標題: Titlebook: Developmental Toxicology; Methods and Protocol Craig Harris,Jason M. Hansen Book 2012 Springer Science+Business Media, LLC 2012 antioxidant [打印本頁] 作者: 葉子 時間: 2025-3-21 18:56
書目名稱Developmental Toxicology影響因子(影響力)
書目名稱Developmental Toxicology影響因子(影響力)學科排名
書目名稱Developmental Toxicology網(wǎng)絡公開度
書目名稱Developmental Toxicology網(wǎng)絡公開度學科排名
書目名稱Developmental Toxicology被引頻次
書目名稱Developmental Toxicology被引頻次學科排名
書目名稱Developmental Toxicology年度引用
書目名稱Developmental Toxicology年度引用學科排名
書目名稱Developmental Toxicology讀者反饋
書目名稱Developmental Toxicology讀者反饋學科排名
作者: phlegm 時間: 2025-3-22 00:10
In Vivo Models of Developmental Toxicology,d at a sufficient dosage during a sensitive period of development in a sensitive species. While in vitro approaches in developmental toxicology can provide a means to assess the potency of toxicants, ultimately, the need to use whole animal models to demonstrate embryotoxicity is necessary to fully 作者: 決定性 時間: 2025-3-22 00:29
, as a Model in Developmental Toxicology,ng with conservation of disease and stress response pathways, availability of mutant and transgenic strains, and wealth of biological information, have led to the increased use of . in toxicological studies. Although the potential to study the mechanisms of developmental toxicology in . is promising作者: Noctambulant 時間: 2025-3-22 08:12
Zebrafish Embryo Developmental Toxicology Assay,y is approximately 87% in AB strain fish (Brannen KC et al., Birth Defects Res B Dev Reprod Toxicol 89:66–77, 2010). The procedure entails exposing dechorionated gastrulation-stage embryos to a range of compound concentrations for 5 days throughout embryonic and larva development. The larvae are eva作者: Neolithic 時間: 2025-3-22 12:25
Gene Knockdown by Morpholino-Modified Oligonucleotides in the Zebrafish (,) Model: Applications forany advantages of zebrafish include their small size, prolific spawning, rapid development, and transparent embryos. They can be easily manipulated genetically through the use of transgenic technology and gene knockdown via morpholino-modified antisense oligonucleotides (MOs). Knocking down specific作者: 縫紉 時間: 2025-3-22 15:08
An Amphibian Model for Studies of Developmental Reproductive Toxicity,ces of early life-stage exposure to endocrine disrupting chemicals. The African clawed frog . has several characteristics which facilitates studies of developmental reproductive toxicity. Here, I present a . test protocol, including study design, exposure regime, and endpoints for chemical disruptio作者: 縫紉 時間: 2025-3-22 19:12
Avian Models in Teratology and Developmental Toxicology,plant culture. Like mammals, avian embryos have an allantois and their developmental pathways are highly conserved with those of mammals, thus avian models have biomedical relevance. Fertile eggs are inexpensive and the embryo develops rapidly, allowing for high-throughput. The chick genome is seque作者: liposuction 時間: 2025-3-22 22:06
Primary Cell and Micromass Culture in Assessing Developmental Toxicity,of which was reproductive/developmental toxicity. Thousands of chemicals will need testing which will require a large number of laboratory animals. In vitro systems (as pre-screens or as validated alternatives) appear to be useful tools to reduce the number of whole animals used or refine procedures作者: degradation 時間: 2025-3-23 01:33
Embryonic Stem Cell Test: Stem Cell Use in Predicting Developmental Cardiotoxicity and Osteotoxicit With appropriate toxicity data sets, acceptable exposure levels and actual safety of prescription and nonprescription drugs as well as environmental chemicals could be established for individuals that are more vulnerable to chemical exposure, such as pregnant women and their unborn children. The ga作者: 折磨 時間: 2025-3-23 07:37 作者: Gourmet 時間: 2025-3-23 09:59 作者: Initiative 時間: 2025-3-23 17:18 作者: 畸形 時間: 2025-3-23 18:15
Rabbit Whole Embryo Culture,his species let alone mechanisms underlying developmental toxicity. This paucity of information about the rabbit is partly due to the historic lack of whole embryo culture (WEC) methods for the rabbit, which have only been made available fairly recently. In rabbit WEC, early somite stage embryos (ge作者: 大吃大喝 時間: 2025-3-23 22:23 作者: fixed-joint 時間: 2025-3-24 06:05
Methodological Approaches to Cytochrome P450 Profiling in Embryos,normal metabolic function. CYP enzymes catalyze the oxidative biotransformation of many endogenous and exogenous chemicals, including steroids and eicosanoids, and drugs and other xenobiotic toxicants. Many CYPs have known for their potential roles in development, and many chemicals that cause devel作者: 枯燥 時間: 2025-3-24 07:13 作者: 丑惡 時間: 2025-3-24 12:06
Regulation and Control of AP-1 Binding Activity in Embryotoxicity,eractions. It is the fundamental procedure of several variants that allow qualitative and quantitative assessments of protein–nucleic acid complexes. Classically, nuclear proteins and DNA are combined and the resulting mixture is electrophoretically separated in polyacrylamide or agarose gel under n作者: 危機 時間: 2025-3-24 17:24 作者: bizarre 時間: 2025-3-24 22:09 作者: 譏諷 時間: 2025-3-25 01:34
https://doi.org/10.1007/978-3-642-69257-4cular and mechanistic level while establishing a relationship between these molecular events and morphological, behavioral, and/or physiological effects (i.e., phenotypic anchoring)..In this chapter, we address important considerations for using MOs to study developmental toxicology in zebrafish embryos and provide a protocol for their use.作者: 禍害隱伏 時間: 2025-3-25 05:19 作者: 連接 時間: 2025-3-25 11:18 作者: 漂泊 時間: 2025-3-25 13:07 作者: MARS 時間: 2025-3-25 17:43 作者: 是比賽 時間: 2025-3-25 21:25
Gene Knockdown by Morpholino-Modified Oligonucleotides in the Zebrafish (,) Model: Applications forcular and mechanistic level while establishing a relationship between these molecular events and morphological, behavioral, and/or physiological effects (i.e., phenotypic anchoring)..In this chapter, we address important considerations for using MOs to study developmental toxicology in zebrafish embryos and provide a protocol for their use.作者: 搜尋 時間: 2025-3-26 04:10
Avian Models in Teratology and Developmental Toxicology,e direct study of an agent’s embryotoxic effects. Here, we present protocols for using avian embryos in toxicology research, including egg husbandry and hatch, toxicant delivery, and assessment of proliferation, apoptosis, and cardiac structure and function.作者: Ovulation 時間: 2025-3-26 08:16 作者: 頑固 時間: 2025-3-26 09:01
The Murine Limb Bud in Culture as an In Vitro Teratogenicity Test System,during embryogenesis and the mechanisms by which chemicals interfere with critical signaling pathways. In this system, uniform developmental stages are selected for assessment, exposures are controlled precisely, and the confounding influences of maternal metabolism and transport are avoided.作者: 激勵 時間: 2025-3-26 13:20
Analysis of Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Early Embryos,hods used to analyze Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos. Data which have been generated by using these methods have also been included to provide examples of their usefulness in evaluating Nrf2-mediated antioxidant response in early embryos.作者: 核心 時間: 2025-3-26 19:42 作者: enterprise 時間: 2025-3-26 22:21 作者: 一再煩擾 時間: 2025-3-27 04:02 作者: nonplus 時間: 2025-3-27 06:35 作者: Peak-Bone-Mass 時間: 2025-3-27 09:42 作者: inhibit 時間: 2025-3-27 17:08 作者: Choreography 時間: 2025-3-27 19:39 作者: overreach 時間: 2025-3-28 00:40 作者: concubine 時間: 2025-3-28 04:41
, as a Model in Developmental Toxicology,, embryonic and larval growth tests to identify compounds that affect the nematode have remained the primary use of . in developmental toxicology. Here, we describe a . larval growth and development assay for medium- and high-throughput screening using the COPAS Biosort flow cytometer and provide descriptions of the data and subsequent analysis.作者: 小官 時間: 2025-3-28 06:55
1064-3745 -step detail essential for reproducible results.Contains key.The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology.? The science of developmental toxi作者: 山間窄路 時間: 2025-3-28 12:35
R. L. Smith,R. D. Frisina,D. A. Goodman developmental reproductive toxicity. Here, I present a . test protocol, including study design, exposure regime, and endpoints for chemical disruption of sex differentiation, reproductive organ development, the thyroxin-regulated metamorphosis, oestrogen synthesis (activity of the CYP19 aromatase enzyme), and fertility.作者: 使顯得不重要 時間: 2025-3-28 15:15 作者: Esophagitis 時間: 2025-3-28 19:53 作者: Vertebra 時間: 2025-3-29 01:51
Developmental Toxicology978-1-61779-867-2Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: dysphagia 時間: 2025-3-29 04:55 作者: inscribe 時間: 2025-3-29 08:37 作者: Psychogenic 時間: 2025-3-29 13:32 作者: 博愛家 時間: 2025-3-29 16:56
Effects of HDACi on Immunological Functionsd at a sufficient dosage during a sensitive period of development in a sensitive species. While in vitro approaches in developmental toxicology can provide a means to assess the potency of toxicants, ultimately, the need to use whole animal models to demonstrate embryotoxicity is necessary to fully 作者: 啞巴 時間: 2025-3-29 21:55 作者: 完全 時間: 2025-3-30 02:32 作者: dagger 時間: 2025-3-30 06:07 作者: 是突襲 時間: 2025-3-30 08:13 作者: vasculitis 時間: 2025-3-30 15:33
Computerized Respiratory Care Chartingplant culture. Like mammals, avian embryos have an allantois and their developmental pathways are highly conserved with those of mammals, thus avian models have biomedical relevance. Fertile eggs are inexpensive and the embryo develops rapidly, allowing for high-throughput. The chick genome is seque作者: Pelvic-Floor 時間: 2025-3-30 19:58 作者: 男學院 時間: 2025-3-31 00:18
Tarun Mishra,Stacia Phillips,Li Wu With appropriate toxicity data sets, acceptable exposure levels and actual safety of prescription and nonprescription drugs as well as environmental chemicals could be established for individuals that are more vulnerable to chemical exposure, such as pregnant women and their unborn children. The ga作者: Rebate 時間: 2025-3-31 03:45
Tarun Mishra,Stacia Phillips,Li Wuvitro systems to profile the biological effects of xenobiotic exposure and predict their potential developmental hazard. An adherent cell differentiation and cytotoxicity (ACDC) assay was developed using pluripotent mouse embryonic stem cells (mESCs) to evaluate chemical-induced effects on both stem作者: 眉毛 時間: 2025-3-31 07:57
Tarun Mishra,Stacia Phillips,Li Wunce much is known about pattern formation during limb development. The murine limb bud culture technique described in this chapter was developed and refined in the 1970s. In this culture system, limb development mimics that in vivo, although the rate is slower. Growth and cartilage differentiation l作者: intellect 時間: 2025-3-31 11:48
https://doi.org/10.1007/978-1-0716-3862-0 due to their anatomical inaccessibility, paucity of tissues, and other factors such as real ethical concerns in human studies. Many acute and chronic developmental anomalies can trace their origins to postimplantation phases of gestation where the organs are first being established and growth and d作者: modest 時間: 2025-3-31 14:24 作者: 假裝是你 時間: 2025-3-31 18:46 作者: 鎮(zhèn)痛劑 時間: 2025-3-31 22:37
Vinayaka R. Prasad,Ganjam V. Kalpananormal metabolic function. CYP enzymes catalyze the oxidative biotransformation of many endogenous and exogenous chemicals, including steroids and eicosanoids, and drugs and other xenobiotic toxicants. Many CYPs have known for their potential roles in development, and many chemicals that cause devel作者: expansive 時間: 2025-4-1 02:58 作者: placebo-effect 時間: 2025-4-1 09:57
https://doi.org/10.1007/978-1-59745-170-3eractions. It is the fundamental procedure of several variants that allow qualitative and quantitative assessments of protein–nucleic acid complexes. Classically, nuclear proteins and DNA are combined and the resulting mixture is electrophoretically separated in polyacrylamide or agarose gel under n作者: 存心 時間: 2025-4-1 12:50
https://doi.org/10.1007/978-1-59745-170-3have evolved to counteract the detrimental consequences of oxidative insult. Numerous antioxidant systems exist in developing organisms but have been shown to be dynamically expressed and may only become functional during specific periods of development. Thioredoxins (Trxs) are a class of low-molecu作者: febrile 時間: 2025-4-1 16:07 作者: Nausea 時間: 2025-4-1 21:05 作者: Pander 時間: 2025-4-2 00:57
