標題: Titlebook: Drug Discovery and Evaluation: Methods in Clinical Pharmacology; Franz J. Hock,Michael R. Gralinski Living reference work 20200th edition [打印本頁] 作者: HBA1C 時間: 2025-3-21 19:28
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology影響因子(影響力)
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology影響因子(影響力)學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology網絡公開度
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology網絡公開度學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology被引頻次
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology被引頻次學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology年度引用
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology年度引用學科排名
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology讀者反饋
書目名稱Drug Discovery and Evaluation: Methods in Clinical Pharmacology讀者反饋學科排名
作者: 悲觀 時間: 2025-3-21 23:53 作者: TRUST 時間: 2025-3-22 03:40 作者: animated 時間: 2025-3-22 07:25 作者: Monocle 時間: 2025-3-22 12:48 作者: 鞏固 時間: 2025-3-22 16:29
Exchange Rates: Systems and Policiesnt parameters to be considered in this context are discussed in this chapter. Since there are still certain differences between the main guidelines activities have been started to discuss the basis for science-driven regulations and to harmonize the existing requirements. In particular the Global Bi作者: 鞏固 時間: 2025-3-22 17:51
An Agenda for International Financial Reformrate measurement of electrocardiograms (ECG) is critical for effective diagnosis of patient’s cardiac functions. Detailed examination of filters’ effects on ECG accuracy, reproducibility and robustness covering a wide range of available commercial products can provide valuable information on the rel作者: 擋泥板 時間: 2025-3-22 21:51 作者: 或者發(fā)神韻 時間: 2025-3-23 03:57
Helen Austerberry,Sophie Watson Advisory Network, iCAN), recruitment challenges, and research capacity building. We hereby tried to focus on recent evolutions, including initiatives to further develop this research capacity (Institute for Advanced Clinical Trials, iACT for children; Innovative Medicines Initiative, IMI2)..Perhaps作者: TOXIC 時間: 2025-3-23 06:01 作者: 我沒有強迫 時間: 2025-3-23 12:57
ical research although they lack many features of the human condition. The primary characteristic of COPD that is replicated in animal models is non-allergic inflammation. The main challenge with this is that COPD often develops over a significant period of time which is difficult to accurately repl作者: dithiolethione 時間: 2025-3-23 14:57
(1791–2) cases contain low-dosed drugs, delimitation questions occur frequently..Hence the issue, whether some of these products are to be classified as medicinal products and how they are to be differentiated..Subsequently, we would like to introduce the basic requirements to put those food supplements leg作者: Fecal-Impaction 時間: 2025-3-23 21:11 作者: 萬靈丹 時間: 2025-3-24 00:54
sign, ensuring adequate statistical power to discriminate sex-gender differences. This has led to a gradual but steady increase in published data, which highlights sexually dimorphic differences in the pharmacokinetics, pharmacodynamics, and pharmacogenetics of several drugs. Male and female drug me作者: 裂隙 時間: 2025-3-24 03:53
hese tools, possible applications, and how different inputs can influence results is essential in order that users can maximize the potential of such in silico analyses. This in turn will accelerate the preclinical stage of the biomarker translational pipeline, often perceived as a key bottleneck.作者: 無法解釋 時間: 2025-3-24 08:15
Absolute and Relative Bioavailability,tical agency. The achievement of this target gives positive economic benefits as reducing drug dosage and frequency and medical impacts in decreasing toxicity and bacterial resistance in case of antimicrobials. A drug may be well absorbed orally because of good lipid solubility and yet not has a goo作者: 暗諷 時間: 2025-3-24 11:05 作者: 逢迎春日 時間: 2025-3-24 15:07
Characterization of Cardiac Electrophysiology Including ECG-Analysis,rate measurement of electrocardiograms (ECG) is critical for effective diagnosis of patient’s cardiac functions. Detailed examination of filters’ effects on ECG accuracy, reproducibility and robustness covering a wide range of available commercial products can provide valuable information on the rel作者: 裝入膠囊 時間: 2025-3-24 21:06
Clinical Aspects in Sleep Disorders and Apnea,ior, activity, and physiological signals; and finally a sleep laboratory investigation, cardiorespiratory polysomnography, with all signals recorded which change during normal and pathological sleep. Quantitative assessment of sleep, sleep stages, arousals from sleep, and vegetative functions during作者: 袖章 時間: 2025-3-25 00:07
Clinical Studies in Infants (Pediatric Pharmacology), Advisory Network, iCAN), recruitment challenges, and research capacity building. We hereby tried to focus on recent evolutions, including initiatives to further develop this research capacity (Institute for Advanced Clinical Trials, iACT for children; Innovative Medicines Initiative, IMI2)..Perhaps作者: Paraplegia 時間: 2025-3-25 05:47 作者: 思鄉(xiāng)病 時間: 2025-3-25 08:48
Experimental Methods for Evaluating Pharmacodynamic Effects of Drugs for the Pulmonary System,ical research although they lack many features of the human condition. The primary characteristic of COPD that is replicated in animal models is non-allergic inflammation. The main challenge with this is that COPD often develops over a significant period of time which is difficult to accurately repl作者: 招募 時間: 2025-3-25 15:24
Food Supplements: Definition and Classification, cases contain low-dosed drugs, delimitation questions occur frequently..Hence the issue, whether some of these products are to be classified as medicinal products and how they are to be differentiated..Subsequently, we would like to introduce the basic requirements to put those food supplements leg作者: 鐵砧 時間: 2025-3-25 16:02 作者: MAIZE 時間: 2025-3-25 19:58 作者: SENT 時間: 2025-3-26 02:36
In silico Drug Repositioning Using Omics Data: The Potential and Pitfalls,hese tools, possible applications, and how different inputs can influence results is essential in order that users can maximize the potential of such in silico analyses. This in turn will accelerate the preclinical stage of the biomarker translational pipeline, often perceived as a key bottleneck.作者: 參考書目 時間: 2025-3-26 06:09 作者: 培養(yǎng) 時間: 2025-3-26 12:18 作者: 他日關稅重重 時間: 2025-3-26 16:29
Helen Austerberry,Sophie Watsont of this Guideline but introduced technology and approaches that were unknown when the GCP Guideline got issued for the first time. Twenty years ago clinical development was largely a paper-based process, and the Internet and even more so the . were technology and tools only known to a few ..作者: Hiatus 時間: 2025-3-26 19:27
Clinical Pharmacology of Tinnitus: Design and Evaluation,at should be taken under consideration when designing clinical pharmacological study for tinnitus is presented in an anticipation to help design trials producing meaningful clinical data and identifying clinically relevant substances effective in tinnitus treatment.作者: 表示向前 時間: 2025-3-27 00:32
General Principles of Pharmacovigilance in Clinical Development,ing the safety profile of an investigational medicinal product. Regulations and requirements across the globe are complex and national, while certain international standards through the ICH guideleines form a common basic platform through which multinational clinical trials can harmonise.作者: APRON 時間: 2025-3-27 01:51
An Agenda for International Financial Reforme can contribute to variations in time-dependent drug treatments. The results of clinical chronopharmacological studies in hypertension, asthma, and ulcer disease and treatment of antihyperlipidemia are reviewed.作者: 我怕被刺穿 時間: 2025-3-27 06:06 作者: fulmination 時間: 2025-3-27 12:43
Helen Austerberry,Sophie Watsonlines from EMA (2012), FDA (2012), and PMDA (2014). This section is aiming to give a summary of the respective considerations of these guidelines for the design of DDI studies and also contains many aspects of the respective guidelines including the most relevant decision trees and tables.作者: Adulterate 時間: 2025-3-27 14:33
Chronopharmacology in Drug Development,e can contribute to variations in time-dependent drug treatments. The results of clinical chronopharmacological studies in hypertension, asthma, and ulcer disease and treatment of antihyperlipidemia are reviewed.作者: Frequency 時間: 2025-3-27 19:34 作者: 世俗 時間: 2025-3-27 22:26
,Drug–Drug Interaction Studies,lines from EMA (2012), FDA (2012), and PMDA (2014). This section is aiming to give a summary of the respective considerations of these guidelines for the design of DDI studies and also contains many aspects of the respective guidelines including the most relevant decision trees and tables.作者: nonplus 時間: 2025-3-28 02:50 作者: 正面 時間: 2025-3-28 08:25
Helen Austerberry,Sophie Watsonat should be taken under consideration when designing clinical pharmacological study for tinnitus is presented in an anticipation to help design trials producing meaningful clinical data and identifying clinically relevant substances effective in tinnitus treatment.作者: 敲竹杠 時間: 2025-3-28 10:41 作者: heterogeneous 時間: 2025-3-28 15:28
Absolute and Relative Bioavailability,pect for the pharmaceutical agency. The achievement of this target gives positive economic benefits as reducing drug dosage and medical impacts in decreasing toxicity and bacterial resistance in case of antimicrobials. Various factors may reduce the availability of drugs. There are numerous ways to 作者: myocardium 時間: 2025-3-28 19:45 作者: lactic 時間: 2025-3-29 01:54 作者: 材料等 時間: 2025-3-29 06:02
Chronopharmacology in Drug Development, as well in the peripheral tissues has been convincingly demonstrated to be circadian phase dependent for many genes. In addition, seasonal gene expression – with inverse rhythms in the Northern and Southern Hemisphere – has been evidenced as well. Taking into account these rhythmic changes in the b作者: homeostasis 時間: 2025-3-29 07:22 作者: 必死 時間: 2025-3-29 14:57
Clinical Pharmacology of Tinnitus: Design and Evaluation,t an attractive target for pharmacotherapy. However, none of the so far conducted clinical trials with the use of pharmacological substances could be called a thrilling success. There are multiple reasons for this, which are discussed in this chapter. Moreover, a comprehensive overview of factors th作者: Abominate 時間: 2025-3-29 16:35
Clinical Quality Management System,e updates of the Guidelines and especially its Addendum [ICH E6(R2)] that in Europe became effective in 2017 have not fundamentally changed the content of this Guideline but introduced technology and approaches that were unknown when the GCP Guideline got issued for the first time. Twenty years ago 作者: 錫箔紙 時間: 2025-3-29 22:54
Clinical Studies in Geriatric Population,ps. When considering the demographic change in most industrialized countries and the fact that seniors receive the highest share of all drugs, a need for clinical trials with elderly patients is obvious. Potential pharmacokinetic as well as pharmacodynamic changes in comparison to younger adults hav作者: 準則 時間: 2025-3-30 01:35
Clinical Studies in Infants (Pediatric Pharmacology),ildren to administer medicines outside their market authorization. Even if authorized, pediatric medicines may not be age-appropriate for a broad range of therapeutic areas. This has been recognized as very unsatisfactory by all stakeholders involved and makes clinical pharmacological studies in chi作者: 要素 時間: 2025-3-30 06:52 作者: 細節(jié) 時間: 2025-3-30 10:31
Dose Linearity and Proportionality,kinetics” implies that any concentration–time profiles normalized for dose and time are superimposable (Ludden 1991). Thus, one of the necessary conditions for linear pharmacokinetics is dose proportionality, and its assessment is a fundamental pharmacokinetic analysis conducted during the clinical 作者: Presbycusis 時間: 2025-3-30 16:25
,Drug–Drug Interaction Studies, DDIs during clinical development is a part of the general clinical pharmacology and safety assessment of a new investigational compound. Market withdrawals of drugs were frequently caused by DDIs which underlines the importance of addressing these issues during drug development. This is also reflec作者: 衣服 時間: 2025-3-30 18:49
Effects of Food Intake,hange the effects of drugs, and the therapeutic effects or side effects of medications can affect the nutritional status. Alternatively, the diet and the use of supplements or the nutritional status of the patient can decrease a drug’s efficacy or increase its toxicity.作者: 取回 時間: 2025-3-30 21:27
Experimental Methods for Evaluating Pharmacodynamic Effects of Drugs for the Pulmonary System,atients worldwide. While asthma and COPD do share a number of common features as they are chronic inflammatory conditions of the lung, they are clearly different diseases with unique characteristics and causes. However, treatment of both these diseases remains primarily the same. There is clearly a 作者: 戲服 時間: 2025-3-31 01:14 作者: Aggrandize 時間: 2025-3-31 08:32
Future of Regulatory Safety Assessments,cal need for many pathological processes continues. Concerns appear that in spite of extensive workload, success of pharmaceutical activity, and included facilitated access to novel drugs, may slow down. The preclinical testing via in vitro and animal experimentation reveals limitations to select th作者: 我們的面粉 時間: 2025-3-31 12:57
Gender Differences in Drug Therapy,a personalized model that focusses on the characteristics of each individual patient and tailors treatment accordingly. In order to achieve the maximum benefit and minimum risk, personalized medicine needs to address multiple individual parameters including pathology, physiology, genetics, comorbidi作者: 極少 時間: 2025-3-31 13:28 作者: 昏迷狀態(tài) 時間: 2025-3-31 18:11
In silico Drug Repositioning Using Omics Data: The Potential and Pitfalls, approach to treatment. Patients with different underlying biologies originating at the genomic, epigenetic, or transcriptomics levels may present with similar phenotypes at diagnosis. The same treatment may thus result in different outcomes. Using the wealth of public information that is available,作者: Agronomy 時間: 2025-4-1 01:03 作者: fledged 時間: 2025-4-1 04:53
