標題: Titlebook: Drug Addiction; From Basic Research Rao S. Rapaka,Wolfgang Sadée Book 2008 Springer-Verlag New York 2008 Addiction.Basic.Cannabinoid.Chemo [打印本頁] 作者: 歸納 時間: 2025-3-21 18:10
書目名稱Drug Addiction影響因子(影響力)
書目名稱Drug Addiction影響因子(影響力)學科排名
書目名稱Drug Addiction網絡公開度
書目名稱Drug Addiction網絡公開度學科排名
書目名稱Drug Addiction被引頻次
書目名稱Drug Addiction被引頻次學科排名
書目名稱Drug Addiction年度引用
書目名稱Drug Addiction年度引用學科排名
書目名稱Drug Addiction讀者反饋
書目名稱Drug Addiction讀者反饋學科排名
作者: ABOUT 時間: 2025-3-21 20:48 作者: collagen 時間: 2025-3-22 02:29 作者: 蟄伏 時間: 2025-3-22 06:37 作者: aspect 時間: 2025-3-22 11:46 作者: Torrid 時間: 2025-3-22 14:30
Symbiotic Relationship of Pharmacogenetics and Drugs of Abuseing of the human genome and high-throughput technologies are enabling pharmacogenetics to have greater influence on treatment approaches. This review highlights key studies and identifies important genes in drug abuse pharmacogenetics that provide a basis for better diagnosis and treatment of drug abuse disorders.作者: Torrid 時間: 2025-3-22 21:02
Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuseonoclonal antibodies may be needed for each patient, efficient antibody production technology is essential. In this minireview we discuss some of the antibody forms that may be effective clinical treatments for drug abuse, as well as several current and emerging production systems that could bridge the gap from discovery to patient use.作者: Accord 時間: 2025-3-22 22:14 作者: 天賦 時間: 2025-3-23 04:46
Serotonin Transporters: Implications for Antidepressant Drug Developmentdepressants will be discussed. Furthermore, the effects of . gene polymorphisms on antidepressant efficacy will be examined. Finally, a brief overview of other hypotheses of depression will be addressed as well as factors that must be considered for future antidepressant development.作者: attenuate 時間: 2025-3-23 08:53 作者: 敲竹杠 時間: 2025-3-23 13:36
https://doi.org/10.1007/978-3-662-10798-0nfluencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of κ opioid agonists. The κ receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes of κ opioid ligands that have been explored for this purpose.作者: 執(zhí) 時間: 2025-3-23 16:15 作者: anticipate 時間: 2025-3-23 21:12
κ Opioids as Potential Treatments for Stimulant Dependencenfluencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of κ opioid agonists. The κ receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes of κ opioid ligands that have been explored for this purpose.作者: 表示問 時間: 2025-3-24 01:12 作者: fiscal 時間: 2025-3-24 04:58 作者: 前面 時間: 2025-3-24 09:08
DARPP-32 Mediates the Actions of Multiple Drugs of Abuseadditional neurotransmitters, including glutamate, serotonin and adenosine. All these neurotransmitters regulate the phosphorylation state of Dopaminal serine/threonine protein phosphatase, PP-1. Phosphorylatine- and cAMP-regulated phosphoprotein, Mr 32kDa (DARPP-32). Phosphorylation at Thr. by prot作者: textile 時間: 2025-3-24 14:20
Drug Discovery From Natural Sourcesf interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 and 2005, originating from terrestrial plants, terrestrial microorganisms, marine organisms, and terrestrial vertebrates and invertebrates, are described. These ap作者: ALIBI 時間: 2025-3-24 18:14
Computational Methods in Drug Design: Modeling G Protein-Coupled Receptor Monomers, Dimers, and Olig activated. Many vital physiological events such as sensory perception, immune defense, cell communication, chemotaxis, and neurotransmission are mediated by GPCRs. Not surprisingly, GPCRs are major targets for drug development today. Most modeling studies in the GPCR field have focused upon the cre作者: 孤僻 時間: 2025-3-24 19:16
Symbiotic Relationship of Pharmacogenetics and Drugs of Abusere predicted in advance, it is easier to tailor medications to different diseases and individuals. Pharmacogenetics provides the tools required to identify genetic predictors of probable drug response, drug efficacy, and drug-induced adverse events—identifications that would ideally precede treatmen作者: stroke 時間: 2025-3-25 02:29 作者: 向外 時間: 2025-3-25 06:40 作者: 虛假 時間: 2025-3-25 11:14 作者: 我怕被刺穿 時間: 2025-3-25 14:14
Viewing Chemokines as a Third Major System of Communication in the Brainhat products of the immune system, such as chemokines, can reciprocally alter the actions of these drugs and the endogenous ligands for their receptors. Chemokines are a family of small (8 to 12 kDa) proteins involved in cellular migration and intercellular communication. With a few exceptions, they作者: Chagrin 時間: 2025-3-25 18:54
Targeting the PDZ Domains of Molecular Scaffolds of Transmembrane Ion Channelsling and maintenance of several receptors and channels. The SAPs consist of 5 individual protein domains: 3 PDZ (PSD95, Disc Large, Zol) domains, an SH3 domain, and an inactive guanyl kinase (GK) domain. The 3 PDZ domains bind the C-termini of specific receptors and channels, leading to the transien作者: Demulcent 時間: 2025-3-25 21:18 作者: chronicle 時間: 2025-3-26 03:40
Role of Monoamine Transporters in Mediating Psychostimulant Effectssposition within the brain. Alterations in DA disposition can lead to conditions such as drug addiction, Parkinson’s disease, and schizophrenia, a fact that underscores the importance of understanding DAergic signaling. Psychostimulants alter DAergic signaling by influencing both DAT and VMAT-2, and作者: 奴才 時間: 2025-3-26 06:12 作者: 矛盾心理 時間: 2025-3-26 09:58
Serotonin Transporters: Implications for Antidepressant Drug Development disruptions in the serotonergic and noradrenergic systems result in depressive symptoms. Therefore, the serotonin transporter (SERT) has become a pharmacological target for treating these symptoms. This review will discuss what is known about the molecular interactions of antidepressants with SERT.作者: 揮舞 時間: 2025-3-26 14:47 作者: 嘲笑 時間: 2025-3-26 18:26
κ Opioids as Potential Treatments for Stimulant Dependencerapeutic goal. Classically, the “dopamine hypothesis” has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor in mediating the abuse effects. Therefore, most treatments have focused on directly i作者: gout109 時間: 2025-3-26 23:51
Regulation of Monoamine Transporters: Influence of Psychostimulants and Therapeutic Antidepressantson at specific molecular targets. At the molecular level, neurotransmitter signaling is dynamically regulated by a diverse set of macromolecules including biosynthetic enzymes, secretory proteins, ion channels, pre- and postsynaptic receptors and transporters. Monoamines, 5-hydroxytryptamine or sero作者: radiograph 時間: 2025-3-27 04:56
Hallucinogen Actions on 5-HT Receptors Reveal Distinct Mechanisms of Activation and Signaling by G Purrent understanding of mechanisms of drugs of abuse. These advances are illustrated by results from our ongoing work on the actions of hallucinogens on serotonin (5-HT) receptors. We show how a combined computational and experimental approach can reveal specific modes of receptor activation underly作者: Pelvic-Floor 時間: 2025-3-27 09:08
Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter een neurons. Specific inhibitors for these transporters, including the abused psychostimulants cocaine and amphetamine and the tricyclic and SSRI classes of antidepressants, exert their physiological effects by interfering with synaptic uptake and thus prolonging the actions of the monoamine. Pharma作者: 弄污 時間: 2025-3-27 10:25 作者: coalition 時間: 2025-3-27 15:42 作者: Angioplasty 時間: 2025-3-27 19:08 作者: headlong 時間: 2025-3-27 22:54
Cocaine- and Amphetamine-Regulated Transcript Peptides Play a Role in Drug Abuse and Are Potential T, DA can influence CART in the accumbens. Thus a complex interacting circuitry likely exists. Fifth, in humans, CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene associates with alcoholism..Overall, it is clear that there are functional intera作者: 嘮叨 時間: 2025-3-28 04:50
RNAi-Directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapywever, given the sequence diversity of the HIV genomes of infected subjects, it is difficult to target a specific HIV sequence. Therefore, targeting nonvariable HIV binding receptors on susceptible cells or other molecules of host cells that are directly or indirectly involved in HIV infections may 作者: 一再煩擾 時間: 2025-3-28 09:53
Viewing Chemokines as a Third Major System of Communication in the BrainXCL10/IP 10, CCL3/MIP-1α, and CCL5/RANTES. Functional roles for the chemokine system, composed of the chemokine ligands and their receptors, have been suggested in brain development and heterologous desensitization. The system can alter the actions of neuronally active pharmacological agents such as作者: 無法破譯 時間: 2025-3-28 13:27
Neuronal Nicotinic Acetylcholine Receptor Expression and Function on Nonneuronal Cellshe expression of peripheral nAChRs in cells other than neurons and how they participate in fundamental processes, such as inflammation. Understanding these processes may offer novel therapeutic strategies to approach inflammatory diseases, as well as precautions in the design of interventional drugs作者: 史前 時間: 2025-3-28 16:04 作者: 沉著 時間: 2025-3-28 22:02 作者: ASTER 時間: 2025-3-29 01:26 作者: 無可爭辯 時間: 2025-3-29 04:53 作者: Gesture 時間: 2025-3-29 09:53 作者: annexation 時間: 2025-3-29 13:02 作者: 到婚嫁年齡 時間: 2025-3-29 17:13
Dual Dopamine/Serotonin Releasers as Potential Medications for Stimulant and Alcohol Addictionsexistence of a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Then we summarize studies that have tested the hypothesis that 5-HT neurons can dampen the effects mediated by mesolimbic DA. For example, it has been shown that pharmacological manipulations作者: 凹處 時間: 2025-3-29 23:25 作者: 偏狂癥 時間: 2025-3-30 02:14
Low Cost-3D Visualization of Neural NetworksDARPP-32 plays a key role in integrating a variety of biochemical, electrophysiological, and behavioral responses controlled by dopamine and other neurotransmitters. Importantly, there is now a large body of evidence that supports a key role for DARPP-32-dependent signaling in mediating the actions 作者: 細微差別 時間: 2025-3-30 04:13 作者: commodity 時間: 2025-3-30 11:02
https://doi.org/10.1007/978-3-662-10798-0, DA can influence CART in the accumbens. Thus a complex interacting circuitry likely exists. Fifth, in humans, CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene associates with alcoholism..Overall, it is clear that there are functional intera作者: 暖昧關系 時間: 2025-3-30 13:19 作者: collagen 時間: 2025-3-30 18:58
https://doi.org/10.1007/978-3-662-10798-0XCL10/IP 10, CCL3/MIP-1α, and CCL5/RANTES. Functional roles for the chemokine system, composed of the chemokine ligands and their receptors, have been suggested in brain development and heterologous desensitization. The system can alter the actions of neuronally active pharmacological agents such as作者: Microaneurysm 時間: 2025-3-30 21:26
https://doi.org/10.1007/978-3-662-10798-0he expression of peripheral nAChRs in cells other than neurons and how they participate in fundamental processes, such as inflammation. Understanding these processes may offer novel therapeutic strategies to approach inflammatory diseases, as well as precautions in the design of interventional drugs作者: EXULT 時間: 2025-3-31 04:14
https://doi.org/10.1007/978-3-662-10798-0tivity and subcellular distribution of monoamine transporters, a phenomenon likely related to the neurotoxic potential of these drugs to DAergic neurons. This article will review some of the recent findings whereby releasers and uptake blockers alter DAT and VMAT-2 activity and how these alterations作者: evanescent 時間: 2025-3-31 07:21
https://doi.org/10.1007/978-3-662-10798-0pounds substitute for cocaine, reduce the intake of cocaine in rats and rhesus monkeys trained to self-administer cocaine, and have demonstrated a slow onset and long duration of action and lack of sensitization. The 3-phenyltropane analogs were also tested in a rhesus monkey self-administration mod作者: 過剩 時間: 2025-3-31 12:39 作者: 粘土 時間: 2025-3-31 17:07
https://doi.org/10.1007/978-3-662-10798-0gh affinity molecular targets for drugs of abuse including cocaine, amphetamine, and 3,4-methylenedioxymetamphetamine (MDMA) “Ecstasy.” Monoamine transporters also serve as molecular gateways for neurotoxins. Emerging evidence indicates that regulation of transporter function and surface expression 作者: alcohol-abuse 時間: 2025-3-31 20:14 作者: 少量 時間: 2025-4-1 01:37 作者: avarice 時間: 2025-4-1 05:49
https://doi.org/10.1007/978-3-662-10798-0existence of a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Then we summarize studies that have tested the hypothesis that 5-HT neurons can dampen the effects mediated by mesolimbic DA. For example, it has been shown that pharmacological manipulations作者: pulmonary-edema 時間: 2025-4-1 09:15 作者: 生命層 時間: 2025-4-1 12:34 作者: 野蠻 時間: 2025-4-1 15:47
Rao S. Rapaka,Wolfgang SadéeProvides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction作者: Individual 時間: 2025-4-1 20:27 作者: DNR215 時間: 2025-4-1 23:50
Low Cost-3D Visualization of Neural Networksadditional neurotransmitters, including glutamate, serotonin and adenosine. All these neurotransmitters regulate the phosphorylation state of Dopaminal serine/threonine protein phosphatase, PP-1. Phosphorylatine- and cAMP-regulated phosphoprotein, Mr 32kDa (DARPP-32). Phosphorylation at Thr. by prot作者: 不如屎殼郎 時間: 2025-4-2 02:54 作者: 心神不寧 時間: 2025-4-2 07:21
https://doi.org/10.1007/978-3-662-10798-0 activated. Many vital physiological events such as sensory perception, immune defense, cell communication, chemotaxis, and neurotransmission are mediated by GPCRs. Not surprisingly, GPCRs are major targets for drug development today. Most modeling studies in the GPCR field have focused upon the cre
