作者: epinephrine 時(shí)間: 2025-3-22 00:18 作者: persistence 時(shí)間: 2025-3-22 04:07
Mechanism and Specificity of two Restriction Enzymes, ,I and ,II, that Recognize Asymmetrical DNA Seom their recognition sites (2). Hence, the study of type II restriction enzymes was initially motivated by their unique applications in the analysis of DNA and in the construction of recombinant DNA molecules (3). However, these enzymes also provide examples of DNA-protein interactions whose mechanisms are amenable to molecular analysis.作者: cipher 時(shí)間: 2025-3-22 06:32 作者: 消息靈通 時(shí)間: 2025-3-22 12:27 作者: Solace 時(shí)間: 2025-3-22 14:52
DNA Methylation and Mismatch Repair: Molecular SpecificitiesDNA replication a single heteroduplex molecule segregates genetically, i.e. yields mixed progeny consisting of DNA duplexes with the sequence of individual heteroduplex strands. The mismatch repair process transforms a heteroduplex molecule into a homoduplex which yields pure progeny of a single genotype.作者: Solace 時(shí)間: 2025-3-22 19:51
Antibodies to Nucleic Acidslins are biologically active glycoproteins capable of carrying out several different functions. They can bind specifically to antigens, activate the complement systems, mediate cytotropic reactions and act as antigen receptors on lymphocyte membranes.作者: 指數(shù) 時(shí)間: 2025-3-22 21:24 作者: 寬容 時(shí)間: 2025-3-23 01:24
https://doi.org/10.1007/978-3-030-00238-1underlying their mode of recognition.. Among approximately 500 type II restriction endonucleases described, EcoRI is the so far best studied enzyme. EcoRI is a dimeric protein with two identical sub-units, the aminoacid sequence of which is known..作者: ALB 時(shí)間: 2025-3-23 07:13 作者: Explosive 時(shí)間: 2025-3-23 09:55
proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Mara作者: PAEAN 時(shí)間: 2025-3-23 16:28
https://doi.org/10.1007/978-94-009-1900-6inations of synthetic DNA oligomers of defined sequence, both alone and complexed with control proteins such as repressors and with antitumor drugs. It is an attractive idea to a structurally-minded molecular biologist to ask precisely how the information inherent in DNA gets out, in a way that allows it to be used by the host organism.作者: 不持續(xù)就爆 時(shí)間: 2025-3-23 19:57 作者: 全面 時(shí)間: 2025-3-24 00:19 作者: 為現(xiàn)場(chǎng) 時(shí)間: 2025-3-24 03:41 作者: FLIT 時(shí)間: 2025-3-24 08:24 作者: Occupation 時(shí)間: 2025-3-24 12:50 作者: 填料 時(shí)間: 2025-3-24 17:18 作者: textile 時(shí)間: 2025-3-24 21:00 作者: OVERT 時(shí)間: 2025-3-25 01:13 作者: amenity 時(shí)間: 2025-3-25 06:55
Dynamic Aspects of Antibiotic-DNA Interactionactivity (Gale et al., 1981; Waring, 1981). Here we shall be mainly concerned with a group of cyclic depsipeptide antibiotics called the quinoxalines, of which echinomycin (Figure 2) is the best-known member (Waring, 1979; Waring and Fox, 1983).作者: Blatant 時(shí)間: 2025-3-25 11:06 作者: Blood-Clot 時(shí)間: 2025-3-25 14:15
Elena G. Popkova,Bruno S. SergiAlso included are diagrams illustrating some of the geometrical features which are fundamental to an understanding of the differentiation between the various DNA conformations. Finally a selected list of references is given to individual structure determinations, to a textbook, and to some of the mo作者: 好色 時(shí)間: 2025-3-25 18:55
Symbol Systems and Semiotic Systemsevelopment of DNA sequencing and footprinting methods, techniques for cloning and overproduction of proteins, and the crystallization of DNA, proteins and their complexes. Many of the original problems have been solved but important questions remain unanswered. Perhaps one of the most important ques作者: 謙卑 時(shí)間: 2025-3-25 23:20 作者: Spinal-Fusion 時(shí)間: 2025-3-26 01:29 作者: Arthritis 時(shí)間: 2025-3-26 04:23 作者: 和平主義者 時(shí)間: 2025-3-26 11:33 作者: Initiative 時(shí)間: 2025-3-26 16:21
Momchil Hardalov,Ivan Koychev,Preslav Nakovral and antiprotozoal compounds, but probably most important as regards the frontiers of chemotherapy are the anticancer drugs. A quarter of a century has elapsed since actinomycin was first identified as a DNA-binder whose antitumour activity could be attributed to its capacity to distort the struc作者: 罵人有污點(diǎn) 時(shí)間: 2025-3-26 19:37 作者: 有常識(shí) 時(shí)間: 2025-3-26 22:15 作者: Urgency 時(shí)間: 2025-3-27 05:08 作者: Inflammation 時(shí)間: 2025-3-27 08:21 作者: congenial 時(shí)間: 2025-3-27 12:50
https://doi.org/10.1007/978-3-030-72711-6llographic dyad. Each subunit is composed of six helices, five of which intertwine about each other in a way that may make it seemingly impossible to disengage the subunits without altering their tertiary structure. The two symmetrically related L-tryptophan binding sites are formed by this interfac作者: 不透明性 時(shí)間: 2025-3-27 15:22 作者: Glossy 時(shí)間: 2025-3-27 20:00
Problem Description and Related Workes coding for the lactose enzymes. Genetic and biochemical data have implicated the N-terminal part or ‘headpiece’ of the repressor as the DNA binding domain.. The precise way in which . repressor recognizes its operator is, however, not known.作者: 鑲嵌細(xì)工 時(shí)間: 2025-3-27 23:29
Problem Description and Related Workis called DNA heteroduplex. A DNA heteroduplex is characterized by non-identical genetic information of the two complementary strands, such that upon DNA replication a single heteroduplex molecule segregates genetically, i.e. yields mixed progeny consisting of DNA duplexes with the sequence of indiv作者: 對(duì)手 時(shí)間: 2025-3-28 05:17
https://doi.org/10.1007/978-3-030-00238-1g sites. They cleave the DNA within or in the immediate vicinity of the recognition sequence. Because of the immense importance of these enzymes in analysis, preparation and in vitro recombination of DNA many investigations have been carried out to understand the structural and mechanistic features 作者: saturated-fat 時(shí)間: 2025-3-28 09:06 作者: 盲信者 時(shí)間: 2025-3-28 13:39
https://doi.org/10.1007/978-3-030-00238-1SIR method using a platinum isomorphous derivative [1,2,3]. Refinement is in progress. The endonuclease-DNA recognition complex consists of a distorted double helix and a protein dimer composed of identical subunits related by a two-fold axis of rotational symmetry (see Fig. 1). The distortions of t作者: 骯臟 時(shí)間: 2025-3-28 17:44 作者: palette 時(shí)間: 2025-3-28 19:00
http://image.papertrans.cn/d/image/260233.jpg作者: Inscrutable 時(shí)間: 2025-3-29 00:52
Tariq Ahmad,Allan Ramsay,Hanady Ahmedit. In this article we will review the effect on DNA of counterions, including basic proteins. We will not deal with sequence effects and thus we will not consider specific protein-DNA interactions. We will also not consider the influence of ions on the denaturation of DNA in solution.作者: Seminar 時(shí)間: 2025-3-29 04:19 作者: 問(wèn)到了燒瓶 時(shí)間: 2025-3-29 07:28 作者: 存心 時(shí)間: 2025-3-29 11:25 作者: 魅力 時(shí)間: 2025-3-29 18:41
https://doi.org/10.1007/978-1-4684-5383-6DNA; biology; molecular biology; nucleic acid; protein; proteins作者: 彈藥 時(shí)間: 2025-3-29 20:47
978-1-4684-5385-0The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: vanquish 時(shí)間: 2025-3-30 01:22
Unusual DNA Structures and Gene RegulationSegments of recombinant plasmids containing pur·pyr sequences adopt unusual helical conformations under the influence of negative supercoiling. This feature is recognized and specifically cleaved by Sl nuclease. The major late promoter of adenovirus exhibits this property at the TATA box. A variety 作者: OTHER 時(shí)間: 2025-3-30 06:58 作者: d-limonene 時(shí)間: 2025-3-30 08:23 作者: 注意 時(shí)間: 2025-3-30 14:20
On the Nature and Specificity of DNA-Protein Interactions in the Regulation of Gene Expressionand (v) equilibrium binding selection, which determines the actual level of saturation of the specific (regulatory) target under various environmental conditions. These aspects are all interdependent, and a coherent picture of the specificity of such interactions can only be obtained by considering 作者: conquer 時(shí)間: 2025-3-30 19:23
Repressor, A Crystallographic Study of Allostery in Genetic Regulation of the repressor surface where the DNA backbone most closely approaches the protein. (iii) The amino group of the tryptophan mitigates the negative charge potential arising from the carboxyl terminus of the B helix..The crystal structure of . aporepressor (2,3) has also been solved (by molecular re作者: AMEND 時(shí)間: 2025-3-30 23:09 作者: 無(wú)法治愈 時(shí)間: 2025-3-31 02:26
Structure of the DNA-EcoRI Endonuclease Recognition Complex(see Figs. 2 and 3). The type I neo-kink spans the central two-fold symmetry axis of the complex and it introduces a net unwinding of 25° into the DNA. This increases the separation of the DNA backbones across the major groove thereby facilitating access by the protein to the base edges, which are a作者: 機(jī)構(gòu) 時(shí)間: 2025-3-31 08:29 作者: 啤酒 時(shí)間: 2025-3-31 12:04 作者: 平常 時(shí)間: 2025-3-31 16:08
Jan Géryk,Lubo? Popelínsky,Jozef Tri??íkmall RNA (RNA I) which arises from transcription in the reverse direction as compared to that of the primer RNA (RNA II) utilized to initiate plasmid replication. Being transcribed from opposite strands the two RNAs are fully complementary and their association prevents replication initiation (see T作者: machination 時(shí)間: 2025-3-31 18:49 作者: 古文字學(xué) 時(shí)間: 2025-4-1 01:04 作者: Certainty 時(shí)間: 2025-4-1 03:26
https://doi.org/10.1007/978-3-030-72711-6ecific interaction appear to be very similar: side-chains from protruding alpha-helices penetrate the DNA major groove and interact with the exposed edges of base pairs. DNA polymerase, on the other hand, contains a very large cleft which is able to nearly surround a double-stranded DNA substrate.
