:42
Biosynthesis and turnover of nicotinic acetylcholine receptors, considered as a lipid bilayer with associated proteins or a two-dimensional micellar array of ordered units. Today most students of plasma membrane structure consider this matter settled in favour of the lipid bilayer, and the overall focus of today is on the dynamic aspects of plasma membrane; the作者: 議程 時(shí)間: 2025-3-24 02:33
The summing up,ed to the cell interior and those already in the interior. The first of these classes is embedded in a membrane and is constrained to act in two dimensions, and it is all too tempting to regard the lipid phase of the membrane as a passive supporting matrix, yet the effects on phospholipid turnover d作者: hypnotic 時(shí)間: 2025-3-24 08:57 作者: cortex 時(shí)間: 2025-3-24 14:45 作者: NOTCH 時(shí)間: 2025-3-24 17:11
Implantation of hormone receptors: fusion of membrane components with cell membranes,nditions of concentration, polarity, etc., under which the solubilised components would associate properly to produce the functional complex. Thus, crude and purified preparations of receptors were obtained which demonstrated specific binding of antagonists or agonists but failed to demonstrate biol作者: 多骨 時(shí)間: 2025-3-24 22:52
Hormonal control of ion permeability of the pancreatic acinar cell membrane mediated by intracellul 1978.). Electrophysiological investigations with several intracellular microelectrodes and extra- and intracellular micro-application of drugs are feasible due to the thinness of the mouse pancreas, allowing easy visualisation of individual cells in the living tissue (Iwatsuki and Petersen, 1978., 作者: 沒有貧窮 時(shí)間: 2025-3-25 00:53 作者: Physiatrist 時(shí)間: 2025-3-25 05:40
Novel regulations in steroid action: role of receptor subunits and chromosomal proteins in nuclear iefly reviews recent investigations of the function of certain non-histone chromosomal proteins and DNA in the binding of the chick oviduct progesterone receptor (P-R) to nuclear binding sites (or nuclear ‘a(chǎn)cceptor’ sites). During the course of these studies, significant modulations in the capacity 作者: Diuretic 時(shí)間: 2025-3-25 10:29 作者: 枯萎將要 時(shí)間: 2025-3-25 11:44
https://doi.org/10.1057/9781137029256in detail, the biochemical bases for one possible opiate receptor function. Although there are a considerable number of similarities between brain and NG108-15 opiate receptors, it should be noted that at present there is not any conclusive evidence that any of the physiological actions of opiates a作者: Bombast 時(shí)間: 2025-3-25 19:17 作者: disparage 時(shí)間: 2025-3-25 19:57 作者: 偉大 時(shí)間: 2025-3-26 00:51
A Virtue Ethical Case for Pacifismhanisms responsible for generating these second messengers. In the case of those receptors which function through cyclic AMP, a detailed biochemical description of how the receptor subunit may be coupled to adenylate cyclase is now available (Rodbell, 1980). Our understanding of how agonists activat作者: ascend 時(shí)間: 2025-3-26 04:52 作者: Banquet 時(shí)間: 2025-3-26 10:23 作者: VALID 時(shí)間: 2025-3-26 13:55 作者: 親愛 時(shí)間: 2025-3-26 18:13
Adrenocorticotrophin-(1-24)-tetrakosipeptide spans lipid membranes: experiments with liposomes,brane, the hormone molecules are adsorbed in a rapid, reversible reaction, whereupon, in a slow reaction, parts of the individual molecules, presumably their .-termini, become exposed to the aqueous solution on the opposite side (Schoch ., 1979.; see figure 12.1).作者: Water-Brash 時(shí)間: 2025-3-26 22:24
https://doi.org/10.1057/9781137280299operties, such as fluorescence with high quantum yield, and excitation and emission remote from the ultraviolet-absorption range of proteins; (2) their pharmacological properties must closely resemble those of the natural transmitter and, in particular, must be uncomplicated by side effects which may obscure interpretation of kinetic data.作者: Euphonious 時(shí)間: 2025-3-27 04:30
Kate Vitasek,Mike Ledyard,Karl Manrodt thermal motions of membrane lipid and protein molecules, the mechanisms of association of some integral and peripheral membrane proteins with the membrane, the importance of cytoskeleton-membrane interactions, and metabolic studies of the membrane constituents.作者: Credence 時(shí)間: 2025-3-27 06:37
Robert K. Garcia,Nathan L. Kingon of agents that block neurotransmission (see, for example, Paton and Zaimis, 1949). But it is only recently that the reasons for these differences at the level of the receptors and ion channels have been investigated rigorously.作者: 襲擊 時(shí)間: 2025-3-27 12:23
The kinetics of conductance changes at nicotinic receptors of the muscle end-plate and of ganglia,on of agents that block neurotransmission (see, for example, Paton and Zaimis, 1949). But it is only recently that the reasons for these differences at the level of the receptors and ion channels have been investigated rigorously.作者: 反抗者 時(shí)間: 2025-3-27 15:05 作者: Vasoconstrictor 時(shí)間: 2025-3-27 21:12
Biosynthesis and turnover of nicotinic acetylcholine receptors, thermal motions of membrane lipid and protein molecules, the mechanisms of association of some integral and peripheral membrane proteins with the membrane, the importance of cytoskeleton-membrane interactions, and metabolic studies of the membrane constituents.作者: morale 時(shí)間: 2025-3-27 23:57 作者: Enteropathic 時(shí)間: 2025-3-28 02:36 作者: Banister 時(shí)間: 2025-3-28 10:01 作者: Oscillate 時(shí)間: 2025-3-28 14:09 作者: Cirrhosis 時(shí)間: 2025-3-28 18:06
https://doi.org/10.1057/9781137029256ite the identification and characterisation of a plethora of responses elicited by muscarinic agonists in whole cells and tissues (Birdsall and Hulme, 1976), the nature of the membrane macromolecules with which the receptor interacts . has, until recently, been more a matter for speculation than of firm evidence.作者: fibroblast 時(shí)間: 2025-3-28 22:21
Victor Dudman‘s Grammar and Semanticswithin the membrane which finally lead to the characteristic response of the cell. Recent work in our laboratory has shown that the methylation of phospholipids are important events in the receptor-mediated transmission of signals through membranes.作者: Hiatal-Hernia 時(shí)間: 2025-3-29 01:00 作者: Console 時(shí)間: 2025-3-29 03:19
Robert K. Garcia,Nathan L. Kingused on the channel associated with the acetylcholine receptor in the postsynaptic membrane of the nicotinic synapse. For several decades this junction has provided advances in our understanding of synaptic transmission.作者: ERUPT 時(shí)間: 2025-3-29 08:55 作者: 容易做 時(shí)間: 2025-3-29 11:48
https://doi.org/10.1057/9781137020406tion of drugs resulted from their physicochemical interaction with a defined site. At that time this principle was revolutionary and presaged the development of modern pharmacology, starting with the classification of different drug receptors (see, for example, Dale, 1914) and the quantitation of dr作者: 微不足道 時(shí)間: 2025-3-29 19:22 作者: florid 時(shí)間: 2025-3-29 19:59
https://doi.org/10.1057/9781137029256detailed knowledge of the properties of the binding site, particularly in the brain (Hulme ., 1978; Birdsall ., 1978, 1980.; Galper ., 1977), and despite the identification and characterisation of a plethora of responses elicited by muscarinic agonists in whole cells and tissues (Birdsall and Hulme,作者: duplicate 時(shí)間: 2025-3-30 01:18
https://doi.org/10.1057/9781137029256 reviews see Reynolds and Randall, 1957; Lewis ., 1971; Clouet, 1971, Winter, 1975; Kosterlitz ., 1973). However, with the exception of studies indicating a presynaptic action of opiates which prevents Ca.-dependent transmitter release and the more recent findings of a postsynaptic action of opiates作者: 光亮 時(shí)間: 2025-3-30 04:54 作者: 租約 時(shí)間: 2025-3-30 08:58 作者: Interferons 時(shí)間: 2025-3-30 13:05 作者: enfeeble 時(shí)間: 2025-3-30 17:11
A Virtue Ethical Case for Pacifismonsible for generating intracellular signals such as cyclic AMP or calcium. These two second messengers seem to be associated with the action of a wide range of agonists. The generation of these messengers is mediated through two different types of receptor. The adrenergic system is a good example i
