標(biāo)題: Titlebook: Developments in Statistical Evaluation of Clinical Trials; Kees van Montfort,Johan Oud,Wendimagegn Ghidey Book 2014 Springer-Verlag Berlin [打印本頁] 作者: deferential 時間: 2025-3-21 16:14
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書目名稱Developments in Statistical Evaluation of Clinical Trials讀者反饋
書目名稱Developments in Statistical Evaluation of Clinical Trials讀者反饋學(xué)科排名
作者: 伸展 時間: 2025-3-21 22:06
Recent Developments in Group-Sequential Designs,detailed description of an R package that implements a quick search procedure. Recent applications of group-sequential methodology to trials with multiple experimental treatments being tested against a single control treatment are also described.作者: LITHE 時間: 2025-3-22 00:38 作者: 耕種 時間: 2025-3-22 05:58
Different Methods to Analyse the Results of a Randomized Controlled Trial with More Than One FollowThe choice for a particular method depends on the characteristics of the data. For dichotomous outcome variables, an adjustment for baseline differences between the groups is mostly not necessary. Regarding the more advanced statistical techniques it was shown that the effect measures (i.e. odds rat作者: macular-edema 時間: 2025-3-22 11:06
Dose-Finding Methods for Two-Agent Combination Phase I Trials,e models and partial orderings across dose levels for two-agent combination trials. We also supply examples of successful software implementations and discuss the operating characteristics of these approaches.作者: Interim 時間: 2025-3-22 15:32
Multi-state Models Used in Oncology Trials,del and compared to the estimations based on exponentially distributed OS times. These sample size calculations are based on the assumption of piecewise uniformly accrual and exponentially distributed censoring time. The new three-state model approach results in a 10–30?% lower sample size and a cor作者: Interim 時間: 2025-3-22 18:32 作者: Epithelium 時間: 2025-3-23 00:58 作者: GIBE 時間: 2025-3-23 01:28
Developments in Statistical Evaluation of Clinical Trials作者: BLA 時間: 2025-3-23 08:25
Developments in Statistical Evaluation of Clinical Trials978-3-642-55345-5作者: reserve 時間: 2025-3-23 11:58
cal trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.978-3-662-52211-0978-3-642-55345-5作者: Abjure 時間: 2025-3-23 16:27
Handbook of Mindfulness and Self-Regulationraud within multi-centre trials is developed as part of a system of central statistical monitoring. There are many more unanswered questions about efficiencies in clinical trials methodology that need to be examined by statisticians and researchers.作者: 高興去去 時間: 2025-3-23 18:37
Handbook of Mindfulness and Self-Regulationdetailed description of an R package that implements a quick search procedure. Recent applications of group-sequential methodology to trials with multiple experimental treatments being tested against a single control treatment are also described.作者: 知識 時間: 2025-3-23 22:14 作者: enumaerate 時間: 2025-3-24 05:49 作者: ornithology 時間: 2025-3-24 08:49
Handbook of Mobile Teaching and Learninge models and partial orderings across dose levels for two-agent combination trials. We also supply examples of successful software implementations and discuss the operating characteristics of these approaches.作者: 牢騷 時間: 2025-3-24 11:16
Handbook of Mobile Teaching and Learningdel and compared to the estimations based on exponentially distributed OS times. These sample size calculations are based on the assumption of piecewise uniformly accrual and exponentially distributed censoring time. The new three-state model approach results in a 10–30?% lower sample size and a cor作者: 索賠 時間: 2025-3-24 16:19
Design Considerations for Mobile Learningifference is attributable to treatments); selection effect (a measure of the extent to which treatment response is influenced by self-selection of treatment by patients); and preference effect (a measure of the extent to which treatment difference is caused by an interaction between the patient’s ch作者: CHURL 時間: 2025-3-24 21:07
Marcello Farina,Riccardo Scattolinitreatment and not only the first one; some authors have proposed to consider the DLT as a time to event variable while others have analyzed the longitudinal measurements of toxic side events. This however raises the delicate issue of the definition of the optimal dose. These approaches are illustrat作者: AXIOM 時間: 2025-3-25 02:32
Book 2014l role that biostatistics plays in clinical trials..Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial imp作者: 有惡意 時間: 2025-3-25 03:53 作者: 野蠻 時間: 2025-3-25 08:35 作者: 脖子 時間: 2025-3-25 13:29
https://doi.org/10.1007/978-1-4419-6050-4r the assessment of clinical relevance. The properties of these procedures are investigated and contrasted. Furthermore, an overview of effect measures used for relevance assessment is given and their characteristics are illustrated. Application of the methods is illustrated with a clinical trial example.作者: 使無效 時間: 2025-3-25 18:35 作者: 中和 時間: 2025-3-25 22:51
Statistical Inference for Non-inferiority of a Diagnostic Procedure Compared to an Alternative Proc, we illustrate the methods with data from studies of diagnostic procedures for the diagnosis of oesophageal carcinoma infiltrating the tracheobronchial tree and for the diagnosis of aneurysm in patients with acute subarachnoid hemorrhage.作者: altruism 時間: 2025-3-26 02:46
Statistical Methods for the Assessment of Clinical Relevance,r the assessment of clinical relevance. The properties of these procedures are investigated and contrasted. Furthermore, an overview of effect measures used for relevance assessment is given and their characteristics are illustrated. Application of the methods is illustrated with a clinical trial example.作者: Spina-Bifida 時間: 2025-3-26 06:26
https://doi.org/10.1007/978-3-319-44019-4M algorithm, multiple imputation, and inverse probability weighted estimating equations. Simulation studies are reported which demonstrate how to implement these procedures and examine performance empirically.作者: Parabola 時間: 2025-3-26 08:58 作者: stress-response 時間: 2025-3-26 13:18 作者: 字的誤用 時間: 2025-3-26 19:11
Statistical Validation of Surrogate Markers in Clinical Trials, so-called meta-analytic approach and its information-theoretic version, where information from several units is combined to carry out the validation exercise. The methods will be illustrated using a case study in ophthalmology.作者: 線 時間: 2025-3-26 22:22
Designing Multi-arm Multi-stage Clinical Studies,rovide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.作者: cauda-equina 時間: 2025-3-27 03:07 作者: corpus-callosum 時間: 2025-3-27 07:04
Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses,in cardiovascular disease where individuals are at increased risk of myocardial infarction, angina, or stroke. In such settings it is common for clinical trialists to adopt composite endpoints on which to base treatment comparisons. We discuss issues in the use of composite endpoints and emphasize the difficulty in interpreting measures of effect.作者: 彎曲的人 時間: 2025-3-27 12:21 作者: Rejuvenate 時間: 2025-3-27 17:09 作者: 狗窩 時間: 2025-3-27 19:20
Design and Analysis of Clinical Trial Simulations, this chapter, we present points to consider when planning a clinical trial simulation, and discuss how to design a clinical trial simulation employing a fractional factorial design and how to analyze the simulation results.作者: 察覺 時間: 2025-3-28 01:32
Mindfulness in Behavioral Healthrovide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.作者: 愉快么 時間: 2025-3-28 02:24
Handbook of Mindfulness and Self-Regulationtistic, and the multi-stage models for analysing competing risks data are explained. Furthermore, we apply the theoretical methodology and illustrate the fundamental problems of interpreting the results of competing risk analyses by using empirical data in the field of outcome research in orthopaedics.作者: attenuate 時間: 2025-3-28 06:32 作者: 雄辯 時間: 2025-3-28 11:43 作者: 負(fù)擔(dān) 時間: 2025-3-28 17:19 作者: 有常識 時間: 2025-3-28 21:48 作者: 不遵守 時間: 2025-3-29 01:37
https://doi.org/10.1007/978-3-319-44019-4g different missing data mechanisms for incomplete responses in short-term and longitudinal studies, as well as for missing covariates. We critically discuss common ad hoc strategies for dealing with incomplete data, such as complete-case analyses and naive methods of imputation, and we review more 作者: 機密 時間: 2025-3-29 04:26 作者: 疏遠(yuǎn)天際 時間: 2025-3-29 09:42
Mindfulness in Behavioral Healthe same treatment or sets of combinations of treatments. An efficient solution to determine which intervention is most promising are multi-arm multi-stage clinical studies (MAMS). In this chapter we will discuss the general concept to designing MAMS studies within the group sequential framework and p作者: Ligneous 時間: 2025-3-29 12:17
Handbook of Mindfulness and Self-Regulationetect clinically meaningful treatment effects. In order to continue to perform important research in the future, we need to make clinical trial designs more efficient. Through the retrospective statistical analysis of variation in the design of past trials and the prospective comparisons of clinical作者: MIRE 時間: 2025-3-29 19:31 作者: 披肩 時間: 2025-3-29 20:59
Handbook of Mindfulness and Self-Regulationnalysis is conducted. At each interim analysis, the trial can stop for futility, stop for efficacy, or continue. The main advantage of group-sequential designs is that the expected number of patients is reduced compared to a design without interim analyses. There are infinitely many possible group-s作者: 索賠 時間: 2025-3-30 02:29 作者: Altitude 時間: 2025-3-30 07:48 作者: 混沌 時間: 2025-3-30 10:57
Mindfulness in Behavioral Healthharmacokinetic exposure-response relationship and (2) dose-response relationship when dose-adjustment depends on potential responses. Dose adjustment often happens in clinical trials either designed for therapeutic dose monitoring, or spontaneously due to, for example, adverse events. It makes causa作者: 關(guān)節(jié)炎 時間: 2025-3-30 14:04
Realistic Random Direction Mobilityrement. For a continuous outcome variable, a classical GLM for repeated measurements can be used to analyse the difference in development over time between the intervention and control group. However, because GLM for repeated measurements has some major disadvantages (e.g., only suitable for complet作者: 混亂生活 時間: 2025-3-30 18:28 作者: 脫落 時間: 2025-3-30 22:09 作者: 完成 時間: 2025-3-31 02:13
Handbook of Mobile Data Privacycal trials. However, failed past attempts to use surrogate endpoints made it clear that, before deciding on the use of a candidate surrogate endpoint, it is of the utmost importance to investigate its validity. Such validation process has proven challenging for conceptual and practical reasons. In t作者: 收集 時間: 2025-3-31 08:27
Handbook of Mobile Data Privacycularly, in oncology. This chapter provides an overview of various biomarker-based designs for phase III randomized clinical trials to evaluate clinical utility of a biomarker or biomarker-based treatment, including biomarker-strategy, enrichment, and randomize-all designs. We also provide a simulat作者: Missile 時間: 2025-3-31 11:16
Handbook of Mobile Teaching and Learning such as the continual reassessment method (CRM), have been gradually applied to single-agent trials to determine the maximum tolerated dose (MTD). By contrast, the rule-based approaches have commonly been applied to two-agent combination trials, probably due to the absence of well-understood model-作者: notice 時間: 2025-3-31 15:33
Handbook of Mobile Teaching and Learningally in first or second line of cancer therapies. Basic formulae for the determination of sample sizes based on time to event data can be found in the literature. Assumptions about the distributions of the survival time for OS and PFS, the accrual time and the censoring time are of key importance. M作者: Acquired 時間: 2025-3-31 18:29 作者: Interstellar 時間: 2025-4-1 01:44
Marcello Farina,Riccardo Scattolinid as the dose associated with a certain probability of dose limiting toxicity (DLT) during the first cycle of treatment, although toxicity is repeatedly measured over cycles on an ordinal scale. We present the main dose finding methods developed in the era of cytotoxic agents. We illustrate their pr
