標題: Titlebook: Drug Discovery and Development; Michael Williams,Jeffrey B. Malick Book 1987 The Humana Press Inc. 1987 autoimmune disease.cannabinoid.dev [打印本頁] 作者: mandatory 時間: 2025-3-21 16:21
書目名稱Drug Discovery and Development影響因子(影響力)
書目名稱Drug Discovery and Development影響因子(影響力)學科排名
書目名稱Drug Discovery and Development網(wǎng)絡公開度
書目名稱Drug Discovery and Development網(wǎng)絡公開度學科排名
書目名稱Drug Discovery and Development被引頻次
書目名稱Drug Discovery and Development被引頻次學科排名
書目名稱Drug Discovery and Development年度引用
書目名稱Drug Discovery and Development年度引用學科排名
書目名稱Drug Discovery and Development讀者反饋
書目名稱Drug Discovery and Development讀者反饋學科排名
作者: 終端 時間: 2025-3-21 22:00
Aufgaben und Werkzeuge der Verdauungwide use and acceptance. The science surrounding these dosage forms has progressed significantly in terms of the knowledge required to make better tablets, to understand the role of disintegrants, and to optimize inert ingredient ratios through sophisticated formulation design (Lachman et al., 1976; Lieberman and Lachman, 1980).作者: 雄偉 時間: 2025-3-22 01:32
Biochemical Approaches for Evaluating Drug—Receptor Interactionsn be used for analyzing dozens of compounds in a matter of hours. By providing the pharmacologist and chemist with information about potency, efficacy, and structure-activity characteristics, this methodology enables them to select a few lead agents that can then be subjected to more detailed examination in secondary and tertiary screens.作者: 帶來墨水 時間: 2025-3-22 05:58 作者: ingrate 時間: 2025-3-22 10:25 作者: palpitate 時間: 2025-3-22 15:09 作者: palpitate 時間: 2025-3-22 17:50
Drug Discovery at the Enzyme Levelir efficacy. We will consider how enzyme activity is assayed, how inhibitors are found (or made) and characterized, how enzyme inhibition is demonstrated in vivo, and some specific examples of enzyme inhibitors that are used as drugs.作者: 起來了 時間: 2025-3-22 23:17
Immunopharmacological Approaches to Drug Developmente biological and biochemical effects of synthetic and natural products on immune responsiveness, elucidate the mechanism(s) through which such effects are mediated, and evaluate the clinical potential of such agents.作者: Coma704 時間: 2025-3-23 03:11 作者: NIP 時間: 2025-3-23 06:35
Drug Designhis strategy and dictate the type of approach; that is, either a rational or an empirical one. Depending on this selection, the synthetic targets then will either be derived from drug design concepts for the former or developed around systematic variation of a lead compound for the latter.作者: 斥責 時間: 2025-3-23 12:07 作者: inflate 時間: 2025-3-23 15:39
Wie einheitlich ist ?ein Instinkt“?global in nature, e.g., clinical significance in comparison to known active agents. Usually, the more that is known about a chemical entity or clinical disorder, the more relevant are the in vitro tissue screens (. Williams and Malick, this volume).作者: 災禍 時間: 2025-3-23 20:37 作者: 墊子 時間: 2025-3-24 00:41 作者: 飛鏢 時間: 2025-3-24 05:17 作者: PHIL 時間: 2025-3-24 08:01 作者: 走路左晃右晃 時間: 2025-3-24 11:07 作者: 陳腐的人 時間: 2025-3-24 16:47 作者: intricacy 時間: 2025-3-24 21:45 作者: 場所 時間: 2025-3-25 00:00
Calcium Channel Antagonists cytosolic calcium contractions to 1–10 . initiates physiologic responses appropriate to the cell type. In muscle, interaction with troponin C or other calcium-binding regulatory proteins initiates contraction. In neuronal, exocrine, and endocrine tissue, secretion ensues. The diversity of responses作者: Expediency 時間: 2025-3-25 04:04
M. Mei?ner,M. Doggett,J. Hirche,U. Kanusvenues of pharmacotherapy, we must rely upon imperfect, evolving knowledge about disease states and inferences we may make based upon a similarly incomplete appreciation of the mechanism of action of drugs known to be effective against clinical targets.作者: 熱心助人 時間: 2025-3-25 11:19 作者: 財產(chǎn) 時間: 2025-3-25 12:14
Overview: 978-1-4612-9180-0978-1-4612-4828-6作者: PRISE 時間: 2025-3-25 18:39 作者: Esalate 時間: 2025-3-25 21:37 作者: 清晰 時間: 2025-3-26 04:11 作者: Arteriography 時間: 2025-3-26 06:59
http://image.papertrans.cn/e/image/283067.jpg作者: Deference 時間: 2025-3-26 09:17 作者: anesthesia 時間: 2025-3-26 16:09 作者: 摸索 時間: 2025-3-26 18:41
Clinical Evaluation of Drug Candidates than 10 years of research and approximately $65 million may be required from the time of original identification or synthesis of a compound to its commercial introduction as a marketed drug. The majority of the time and money are usually spent on clinical development.作者: 面包屑 時間: 2025-3-26 21:56 作者: 羅盤 時間: 2025-3-27 04:51
Cimetidine and Other Histamine H2-Receptor AntagonistsThe treatment of peptic ulcer disease (both duodenal and gastric ulcers) and other acid-related diseases has been revolutionized by the discovery of the antagonist drugs that act at the histamine H.-receptor.作者: 廢墟 時間: 2025-3-27 06:09
https://doi.org/10.1007/978-1-4612-4828-6autoimmune disease; cannabinoid; development; drug; drug discovery; drugs; dynamics; ethanol; methodology; ne作者: 解脫 時間: 2025-3-27 09:56
978-1-4612-9180-0The Humana Press Inc. 1987作者: 尖 時間: 2025-3-27 16:27
https://doi.org/10.1007/978-3-7091-1654-8e compound in the test tube. The discovery of a novel chemical entity that modulates some aspect of cell or tissue function is but the first step in the drug development process. Once shown to be selective and efficacious, a compound must also be relatively free of toxicity, bioavailable, and market作者: noxious 時間: 2025-3-27 17:59
Leif Erik Walther Prof. Dr. med. habil.successful program is a clearly delineated strategy based on quantitative pharmacological assays. The particular problem chosen often will influence this strategy and dictate the type of approach; that is, either a rational or an empirical one. Depending on this selection, the synthetic targets then作者: 對手 時間: 2025-3-28 01:10
https://doi.org/10.1007/978-3-7091-3097-1The first of these has been the increased availability of powerful, but relatively inexpensive, computer systems in both academic and industrial research laboratories. This provided researchers with direct access to a level of computational capacity that had previously been available only on large a作者: circumvent 時間: 2025-3-28 05:23
Wie einheitlich ist ?ein Instinkt“?drug, the question of relevance must be ascertained. The biologist usually interprets the effects of a drug on isolated tissues or organs as an action at the receptor level. However, the question does not have to be targeted toward a particular cellular or mechanistic parameter; it can also be more 作者: 打火石 時間: 2025-3-28 06:56 作者: HUMP 時間: 2025-3-28 13:20 作者: Overstate 時間: 2025-3-28 16:37 作者: Servile 時間: 2025-3-28 21:28 作者: LEVER 時間: 2025-3-29 02:24
https://doi.org/10.1007/978-3-7091-4437-4ew discipline that began to flourish in the 1970s, and that broadly addresses the effects of synthetic and natural products on the immune response (Mullen, 1979). The field of immunopharmacology encompasses the development of immunologically based assays and their research and clinical applications,作者: 高貴領導 時間: 2025-3-29 06:59 作者: 被告 時間: 2025-3-29 10:08
Aufgaben und Werkzeuge der Verdauung; Hildebrand, 1983; Banakar, 1984; Rogers, 1982; Check, 1984; Anderson and Kim, 1984; Zaffaroni, 1980; Inhorn, 1981; Banker and Rhodes, 1979; Senyie et al., 1985). However, although these newer concepts in drug delivery point toward a disappearance of traditional methods of drug therapy, it is likel作者: FLORA 時間: 2025-3-29 14:52
H. Borchardt,R. Borrmann,O. Stoerk than 10 years of research and approximately $65 million may be required from the time of original identification or synthesis of a compound to its commercial introduction as a marketed drug. The majority of the time and money are usually spent on clinical development.作者: Addictive 時間: 2025-3-29 17:06
M. Mei?ner,M. Doggett,J. Hirche,U. Kanusprototypical class of compounds and demonstrating that it retains a desired pharmacological profile. The identification of novel molecules with potential for clinical application is often hampered by the preconceived notions of structure-activity requirements, desired neurochemical effects, and empi作者: 比喻好 時間: 2025-3-29 23:27
M. Mei?ner,M. Doggett,J. Hirche,U. Kanuslcium as a transducer for coupling of biological signals has become evident. The signal transduction role of calcium is made possible by a large, inward-directed gradient of ionized calcium across the plasma membrane. Cytosolic concentrations of calcium in a resting, nonstimulated cell are some 10,0作者: 鐵砧 時間: 2025-3-30 00:33
Drug Discovery and Developmente compound in the test tube. The discovery of a novel chemical entity that modulates some aspect of cell or tissue function is but the first step in the drug development process. Once shown to be selective and efficacious, a compound must also be relatively free of toxicity, bioavailable, and market作者: altruism 時間: 2025-3-30 06:45 作者: 散步 時間: 2025-3-30 12:10 作者: STALE 時間: 2025-3-30 14:53
Use of Intact Tissue Preparations in the Drug Discovery Processdrug, the question of relevance must be ascertained. The biologist usually interprets the effects of a drug on isolated tissues or organs as an action at the receptor level. However, the question does not have to be targeted toward a particular cellular or mechanistic parameter; it can also be more 作者: 大暴雨 時間: 2025-3-30 19:24
Neuropsychopharmacological Drug Developments of drugs on nervous tissue. Thus, neuropsychopharmacology encompasses the whole spectrum, being concerned with the study of the effects of drugs on both nervous tissue in general and on behavior in particular.作者: Flustered 時間: 2025-3-30 20:49
Biochemical Approaches for Evaluating Drug—Receptor Interactionsact animals, in vivo tests are labor-intensive and require significant quantities of compound, limiting their utility as primary screens. More desirable are simple, inexpensive tests that allow for the rapid identification of inactive or less active compounds. This can be achieved in many instances 作者: Incise 時間: 2025-3-31 04:23
Drug Discovery at the Enzyme Levelenzymes are possible, such as activation or allosteric modification of enzyme function. This chapter will not deal with enzymes themselves as drugs, e. g., L-asparaginase in the treatment of acute lymphocytic leukemia, papain used for proteolysis in wound debridement, and urokinase used in thromboly作者: Anthropoid 時間: 2025-3-31 06:45
EEG, EEG Power Spectra, and Behavioral Correlates of Opioids and Other Psychoactive Agentsts and monkeys to the British Medical Association in Edinburgh. Half a century later in Jena, Austria, Hans Berger (1929) discovered human brain waves and, hence, Berger is recognized as the father of electroencephalography, the recording of oscillations in the potential differences between two poin作者: 卷發(fā) 時間: 2025-3-31 12:38 作者: 教唆 時間: 2025-3-31 13:40
Toxicological Evaluation of Drugsis termed the therapeutic index. Toxicity should be clearly dissociable from efficacy. The goal of toxicity testing is therefore to determine the adverse effects of drugs in well- defined biological systems, which have their own unique susceptibility to toxicity. Once determined, these effect(s) of 作者: GROUP 時間: 2025-3-31 20:09 作者: DIS 時間: 2025-4-1 01:05
Clinical Evaluation of Drug Candidates than 10 years of research and approximately $65 million may be required from the time of original identification or synthesis of a compound to its commercial introduction as a marketed drug. The majority of the time and money are usually spent on clinical development.作者: 周興旺 時間: 2025-4-1 05:17
