標(biāo)題: Titlebook: DNA Methylation and Cancer Therapy; Moshe Szyf Book 2005 Springer-Verlag US 2005 DNA.Expression.Microarray.Purine.enzymes.gene expression. [打印本頁(yè)] 作者: 懇求 時(shí)間: 2025-3-21 16:28
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy影響因子(影響力)
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy被引頻次
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy被引頻次學(xué)科排名
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy年度引用
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy年度引用學(xué)科排名
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy讀者反饋
書(shū)目名稱(chēng)DNA Methylation and Cancer Therapy讀者反饋學(xué)科排名
作者: 馬籠頭 時(shí)間: 2025-3-21 23:24 作者: Nebulous 時(shí)間: 2025-3-22 03:26 作者: FECK 時(shí)間: 2025-3-22 07:06
DNA Methylation in Urological Cancers,s has been described. In contrast, methylation of repetitive sequences is often diminished, resulting in decreased overall methylation levels (“global hypomethylation”). Altered imprinting is also found. Testicular tumors are derived from more or less immature germ cells whose methylation patterns t作者: 興奮過(guò)度 時(shí)間: 2025-3-22 12:44 作者: 阻礙 時(shí)間: 2025-3-22 14:24
CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer,methylation of CpG islands of tumor suppressor genes associated with their transcriptional silencing. The target genes are distributed in all cellular pathways (apoptosis, DNA repair, cell cycle, cell adherence, etc.). They are “classical” tumor suppressor genes with associated familial cancers (BRC作者: 阻礙 時(shí)間: 2025-3-22 18:56 作者: FLAG 時(shí)間: 2025-3-22 21:44
Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Micility as molecular markers for cancer diagnosis. Here we describe a microarray-based technique, called differential methylation hybridization (DMH), for simultaneous screening of methylation alteration across thousands of CpG island loci in one tumor sample at a time. We also describe a second appro作者: Etymology 時(shí)間: 2025-3-23 04:19 作者: flutter 時(shí)間: 2025-3-23 08:33
Regulation of DNA Methyltransferases in Cancer,aintaining the cell’s methylation pattern, as well for transcriptional repression through both methylation dependent and independent mechanisms. It is therefore fitting that the cell has evolved a number of layers of regulation to manage the appropriate expression of the DNMTs. While transcriptional作者: Fortuitous 時(shí)間: 2025-3-23 11:02
Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation,er than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin. In fact, several lines of in vitro and in vivo evidence have shown that poly(ADP-ribosyl)ation is involved in the control of DNA methylation pattern, prote作者: 一個(gè)攪動(dòng)不安 時(shí)間: 2025-3-23 15:26 作者: 谷物 時(shí)間: 2025-3-23 20:06 作者: Acetabulum 時(shí)間: 2025-3-24 00:44
DNA Methyltransferase Inhibitors, regional hypermethylation in cancer is required for the proper design of therapeutic strategies targeting the DNA methylation machinery. This chapter discusses different models explaining this paradox. Global hypomethylation is proposed to be associated with activation by demethylation of metastasi作者: 巨大沒(méi)有 時(shí)間: 2025-3-24 04:35 作者: peptic-ulcer 時(shí)間: 2025-3-24 06:51 作者: Concerto 時(shí)間: 2025-3-24 14:08
Epilogue,rogram of multicellular organisms such as humans. The epigenome is composed of two distinctly different layers of information, chromatin and DNA methylation. While chromatin is associated with the genome and serves to package its different regions in either tight or open structures, DNA methylation 作者: 魔鬼在游行 時(shí)間: 2025-3-24 16:00 作者: Polydipsia 時(shí)間: 2025-3-24 21:51
https://doi.org/10.1007/978-3-642-24996-9encing, X chromosome inactivation, and imprinting. Genome-wide DNA methylation patterns are nonrandomly distributed and undergo significant remodeling events during embryogenesis. DNA methylation patterns are also frequently ‘remodeled’ in tumor cells in a way that directly contributes to tumor supp作者: characteristic 時(shí)間: 2025-3-25 02:38 作者: Coeval 時(shí)間: 2025-3-25 03:30 作者: 易于 時(shí)間: 2025-3-25 07:33 作者: Pert敏捷 時(shí)間: 2025-3-25 12:17
https://doi.org/10.1007/978-3-642-24996-9methylation of CpG islands of tumor suppressor genes associated with their transcriptional silencing. The target genes are distributed in all cellular pathways (apoptosis, DNA repair, cell cycle, cell adherence, etc.). They are “classical” tumor suppressor genes with associated familial cancers (BRC作者: obsession 時(shí)間: 2025-3-25 18:07 作者: Herpetologist 時(shí)間: 2025-3-25 23:34 作者: Pericarditis 時(shí)間: 2025-3-26 03:35 作者: 職業(yè)拳擊手 時(shí)間: 2025-3-26 07:47 作者: 聯(lián)想 時(shí)間: 2025-3-26 09:19
https://doi.org/10.1007/978-3-642-24996-9er than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin. In fact, several lines of in vitro and in vivo evidence have shown that poly(ADP-ribosyl)ation is involved in the control of DNA methylation pattern, prote作者: 間接 時(shí)間: 2025-3-26 16:02 作者: 慢慢啃 時(shí)間: 2025-3-26 17:00
https://doi.org/10.1007/978-3-642-24996-9cleosides and their corresponding nucleobases are the fundamental building blocks of many biological systems and as a result, have been extensively investigated due to their inherent structural resemblance to the naturally occurring nucleosides and nucleobases. Due to the intertwined relationship be作者: 吹牛需要藝術(shù) 時(shí)間: 2025-3-27 00:19
https://doi.org/10.1007/978-3-642-24996-9 regional hypermethylation in cancer is required for the proper design of therapeutic strategies targeting the DNA methylation machinery. This chapter discusses different models explaining this paradox. Global hypomethylation is proposed to be associated with activation by demethylation of metastasi作者: 厚顏 時(shí)間: 2025-3-27 03:54
https://doi.org/10.1007/978-3-476-05319-0ethylation are reviewed. These include studies on the molecular, cellular and animal pharmacology of 5AZA. These preclinical studies indicated that 5AZA has enormous potential in cancer therapy. This potential is supported by reports in the literature indicate that 5AZA can reactivate many different作者: 危險(xiǎn) 時(shí)間: 2025-3-27 06:21
https://doi.org/10.1007/978-3-476-05319-0RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an antican作者: vasculitis 時(shí)間: 2025-3-27 11:21 作者: 阻撓 時(shí)間: 2025-3-27 15:57
https://doi.org/10.1007/978-3-476-05319-0RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.作者: Devastate 時(shí)間: 2025-3-27 21:43
Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense,RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.作者: adequate-intake 時(shí)間: 2025-3-28 01:52
Moshe SzyfDNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials..The chapters are 作者: lipids 時(shí)間: 2025-3-28 02:59
Medical Intelligence Unithttp://image.papertrans.cn/d/image/260157.jpg作者: licence 時(shí)間: 2025-3-28 09:37 作者: endure 時(shí)間: 2025-3-28 10:40
978-1-4419-3416-1Springer-Verlag US 2005作者: magnate 時(shí)間: 2025-3-28 18:29 作者: Introduction 時(shí)間: 2025-3-28 20:46 作者: 輕率看法 時(shí)間: 2025-3-28 23:50 作者: BADGE 時(shí)間: 2025-3-29 03:33 作者: 徹底明白 時(shí)間: 2025-3-29 09:35
https://doi.org/10.1007/978-3-642-24996-9ibition of the poly(ADP-ribosyl)ation process in the cell may be responsible for the anomalous hypermethylation of oncosuppressor gene promoters during tumorigenesis and to suggest the possibility that an active poly(ADP-ribosyl)ation process is also involved in maintaining the unmethylated state of作者: ARCHE 時(shí)間: 2025-3-29 12:27
Oliver Marchart,Wolfgang Heuer,Thomas Meyers in understanding the relation between chromatin and DNA methylation have provided some insights into the mechanisms that tie these processes to each other. It is clear that DNA methy-lation has to be understood within its chromatin context and aberrations in DNA methylation must be understood in r作者: CREEK 時(shí)間: 2025-3-29 15:37
Epigenetic Mechanisms of Gene Regulation, tail modifications and chromatin remodeling, directly determine which regions of the genome are to be methylated. By studying these mechanisms in detail we should be able gain insights into how DNA methylation patterns become disrupted in tumor cells and how these defects may be corrected.作者: Herpetologist 時(shí)間: 2025-3-29 22:40
DNA Hypo- vs. Hypermethylation in Cancer,ypermethylation. Because of this finding and the very frequent targeting of DNA sequences for this hypomethylation in diverse cancers, genomic hypomethylation is likely to contribute to carcinogenesis and not to be just a byproduct of oncogenic transformation. Therefore, caution should be used in de作者: 公社 時(shí)間: 2025-3-30 01:29 作者: 歸功于 時(shí)間: 2025-3-30 04:21
The Loss of Methyl Groups in DNA of Tumor Cells and Tissues,ucleases and reverse phase high pressure liquid chromatography analysis. The development of gene-specific hybridization techniques together with the availability of an ever-increasing number of methylation-sensitive restriction enzymes allowed the methylation status of numerous genes to be investiga作者: 脆弱吧 時(shí)間: 2025-3-30 08:54 作者: 演講 時(shí)間: 2025-3-30 13:15 作者: Expertise 時(shí)間: 2025-3-30 18:33 作者: 解脫 時(shí)間: 2025-3-30 22:21 作者: 向外才掩飾 時(shí)間: 2025-3-31 01:25 作者: 清楚 時(shí)間: 2025-3-31 08:56
The Role of Active Demethylation in Cancer and Its Therapeutic Potential,s-associated genes. Thus, anticancer therapy directed at DNA methyltransferase might have the untoward effect of promoting metastasis. Inhibition of demethylase activity on the other hand could potentially inhibit metastasis. It is therefore important to identify and characterize the enzymes responsible for global hypomethylation in cancer.作者: 1FAWN 時(shí)間: 2025-3-31 12:17
Purine Analogues and Their Role in Methylation and Cancer Chemotherapy,tween purine and pyrimidine nucleotide metabolism, cell proliferation and tumor cell differentiation, inhibition of key enzymes in nucleotide metabolism and DNA synthesis can be used as a chemotherapeutic approach to treating cancer.
