標(biāo)題: Titlebook: DNA Methyltransferases - Role and Function; Albert Jeltsch,Renata Z. Jurkowska Book 20161st edition The Editor(s) (if applicable) and The [打印本頁(yè)] 作者: fumble 時(shí)間: 2025-3-21 17:31
書目名稱DNA Methyltransferases - Role and Function影響因子(影響力)
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書目名稱DNA Methyltransferases - Role and Function讀者反饋學(xué)科排名
作者: 喚起 時(shí)間: 2025-3-21 22:46
DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position,uridine at this position is methylation leading to thymine. Thymine is an integral part of the standard nucleobase repertoire of DNA that is synthesized at the nucleotide level. However, it also occurs in RNA, where it is synthesized posttranscriptionally at the polynucleotide level. The cytidine an作者: 縫紉 時(shí)間: 2025-3-22 00:34 作者: 虛情假意 時(shí)間: 2025-3-22 07:56 作者: Mast-Cell 時(shí)間: 2025-3-22 09:47
Enzymology of Mammalian DNA Methyltransferases,nd biochemical properties of the mammalian DNA nucleotide methyltransferases (DNMTs), principles of their regulation in cells have only begun to be uncovered. In mammals, DNA methylation is introduced by the DNMT1, DNMT3A, and DNMT3B enzymes, which are all large multi-domain proteins. These enzymes 作者: 線 時(shí)間: 2025-3-22 14:05
Genetic Studies on Mammalian DNA Methyltransferases, plants, invertebrates, and vertebrates, albeit its levels vary greatly in different organisms. In mammals, cytosine methylation occurs predominantly in the context of CpG dinucleotides, with the majority (60–80 %) of CpG sites in their genomes being methylated. DNA methylation plays crucial roles i作者: 線 時(shí)間: 2025-3-22 20:20 作者: 不能和解 時(shí)間: 2025-3-23 00:40 作者: athlete’s-foot 時(shí)間: 2025-3-23 03:30 作者: 不真 時(shí)間: 2025-3-23 09:17 作者: mighty 時(shí)間: 2025-3-23 10:26 作者: 羊齒 時(shí)間: 2025-3-23 17:42
Structure and Function of TET Enzymes,omethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In thi作者: Rebate 時(shí)間: 2025-3-23 18:42 作者: nascent 時(shí)間: 2025-3-23 23:56 作者: Provenance 時(shí)間: 2025-3-24 05:46 作者: 精密 時(shí)間: 2025-3-24 08:03
DNA Methyltransferase Inhibitors: Development and Applications,thyltransferases (DNMTs) is a powerful strategy to modulate, restore, or reduce DNA methylation. In this chapter, we will present examples of inhibitors of DNMTs (DNMTi) and review the fields of applications of DNMTi mainly as therapeutic molecules, for example, in cancers, cardiovascular or neurolo作者: 無(wú)思維能力 時(shí)間: 2025-3-24 13:30 作者: 休息 時(shí)間: 2025-3-24 18:29
Engineering and Directed Evolution of DNA Methyltransferases,ique and selective manner. Here, we review various aspects of MTase engineering, both methodological and conceptual, and also discuss future directions and challenges. Bacterial MTases that are part of restriction/modification (R/M) systems offer a convenient way for the selection of large gene libr作者: Lipohypertrophy 時(shí)間: 2025-3-24 20:05
DNA Labeling Using DNA Methyltransferases,cofactor S-adenosyl-L-methionine (AdoMet). Although DNA methylation plays important roles in biological signaling, the transferred methyl group is a poor reporter and is highly inert to further biocompatible derivatization. To unlock the biotechnological power of these enzymes, two major types of co作者: Curmudgeon 時(shí)間: 2025-3-25 00:46 作者: tariff 時(shí)間: 2025-3-25 05:48
Wrongs Make Rebels: Polemical Voicesuridine at this position is methylation leading to thymine. Thymine is an integral part of the standard nucleobase repertoire of DNA that is synthesized at the nucleotide level. However, it also occurs in RNA, where it is synthesized posttranscriptionally at the polynucleotide level. The cytidine an作者: 哀悼 時(shí)間: 2025-3-25 10:19 作者: 捐助 時(shí)間: 2025-3-25 14:23
https://doi.org/10.1007/978-3-658-08104-1ylation patterns produced through their de novo-type DNA methylation activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l), which is a member of the Dnmt3 family but does not possess DNA methylation activity, was reported to be indispensable for global meth作者: 鐵塔等 時(shí)間: 2025-3-25 19:45
Problemstellung und Gedankengangnd biochemical properties of the mammalian DNA nucleotide methyltransferases (DNMTs), principles of their regulation in cells have only begun to be uncovered. In mammals, DNA methylation is introduced by the DNMT1, DNMT3A, and DNMT3B enzymes, which are all large multi-domain proteins. These enzymes 作者: 表否定 時(shí)間: 2025-3-25 23:42 作者: enmesh 時(shí)間: 2025-3-26 02:34
https://doi.org/10.1007/978-3-476-05321-3-scale multinational consortium studies, it has become possible to profile the genomes and epigenomes of thousands of primary tumors from nearly every cancer type. From these genome-wide studies, it became clear that the dynamic regulation of DNA methylation is a critical epigenetic mechanism of can作者: 的闡明 時(shí)間: 2025-3-26 07:19 作者: 積極詞匯 時(shí)間: 2025-3-26 08:34 作者: Control-Group 時(shí)間: 2025-3-26 14:42 作者: 致命 時(shí)間: 2025-3-26 18:03 作者: garrulous 時(shí)間: 2025-3-26 22:07
https://doi.org/10.1007/978-3-476-05742-6omethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In thi作者: 強(qiáng)所 時(shí)間: 2025-3-27 01:27
https://doi.org/10.1007/978-3-476-05742-6tion in the major groove of DNA. The information content inherent in this modification alters the affinity and the specificity of DNA binding; some proteins favor interaction with methylated DNA, and others disfavor it. Molecular recognition of cytosine methylation by proteins often initiates sequen作者: 禁令 時(shí)間: 2025-3-27 06:05 作者: CRACK 時(shí)間: 2025-3-27 10:16
https://doi.org/10.1007/978-3-476-05742-6o in many other complex diseases. Furthermore, DNA methylation is influenced by a variety of environmental factors, and the analysis of DNA methylation patterns might allow deciphering previous exposure. Although a large number of techniques to study DNA methylation either genome-wide or at specific作者: 不確定 時(shí)間: 2025-3-27 17:11
https://doi.org/10.1007/978-3-476-05742-6thyltransferases (DNMTs) is a powerful strategy to modulate, restore, or reduce DNA methylation. In this chapter, we will present examples of inhibitors of DNMTs (DNMTi) and review the fields of applications of DNMTi mainly as therapeutic molecules, for example, in cancers, cardiovascular or neurolo作者: fringe 時(shí)間: 2025-3-27 20:36
https://doi.org/10.1007/978-3-476-05742-6e underlying epigenetic mutations, and understanding their role and function may unravel new insights for diagnosis, treatment, and even prevention of diseases. It was an important breakthrough when epigenetic alterations could be gene-specifically manipulated using epigenetic regulatory proteins in作者: 異端 時(shí)間: 2025-3-27 23:24 作者: 溝通 時(shí)間: 2025-3-28 05:02 作者: Exclude 時(shí)間: 2025-3-28 07:10 作者: Celiac-Plexus 時(shí)間: 2025-3-28 13:28 作者: 冥界三河 時(shí)間: 2025-3-28 14:35
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/d/image/260163.jpg作者: 幻想 時(shí)間: 2025-3-28 21:56 作者: 半身雕像 時(shí)間: 2025-3-29 02:16 作者: Diluge 時(shí)間: 2025-3-29 04:48 作者: 漸強(qiáng) 時(shí)間: 2025-3-29 11:01 作者: ovation 時(shí)間: 2025-3-29 11:55
Problemstellung und Gedankengangerochromatin via protein multimerization and are targeted to chromatin by their ADD and PWWP domains. Recently, a novel regulatory mechanism has been discovered in DNMTs, as latest structural and functional data demonstrated that the catalytic activities of all three enzymes are under tight alloster作者: 天氣 時(shí)間: 2025-3-29 19:24 作者: BULLY 時(shí)間: 2025-3-29 22:48
https://doi.org/10.1007/978-3-476-05321-3ed its presence in metazoa. Here, we will briefly describe the history of 6mA, examine its evolutionary conservation, and evaluate the current methods for detecting 6mA. We will discuss the enzymes that bind and regulate this mark and finally examine known and potential functions of 6mA in eukaryote作者: Inveterate 時(shí)間: 2025-3-30 01:13 作者: 要塞 時(shí)間: 2025-3-30 05:50 作者: 狗窩 時(shí)間: 2025-3-30 09:26 作者: Eosinophils 時(shí)間: 2025-3-30 14:44
https://doi.org/10.1007/978-3-476-05742-6 chapter, the currently used methods for both genome-wide and locus-specific analysis of 5-methylcytosine and as its oxidative derivatives, such as 5-hydroxymethylcytosine, are reviewed in detail, and the advantages and limitations of each approach are discussed. Furthermore, emerging technologies a作者: archenemy 時(shí)間: 2025-3-30 16:54 作者: headway 時(shí)間: 2025-3-30 23:38
https://doi.org/10.1007/978-3-476-05742-6eering of the DNA target specificity, and engineering for the usage of S-adenosyl-L-methionine (AdoMet) analogs. Directed evolution of bacterial MTases also offers insights into how these enzymes readily evolve in nature, thus yielding MTases with a huge spectrum of DNA target specificities. Enginee作者: 勛章 時(shí)間: 2025-3-31 03:02
https://doi.org/10.1007/978-3-476-05742-6ctivated groups, mTAG) uses AdoMet analogs with a sulfonium-bound extended side chain replacing the methyl group, which permits MTase-directed covalent transfer of the activated side chain alone. As the enlarged cofactors are not always compatible with the active sites of native MTases, steric engin作者: 你不公正 時(shí)間: 2025-3-31 05:44 作者: Negligible 時(shí)間: 2025-3-31 11:00
Enzymology of Mammalian DNA Methyltransferases,erochromatin via protein multimerization and are targeted to chromatin by their ADD and PWWP domains. Recently, a novel regulatory mechanism has been discovered in DNMTs, as latest structural and functional data demonstrated that the catalytic activities of all three enzymes are under tight alloster作者: CLOWN 時(shí)間: 2025-3-31 16:14
Genetic Studies on Mammalian DNA Methyltransferases, their regulators, in mice have greatly contributed to our understanding of the biological functions of DNA methylation in mammals. In this chapter, we discuss genetic studies on mammalian Dnmts, focusing on their roles in embryogenesis, cellular differentiation, genomic imprinting, and X-chromosome作者: 生命層 時(shí)間: 2025-3-31 21:05 作者: 設(shè)想 時(shí)間: 2025-4-1 01:30
Pathways of DNA Demethylation,nt barriers to induced pluripotency and is a prerequisite for the generation of iPS cells. Taking fully differentiated cells, such as skin cells, and turning back the developmental clock heralded a technological breakthrough discovery in 2006 (Takahashi and Yamanaka .) with unprecedented promise in 作者: 鋼盔 時(shí)間: 2025-4-1 02:40 作者: 惡意 時(shí)間: 2025-4-1 06:59
