標(biāo)題: Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer [打印本頁(yè)] 作者: miserly 時(shí)間: 2025-3-21 18:11
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries影響因子(影響力)
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries被引頻次
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries被引頻次學(xué)科排名
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries年度引用
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries年度引用學(xué)科排名
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries讀者反饋
書(shū)目名稱(chēng)DNA-Encoded Chemical Libraries讀者反饋學(xué)科排名
作者: 潛伏期 時(shí)間: 2025-3-21 20:54
Library Synthesis: Building Block Validation,nsuring the quality of a library. Here we describe the validation method used to assess the reactivity of potential building blocks to be included in a DNA-encoded library, with HATU acylation of carboxylic acid building blocks with an on-DNA amine substrate as an example.作者: Congestion 時(shí)間: 2025-3-22 03:11
Library Synthesis and Analytics,to billions of compounds can be prepared by a combination of chemical and enzymatic synthesis. Here we describe the analytics methods used in the library synthesis with one cycle of synthesis as an example.作者: 我說(shuō)不重要 時(shí)間: 2025-3-22 05:49 作者: fixed-joint 時(shí)間: 2025-3-22 11:29 作者: cultivated 時(shí)間: 2025-3-22 13:34
DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles,rary structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Herein, we describe a facile process for reducing aryl nitro groups to aryl amines by using sodium dithionite (Na.S.O.). The new protocol offers simple operation and circumvents the pyrophoric potential 作者: cultivated 時(shí)間: 2025-3-22 17:07
DNA Encoding of Natural Products,mbinatorial synthesis. Natural products (NPs) are evolutionary optimized compounds that have played a key role in the history of human drug discovery. Herein, we describe a method for functionality-independent annotation of complex natural products with amplifiable DNA barcodes to generate a DNA-enc作者: 違反 時(shí)間: 2025-3-23 00:32 作者: Isthmus 時(shí)間: 2025-3-23 01:26
One Bead-One Compound (OBOC) Peptidomimetic-Encoded Library Synthesis via Split-and-Pool Methods, of therapeutically important compounds with higher affinity and improved pharmacological properties against different protein targets..Here we describe a simple and general method for the submonomer solid phase synthesis of large one bead-one compound (OBOC) peptidomimetic libraries of structurally作者: 網(wǎng)絡(luò)添麻煩 時(shí)間: 2025-3-23 09:07
DNA Conjugates as Tool Compounds for DEL Selections,e ligand that binds to the target protein can be conjugated to DNA to mimic compounds contained in DEL libraries. The conjugate can be used as a ligand in preselection binding assays to validate a target protein and optimize selection methods and serve as a positive control in selection experiments.作者: MEAN 時(shí)間: 2025-3-23 11:34 作者: Metamorphosis 時(shí)間: 2025-3-23 17:34
Target Protein Design and Preselection Analysis,ures compared to other small molecule screening technologies, such as the use of DNA identification tags and use of target protein immobilization in the standard library screening process. Therefore, it is of great importance to ensure the target protein is properly designed for DEL selections, that作者: 儀式 時(shí)間: 2025-3-23 21:03
DEL Selections Against a Soluble Protein Target,process that involves incubation of a target protein with the DEL, capture of the protein and associated DEL compounds on a solid support, separation of bound molecules from the bulk DEL that is unbound, and recovery of bound DEL molecules. Each step is of great importance in order to achieve succes作者: Onerous 時(shí)間: 2025-3-23 23:16
Adaptive Learning Goes to Chinacts the quality of the hits arising out of a selection assay, while proper sample handling and tracking ensure follow-up synthetic work is done with the appropriate synthetic map in mind. In this chapter, possible strategies for building block selection are outlined, as well as best practices for ha作者: Triglyceride 時(shí)間: 2025-3-24 02:41 作者: Functional 時(shí)間: 2025-3-24 06:55 作者: 殘廢的火焰 時(shí)間: 2025-3-24 14:09 作者: accrete 時(shí)間: 2025-3-24 16:19
Tianchong Wang,Eric C. K. Chenginteresting target; several small molecular inhibitors have moved into the late-stage clinical development. The success of DEL is heavily dependent on the chemical space which was assembled by the on-DNA chemical reactions. On-DNA C-N cross-coupling has great value for expanding the chemical space o作者: 運(yùn)氣 時(shí)間: 2025-3-24 20:23 作者: Silent-Ischemia 時(shí)間: 2025-3-25 02:15 作者: Gesture 時(shí)間: 2025-3-25 06:46 作者: Indict 時(shí)間: 2025-3-25 10:46 作者: FELON 時(shí)間: 2025-3-25 12:42 作者: exhibit 時(shí)間: 2025-3-25 16:38 作者: 不開(kāi)心 時(shí)間: 2025-3-25 20:19
Ala’a Gharaibeh,Normalini Md Kassimures compared to other small molecule screening technologies, such as the use of DNA identification tags and use of target protein immobilization in the standard library screening process. Therefore, it is of great importance to ensure the target protein is properly designed for DEL selections, that作者: epicondylitis 時(shí)間: 2025-3-26 03:13 作者: 護(hù)航艦 時(shí)間: 2025-3-26 06:42
Artificial Intelligence in EducationOn-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.作者: 紳士 時(shí)間: 2025-3-26 09:04
Vaclav Bayer,Martin Hlosta,Miriam FernandezCopper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO.-catalyzed cycloaddition between alkynes and DNA-appended azides.作者: Lignans 時(shí)間: 2025-3-26 14:21
Tianchong Wang,Eric C. K. ChengSuzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh.). as coupling catalyst.作者: Arteriography 時(shí)間: 2025-3-26 16:48
Xinqiang Meng,Le Qi,Mengyang LiuOptimal conditions of palladium-catalyzed on-DNA Heck reactions were developed between DNA-conjugated acryl amide/styrene/aryl iodide and broad substrate scopes (aromatic borates/halides/styrene), which can introduce the diversity of building blocks to DNA-encoded libraries.作者: 纖細(xì) 時(shí)間: 2025-3-26 23:26
Yongbin Zhang,Xiuli Fu,Li Wei,Yanying ZhengDNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.作者: conceal 時(shí)間: 2025-3-27 01:11
Tim Schlippe,Eric C. K. Cheng,Tianchong WangCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.作者: galley 時(shí)間: 2025-3-27 06:47
On-DNA Reductive Amination and Alkylation,On-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.作者: 玩忽職守 時(shí)間: 2025-3-27 10:12 作者: obsession 時(shí)間: 2025-3-27 14:00
On-DNA Suzuki-Miyaura Cross-Coupling,Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh.). as coupling catalyst.作者: 安撫 時(shí)間: 2025-3-27 20:05 作者: preservative 時(shí)間: 2025-3-28 00:00
Ruthenium-Promoted On-DNA C-H Activation Reaction,DNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.作者: BADGE 時(shí)間: 2025-3-28 03:49
Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of IsoquinoloneCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.作者: PHONE 時(shí)間: 2025-3-28 06:53 作者: 波動(dòng) 時(shí)間: 2025-3-28 14:26
978-1-0716-2547-7Springer Science+Business Media, LLC, part of Springer Nature 2022作者: Gesture 時(shí)間: 2025-3-28 14:35 作者: invulnerable 時(shí)間: 2025-3-28 21:02 作者: HATCH 時(shí)間: 2025-3-28 23:43
Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide,starts with a solid phase-bound, chemically very stable hexathymidine DNA sequence “hexT.” Different heterocycle conjugates of the hexT oligonucleotide were synthesized from simple starting materials using metal or acid catalysts. The hexT conjugates were isolated, characterized, and ligated to coding DNA sequences.作者: Rotator-Cuff 時(shí)間: 2025-3-29 05:36
DNA-Encoded Chemical Libraries978-1-0716-2545-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 輪流 時(shí)間: 2025-3-29 07:58
Lecture Notes in Computer Sciencensuring the quality of a library. Here we describe the validation method used to assess the reactivity of potential building blocks to be included in a DNA-encoded library, with HATU acylation of carboxylic acid building blocks with an on-DNA amine substrate as an example.作者: 豎琴 時(shí)間: 2025-3-29 12:19 作者: Vulnerary 時(shí)間: 2025-3-29 16:02 作者: 自作多情 時(shí)間: 2025-3-29 20:43 作者: Agnosia 時(shí)間: 2025-3-29 23:52 作者: Oversee 時(shí)間: 2025-3-30 07:18
Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis,pargyl and 5′-azido oligonucleotides. We also present methods for the synthesis of phosphorothioate junctions from 3′-thiophospho and 5′-iodo oligonucleotides and for the synthesis of phosphodiester junctions from both 3′-hydroxy and 5′-phospho- and 3′-phospho and 5′-hydroxy oligonucleotides using 1-cyanoimidazole.作者: 有組織 時(shí)間: 2025-3-30 10:30
Quantitation of DNA-Encoded Libraries by qPCR,eneral protocol using a double-stranded DNA binding dye for reaction monitoring. This allows the selection process to be assessed at each step prior to preparation for sequencing. The same method has additional applications in the practice of DEL technology.作者: 沒(méi)收 時(shí)間: 2025-3-30 13:23
Target Protein Design and Preselection Analysis, the protein is of high quality, and that ligand binding sites are accessible under DEL selection conditions. Here we describe general considerations for target protein design and expression and experiments that are conducted before initiating selections to assess?protein quality and validate methods that will be used for the DEL selection.作者: LINES 時(shí)間: 2025-3-30 20:36 作者: Cytokines 時(shí)間: 2025-3-31 00:46
On-DNA Pd and Cu-Promoted C-N Cross-Coupling Reactions, the chemical space which was assembled by the on-DNA chemical reactions. On-DNA C-N cross-coupling has great value for expanding the chemical space of DEL as amines are most abundant organic reagents available. Here we described the first on-DNA C-N cross-coupling reactions promoted by both Pd and Cu.作者: integrated 時(shí)間: 2025-3-31 01:23
DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles,l nitro groups to aryl amines by using sodium dithionite (Na.S.O.). The new protocol offers simple operation and circumvents the pyrophoric potential of the conventional method (Raney nickel). The utility of this method is demonstrated by the versatile synthesis of benzimidazoles on DNA.作者: OWL 時(shí)間: 2025-3-31 07:29
DNA Encoding of Natural Products, Herein, we describe a method for functionality-independent annotation of complex natural products with amplifiable DNA barcodes to generate a DNA-encoded natural product library (.DEL). This method provides a simple and practical solution to leverage natural products by DNA barcoding.作者: Irascible 時(shí)間: 2025-3-31 13:16
One Bead-One Compound (OBOC) Peptidomimetic-Encoded Library Synthesis via Split-and-Pool Methods,be a simple and general method for the submonomer solid phase synthesis of large one bead-one compound (OBOC) peptidomimetic libraries of structurally diverse compounds that can be encoded by mass or genetic methods.作者: 無(wú)瑕疵 時(shí)間: 2025-3-31 15:53 作者: 愛(ài)了嗎 時(shí)間: 2025-3-31 18:20
Artificial Intelligencein Educationpargyl and 5′-azido oligonucleotides. We also present methods for the synthesis of phosphorothioate junctions from 3′-thiophospho and 5′-iodo oligonucleotides and for the synthesis of phosphodiester junctions from both 3′-hydroxy and 5′-phospho- and 3′-phospho and 5′-hydroxy oligonucleotides using 1-cyanoimidazole.作者: hermitage 時(shí)間: 2025-3-31 23:39 作者: Onerous 時(shí)間: 2025-4-1 04:45
