作者: Countermand 時間: 2025-3-21 21:14 作者: ILEUM 時間: 2025-3-22 03:20 作者: 四牛在彎曲 時間: 2025-3-22 05:53
Pharmacological Classification of High-Threshold Calcium Channels in Rat Neurons,zed by an action potential. One important function of calcium channels in neurons is to mediate release of neurotransmitter from presynaptic nerve terminals. In addition, calcium channels help initiate electrical action potentials in various cell bodies and dendrites. It is very likely that calcium 作者: Prologue 時間: 2025-3-22 11:23
Effects of Dihydropyridine Calcium Antagonists upon Microvascular Function Following Ischemia and Oion before the induction of ischemia (Nayler 1988). The components of protection probably involve a combination of several factors occurring during the ischemic period. These factors include energy preservation (Watts et al. 1980), decreased accumulation of cytosolic calcium and lactic acid (Watts e作者: 可耕種 時間: 2025-3-22 15:07 作者: 可耕種 時間: 2025-3-22 19:52 作者: 表臉 時間: 2025-3-22 23:25
Nimodipine and Learning in Aging Rabbits,e aging brain may be impaired in their ability to produce such changes. In our approach we have utilized eyeblink conditioning and the in vivo and in vitro rabbit hippocampus for behavioral, neurophysiological, and biophysical studies of associative learning. We have also investigated the potential 作者: 清唱劇 時間: 2025-3-23 03:09
,From the Cardiovascular to the Central Nervous System — An Adventure in the Pharmacology of Dihydroagement of a pharmaceutical company, which employed me at that time, a research project involving a search for novel Ca. antagonists. In the opinion of the research management, however, the blockade of Ca. entry into the cells was most likely to be associated with severe side effects, so that Ca. an作者: Project 時間: 2025-3-23 05:36 作者: monochromatic 時間: 2025-3-23 12:29
Twenty Years of Dihydropyridines,tory article of the January issue of . by Vater et al. [1] remain valid as pars pro toto for the DHP group of calcium antagonists. Only the overall interpretation of these data, which appeared in the discussion in that first DHP paper, should be read in a historical context, based on the knowledge of 1972.作者: Diuretic 時間: 2025-3-23 14:28
Pharmacological Classification of High-Threshold Calcium Channels in Rat Neurons,entry through voltage-dependent calcium channels is also important for a whole range of phenomena triggered by increases in internal calcium levels. Among these phenomena may be cell death resulting from prolonged calcium entry subsequent to long-lasting depolarizations, as may occur during ischemia.作者: 頂點 時間: 2025-3-23 20:41 作者: 遺傳學(xué) 時間: 2025-3-23 22:58
Nimodipine and Nervous System Function, al. 1989). This finding may be highly relevant for nimodipine’s action, given the fact that 50% of the cells in the CNS consist of glial cells which support and modulate the function of neurones in the CNS. Finally, there are binding sites for nimodipine on CNS blood vessels which thus provide another target for the drug.作者: Thyroxine 時間: 2025-3-24 06:23 作者: 陳列 時間: 2025-3-24 08:12 作者: HAWK 時間: 2025-3-24 11:52
,Differenzialdiagnostik und Komorbidit?t,f the research management, however, the blockade of Ca. entry into the cells was most likely to be associated with severe side effects, so that Ca. antagonists were not likely to succeed. The company entered the Ca. antagonist field eventually with a licensed ?me-too“ compound, but 10–15 years too late.作者: 保留 時間: 2025-3-24 18:07 作者: 周年紀念日 時間: 2025-3-24 21:40
1,4-Dihydropyridines: Effects of Chirality and Conformation on Their Activity,m agonists, in this case to BAY K 8644 (Fig. 1, item 2) the best investigated example in this series [1]. After separation of the enantiomers of BAY K 8644 it was discovered that only the (-)-S-enantiomer exhibits the calcium agonistic effects, while the other antipode is still a classical antagonist [2].作者: 周興旺 時間: 2025-3-24 23:09 作者: Evacuate 時間: 2025-3-25 04:58
https://doi.org/10.1007/978-3-658-36754-1tory article of the January issue of . by Vater et al. [1] remain valid as pars pro toto for the DHP group of calcium antagonists. Only the overall interpretation of these data, which appeared in the discussion in that first DHP paper, should be read in a historical context, based on the knowledge of 1972.作者: 文件夾 時間: 2025-3-25 11:08 作者: 思想靈活 時間: 2025-3-25 13:57
Frauenkrankheiten und Geb?rt?tigkeitcium agonists, BAY K 8644 (Schramm et al. 1983), has been intensively investigated and proven to be a valuable pharmacological tool (Bechem et al. 1988). But none of the compounds reported on so far have been suitable for clinical use, mainly because they produce unacceptable vasoconstriction.作者: refraction 時間: 2025-3-25 19:45 作者: Evacuate 時間: 2025-3-25 20:07
Wolf-Dieter Busse (Professor),Bernward Garthoff,Fr作者: Osteoporosis 時間: 2025-3-26 01:55 作者: anus928 時間: 2025-3-26 04:58 作者: Madrigal 時間: 2025-3-26 11:12
Michael Windzio,Annabell Zentarra (Watts et al. 1987a), reduced lysosomal rupture (Ichihara et al. 1987) and reduced incidence of arrhythmia (Nayler 1988) upon reperfusion. The degree of recovery of contractile function following ischemia and reperfusion is in proportion to the degree of depression of preischemic contractile functi作者: propose 時間: 2025-3-26 15:34 作者: PAC 時間: 2025-3-26 19:32 作者: aphasia 時間: 2025-3-26 21:04 作者: Cabg318 時間: 2025-3-27 05:09 作者: 離開 時間: 2025-3-27 08:30
https://doi.org/10.1007/978-3-86226-947-1n, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which owe their cardiovascular properties to a specific interaction with one cellular route of calcium作者: 博識 時間: 2025-3-27 09:54 作者: Reclaim 時間: 2025-3-27 16:34
Enis Bicer,Michael Windzio,Matthias Wingenszed by an action potential. One important function of calcium channels in neurons is to mediate release of neurotransmitter from presynaptic nerve terminals. In addition, calcium channels help initiate electrical action potentials in various cell bodies and dendrites. It is very likely that calcium 作者: Charitable 時間: 2025-3-27 20:31
Michael Windzio,Annabell Zentarraion before the induction of ischemia (Nayler 1988). The components of protection probably involve a combination of several factors occurring during the ischemic period. These factors include energy preservation (Watts et al. 1980), decreased accumulation of cytosolic calcium and lactic acid (Watts e作者: 冷淡一切 時間: 2025-3-28 00:31 作者: 大方一點 時間: 2025-3-28 04:51 作者: LUMEN 時間: 2025-3-28 08:11 作者: Vertebra 時間: 2025-3-28 10:32 作者: hair-bulb 時間: 2025-3-28 17:12
https://doi.org/10.1007/978-3-322-83442-3the impact of such articles on xenobiotics, Bayer/Miles ranked number 8. To a great part it has been Alexander Scriabine’s contribution that helped Bayer/Miles achieve that ranking. The papers presented at this workshop provide proof of his scientific impact, specifically in the development of calci作者: coagulate 時間: 2025-3-28 21:02 作者: 大暴雨 時間: 2025-3-29 02:23
https://doi.org/10.1007/978-3-642-95716-1calcium antagonist; calcium channel; cardiovascular; coronary heart disease; hypertension
