標(biāo)題: Titlebook: Drug Absorption Studies; In Situ, In Vitro an Carsten Ehrhardt,Kwang-Jin Kim Book 2008 Springer-Verlag US 2008 Assessment.Expression.Transp [打印本頁(yè)] 作者: 抵押證書(shū) 時(shí)間: 2025-3-21 16:57
書(shū)目名稱(chēng)Drug Absorption Studies影響因子(影響力)
作者: BADGE 時(shí)間: 2025-3-21 20:22 作者: 邊緣 時(shí)間: 2025-3-22 00:56
Entangling Bodies and Objects in the Airt, following oral administration, and this has raised the general interest in colonic drug absorption. Although the colon cannot match the small intestine in many of its morphological and functional aspects related to drug absorption, it notably has several carrier-mediated transport systems that mi作者: INCUR 時(shí)間: 2025-3-22 06:36 作者: Tinea-Capitis 時(shí)間: 2025-3-22 10:50
Clemens Eisenmann,Kathrin Englert,Ehler Voss, methodological, and ethical limitations associated with the use of the human species, animal models are routinely used for drug delivery studies, especially during early stages of drug development. The use of excised and cultured human or animal tissues as in vitro models to study nasal drug absor作者: 符合國(guó)情 時(shí)間: 2025-3-22 13:03
https://doi.org/10.1007/978-3-658-40063-7 The procedure for establishing the model requires a skilled operator, a validated technique for intra-tracheal drug delivery and a system for maintenance and monitoring of the preparation. Most absorption studies to date have utilised the ex vivo rat lung maintained by ventilation and perfusion in 作者: 符合國(guó)情 時(shí)間: 2025-3-22 20:38
Diskurstheorie als Forschungsperspektivefirst-pass metabolism. However, despite offering the possibility of improved systemic drug delivery, buccal administration has been utilized for relatively few pharmaceutical products so far. One of the reasons is costly preclinical development, which includes laborious pharmacokinetic evaluation in作者: Monocle 時(shí)間: 2025-3-22 22:51
Diskurstheorie als Forschungsperspektiveted site of action. Different models have been established for the parallel screening of these biopharmaceutical properties, including membrane-based models (PAMPA), cell culture-based models (such as Caco-2 and MDCK cell lines), and the Ussing chambers technique. In this chapter, the strengths and 作者: 撫育 時(shí)間: 2025-3-23 05:25 作者: 高度贊揚(yáng) 時(shí)間: 2025-3-23 07:32 作者: definition 時(shí)間: 2025-3-23 13:27 作者: FLAG 時(shí)間: 2025-3-23 15:52
Diskurstheorie als Forschungsperspektiver for topically applied drugs is represented by the cornea. Therefore, examining the corneal tissue is an important subject in ocular research. In vitro examinations on transcorneal permeation are often performed with excised corneal tissues from laboratory animals or killed livestock. But the use o作者: 不適 時(shí)間: 2025-3-23 19:12 作者: 世俗 時(shí)間: 2025-3-24 01:55
Diskurstheorie als Forschungsperspektiven the circulating blood and the neural retina. Thus, understanding of inner BRB transport mechanisms is an important step toward drug targeting of the retina. Nevertheless, information of inner BRB transport is very limited due in part to the difficulty in precise determination of inner BRB transpor作者: 專(zhuān)橫 時(shí)間: 2025-3-24 05:19 作者: NOT 時(shí)間: 2025-3-24 10:05 作者: 詼諧 時(shí)間: 2025-3-24 11:55 作者: 對(duì)手 時(shí)間: 2025-3-24 15:40 作者: Mri485 時(shí)間: 2025-3-24 21:45 作者: Foam-Cells 時(shí)間: 2025-3-24 23:35 作者: Alveolar-Bone 時(shí)間: 2025-3-25 04:11 作者: 令人不快 時(shí)間: 2025-3-25 09:31 作者: 靈敏 時(shí)間: 2025-3-25 15:35 作者: 恫嚇 時(shí)間: 2025-3-25 19:14
Models for Skin Absorption and Skin Toxicity Testingfunction of human skin is described discussing the contribution of the different skin layers and skin appendages to skin absorption. Moreover, various skin absorption pathways are discussed. Particular attention is paid to the strategies used to test skin invasion. This chapter includes in vivo, ex 作者: 露天歷史劇 時(shí)間: 2025-3-25 20:24 作者: Admire 時(shí)間: 2025-3-26 02:24 作者: Feature 時(shí)間: 2025-3-26 08:16 作者: HUMID 時(shí)間: 2025-3-26 10:35 作者: 厚顏 時(shí)間: 2025-3-26 14:29
The Isolated Perfused Lung for Drug Absorption Studies The procedure for establishing the model requires a skilled operator, a validated technique for intra-tracheal drug delivery and a system for maintenance and monitoring of the preparation. Most absorption studies to date have utilised the ex vivo rat lung maintained by ventilation and perfusion in 作者: ONYM 時(shí)間: 2025-3-26 19:15 作者: sulcus 時(shí)間: 2025-3-26 23:33
In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolismted site of action. Different models have been established for the parallel screening of these biopharmaceutical properties, including membrane-based models (PAMPA), cell culture-based models (such as Caco-2 and MDCK cell lines), and the Ussing chambers technique. In this chapter, the strengths and 作者: 極小量 時(shí)間: 2025-3-27 02:17
In Vitro Cellular Models for Nasal Drug Absorption Studiesations, reliable in vivo and/or in vitro models are needed. In vivo animal models or in vitro excised animal tissue models are frequently used for nasal drug absorption studies due to various methodological and ethical limitations associated with the use of human nasal specimens. However, there are 作者: Kindle 時(shí)間: 2025-3-27 09:08
In Vitro Models of the Tracheo-Bronchial Epitheliumlveolar region). The conducting airways can be further subdivided into the trachea plus larger bronchi and the distal bronchiolar airways. Each of these regions consists of distinct types of epithelial cells with unique phenotypes, morphologies and associated physiological functions. This chapter fo作者: NAG 時(shí)間: 2025-3-27 09:30
In Vitro Models of the Alveolar Epithelial Barrierand macromolecules, including recently engineered peptide and protein therapeutics. Advantages of aerosol administration include a more rapid absorption into the systemic circulation (this may be particularly important for drugs where fast onset of action is critical), a higher bioavailability than 作者: happiness 時(shí)間: 2025-3-27 13:39 作者: deriver 時(shí)間: 2025-3-27 21:25 作者: Noctambulant 時(shí)間: 2025-3-27 22:19 作者: phytochemicals 時(shí)間: 2025-3-28 03:05
Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epitheliamposed of the tight junctional resistance (.TJ) and the resistance of the lateral intercellular space (.LIS). Recent studies in human vaginal-cervical epithelia revealed novel mechanisms of regulation of the paracellular resistance (.PCR), including both the .TJ and the .LIS. Steroid hormones and pa作者: Fecundity 時(shí)間: 2025-3-28 06:28 作者: COM 時(shí)間: 2025-3-28 13:14 作者: brachial-plexus 時(shí)間: 2025-3-28 15:28 作者: eustachian-tube 時(shí)間: 2025-3-28 22:25
Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formth epithelial cell cultures in vitro. The first section is focused on the combined assessment of drug release/dissolution and subsequent absorption/permeation for solid oral dosage forms. Experimental approaches to mimic the complex physiologically surroundings in the gastrointestinal tract are pres作者: Organization 時(shí)間: 2025-3-28 23:44
Claudia Müller,Marén Schorch,David Struzekskin sensitization, skin irritation and corrosion, and skin phototoxicity testing. Altogether an up-to-date status on techniques concerning skin invasion testing and skin toxicity testing is provided.作者: 暫時(shí)別動(dòng) 時(shí)間: 2025-3-29 05:04
Reinventing the Wheel of Media Theoryble and the issues associated with choice of animal tissue used in preclinical drug absorption studies. Most of our work in this field has been performed using porcine buccal mucosa in modified Ussing chambers, and the reader is referred to the appendix (available online) for a comprehensive protocol on this technique.作者: 鎮(zhèn)壓 時(shí)間: 2025-3-29 07:22
Clemens Eisenmann,Kathrin Englert,Ehler Vossitro nasal drug transport and metabolism studies are based on animal tissues. A comparative treatise of various in situ and ex vivo nasal models is presented in this chapter. The advantages, limitations, specific applications of the various models in preclinical drug development, and in vivo/in vitro correlations are highlighted.作者: DRILL 時(shí)間: 2025-3-29 13:28 作者: Horizon 時(shí)間: 2025-3-29 17:37
Models for Skin Absorption and Skin Toxicity Testingskin sensitization, skin irritation and corrosion, and skin phototoxicity testing. Altogether an up-to-date status on techniques concerning skin invasion testing and skin toxicity testing is provided.作者: Debate 時(shí)間: 2025-3-29 20:42
In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosable and the issues associated with choice of animal tissue used in preclinical drug absorption studies. Most of our work in this field has been performed using porcine buccal mucosa in modified Ussing chambers, and the reader is referred to the appendix (available online) for a comprehensive protocol on this technique.作者: TRUST 時(shí)間: 2025-3-30 00:51 作者: packet 時(shí)間: 2025-3-30 07:32
Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epitheliaeformability and the .LIS. The knowledge gained from these studies on the molecular mechanisms involved may improve the understanding of dysregulation of water and solutes, and related diseases. The data may be also used in future clinical trials to improve topical drug delivery via the vaginal route in women.作者: originality 時(shí)間: 2025-3-30 08:36 作者: flammable 時(shí)間: 2025-3-30 13:36
Diskurstheorie als Forschungsperspektive regulating drug distribution is key to the future of design of therapeutic agents that are safe for use in pregnancy. Reviewed herein are in vitro model systems for studying placental transport as well as consideration of some of the well-represented multidrug resistance transporters naturally expressed in this unique tissue.作者: fodlder 時(shí)間: 2025-3-30 18:39
https://doi.org/10.1007/978-3-658-40590-8ort proteins, such as P-glycoprotein. Regulatory mechanisms underlying P-glycoprotein expression and function will be discussed. Ex vivo and in vitro models are introduced and methods to study drug permeation across the endothelial cell barrier will be described.作者: Magisterial 時(shí)間: 2025-3-30 22:28 作者: 助記 時(shí)間: 2025-3-31 01:52 作者: 苦笑 時(shí)間: 2025-3-31 08:09 作者: 充滿(mǎn)裝飾 時(shí)間: 2025-3-31 11:16 作者: GLIDE 時(shí)間: 2025-3-31 13:23 作者: Cacophonous 時(shí)間: 2025-3-31 19:23 作者: CLOWN 時(shí)間: 2025-4-1 00:41
In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolismmultitude of parameters, a single universal model accounting for all these parameters does not exist. Therefore, combination of different in vitro models should be considered in order to obtain better insights in intestinal drug absorption in the different phases of drug discovery and development.作者: 縮減了 時(shí)間: 2025-4-1 05:28
Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formcommodate pulmonary epithelial cell culture systems. Differences between longtime and low-dose aerosol deposition in environmental toxicology and short time bolus inhalation of pharmaceutical aerosols are elucidated.
