標(biāo)題: Titlebook: DNA Topoisomerases and Cancer; Yves Pommier Book 2012 Springer Science+Business Media, LLC 2012 Tyrosyl-DNA-Phosphodiesterase.Ubiquitin.an [打印本頁] 作者: Addendum 時(shí)間: 2025-3-21 18:46
書目名稱DNA Topoisomerases and Cancer影響因子(影響力)
書目名稱DNA Topoisomerases and Cancer影響因子(影響力)學(xué)科排名
書目名稱DNA Topoisomerases and Cancer網(wǎng)絡(luò)公開度
書目名稱DNA Topoisomerases and Cancer網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱DNA Topoisomerases and Cancer被引頻次
書目名稱DNA Topoisomerases and Cancer被引頻次學(xué)科排名
書目名稱DNA Topoisomerases and Cancer年度引用
書目名稱DNA Topoisomerases and Cancer年度引用學(xué)科排名
書目名稱DNA Topoisomerases and Cancer讀者反饋
書目名稱DNA Topoisomerases and Cancer讀者反饋學(xué)科排名
作者: Ethics 時(shí)間: 2025-3-21 20:46 作者: Allowance 時(shí)間: 2025-3-22 01:02 作者: GAVEL 時(shí)間: 2025-3-22 05:00
Structure and Mechanism of Eukaryotic Type IIA Topoisomerases,rried out by an ATP-dependent, duplex strand-passage mechanism that relies on the transient and reversible enzyme-mediated cleavage of DNA. A wealth of biochemical and structural data on Top2 (topo II), the eukaryotic member of this topoisomerase family, as well as complementary studies on its bacte作者: Affirm 時(shí)間: 2025-3-22 10:53 作者: myriad 時(shí)間: 2025-3-22 15:11 作者: myriad 時(shí)間: 2025-3-22 20:50
Topoisomerase-Induced DNA Damage,o DNA structure. Here, we will review how topoisomerases can damage the genome when it contains preexisting DNA lesions at the enzyme sites of action. This brief chapter gives an overview of the broad range of lesions that lead to the accumulation of cleavage complexes produced by DNA topoisomerases作者: padding 時(shí)間: 2025-3-22 22:36 作者: adulterant 時(shí)間: 2025-3-23 03:55 作者: Dri727 時(shí)間: 2025-3-23 05:58 作者: 感情 時(shí)間: 2025-3-23 12:23
Topoisomerase II Inhibitors: Chemical Biology, etoposide are FDA approved for the treatment of both leukemias and solid tumors. Most clinically active drugs targeting Top2 lead to elevated levels of covalent Top2-cleaved DNA complexes and exert their antitumor effect through enzyme-mediated DNA damage. Drugs targeting Top2 are accompanied by su作者: 輕打 時(shí)間: 2025-3-23 14:31
Topoisomerase I Inhibitors: Current Use and Prospects,h other agents have ensured their clinical role. c has been part of drug regimens for ovarian cancer, small cell lung cancer (SCLC), and cancer of the uterine cervix; it has also been used as a radiosensitizer in non-small cell lung cancer (NSCLC). Irinotecan was the second drug with activity in col作者: 硬化 時(shí)間: 2025-3-23 20:51
Topoisomerase II Inhibitors: Current Use and Prospects,because of their long successful track record, provide an element of comfort for treating physicians. Contained within this larger category are the epipodophyllotoxins (VP-16, or etoposide; and VM-26, or teniposide), anthracyclines (doxorubicin, or adriamycin; daunorubicin, or daunomycin; idarubicin作者: Dictation 時(shí)間: 2025-3-23 22:46 作者: 政府 時(shí)間: 2025-3-24 05:53
Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents,nscription, and recombination. The enzyme clamps around duplex DNA and forms a transient 3′ phosphotyrosyl linkage with a single DNA end. This covalent intermediate is the cellular target of the camptothecin class of chemotherapeutics, which at clinically relevant concentrations induces DNA replicat作者: Ondines-curse 時(shí)間: 2025-3-24 07:05 作者: 可商量 時(shí)間: 2025-3-24 12:13 作者: Cursory 時(shí)間: 2025-3-24 16:54 作者: 租約 時(shí)間: 2025-3-24 20:45 作者: judicial 時(shí)間: 2025-3-25 02:47 作者: 懶惰民族 時(shí)間: 2025-3-25 05:15
Rian Dolphin,Barry Smyth,Ruihai Donglication, transcription, and chromatin assembly. The cleavage reaction occurs with the covalent attachment of an active-site tyrosine to the 3′ end of the broken strand; religation restores continuity to the DNA and releases the enzyme. During the cleaved state, relaxation of torsionally strained su作者: 考博 時(shí)間: 2025-3-25 08:08 作者: condemn 時(shí)間: 2025-3-25 13:54
Artificial Intelligence and Creativityrried out by an ATP-dependent, duplex strand-passage mechanism that relies on the transient and reversible enzyme-mediated cleavage of DNA. A wealth of biochemical and structural data on Top2 (topo II), the eukaryotic member of this topoisomerase family, as well as complementary studies on its bacte作者: daredevil 時(shí)間: 2025-3-25 17:39
Introduction: Creativity and Cognitiony in fruit flies and mice. One of the main roles of the enzyme in the nucleus appears to be prevention of aberrant recombination by resolving double Holliday junction structures into non-crossover products; this role requires the formation of a complex with functional Bloom’s helicase as well as the作者: 內(nèi)部 時(shí)間: 2025-3-25 23:27
Artificial Intelligence and Creativityn by introducing transient single-strand breaks in duplex DNA. Once supercoils are suppressed, DNA breaks are rapidly resealed during the religation step of the Top1 reaction. The striking similarity between Top1-mediated religation and the strand transferase activity of various recombinases have su作者: AND 時(shí)間: 2025-3-26 03:25
Automation of Cybersecurity Worko DNA structure. Here, we will review how topoisomerases can damage the genome when it contains preexisting DNA lesions at the enzyme sites of action. This brief chapter gives an overview of the broad range of lesions that lead to the accumulation of cleavage complexes produced by DNA topoisomerases作者: 軟弱 時(shí)間: 2025-3-26 06:30 作者: 疾馳 時(shí)間: 2025-3-26 11:24 作者: 不滿分子 時(shí)間: 2025-3-26 13:08 作者: CHOKE 時(shí)間: 2025-3-26 17:19 作者: Bone-Scan 時(shí)間: 2025-3-26 21:23 作者: 上坡 時(shí)間: 2025-3-27 01:23
https://doi.org/10.1007/978-3-319-66104-9because of their long successful track record, provide an element of comfort for treating physicians. Contained within this larger category are the epipodophyllotoxins (VP-16, or etoposide; and VM-26, or teniposide), anthracyclines (doxorubicin, or adriamycin; daunorubicin, or daunomycin; idarubicin作者: Terrace 時(shí)間: 2025-3-27 07:48
https://doi.org/10.1007/978-3-319-63519-4ng to irreversible DNA double-strand breaks and apoptosis. In addition, recent evidences demonstrated that camptothecins have specific transcription-dependent effects that are independent from DNA breaks at replication forks. Here, we focus on the latter drug effects, discussing the influence of Top作者: 凝乳 時(shí)間: 2025-3-27 10:28 作者: saphenous-vein 時(shí)間: 2025-3-27 14:03 作者: Embolic-Stroke 時(shí)間: 2025-3-27 18:18
Artificial Intelligence and Green Computing). The main function of all topoisomerases is to dissipate the torsional stress (supercoiling of the DNA) generated during DNA transactions such as transcription, replication, chromosome condensation, and segregation (Castano et al. 1996; Champoux 2001; Leppard and Champoux 2005; Zhang et al. 1988, 作者: defeatist 時(shí)間: 2025-3-27 22:33
Hamza Hamout,Abderrahmane Elyousfiagents, termed topoisomerase poisons generate protein-linked DNA strand that block transcription and replication, leading to cell death. Cells treated with topoisomerase targeting drugs rely on diverse repair pathways to maintain genome stability and cell survival. This chapter summarizes current in作者: 船員 時(shí)間: 2025-3-28 06:08 作者: 尖叫 時(shí)間: 2025-3-28 10:14
DNA Topoisomerases and Cancer978-1-4614-0323-4Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: bronchiole 時(shí)間: 2025-3-28 11:16 作者: 易于出錯(cuò) 時(shí)間: 2025-3-28 17:50 作者: 謙虛的人 時(shí)間: 2025-3-28 22:20 作者: CAMP 時(shí)間: 2025-3-29 01:44
https://doi.org/10.1007/978-1-4614-0323-4Tyrosyl-DNA-Phosphodiesterase; Ubiquitin; antigens; camptothecins; transcriptional stress作者: catagen 時(shí)間: 2025-3-29 04:59 作者: 顧客 時(shí)間: 2025-3-29 10:53 作者: 焦慮 時(shí)間: 2025-3-29 15:07
Introduction and Historical Perspective,Topo III, and Topo IV) and eukaryotic cells (Topo IB, Topo II, Topo III). Later on, new families and subfamilies of DNA topoisomerases were discovered in Archaea, the third domain of life (reverse gyrase, Topo V, Topo VI), challenging the prokaryote/eukaryote dichotomy. DNA topoisomerases are now cl作者: 多節(jié) 時(shí)間: 2025-3-29 18:57
,Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM,Lengthening of Telomeres) in cells lacking telomerase activity. The recent implication of some variants of . and . genes in cancer risk in the general population underline the importance of the BLM-Top3α complex in maintaining genomic stability and preventing cancer.作者: 手榴彈 時(shí)間: 2025-3-29 21:04
Topoisomerase I Inhibitors: Chemical Biology,thecins include edotecarin, an indolocarbazole that results in DNA C/T-G cleavage compared with T-G/A for camptothecins. Indenoisoquinolines identified as Top1 inhibitors by the “NCI 60-cell line COMPARE” analysis are in clinical development. Dibenzonaphthyridinone Top1 inhibitors have undergone ext作者: Hormones 時(shí)間: 2025-3-30 00:19
Topoisomerase II Inhibitors: Chemical Biology,that may have clinical promise. Although currently used Top2 targeting drugs act by generating enzyme-mediated DNA damage, catalytic inhibition remains a tantalizing possibility. Since current results suggest that topoisomerase IIβ, one of the two mammalian isoforms of topoisomerase II, is important作者: 易于出錯(cuò) 時(shí)間: 2025-3-30 04:03
Topoisomerase I Inhibitors: Current Use and Prospects,also provides a glimpse at other Top1 inhibitors under development. Advances in our understanding of Top1 action covered elsewhere in this volume, and reasons for selectivity and resistance will undoubtedly extend the clinical applications of these drugs.作者: 優(yōu)雅 時(shí)間: 2025-3-30 10:57
Tyrosyl-DNA-Phosphodiesterase,f 3′-phosphodiester linkages, potentially implicating Tdp1 in other DNA repair pathways. In this chapter we summarize the recent advances in research concerning Tdp1, alternative repair pathways for repairing Top1-induced DNA damage, and the rational for targeting Tdp1 as a potential anticancer ther作者: GREG 時(shí)間: 2025-3-30 12:58 作者: 秘方藥 時(shí)間: 2025-3-30 18:05 作者: 財(cái)主 時(shí)間: 2025-3-30 21:41 作者: abduction 時(shí)間: 2025-3-31 04:46
Joyce Mahon,Brett A. Becker,Brian Mac NameeTopo III, and Topo IV) and eukaryotic cells (Topo IB, Topo II, Topo III). Later on, new families and subfamilies of DNA topoisomerases were discovered in Archaea, the third domain of life (reverse gyrase, Topo V, Topo VI), challenging the prokaryote/eukaryote dichotomy. DNA topoisomerases are now cl作者: 蹣跚 時(shí)間: 2025-3-31 06:11 作者: 六邊形 時(shí)間: 2025-3-31 10:53
B. Samirana Acharya,K. Ramasubramanianthecins include edotecarin, an indolocarbazole that results in DNA C/T-G cleavage compared with T-G/A for camptothecins. Indenoisoquinolines identified as Top1 inhibitors by the “NCI 60-cell line COMPARE” analysis are in clinical development. Dibenzonaphthyridinone Top1 inhibitors have undergone ext作者: aesthetic 時(shí)間: 2025-3-31 15:34
Alexei Gvishiani,Jacques Octave Duboisthat may have clinical promise. Although currently used Top2 targeting drugs act by generating enzyme-mediated DNA damage, catalytic inhibition remains a tantalizing possibility. Since current results suggest that topoisomerase IIβ, one of the two mammalian isoforms of topoisomerase II, is important作者: Offensive 時(shí)間: 2025-3-31 17:43
Alexei Gvishiani,Jacques Octave Duboisalso provides a glimpse at other Top1 inhibitors under development. Advances in our understanding of Top1 action covered elsewhere in this volume, and reasons for selectivity and resistance will undoubtedly extend the clinical applications of these drugs.作者: 征兵 時(shí)間: 2025-3-31 22:42 作者: stratum-corneum 時(shí)間: 2025-4-1 03:09 作者: 搬運(yùn)工 時(shí)間: 2025-4-1 07:56
Hamza Hamout,Abderrahmane Elyousfi generated DNA damage. These newly identified genes will be important in understanding the repair processes that occur with this unique type of DNA damage, and promise to provide new markers for predicting the therapeutic efficacy of this important class of anticancer drugs.作者: 支柱 時(shí)間: 2025-4-1 13:47
Rian Dolphin,Barry Smyth,Ruihai Dongr in the presence of drugs such as camptothecin causes DNA damage that must be repaired if the cell is to survive. The list of proteins known to interact with Top1 suggests that the enzyme has functions . that extend well beyond the previously characterized roles in replication, transcription, and chromatin assembly.作者: adj憂郁的 時(shí)間: 2025-4-1 15:33 作者: 松雞 時(shí)間: 2025-4-1 19:02
Georgios N. Yannakakis,Julian Togeliuslication machinery that may contribute to CPT toxicity, while recent biochemical, genetic, and genome-wide studies provide novel insights into mechanisms regulating the stability of replication forks and recombinational processing of replicative lesions in CPT-treated cells.作者: 榨取 時(shí)間: 2025-4-1 23:39
