標(biāo)題: Titlebook: Drug Metabolite Isolation and Determination; Eric Reid,J. P. Leppard Book 1983 Plenum Press, New York 1983 carboxylic acid.chromatography. [打印本頁(yè)] 作者: Denial 時(shí)間: 2025-3-21 18:50
書(shū)目名稱Drug Metabolite Isolation and Determination影響因子(影響力)
書(shū)目名稱Drug Metabolite Isolation and Determination影響因子(影響力)學(xué)科排名
書(shū)目名稱Drug Metabolite Isolation and Determination網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Drug Metabolite Isolation and Determination網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Drug Metabolite Isolation and Determination被引頻次
書(shū)目名稱Drug Metabolite Isolation and Determination被引頻次學(xué)科排名
書(shū)目名稱Drug Metabolite Isolation and Determination年度引用
書(shū)目名稱Drug Metabolite Isolation and Determination年度引用學(xué)科排名
書(shū)目名稱Drug Metabolite Isolation and Determination讀者反饋
書(shū)目名稱Drug Metabolite Isolation and Determination讀者反饋學(xué)科排名
作者: TOXIN 時(shí)間: 2025-3-21 22:49
of conjugation reactions at end of concluding article). Appre- ciation is also expressed for permission to reproduce published mat- erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.978-1-4684-4486-5978-1-4684-4484-1作者: IRK 時(shí)間: 2025-3-22 02:55 作者: 變化 時(shí)間: 2025-3-22 05:15
A Novel Use of RIA and HPLC in the Identification of Plasma Metabolites of HR 158tabolites. The latter was used on eluate fractions in an HPLC system capable of separating the known and putative metabolites in human plasma. The resulting RIA-chromatogram allowed identification at ng/ml level.作者: Myofibrils 時(shí)間: 2025-3-22 12:36
Book 1983eparation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden- tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in thera作者: prostate-gland 時(shí)間: 2025-3-22 14:18 作者: prostate-gland 時(shí)間: 2025-3-22 20:04
https://doi.org/10.1007/b138974of these columns and of their use in examining urinary constituents (human, rat) and in metabolic work with compounds related to catecholamines. When measuring previously unauthenticated compounds, identities must be confirmed by independent means because some of the numerous urinary constituents may interfere.作者: 外露 時(shí)間: 2025-3-22 23:19
Visual Content Processing and Representationh a large range of particle sizes. It is essential to remove the finer particles, since they drastically reduce the flow rate through an alumina column. The traditional way [1] entailing washing with water is inefficient as it removes little more than colloidal material, and is very-time consuming.作者: 半導(dǎo)體 時(shí)間: 2025-3-23 04:57 作者: 夾死提手勢(shì) 時(shí)間: 2025-3-23 07:53
Basic Steps in Vascular Reconstructionsthe most suitable analytical methods for monitoring exposure. These typically entail GC-ECD, and their development is in general based on a common major urinary metabolite or on the pesticide itself. Dose-excretion studies enable assays to be made on manufacturing operatives, formulators and sprayers.作者: 針葉類的樹(shù) 時(shí)間: 2025-3-23 10:29
Preparative Liquid-Chromatographic Methods in Drug Metabolism Studies isolated in quantities sufficient for full structure elucidation by spectroscopic and chemical methods. It can be applied to complex mixtures of metabolites of widely varying polarities. Since separation is done at low temperature, normally no stability problems arise. Recoveries can easily be checked if radioactively labelled drugs are used.作者: 得罪 時(shí)間: 2025-3-23 14:34
Assessment of Radioactivity Measurements on HPLC Effluents.D. of the peak volume should be less than 0.5, to minimize the possible influence of collection regime. With small fractions, however, the long counting periods needed for high sensitivity and precision [3] delay the procurement of the chromatographic results. Off-line counting is also disadvantageous in respect of time and materials costs.作者: Conflict 時(shí)間: 2025-3-23 18:29
The Use of Long Capillary GC Columns for Urinary Phenolic Acids from Catecholamines and Analoguesof these columns and of their use in examining urinary constituents (human, rat) and in metabolic work with compounds related to catecholamines. When measuring previously unauthenticated compounds, identities must be confirmed by independent means because some of the numerous urinary constituents may interfere.作者: 天賦 時(shí)間: 2025-3-23 23:53 作者: Horizon 時(shí)間: 2025-3-24 04:42
Examples of Approaches to Isolating and Identifying Phase I Metabolites in vivo in the target species, the cow. GC-MS was used to identify drug-derived urinary components that had been isolated by a range of chromatographic procedures. In the study of cloprostenol metabolism the high isotopic abundance of.C in radio-labelled cloprostenol allowed an unusual method of detecting metabolites.作者: 有惡臭 時(shí)間: 2025-3-24 10:27 作者: 老人病學(xué) 時(shí)間: 2025-3-24 13:04 作者: VERT 時(shí)間: 2025-3-24 16:27 作者: 使乳化 時(shí)間: 2025-3-24 21:49
Narciso García,Luis Salgado,José M. Martínezer which can quantitate compounds on TLC plates by direct absorption in visible or UV light, by fluorescence quenching (a fluorescent substance being incorporated in the absorbent layer), or by fluorescence emission. Examples are now given.作者: 切碎 時(shí)間: 2025-3-24 23:45 作者: Aviary 時(shí)間: 2025-3-25 05:20 作者: 使顯得不重要 時(shí)間: 2025-3-25 09:18 作者: GRUEL 時(shí)間: 2025-3-25 12:22 作者: Innovative 時(shí)間: 2025-3-25 18:51
Von der Wahrnehmung zur Erkenntnisment of new extraction procedures for determining drugs and metabolites in biological fluids has been relatively neglected. Yet there have been advances in extraction procedures, and this article summarizes the options available and gives examples of their use. Deproteinization, solvent extraction a作者: 節(jié)省 時(shí)間: 2025-3-25 23:25
https://doi.org/10.1007/b138974 100 m columns of 0.5 mm bore. These have a resolving power of ~10.plates, depending on the compound analyzed. An account is given of the preparation of these columns and of their use in examining urinary constituents (human, rat) and in metabolic work with compounds related to catecholamines. When 作者: gonioscopy 時(shí)間: 2025-3-26 02:07
Anwendungsbeispiele und übungens such as sensitivity. Commercially available instrumentation, e.g. for plate development in its different modes, is considered, and the optimization of a spotting device (see.); Examples of applications are given later (art. #D-5).作者: cochlea 時(shí)間: 2025-3-26 04:39
Narciso García,Luis Salgado,José M. Martínezysis of drugs and metabolites in body fluids. This approach is not often discussed but deserves mention since the equipment is simple and the thin-layer plate can accept heavy loading of relatively crude extracts of plasma. Analytical methods can be developed quickly as extensive ‘clean-up’ is not n作者: cartilage 時(shí)間: 2025-3-26 09:29 作者: 脖子 時(shí)間: 2025-3-26 16:22
Visual Content Processing and Representatione fairly specifically adsorbed at slightly alkaline pH and are readily eluted at acidic pH. After the requisite acid pre-wash, alumina is a powder with a large range of particle sizes. It is essential to remove the finer particles, since they drastically reduce the flow rate through an alumina colum作者: 誘騙 時(shí)間: 2025-3-26 19:08 作者: 中國(guó)紀(jì)念碑 時(shí)間: 2025-3-26 23:24
Nelson Zagalo,Vasco Branco,Anthony Barkerctures determined by NMR spectroscopy. The metabolic fate of the veterinary product cloprostenol (‘Estrumate’*), a prostaglandin analogue, was studied in vivo in the target species, the cow. GC-MS was used to identify drug-derived urinary components that had been isolated by a range of chromatograph作者: Interdict 時(shí)間: 2025-3-27 04:10 作者: 必死 時(shí)間: 2025-3-27 06:22 作者: 產(chǎn)生 時(shí)間: 2025-3-27 09:47
Basic Steps in Vascular Reconstructions metabolism in man. That of selected pesticides, initially in animals, has been studied as part of industrial hygiene research programmes to indicate the most suitable analytical methods for monitoring exposure. These typically entail GC-ECD, and their development is in general based on a common maj作者: 落葉劑 時(shí)間: 2025-3-27 15:52 作者: Infirm 時(shí)間: 2025-3-27 18:46
Von der Wahrnehmung zur ErkenntnisThe following values (mean ±S.D.) have been found for those compounds in the legend to Fig. 1 that can be satisfactorily assessed (cf. Fig.2).作者: Countermand 時(shí)間: 2025-3-27 23:43 作者: 摻假 時(shí)間: 2025-3-28 03:53
ADDENDUM: Mean excretions of phenolic acids in manThe following values (mean ±S.D.) have been found for those compounds in the legend to Fig. 1 that can be satisfactorily assessed (cf. Fig.2).作者: chandel 時(shí)間: 2025-3-28 10:15
Quantitation of,C Radioactivity in HPLC EluatesThe main advantage associated with the use of radiolabelled compounds in HPLC, as extensively practised in our Section’s studies of potential drugs, is that a simple non-specific method of detection applies to all labelled components derived from the drug without interference from sample-associated impurities.作者: filial 時(shí)間: 2025-3-28 14:11
https://doi.org/10.1007/978-1-4684-4484-1carboxylic acid; chromatography; diagnosis; phenol; reactions; society作者: BLINK 時(shí)間: 2025-3-28 17:34
978-1-4684-4486-5Plenum Press, New York 1983作者: 騷擾 時(shí)間: 2025-3-28 20:15
Evolution der Wahrnehmung erkenntnisf?higimited to the measurement of drugs whose physico-chemical properties are similar to the parent drug, whereas reverse-phase (RP) chromatography in its various forms has made possible the simultaneous measurement of metabolites varying widely in pK..in vitro..作者: acrobat 時(shí)間: 2025-3-29 00:16 作者: BIAS 時(shí)間: 2025-3-29 03:31 作者: 混合物 時(shí)間: 2025-3-29 07:16
Anwendungsbeispiele und übungens such as sensitivity. Commercially available instrumentation, e.g. for plate development in its different modes, is considered, and the optimization of a spotting device (see.); Examples of applications are given later (art. #D-5).作者: 大酒杯 時(shí)間: 2025-3-29 13:05
Towards Semantic Universal Multimedia Accessanalyte completely from 2 ml of aqueous solution into 50 μl of isooctane; but to take an aliquot of the organic layer into a syringe for chromatography was troublesome. It was hardly possible to sample the organic phase without contaminating it with the aqueous phase.作者: 微不足道 時(shí)間: 2025-3-29 16:40 作者: 我沒(méi)有強(qiáng)迫 時(shí)間: 2025-3-29 20:38 作者: drusen 時(shí)間: 2025-3-30 00:10 作者: 人造 時(shí)間: 2025-3-30 06:25 作者: 逗留 時(shí)間: 2025-3-30 11:22
Quantitative HPTLC in Assaying Body Fluids for Drugs and Metabolitess such as sensitivity. Commercially available instrumentation, e.g. for plate development in its different modes, is considered, and the optimization of a spotting device (see.); Examples of applications are given later (art. #D-5).作者: 沖擊力 時(shí)間: 2025-3-30 14:32
Taking Aliquots from Small Volumes of Upper Phasesanalyte completely from 2 ml of aqueous solution into 50 μl of isooctane; but to take an aliquot of the organic layer into a syringe for chromatography was troublesome. It was hardly possible to sample the organic phase without contaminating it with the aqueous phase.作者: 肥料 時(shí)間: 2025-3-30 18:53 作者: 清醒 時(shí)間: 2025-3-31 00:15 作者: 儀式 時(shí)間: 2025-3-31 01:50 作者: Gastric 時(shí)間: 2025-3-31 08:56
Problems Arising from Assaying Low Concentrations by HPLC in train a number of problems; some are well known, others are not suspected by those workers who deal only with samples at high concentration. The examples given represent problems that have occurred in a drug metabolism bioanalytical laboratory. Readers may add to the list.作者: 香料 時(shí)間: 2025-3-31 09:53
Extraction of Drugs and Metabolites from Plasma and Urinement of new extraction procedures for determining drugs and metabolites in biological fluids has been relatively neglected. Yet there have been advances in extraction procedures, and this article summarizes the options available and gives examples of their use. Deproteinization, solvent extraction a作者: 仔細(xì)閱讀 時(shí)間: 2025-3-31 13:23
