標(biāo)題: Titlebook: DNA Topoisomerases in Cancer Therapy; Present and Future Toshiwo Andoh Book 2003 Springer Science+Business Media New York 2003 DNA.biology. [打印本頁] 作者: 斷巖 時間: 2025-3-21 19:39
書目名稱DNA Topoisomerases in Cancer Therapy影響因子(影響力)
書目名稱DNA Topoisomerases in Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱DNA Topoisomerases in Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱DNA Topoisomerases in Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱DNA Topoisomerases in Cancer Therapy被引頻次
書目名稱DNA Topoisomerases in Cancer Therapy被引頻次學(xué)科排名
書目名稱DNA Topoisomerases in Cancer Therapy年度引用
書目名稱DNA Topoisomerases in Cancer Therapy年度引用學(xué)科排名
書目名稱DNA Topoisomerases in Cancer Therapy讀者反饋
書目名稱DNA Topoisomerases in Cancer Therapy讀者反饋學(xué)科排名
作者: 傲慢物 時間: 2025-3-21 23:20 作者: 紳士 時間: 2025-3-22 04:13 作者: foliage 時間: 2025-3-22 07:23
Degradation of topoisomerase cleavable complexes,Pl, hTOP2a and hTOP2β, have been demonstrated to be important molecular targets for anticancer drugs (Liu, 1989; Wang, 1985; Wang, 1996; Chen and Liu, 1994; Hsiang and Liu, 1988; Zhang ., 2001; Li and Liu, 2001; Mao .., 1999; Nitiss and Wang, 1996; Kingma and Oscheroff, 1998).作者: 消滅 時間: 2025-3-22 08:50
Yeast as a model system in the analysis of DNA topoisomerase I poisons,anied by the formation of a covalent Top1-DNA intermediate, in which the active site tyrosine of Top1 is linked to a 3’ phosphoryl DNA end. This distinguishes type IB enzymes from other DNA topoisomerases, which form a 5’ phospho-tyrosyl linkage.作者: 不來 時間: 2025-3-22 16:12
Approaches to Artificial Intelligence,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.作者: 不來 時間: 2025-3-22 17:59
Understanding the action of drugs targeting TOP2: ,,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.作者: 訓(xùn)誡 時間: 2025-3-22 22:43
at Harvard University, contributed an article: `Reflections .In the mid 80‘s type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investiga作者: flaunt 時間: 2025-3-23 02:08
https://doi.org/10.1007/978-3-031-08743-1ing of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin.作者: 脆弱帶來 時間: 2025-3-23 08:31
Gunay Kazimzade,Yasmin Patzer,Niels Pinkwartaction. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin, and stimulated the search of non-camptothecin inhibitors (5, 6).作者: Prophylaxis 時間: 2025-3-23 13:15
Mechanisms of topoisomerase I inhibition by anticancer drugs,ing of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin.作者: 絆住 時間: 2025-3-23 15:58
Development of new topoisomerase I-targeting compounds as candidate anticancer drugs,action. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin, and stimulated the search of non-camptothecin inhibitors (5, 6).作者: synchronous 時間: 2025-3-23 21:51 作者: 一小塊 時間: 2025-3-23 22:25 作者: ULCER 時間: 2025-3-24 04:21 作者: POLYP 時間: 2025-3-24 08:56
ML Models: Food Security and Climate Changearrival as an assistant professor of chemistry. The country in general, and Berkeley in particular, was under the dark shadow of the Vietnam War. There were frequent demonstrations on campus, and once the campus was teargassed by a helicopter. For weeks a “stink bomb” left a repugnant smell in our e作者: Alveolar-Bone 時間: 2025-3-24 10:54
https://doi.org/10.1007/978-3-031-08743-1 salt of camptothecin was found to be clinically active but its use was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-作者: BRAVE 時間: 2025-3-24 17:58
https://doi.org/10.1007/978-3-031-08743-1ess and is required for proper chromosomal structure and segregation. The enzyme unknots and untangles DNA by passing an intact helix through a transient double-stranded break that it generates in a separate DNA segment. Beyond its physiological functions, topoisomerase II is the target for some of 作者: 細(xì)胞學(xué) 時間: 2025-3-24 19:31 作者: 搖曳的微光 時間: 2025-3-25 00:36 作者: MOT 時間: 2025-3-25 07:01 作者: 捏造 時間: 2025-3-25 09:30 作者: 我就不公正 時間: 2025-3-25 14:51
Gunay Kazimzade,Yasmin Patzer,Niels Pinkwartecin was found clinically active but was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic a作者: 熔巖 時間: 2025-3-25 18:49
Seungcheol Austin Lee,Yuhua (Jake) Liange dynamics. Two types of enzymes, type I and II, are validated targets of a number of efficacious anticancer drugs. Doxorubicin, etoposide, amsacrine and mitoxantrone are among others are frequently prescribed drugs targeting type II enzyme, topo II. There have been enormous efforts in search for ne作者: Cuisine 時間: 2025-3-25 20:55 作者: overrule 時間: 2025-3-26 00:41
https://doi.org/10.1007/978-1-4615-0141-1DNA; biology; cancer; cell; cell death; enzyme; enzymes; molecular biology; pharmacology; protein; resistance; 作者: Aviary 時間: 2025-3-26 07:29 作者: 細(xì)菌等 時間: 2025-3-26 12:13
Reflections on an accidental discovery,arrival as an assistant professor of chemistry. The country in general, and Berkeley in particular, was under the dark shadow of the Vietnam War. There were frequent demonstrations on campus, and once the campus was teargassed by a helicopter. For weeks a “stink bomb” left a repugnant smell in our e作者: Entirety 時間: 2025-3-26 16:30
Mechanisms of topoisomerase I inhibition by anticancer drugs, salt of camptothecin was found to be clinically active but its use was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-作者: 可用 時間: 2025-3-26 17:54
Mechanism of action of topoisomerase II-targeted anticancer drugs,ess and is required for proper chromosomal structure and segregation. The enzyme unknots and untangles DNA by passing an intact helix through a transient double-stranded break that it generates in a separate DNA segment. Beyond its physiological functions, topoisomerase II is the target for some of 作者: Ejaculate 時間: 2025-3-26 23:57
Degradation of topoisomerase cleavable complexes,NA transcription, chromosomal condensation/ decondensation and chromosome segregation (Castano .., 1996; Champoux and Dulbecco, 1972; Liu, 1989; Wang, 1985; Wang, 1996; Zhang .., 2000). So far, six human DNA topoisomerases, hTOPl, hTOP2a, hTOP2β, hTOP3a, hTOP3β and mitochondrial hTOPl, have been ide作者: Inflammation 時間: 2025-3-27 02:26
Yeast as a model system in the analysis of DNA topoisomerase I poisons,id .., 1998; Champoux, 2001; Wang, 2002). The nuclear enzyme, encoded by the . gene, is highly conserved in terms of reaction mechanism, structure and sensitivity to anticancer agents such as the camptothecins (Redinbo .l., 1999; Fiorani and Bjornsti, 2000; Li and Liu, 2001). As with other DNA topoi作者: 攀登 時間: 2025-3-27 09:21
Understanding the action of drugs targeting TOP2: ,,). The enzyme has been termed a simple molecular machine that orchestrates DNA topology by its ability to pass a double stranded DNA through a transient DNA double strand break (Wang 1998). The complexity of the reactions carried out by topoisomerase II, along with its importance in DNA metabolism h作者: Processes 時間: 2025-3-27 11:08
Cellular resistance to DNA Topoisomerase I-targeting drugs, replication, recombination and transcription. The enzyme catalyzes a concerted chain of reactions, .. DNA single-strand break, concomitant covalent binding of the protein to 3’-end of the DNA break, passage of the other strand through the gap and rejoining of the DNA (Wang, 2002).作者: 提名 時間: 2025-3-27 16:53
Development of new topoisomerase I-targeting compounds as candidate anticancer drugs,ecin was found clinically active but was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic a作者: 咯咯笑 時間: 2025-3-27 18:44
Development of new topoisomerase II-targeting compounds as candidate anticancer drugs,e dynamics. Two types of enzymes, type I and II, are validated targets of a number of efficacious anticancer drugs. Doxorubicin, etoposide, amsacrine and mitoxantrone are among others are frequently prescribed drugs targeting type II enzyme, topo II. There have been enormous efforts in search for ne作者: 追蹤 時間: 2025-3-28 00:40 作者: SEVER 時間: 2025-3-28 05:01
ML Models: Food Security and Climate Changeere trying to take advantage of a report five years earlier that the enzyme . DNA polymerase I could incorporate a ribonucleotide into its product under certain conditions. This misincorporation of a ribo- rather the normal deoxyribonucleotide, I reasoned, might be exploited to generate a set of fou作者: 健壯 時間: 2025-3-28 09:45 作者: Restenosis 時間: 2025-3-28 13:11
Seungcheol Austin Lee,Yuhua (Jake) Liangssential role in survival of cells. Compounds are classified roughly into two, those progressed into the stage of clinical trial and those in preclinical experiments. Among the latter we included topo inhibitors which are being developed by multi-institutional collaboration in Japan.作者: 燕麥 時間: 2025-3-28 15:34 作者: helper-T-cells 時間: 2025-3-28 22:07
Mechanism of action of topoisomerase II-targeted anticancer drugs,A scission. Considering the importance of topoisomerase II-targeted agents to cancer chemotherapy, it is essential to understand how these drugs alter enzyme function. Therefore, this review will focus on the DNA cleavage and ligation reactions of topoisomerase II and the mechanism of action of drug作者: 后天習(xí)得 時間: 2025-3-28 23:40 作者: floodgate 時間: 2025-3-29 05:08
clinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology. .978-1-4613-4941-9978-1-4615-0141-1作者: Indelible 時間: 2025-3-29 07:15
