標(biāo)題: Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus [打印本頁(yè)] 作者: microbe 時(shí)間: 2025-3-21 18:29
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells影響因子(影響力)
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells影響因子(影響力)學(xué)科排名
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells被引頻次
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells被引頻次學(xué)科排名
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells年度引用
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells年度引用學(xué)科排名
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells讀者反饋
書(shū)目名稱DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells讀者反饋學(xué)科排名
作者: 托人看管 時(shí)間: 2025-3-21 21:25
https://doi.org/10.1007/978-3-319-58121-7icipate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C.-O-P bond 5′ to AP sites and the resulting nicks are limited by 3′-OH and 5′-phosphate ends.作者: 煞費(fèi)苦心 時(shí)間: 2025-3-22 01:46 作者: Nmda-Receptor 時(shí)間: 2025-3-22 08:28
Book 1989ications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con- tributions to the DNA repair field include the cO-discovery of the excision 作者: ligature 時(shí)間: 2025-3-22 10:22 作者: 郊外 時(shí)間: 2025-3-22 16:34
Art, Literature, and Passions of the Skiesormal human cells are Mex. but may become Mex. following transformation .. Thus, the phenotype is important from the practical viewpoint of chemotherapy, as well as a more fundamental one of understanding the events which occur during cellular transformation.作者: 郊外 時(shí)間: 2025-3-22 20:31
Investigation of Sequence Specificity in DNA Alkylation and Repair Using Oligodeoxynucleotide Substrethylguanine from DNA and is usually referred to as 3-alkyladenine DNA glycosylase (Margison and Pegg, 1981; Gallagher and Brent, 1984; Male, et al., 1985, 1987). This glycosylase clearly plays a major role in the loss of the N-alkyl purines, which make up the bulk of the DNA base adducts.作者: STERN 時(shí)間: 2025-3-22 21:33 作者: fabricate 時(shí)間: 2025-3-23 04:26
Women, Subject Choice and Employment,at the C8 position. These observations suggest that the Fapy-DNA glycosylase may have a broad substrate specificity which includes all imidazole ring-opened purines modified at the N7 or C8 position in DNA.作者: 一大塊 時(shí)間: 2025-3-23 08:49 作者: Corporeal 時(shí)間: 2025-3-23 10:03
The Roles of Beta- and Delta-Eliminations in the Repair of AP Sites in DNAicipate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C.-O-P bond 5′ to AP sites and the resulting nicks are limited by 3′-OH and 5′-phosphate ends.作者: BULLY 時(shí)間: 2025-3-23 15:59
Inducible Repair in Mammalian Cells Treated with Alkylating Agentse promutagenic lesion O.-methylguanine, is the product of the . gene. It regulates its own synthesis and the expression of the . A gene (Teo, ., 1986) which encodes DNA glycosylase II: this enzyme removes several alkylated bases and especially the toxic lesions 3-methyl-adenine and 3-methylguanine from alkylated DNA (Karran, ., 1982).作者: eulogize 時(shí)間: 2025-3-23 18:47
Towards a Role for Promutagenic Lesions in Carcinogenesiscal properties of these compounds. Until recently, it has not been possible to begin to confirm the relevance of such observations for human disease, but techniques now permit preliminary studies of these potentially initiating events in human tissues.作者: 軍火 時(shí)間: 2025-3-23 23:10 作者: 襲擊 時(shí)間: 2025-3-24 02:40
DNA Damage and Oxygen Speciestive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.作者: Boycott 時(shí)間: 2025-3-24 08:28
Art, Spirituality and EconomicsWhen DNA is exposed to alkylating agents, reactions occur at as many as fifteen different sites on the bases and at the phosphodiester backbone (Beranek, ., 1980). The relative proportion of the alkylation products depends mainly on the nucleophilicity of the reactive sites and on the chemical properties of the alkylating agents (Lawley, 1974).作者: 小蟲(chóng) 時(shí)間: 2025-3-24 14:19 作者: escalate 時(shí)間: 2025-3-24 15:17
The Role of O6-Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating AgenWhen DNA is exposed to alkylating agents, reactions occur at as many as fifteen different sites on the bases and at the phosphodiester backbone (Beranek, ., 1980). The relative proportion of the alkylation products depends mainly on the nucleophilicity of the reactive sites and on the chemical properties of the alkylating agents (Lawley, 1974).作者: acolyte 時(shí)間: 2025-3-24 21:29 作者: 聯(lián)邦 時(shí)間: 2025-3-25 00:37 作者: muster 時(shí)間: 2025-3-25 04:46 作者: capsule 時(shí)間: 2025-3-25 10:42 作者: Offensive 時(shí)間: 2025-3-25 12:32
Anne Laure Bandle,Raphael Contelkylation by simple alkylating agents has increased so that now we know that all oxygens and nitrogens of nucleosides in polynucleotides, DNA and RNA can be modified (Singer, 1976, 1982) (Figure 1). However, each reagent produces characteristic patterns of alkylation, both . and . (Singer & Grunberge作者: BARB 時(shí)間: 2025-3-25 18:49 作者: 通知 時(shí)間: 2025-3-25 20:40 作者: WAX 時(shí)間: 2025-3-26 01:25 作者: Morbid 時(shí)間: 2025-3-26 06:24
Kevin Tavin,Mira Kallio-Tavin,Max Ryyn?nen DNA. Although all of these adducts appear to be repaired ., in the sense that their content declines more rapidly than can be accounted for by cell turnover (Pegg, 1977,1983; Singer and Ku?mierek, 1982; Singer, 1984,1986; Saffhill, ., 1985), only a few of the proteins responsible for such repair ha作者: Obloquy 時(shí)間: 2025-3-26 09:04 作者: 饒舌的人 時(shí)間: 2025-3-26 12:42 作者: avarice 時(shí)間: 2025-3-26 20:41 作者: BIPED 時(shí)間: 2025-3-26 22:22
Art, Literature, and Passions of the Skiesng the compounds to which Mex. cells are sensitive are the alkylnitrosamines and alkylnitrosamides which can form covalent adducts with cellular DNA at the O.-position of guanine. A particularly important class of such compounds is the cross-linking nitrosoureas which are widely used in chemotherapy作者: coagulate 時(shí)間: 2025-3-27 04:33 作者: 前奏曲 時(shí)間: 2025-3-27 08:23 作者: 與野獸博斗者 時(shí)間: 2025-3-27 10:54 作者: 征服 時(shí)間: 2025-3-27 13:39
Luk Bouckaert,Knut J. Ims,Peter Ronaong the induced products there are DNA repair functions and proteins required for mutagenesis. For mammalian cells, formally a similar response has been detected. New gene products are synthesized (Herrlich, ., 1986). No DNA repair induction has yet been characterized although it is likely that it e作者: Spinal-Fusion 時(shí)間: 2025-3-27 20:26
https://doi.org/10.1007/978-3-319-00801-1tive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.作者: 惰性女人 時(shí)間: 2025-3-28 01:52
Public Artifacts, Intentions, and Normsh ultraviolet radiation (UV) . and transfected into xeroderma pigmentosum (XP) and repair proficient human cells. Replicated episomal plasmids were harvested and assayed for survival and mutations by transforming indicator bacteria. Plasmids with mutated . gene yield white or light blue colonies aft作者: 公豬 時(shí)間: 2025-3-28 05:26 作者: reperfusion 時(shí)間: 2025-3-28 08:11
Catecholamines in the Carotid Bodyt that most chemical carcinogens are active only after metabolism to an ultimate carcinogenic and mutagenic form. These ultimate carcinogens tend to be electron deficient and thus react with nuclephilic sites which are abundant in DNA. It has been established that B[a]P is metabolized by the mixed f作者: bleach 時(shí)間: 2025-3-28 13:10 作者: Crumple 時(shí)間: 2025-3-28 18:33
https://doi.org/10.1007/978-3-030-21828-7formation of various alkylated bases in DNA. More than ten kinds of methylated bases are produced by the treatment of cells with a simple methylating agent, such as N-methyl-N-nitrosourea (MNU) and N-methyl-N′-nitro-N-nitrosoguanidine (MNNG).作者: Bouquet 時(shí)間: 2025-3-28 22:44
https://doi.org/10.1007/978-3-319-00801-1tive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.作者: 偽造 時(shí)間: 2025-3-29 01:53
Book 1989 of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.作者: Minutes 時(shí)間: 2025-3-29 06:50
her groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.978-1-4684-1329-8978-1-4684-1327-4作者: 有效 時(shí)間: 2025-3-29 09:27
Anne Laure Bandle,Raphael Conteln be either mutagenic or lethal. Most recently, in order to separate the potential biological effects of each derivative, defined oligonucleotide sequences containing a single adduct have been synthesized and used to study both replication and mutation. These defined oligomers have also been of grea作者: AVANT 時(shí)間: 2025-3-29 14:42
Women, Subject Choice and Employment,lecular weight of 3 0.2 Kd. The protein was purified to apparent homogeneity and exhibited two different enzymatic activities: a DNA glycosylase and an activity incising DNA at apurinic/ apyrimidinic (AP) sites. Moreover, based on restriction maps, the . gene is not associated with known . genes cod作者: 上釉彩 時(shí)間: 2025-3-29 17:18
Cyber-Salvation: Body in Virtual Skies MNNG or nitrosoureas (Day, ., 1980a,b; Erickson, 1980a,b; Scudiero, ., 1984 a,b; Gibson, ., 1986). The results obtained in cell culture are clear-cut; for example, with MNNG as the damaging agent, the inactivation slopes of survival curves of Mer. cells are up to 50 fold steeper than are those of M作者: Hormones 時(shí)間: 2025-3-29 21:18 作者: jettison 時(shí)間: 2025-3-30 00:31
Ove Jakobsen,Vivi M. L. Storslettenr εCdR. Molar ratios of oxetG/εCdR and oxetG/εAdR in DNA were about 3 0 and 80, respectively, in these three organs. In contrast, εAdR and εCdR were not detected (detection limit, 2 5 fmoles/mg DNA) in the kidney of group I nor in the liver from group II rats. These findings are discussed in relatio作者: 掃興 時(shí)間: 2025-3-30 07:56
Luk Bouckaert,Knut J. Ims,Peter Ronaon analyses supplied support for the idea that proneness to mutation is passed on to daughter cells (Maher, ., 1988). As another parallel between bacteria and mammalian cells DNA damage causes reinitiation of replication (Kogoma, ., 1979) which in mammalian cells is observed as gene amplification (L作者: Fantasy 時(shí)間: 2025-3-30 10:06 作者: PANT 時(shí)間: 2025-3-30 13:03
S. F. He,J.-Y. Wei,C. Eyzaguirregle and tandem double base pair substitutions with no preference for a particular type of change, although the GC ? CG transversion was not detected. Mutations in V-H1 cells consisted of single and tandem double base pair changes, which were all GC ? AT transitions, and frame shift mutations. The as作者: 不確定 時(shí)間: 2025-3-30 18:16 作者: Semblance 時(shí)間: 2025-3-31 00:37
Structure-Function Relationships in Alkylation Damage and Repairn be either mutagenic or lethal. Most recently, in order to separate the potential biological effects of each derivative, defined oligonucleotide sequences containing a single adduct have been synthesized and used to study both replication and mutation. These defined oligomers have also been of grea作者: folliculitis 時(shí)間: 2025-3-31 03:12 作者: 抱負(fù) 時(shí)間: 2025-3-31 06:29
The Mer Minus Phenotype, Patient Response to Nitrosoureas, and Protooncogene Activation in Human Gli MNNG or nitrosoureas (Day, ., 1980a,b; Erickson, 1980a,b; Scudiero, ., 1984 a,b; Gibson, ., 1986). The results obtained in cell culture are clear-cut; for example, with MNNG as the damaging agent, the inactivation slopes of survival curves of Mer. cells are up to 50 fold steeper than are those of M作者: Liberate 時(shí)間: 2025-3-31 10:32 作者: synchronous 時(shí)間: 2025-3-31 15:39 作者: 縫紉 時(shí)間: 2025-3-31 21:20
An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Functionon analyses supplied support for the idea that proneness to mutation is passed on to daughter cells (Maher, ., 1988). As another parallel between bacteria and mammalian cells DNA damage causes reinitiation of replication (Kogoma, ., 1979) which in mammalian cells is observed as gene amplification (L作者: employor 時(shí)間: 2025-4-1 00:41
Molecular Studies of Mutagenesis using Plasmid Vectors in Xeroderma Pigmentosum Cellsated that dimers are the major mutagenic lesions. The major UV photoproduct, the TT dimer, was only weakly mutagenic in these human cells. Most mutations occured at cytosines that were 3′ to a cytosine or a thymine. There was a restricted spectrum of UV induced mutations with XP-A and XP-D cells: Pl作者: FUSE 時(shí)間: 2025-4-1 02:23
Molecular Analysis of Mutations at the HPRT Locus: UV Mutation Spectra in Normal and UV-Sensitive V7gle and tandem double base pair substitutions with no preference for a particular type of change, although the GC ? CG transversion was not detected. Mutations in V-H1 cells consisted of single and tandem double base pair changes, which were all GC ? AT transitions, and frame shift mutations. The as作者: 逢迎白雪 時(shí)間: 2025-4-1 07:09
Comparison of the Mutational Specificities Exhibited by BPDE in , and CHO Cells)anti = (+/?)., and remarkably the reverse is seen at the crpt locus in TA100 bacteria (?) anti = (+/?) syn > ( + ) . (Stevens, ., 1985). It is also known that the ( + ) . enantiomer is more than 60 fold more active as a tumor initiator in CD-1 and Sencar mice (Pelling, ., 1984).作者: osteoclasts 時(shí)間: 2025-4-1 10:37 作者: allergy 時(shí)間: 2025-4-1 14:35 作者: Relinquish 時(shí)間: 2025-4-1 21:50 作者: overreach 時(shí)間: 2025-4-1 23:28
The Roles of Beta- and Delta-Eliminations in the Repair of AP Sites in DNAhe AP site. Since in each phosphodiester bond, there are two linkages, C.-O-P and C.-O-P, that can be hydrolyzed, four different hydrolases might participate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C.-O-P bond 5′ to AP sites and t
