標題: Titlebook: Drug Discovery and Evaluation: Methods in Clinical Pharmacology; Franz J. Hock,Michael R. Gralinski Reference work 2020Latest edition Spri [打印本頁] 作者: 吞食 時間: 2025-3-21 18:02
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology影響因子(影響力)
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology影響因子(影響力)學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology網絡公開度
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology網絡公開度學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology被引頻次
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology被引頻次學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology年度引用
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology年度引用學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology讀者反饋
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology讀者反饋學科排名
作者: 者變 時間: 2025-3-21 20:55
Reference work 2020Latest editionhird volume: ?Methods in Clinical Pharmacology"...For the 2nd?edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases..作者: Acetabulum 時間: 2025-3-22 02:15 作者: 山羊 時間: 2025-3-22 06:48 作者: MAG 時間: 2025-3-22 08:47 作者: 無能力之人 時間: 2025-3-22 15:47 作者: 無能力之人 時間: 2025-3-22 18:37
Pharmacodynamic Evaluation: Ocular Pharmacologyhe optic nerve that connects the retina to the brain. Many decades of basic and applied research have resulted in the discovery and development of different types of pharmacological agents (small molecules), peptides, and antibodies that help clinically manage the various ocular disorders mentioned 作者: 催眠 時間: 2025-3-22 23:57
Clinical Aspects in Sleep Disorders and Apneaior, activity, and physiological signals; and finally a sleep laboratory investigation, cardiorespiratory polysomnography, with all signals recorded which change during normal and pathological sleep. Quantitative assessment of sleep, sleep stages, arousals from sleep, and vegetative functions during作者: 獨裁政府 時間: 2025-3-23 04:35 作者: PTCA635 時間: 2025-3-23 06:32
Pharmacodynamic Evaluation: Infectious Diseases citing their advantages and limitations, along with simulations for optimizing treatment regimens. Furthermore, it describes the applications of pharmacodynamic models for treatment of bacterial infections and, finally, the pathophysiological conditions leading to treatment failures and strategies 作者: 售穴 時間: 2025-3-23 12:43
Role of Clinical Pharmacodynamics Studies in the Era of Precision Medicines Against Cancermay provide accurate predictions of the dose-effect relationships by advancing the understanding of target engagement as well as exposure response and therefore has the potential to improve the decision making regarding the optimal dose and schedules as well as risk-benefit assessments for later sta作者: 單獨 時間: 2025-3-23 13:54
Pharmacodynamic Evaluation: Gene Therapylly modify the patient cells in vitro before being reintroduced into the patient..This chapter gives a statement of the art of gene therapy. It describes the different strategies and tools used in this area before describing the seminal clinical trials and the range of diseases for which gene therap作者: Fulminate 時間: 2025-3-23 21:14
Drug Discovery and Evaluation: Methods in Clinical Pharmacology作者: instructive 時間: 2025-3-23 22:13
Drug Discovery and Evaluation: Methods in Clinical Pharmacology978-3-319-68864-0作者: synovium 時間: 2025-3-24 03:33
https://doi.org/10.1007/978-3-8349-9593-3rch, those factors may influence final statistical results. New tests and old proven measures of hemodynamic stabilities are required to evaluate new therapeutics during clinical studies to be able to treat more people on pharmacogenetic basis with pharmacogenomic approach. Safety to treat with new 作者: hyperuricemia 時間: 2025-3-24 08:08 作者: 天真 時間: 2025-3-24 13:23 作者: chassis 時間: 2025-3-24 17:28
Kurz- und Wiederholungsaufgaben substances, their interactions with legal drugs and medications, and their impact on different stages of metabolism. In this chapter we attempted to summarize the available reliable data and suggest some ideas for future observation and research.作者: GLEAN 時間: 2025-3-24 22:35
Datengrundlage und technische Hinweisehe optic nerve that connects the retina to the brain. Many decades of basic and applied research have resulted in the discovery and development of different types of pharmacological agents (small molecules), peptides, and antibodies that help clinically manage the various ocular disorders mentioned 作者: Neutral-Spine 時間: 2025-3-25 03:00
Exemplarische Analyse des Prototyps,ior, activity, and physiological signals; and finally a sleep laboratory investigation, cardiorespiratory polysomnography, with all signals recorded which change during normal and pathological sleep. Quantitative assessment of sleep, sleep stages, arousals from sleep, and vegetative functions during作者: 顛簸地移動 時間: 2025-3-25 05:50
https://doi.org/10.1007/978-3-8350-9323-2ucosal, and local. Furthermore, a targeted and individualized approach for drug monitoring was developed that takes into account individual patient variability through careful gathering of pharmacokinetic and pharmacodynamic data: therapeutic drug monitoring, allowing to really individualize patient作者: BRAWL 時間: 2025-3-25 09:41
https://doi.org/10.1007/978-3-8351-9065-8 citing their advantages and limitations, along with simulations for optimizing treatment regimens. Furthermore, it describes the applications of pharmacodynamic models for treatment of bacterial infections and, finally, the pathophysiological conditions leading to treatment failures and strategies 作者: Congestion 時間: 2025-3-25 13:39
Das kapitalistische Patriarchatmay provide accurate predictions of the dose-effect relationships by advancing the understanding of target engagement as well as exposure response and therefore has the potential to improve the decision making regarding the optimal dose and schedules as well as risk-benefit assessments for later sta作者: 音樂戲劇 時間: 2025-3-25 18:16 作者: 肥料 時間: 2025-3-25 21:22
Reference work 2020Latest editionlects the current state of the art in Clinical Pharmacology...Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the poten作者: Electrolysis 時間: 2025-3-26 02:42
h institutes and in industry.Helps establish official guidel.This is the second edition of a well-received book in the series “Drug Discovery and Evaluation” The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology...Drug Discovery and Evaluatio作者: aerobic 時間: 2025-3-26 07:40 作者: infinite 時間: 2025-3-26 10:39
Dietmar Wellisch,Maik N?th,Kerstin Thielemus-pituitary-adrenal-gonadal axis, while thyroid disorders are viewed separately..There is a focus on the hormone receptor interaction similarities and the drug-ligand-receptor binding..The concept of hormone agonists and antagonists has a prominent place..Neuroendocrinology pharmacodynamic evaluation is not included in this chapter.作者: 搜尋 時間: 2025-3-26 14:46
Methodologies of Safety Assessment in Clinical Pharmacology for what duration and whether these side effects can be monitored and whether they are reversible. The terminology for the safety assessment of drugs has some specifics that need to be explained right at the beginning of this chapter.作者: 制度 時間: 2025-3-26 20:48 作者: 轎車 時間: 2025-3-26 23:04 作者: Mortal 時間: 2025-3-27 03:51 作者: troponins 時間: 2025-3-27 07:44
https://doi.org/10.1007/978-3-8350-9323-2 the terms, the attribution of either type of studies may sometimes be ambiguous. It is impossible to separate immunotoxicology studies required by regulatory agencies basically from the pharmacodynamics of a drug. An initial package of such pharmacological studies is a prerequisite for first-in-human studies for novel drugs.作者: arousal 時間: 2025-3-27 10:58
,Die fünf Beziehungen zur Zeit,of toxic compounds, augmentation of enzyme activity by chaperones, and enzyme replacement therapy (in selected diseases like lysosomal storage diseases) are therapeutic options for alimentary and pharmacological treatment in IEM. In this chapter we will discuss options for pharmacological and/or dietary therapy in selected prototype IEM.作者: Bereavement 時間: 2025-3-27 14:58
https://doi.org/10.1007/978-3-8350-9323-2ble. Immunotherapy with checkpoint inhibitors is a major breakthrough in melanoma and has been rewarded with the Nobel Prize in Physiology and medicine, 2018. All these new systemic therapies are valuable additions to the already existing armentarium of the dermatologist.作者: entice 時間: 2025-3-27 18:19
Pharmacodynamic Evaluation: Dermatologyble. Immunotherapy with checkpoint inhibitors is a major breakthrough in melanoma and has been rewarded with the Nobel Prize in Physiology and medicine, 2018. All these new systemic therapies are valuable additions to the already existing armentarium of the dermatologist.作者: Lyme-disease 時間: 2025-3-28 00:53 作者: analogous 時間: 2025-3-28 06:05
Pharmacodynamic Evaluation: Diabetic Methodologieswhen impending hypoglycemia is detected. Bionic pumps (bihormonal) may also provide a stable glucagon solution for fine-tuning of glucose regulation and emergency release, in case of hypoglycemia developing rapidly or inadvertently, in particular during sleep at night time.作者: Soliloquy 時間: 2025-3-28 09:22
Pharmacodynamic Evaluation: CNS MethodologiesPK/PD) aspects when developing a medication targeting brain disorders. The biomarker section discusses those markers employed in the most common neurological disorders. It addresses their advantages and limitations, and how they serve in confirming efficacy and, in some instances, the safety of therapeutic interventions.作者: 象形文字 時間: 2025-3-28 12:11 作者: 圖畫文字 時間: 2025-3-28 16:46 作者: 展覽 時間: 2025-3-28 22:00 作者: 江湖騙子 時間: 2025-3-29 02:47 作者: Axon895 時間: 2025-3-29 03:34 作者: 窒息 時間: 2025-3-29 08:59 作者: CLOUT 時間: 2025-3-29 13:30
Springer Nature Switzerland AG 2020作者: diathermy 時間: 2025-3-29 17:51 作者: 異教徒 時間: 2025-3-29 21:37
https://doi.org/10.1007/978-3-8349-9593-3thematical approach grows very fast in new algorithms to analyze the heart signal. Many areas of multiple organ damage will relay in very complex software and hardware innovations. Basics for this growth is understanding of previously unknown mechanisms of control of physiological functioning like h作者: 創(chuàng)造性 時間: 2025-3-30 01:00 作者: Resign 時間: 2025-3-30 04:10
Kurz- und Wiederholungsaufgabene failures are multiple and mainly based on the uncertainty around the precise pathological processes, lack of reliable biomarkers, and variability of drug penetration through the blood-brain barrier (BBB) into the brain. The first section of this chapter focuses on pharmacokinetic/pharmacodynamic (作者: 預知 時間: 2025-3-30 11:58
Grundlagen der Haushaltstheoriepment of more targeted analgesic compounds with fewer side effects is therefore essential. With an increased demand to demonstrate pharmacodynamic effects of new analgesic compounds, the importance of human evoked pain models is now higher than ever..Pharmacodynamic evaluation with human evoked pain作者: pericardium 時間: 2025-3-30 13:28 作者: CYN 時間: 2025-3-30 19:18 作者: defray 時間: 2025-3-31 00:04
Datengrundlage und technische Hinweiset an attractive target for pharmacotherapy. However, none of the so far conducted clinical trials with the use of pharmacological substances could be called a thrilling success. There are multiple reasons for this, which are discussed in this chapter. Moreover, a comprehensive overview of factors th作者: constitutional 時間: 2025-3-31 04:26 作者: indices 時間: 2025-3-31 06:32
Regelung der Sozialversicherungspflichtetics), and the coformulation of incretin mimetics and insulins in the same solution. The options of diabetes therapy with sensor-augmented insulin pumps and the clinical pharmacology of bihormonal insulin pumps dispensing insulin and glucagon as required will be presented (bionic pumps). The specif作者: 祖先 時間: 2025-3-31 09:39 作者: synovial-joint 時間: 2025-3-31 14:49
Dietmar Wellisch,Maik N?th,Kerstin Thiele of oral antidiabetics and new sophisticated insulin analogues..Clinical pharmacology in endocrine disorders is reviewed along the classical hypothalamus-pituitary-adrenal-gonadal axis, while thyroid disorders are viewed separately..There is a focus on the hormone receptor interaction similarities a作者: micturition 時間: 2025-3-31 20:12
https://doi.org/10.1007/978-3-8350-9323-2have been developed. For the immune-mediated inflammatory skin diseases, several biologic agents are now available for the chronic plaque psoriasis. These agents target one specific proinflammatory cytokine (TNF-alpha, interleukin (IL)-17, and (IL)-23) or its receptor. The IL-4 receptor blocking dup作者: Prologue 時間: 2025-3-31 23:40
