標(biāo)題: Titlebook: Drug Action at the Molecular Level; G. C. K. Roberts Book 1977 Institute of Biology Endowment Trust Fund 1977 drug.research.Symposium [打印本頁] 作者: 去是公開 時間: 2025-3-21 17:24
書目名稱Drug Action at the Molecular Level影響因子(影響力)
書目名稱Drug Action at the Molecular Level影響因子(影響力)學(xué)科排名
書目名稱Drug Action at the Molecular Level網(wǎng)絡(luò)公開度
書目名稱Drug Action at the Molecular Level網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Drug Action at the Molecular Level被引頻次
書目名稱Drug Action at the Molecular Level被引頻次學(xué)科排名
書目名稱Drug Action at the Molecular Level年度引用
書目名稱Drug Action at the Molecular Level年度引用學(xué)科排名
書目名稱Drug Action at the Molecular Level讀者反饋
書目名稱Drug Action at the Molecular Level讀者反饋學(xué)科排名
作者: 親密 時間: 2025-3-21 20:39
Verteilungskonflikte und Marktverb?ndeins (Ullrich, 1972). Micro-organisms using lipophilic compounds as the sole carbon source rely on the presence of mono-oxygenases for the initial oxidation of the substrate to alcohols, which can be further oxidised with concomitant production of chemical energy.作者: 蘑菇 時間: 2025-3-22 01:48
The conformation of hormonal peptides in solution, data on hormone conformations in hormone — receptor complexes on which to examine these claims. However, the X-ray structures of several enzyme — coenzyme and enzyme — inhibitor complexes indicate that conformational changes often occur on complex formation. If there is a conformational change when作者: faultfinder 時間: 2025-3-22 08:14
The mechanism of cytochrome P450-catalysed drug oxidations,ins (Ullrich, 1972). Micro-organisms using lipophilic compounds as the sole carbon source rely on the presence of mono-oxygenases for the initial oxidation of the substrate to alcohols, which can be further oxidised with concomitant production of chemical energy.作者: 線 時間: 2025-3-22 10:39 作者: 吹氣 時間: 2025-3-22 13:07 作者: 吹氣 時間: 2025-3-22 19:34
Structure and function of carbonic anhydrase: comparative studies of sulphonamide binding to human was shown by Mann and Keilin (1940) that certain sulphonamides were specific and potent inhibitors of this enzyme. It has been well documented (see Maren, 1967, for an extensive review on inhibition and physiology, and Lindskog .. 1971, and Coleman, 1971, for general reviews on carbonic anhydrases) 作者: 山間窄路 時間: 2025-3-22 23:16 作者: Ambiguous 時間: 2025-3-23 02:52 作者: BUST 時間: 2025-3-23 05:33 作者: 無彈性 時間: 2025-3-23 11:01
The molecular basis for the inhibitory action of 6-(arylhydrazino)-pyrimidines on the replication-slazo)pyrimidines were conceived and synthesised by Bernard Langley of Imperial Chemical Industries, Ltd in the early 1960s. Langley and his colleagues, in their initial studies of biological activity of the arylazopyrimidines, observed that they were potent inhibitors of the growth of Gram-positive 作者: palliative-care 時間: 2025-3-23 17:20 作者: 虛構(gòu)的東西 時間: 2025-3-23 20:25 作者: 自戀 時間: 2025-3-24 01:58
The mechanism of cytochrome P450-catalysed drug oxidations,riety of metabolic reactions. Lipophilic molecules, like steroids or the fat-soluble vitamins, are in the minority. These latter compounds consist, in substantial part, of aromatic or alicyclic rings and/or aliphatic side-chains. These hydrocarbon groups are metabolically rather inert and in fact on作者: 混合 時間: 2025-3-24 06:25
,Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic identical with, the sodium pump activity of cell membranes. ., this enzyme pumps sodium out of and potassium into the cell and it has therefore, during its transport cycle, access to both sides of the cell membrane (Post .. 1969). The transport function of Na. + K. — ATPase is required for volume c作者: 公豬 時間: 2025-3-24 07:39
Adenylate cyclase: actions and interactions of regulatory ligands,shed by Sutherland and his associates (Sutherland and Rall, 1960) that the only ingredients necessary to elicit a hormonal effect on the enzyme were magnesium ion, ATP, hormone and membranes bearing the enzyme. This seemingly simple system, in which hormone was shown to increase the . of adenylate c作者: 健忘癥 時間: 2025-3-24 11:31
Properties and function of the acetylcholine receptor of vertebrate skeletal muscle,al synapse. An impressive history of electrophysiological and pharmaco-logical investigation has revealed the outline of the events involved in transmission there (Katz, 1966; Hubbard, 1974; Rang, 1974). The quantal release of ACh,* the activation of receptors by the transmitter, the depolarisation 作者: Optimum 時間: 2025-3-24 17:31
https://doi.org/10.1007/978-1-349-03230-3drug; research; Symposium作者: 異教徒 時間: 2025-3-24 21:45 作者: thwart 時間: 2025-3-25 01:40
Analyse der Kooperation und ComplianceWhat would the molecular pharmacologist really like to know? It may seem arrogant for a theoretician to pose and attempt to answer this question, but it is necessary if the full value of theoretical calculations is to be appreciated.作者: Metamorphosis 時間: 2025-3-25 07:23
Calculation of essential drug conformations and electron distributions,What would the molecular pharmacologist really like to know? It may seem arrogant for a theoretician to pose and attempt to answer this question, but it is necessary if the full value of theoretical calculations is to be appreciated.作者: 潛伏期 時間: 2025-3-25 08:58
Drug Action at the Molecular Level978-1-349-03230-3Series ISSN 2947-1281 Series E-ISSN 2947-129X 作者: 運動的我 時間: 2025-3-25 13:02
2947-1281 Overview: 978-1-349-03232-7978-1-349-03230-3Series ISSN 2947-1281 Series E-ISSN 2947-129X 作者: quiet-sleep 時間: 2025-3-25 18:10
https://doi.org/10.1007/978-3-662-10787-4for a review, see Pestka, 1971). It was the first antibiotic to be synthesised by chemical methods (Controulis, Rebstock and Crooks, 1949). The molecule has a relatively simple structure, which consists of a propanediol moiety (III), carrying a p-nitrobenzene side-chain (I) and a dichloroacetyl side-chain (II) (Fig. 10.1).作者: 大酒杯 時間: 2025-3-25 21:33 作者: 密切關(guān)系 時間: 2025-3-26 03:46 作者: 艱苦地移動 時間: 2025-3-26 05:03 作者: Jejune 時間: 2025-3-26 10:45
Strukturierung des Therapieablaufstors. There exists a very wide range of chemically related specific inhibitors, all of those with high affinity (K.>10. M.) possessing the following properties. The sulphonamide group is unsubstituted on the nitrogen atom and is directly linked to an aromatic nucleus. This nucleus may be homocyclic,作者: Flu表流動 時間: 2025-3-26 15:56 作者: 代理人 時間: 2025-3-26 17:00 作者: glacial 時間: 2025-3-26 22:24 作者: 動脈 時間: 2025-3-27 03:04
Strukturierung des Therapieablaufsnd then attempt to explain the sequence of events which connect that interaction with the physiological response. It is commonly envisaged that the binding of the drug to its receptor provokes conformational changes in the latter which act as the immediate trigger leading to the biological effect. O作者: BOGUS 時間: 2025-3-27 06:10 作者: patella 時間: 2025-3-27 11:27 作者: Nutrient 時間: 2025-3-27 16:30
https://doi.org/10.1007/978-3-662-10791-1 identical with, the sodium pump activity of cell membranes. ., this enzyme pumps sodium out of and potassium into the cell and it has therefore, during its transport cycle, access to both sides of the cell membrane (Post .. 1969). The transport function of Na. + K. — ATPase is required for volume c作者: 不滿分子 時間: 2025-3-27 21:17
Strategische Dimensionen der Virtual Realityshed by Sutherland and his associates (Sutherland and Rall, 1960) that the only ingredients necessary to elicit a hormonal effect on the enzyme were magnesium ion, ATP, hormone and membranes bearing the enzyme. This seemingly simple system, in which hormone was shown to increase the . of adenylate c作者: STERN 時間: 2025-3-28 01:36 作者: 投票 時間: 2025-3-28 03:24
Biological Council Symposia on Drug Actionhttp://image.papertrans.cn/e/image/283023.jpg作者: 出處 時間: 2025-3-28 09:00
The receptor site for chloramphenicol , and ,for a review, see Pestka, 1971). It was the first antibiotic to be synthesised by chemical methods (Controulis, Rebstock and Crooks, 1949). The molecule has a relatively simple structure, which consists of a propanediol moiety (III), carrying a p-nitrobenzene side-chain (I) and a dichloroacetyl side-chain (II) (Fig. 10.1).作者: gonioscopy 時間: 2025-3-28 11:17 作者: Invigorate 時間: 2025-3-28 17:21 作者: Munificent 時間: 2025-3-28 19:30 作者: Frequency-Range 時間: 2025-3-29 01:12 作者: 蕁麻 時間: 2025-3-29 04:21
Substrate and inhibitor binding to dihydrofolate reductase,olate, plays a vital role in intermediary metabolism, acting as a ‘carrier’ of one-carbon fragments in the biosynthesis of a number of amino acids, thymidylate and purines (for a review, see Blakley, 1969).作者: Pert敏捷 時間: 2025-3-29 10:43 作者: 隱士 時間: 2025-3-29 12:57
,Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic ng its transport cycle, access to both sides of the cell membrane (Post .. 1969). The transport function of Na. + K. — ATPase is required for volume control in the cell, but it also subserves many other cellular functions (Post, 1968).作者: 撫慰 時間: 2025-3-29 16:42
Indikation und Behandlungssettingthat aromatic and heterocyclic sulphonamides with unsubstituted R—SO. NH. groups constitute a class of powerful inhibitors, while aliphatic sulphonamides are poor inhibitors of the carbonic anhydrases.作者: Sputum 時間: 2025-3-29 21:25 作者: Keshan-disease 時間: 2025-3-30 01:54
Strukturierung des Therapieablaufsbviously a . for understanding these events is a fairly detailed knowledge of the nature of the receptor and its conformation in the unperturbed state. Needless to say, the receptor is generally reckoned to be a macromolecule of some sort — quite likely (but not necessarily) a protein.作者: Irrepressible 時間: 2025-3-30 07:03
Wolfgang Krueger,Bernd Froehlich particular accessibility of this site to electrophysiological and pharmacological analysis. The underlying molecular determinants of the synaptic activity have not, however, yet been defined. The molecular biology of the functioning cholinergic synapse is still at an early stage.作者: 偽書 時間: 2025-3-30 10:31 作者: Ornament 時間: 2025-3-30 13:11 作者: 傳授知識 時間: 2025-3-30 20:35
https://doi.org/10.1007/978-3-662-10777-5olate, plays a vital role in intermediary metabolism, acting as a ‘carrier’ of one-carbon fragments in the biosynthesis of a number of amino acids, thymidylate and purines (for a review, see Blakley, 1969).作者: entice 時間: 2025-3-30 22:48
Indikation und Behandlungssetting, in their initial studies of biological activity of the arylazopyrimidines, observed that they were potent inhibitors of the growth of Gram-positive bacteria and that they possessed little or no toxicity for Gram-negative organisms or for animal cells.作者: 運動吧 時間: 2025-3-31 00:56
