標(biāo)題: Titlebook: DNA Damage and Repair in Human Tissues; Betsy M. Sutherland,Avril D. Woodhead Book 1990 Plenum Press, New York 1990 DNA.Laboratory.Xeroder [打印本頁] 作者: 一再 時(shí)間: 2025-3-21 19:35
書目名稱DNA Damage and Repair in Human Tissues影響因子(影響力)
書目名稱DNA Damage and Repair in Human Tissues影響因子(影響力)學(xué)科排名
書目名稱DNA Damage and Repair in Human Tissues網(wǎng)絡(luò)公開度
書目名稱DNA Damage and Repair in Human Tissues網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱DNA Damage and Repair in Human Tissues被引頻次
書目名稱DNA Damage and Repair in Human Tissues被引頻次學(xué)科排名
書目名稱DNA Damage and Repair in Human Tissues年度引用
書目名稱DNA Damage and Repair in Human Tissues年度引用學(xué)科排名
書目名稱DNA Damage and Repair in Human Tissues讀者反饋
書目名稱DNA Damage and Repair in Human Tissues讀者反饋學(xué)科排名
作者: 牽連 時(shí)間: 2025-3-21 22:21 作者: 偽善 時(shí)間: 2025-3-22 04:01 作者: SIT 時(shí)間: 2025-3-22 06:43
Lesion Measurement in Non-Radioactive DNA by Quantitative Gel Electrophoresisryotic cells growing in culture. The information obtainable from these model systems, while extremely valuable, can never replace the need for data from intact higher organisms. The gel electrophoresis method developed during the past ten years in our laboratories makes possible the quantitation of 作者: adroit 時(shí)間: 2025-3-22 12:48
Fluorescence Detection of Lesions in DNA through diet, occupation and life-style (World Health Organization, 1973; 1983). Metabolism and activation of chemicals that reach target-organs lead to the formation of carcinogen-DNA adducts, which are recognized as human cancer risk factors (Doll and Peto, 1981)作者: 清楚說話 時(shí)間: 2025-3-22 13:58 作者: 清楚說話 時(shí)間: 2025-3-22 19:36 作者: hurricane 時(shí)間: 2025-3-22 22:06
5-MOP Induced Protection Against Epidermal DNA Damage by Ultraviolet Radiation in Human Skinf skin types I and II who sunburn easily and have a limited ability to tan (MacKie et al., 1987). In the last few years this information has been widely publicized in the press and other media. Despite this, a suntan is still a prized social asset and epidemiological data indicate a continued rise i作者: 食料 時(shí)間: 2025-3-23 01:56
Variability in DNA Repair in Human Skinlation of rates of incidence with latitude and, presumbably, solar exposure (Scotto, 1986), occurence on sun-exposed body regions (Scotto, 1986) and higher incidence in individuals who spend more time outdoors (Urbach et al., 1972) point to the sun as a major etiologic agent. For melanoma, there is 作者: RLS898 時(shí)間: 2025-3-23 06:17 作者: altruism 時(shí)間: 2025-3-23 12:47
DNA Damage and Repair in Human Skin: Pathways and Questionsmoters, and modifiers of biological responses to such agents. DNA is the principal target for most carcinogens, and DNA in skin is particularly at risk. It is subject to damage not only from ingested compounds and their metabolic products, but also from externally applied or encountered chemicals, a作者: heart-murmur 時(shí)間: 2025-3-23 17:41
Unscheduled DNA Synthesis in Human Skinr role in the initiation of UV carcinogenesis (Epstein, 1970; Robbins et al., 1974; Hart et al., 1977; Black and Chan, 1977). The repair of these DNA lesions has been widely studied in the recent past (Sutherland et al., 1980) but relatively little information is available on DNA repair in situ in h作者: tolerance 時(shí)間: 2025-3-23 21:53 作者: 土坯 時(shí)間: 2025-3-24 00:09
Damage Specific Mammalian Endonucleasesmoved. Modified bases in DNA can be excised from DNA by different repair pathways. The process of excision repair involves four major steps: incision, excision, DNA synthesis, and ligation of the repaired sequence. The enzymes responsible for the first step in this scheme are damage-specific enzymes作者: ovation 時(shí)間: 2025-3-24 03:43 作者: 補(bǔ)角 時(shí)間: 2025-3-24 09:05 作者: ethnology 時(shí)間: 2025-3-24 14:44
The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessmentthe macromolecular adduct, DNA repair processes play an important role in removing this initial damage in an attempt to assure cellular proliferation and survival. There has been a rapid increase in our knowledge of DNA damage and repair mechanisms over the last several years, using the tools of mol作者: 落葉劑 時(shí)間: 2025-3-24 15:07
Measurements of Genomic and Gene-Specific DNA Repair of Alkylation Damage in Cultured Human T-Lymphonderstand the mechanism and efficiency of DNA repair in human cells. Most of the mechanisms which have been proposed for the repair of various types of damage in human cells has been based upon prokaryotic models (Friedberg, 1985); however, our knowledge of DNA repair processes in human cells is not作者: ELATE 時(shí)間: 2025-3-24 19:11
Variability in DNA Repair in Human Skinigher incidence in individuals who spend more time outdoors (Urbach et al., 1972) point to the sun as a major etiologic agent. For melanoma, there is a good correlation of rates of mortality with latitude (Mason and Mckay, 1974). However, the relationship between solar UV radiation exposure and cutaneous melanoma is not simple (Sober, 1987).作者: debouch 時(shí)間: 2025-3-25 01:18
Vanessa Miller,Jens U. P?tzmannn the incidence of skin cancers. It also seems reasonable to suppose that the possible depletion of the stratospheric ozone layer, over populated areas of the earth’s surface, would result in a further long-term increase of skin cancer (van der Leun, 1988).作者: 制度 時(shí)間: 2025-3-25 07:21
https://doi.org/10.1007/978-1-4842-5750-0 treat patients with the erythrodermic form of CTCL (Edelson et al., 1987). In this treatment, a patient’s lymphocytes are extracorporeally irradiated with UVA in the presence of 8-methoxy-psoralen (8-MOP), and then are reinfused.作者: 不能逃避 時(shí)間: 2025-3-25 09:18 作者: 教義 時(shí)間: 2025-3-25 15:15 作者: GRIPE 時(shí)間: 2025-3-25 18:34
Architecting Dependable Systems IIt of a population of stem cells that give rise to immunologically competent lymphoid cells. Although many questions need to be answered before we know the efficacy of such therapy, the National Institute of Health has issued guidelines for its use, and clinical trials have already begun (Culliton, 1989).作者: Ebct207 時(shí)間: 2025-3-25 21:47
DNA Damage and Repair in Human Skin: Pathways and Questionsvidual to repair a lesion, and (3) the strategy that skin employs to deal with the different spectra of lesions inflicted under varying environmental conditions. Thus, cellular responses to DNA damage, including repair of DNA lesions, are critical factors in determining the final level of damage and its consequences.作者: Mingle 時(shí)間: 2025-3-26 03:55
Prospects for Epithelial Gene Therapyt of a population of stem cells that give rise to immunologically competent lymphoid cells. Although many questions need to be answered before we know the efficacy of such therapy, the National Institute of Health has issued guidelines for its use, and clinical trials have already begun (Culliton, 1989).作者: 胰臟 時(shí)間: 2025-3-26 06:03
5-MOP Induced Protection Against Epidermal DNA Damage by Ultraviolet Radiation in Human Skinn the incidence of skin cancers. It also seems reasonable to suppose that the possible depletion of the stratospheric ozone layer, over populated areas of the earth’s surface, would result in a further long-term increase of skin cancer (van der Leun, 1988).作者: 燦爛 時(shí)間: 2025-3-26 10:31
Repair of 8-MOP Photoadducts in Human Lymphocytes treat patients with the erythrodermic form of CTCL (Edelson et al., 1987). In this treatment, a patient’s lymphocytes are extracorporeally irradiated with UVA in the presence of 8-methoxy-psoralen (8-MOP), and then are reinfused.作者: mendacity 時(shí)間: 2025-3-26 13:25 作者: 透明 時(shí)間: 2025-3-26 17:09
“Sie ist vieldeutig und autonom.”A does not have to be labeled with radionuclides or of a particular conformation, thus facilitating the use of the method in measuring damage levels and repair rates in the DNA of intact organisms -- including man.作者: 樸素 時(shí)間: 2025-3-26 22:24 作者: Metamorphosis 時(shí)間: 2025-3-27 04:20 作者: extinguish 時(shí)間: 2025-3-27 06:55
The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessmentred (Bohr and Wassermann, 1988). It is not our intent to discuss the advances made in the field of DNA damage and repair, but rather to provide a conceptual outline for considering how such information may be applicable or relevant to the assessment of health risks, particularly those posed by exposure to carcinogens and mutagens.作者: 易彎曲 時(shí)間: 2025-3-27 12:26
integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sens作者: Lamina 時(shí)間: 2025-3-27 15:31 作者: averse 時(shí)間: 2025-3-27 21:03 作者: exostosis 時(shí)間: 2025-3-27 23:03 作者: Enrage 時(shí)間: 2025-3-28 03:54
Measurement of DNA Adducts by Immunoassaysntually demonstrate the dose received and/or allow the prediction of cancer risk. At the present time evidence that the occurrence of certain adducts is associated with specific chemical exposures is accumulating, and multiple methods are being validated to confirm these observations.作者: 扔掉掐死你 時(shí)間: 2025-3-28 09:56 作者: apropos 時(shí)間: 2025-3-28 13:29 作者: 云狀 時(shí)間: 2025-3-28 18:11
Defective DNA Repair in Humans: Clinical and Molecular Studies of Xeroderma Pigmentosum000-fold increased frequency of cancer of the sun exposed portions of the skin and eyes. Cultured cells from XP patients are hypersensitive to the cytotoxic and mutagenic effects of UV radiation and have defective DNA repair (reviewed in Robbins et al, 1974; Kraemer and Slor, 1985; Kraemer, 1987; Cleaver and Kraemer, 1989).作者: mydriatic 時(shí)間: 2025-3-28 19:46 作者: Proponent 時(shí)間: 2025-3-29 01:13
Methods for the Entrepreneurship EcosystemHuman attitudes toward sunlight are equivocal. Almost everyone experiences psychological, and possibly physical benefits from exposure to the sun. In contrast, most people recognize an imminent danger of overexposure, with painful and, occasionally, serious consequences.作者: infatuation 時(shí)間: 2025-3-29 06:01 作者: 假裝是你 時(shí)間: 2025-3-29 10:36
https://doi.org/10.1007/978-3-031-28303-1ntually demonstrate the dose received and/or allow the prediction of cancer risk. At the present time evidence that the occurrence of certain adducts is associated with specific chemical exposures is accumulating, and multiple methods are being validated to confirm these observations.作者: 單調(diào)性 時(shí)間: 2025-3-29 11:34
Bruno Helly,Alain Rideaud,Beno?t Hellyrtain aromatic amines or hydrocarbons in occupational settings, or as incompletely defined complex mixtures such as cigarette smoke. The important role of tumor promoters in multistage carcinogenesis of experimental animals and humans (Pitot, 1986) is documented by many lines of evidence, but no pra作者: perjury 時(shí)間: 2025-3-29 19:32
https://doi.org/10.1007/978-3-476-04249-1e been developed against a number of specific adducts as well as against UV-damaged DNA (Poirier, 1981; Santella, 1988). Antibodies can be developed against either the carcinogen adduct covalently coupled to carrier protein or the modified DNA electrostatically complexed to methylated bovine serum a作者: 諷刺滑稽戲劇 時(shí)間: 2025-3-29 22:00
“Sie ist vieldeutig und autonom.”ryotic cells growing in culture. The information obtainable from these model systems, while extremely valuable, can never replace the need for data from intact higher organisms. The gel electrophoresis method developed during the past ten years in our laboratories makes possible the quantitation of 作者: 歌曲 時(shí)間: 2025-3-30 03:43 作者: 責(zé)問 時(shí)間: 2025-3-30 05:18 作者: 寒冷 時(shí)間: 2025-3-30 08:49
https://doi.org/10.1007/978-3-476-04249-1000-fold increased frequency of cancer of the sun exposed portions of the skin and eyes. Cultured cells from XP patients are hypersensitive to the cytotoxic and mutagenic effects of UV radiation and have defective DNA repair (reviewed in Robbins et al, 1974; Kraemer and Slor, 1985; Kraemer, 1987; Cl作者: 滔滔不絕地說 時(shí)間: 2025-3-30 12:36
Vanessa Miller,Jens U. P?tzmannf skin types I and II who sunburn easily and have a limited ability to tan (MacKie et al., 1987). In the last few years this information has been widely publicized in the press and other media. Despite this, a suntan is still a prized social asset and epidemiological data indicate a continued rise i作者: 積云 時(shí)間: 2025-3-30 18:32
https://doi.org/10.1007/978-3-031-22253-5lation of rates of incidence with latitude and, presumbably, solar exposure (Scotto, 1986), occurence on sun-exposed body regions (Scotto, 1986) and higher incidence in individuals who spend more time outdoors (Urbach et al., 1972) point to the sun as a major etiologic agent. For melanoma, there is 作者: 出價(jià) 時(shí)間: 2025-3-31 00:24 作者: exhilaration 時(shí)間: 2025-3-31 01:34
Architecting Dependable Systemsmoters, and modifiers of biological responses to such agents. DNA is the principal target for most carcinogens, and DNA in skin is particularly at risk. It is subject to damage not only from ingested compounds and their metabolic products, but also from externally applied or encountered chemicals, a作者: Hirsutism 時(shí)間: 2025-3-31 09:05
Architecting Dependable Systemsr role in the initiation of UV carcinogenesis (Epstein, 1970; Robbins et al., 1974; Hart et al., 1977; Black and Chan, 1977). The repair of these DNA lesions has been widely studied in the recent past (Sutherland et al., 1980) but relatively little information is available on DNA repair in situ in h作者: 脆弱么 時(shí)間: 2025-3-31 09:40 作者: Hemiparesis 時(shí)間: 2025-3-31 14:16
Architectural Mismatch Tolerancemoved. Modified bases in DNA can be excised from DNA by different repair pathways. The process of excision repair involves four major steps: incision, excision, DNA synthesis, and ligation of the repaired sequence. The enzymes responsible for the first step in this scheme are damage-specific enzymes作者: 失望未來 時(shí)間: 2025-3-31 20:03 作者: 提名 時(shí)間: 2025-3-31 23:27 作者: Debrief 時(shí)間: 2025-4-1 05:32 作者: scotoma 時(shí)間: 2025-4-1 08:14 作者: 種類 時(shí)間: 2025-4-1 14:09 作者: Limited 時(shí)間: 2025-4-1 16:28
978-1-4612-7903-7Plenum Press, New York 1990作者: 與野獸博斗者 時(shí)間: 2025-4-1 21:33
https://doi.org/10.1007/978-3-031-28303-1ntually demonstrate the dose received and/or allow the prediction of cancer risk. At the present time evidence that the occurrence of certain adducts is associated with specific chemical exposures is accumulating, and multiple methods are being validated to confirm these observations.作者: Migratory 時(shí)間: 2025-4-2 01:39 作者: 通知 時(shí)間: 2025-4-2 03:06
“Sie ist vieldeutig und autonom.”ental studies indicate that the ultraviolet-B (W-B, 290-320 nm) portion of the solar spectrum is primarily responsible for the carcinogenic properties of sunlight (Forbes et al., 1989). This waveband encompasses the short-wavelength end of the solar spectrum that reaches the earth’s surface.作者: 環(huán)形 時(shí)間: 2025-4-2 10:39
https://doi.org/10.1007/978-3-476-04249-1000-fold increased frequency of cancer of the sun exposed portions of the skin and eyes. Cultured cells from XP patients are hypersensitive to the cytotoxic and mutagenic effects of UV radiation and have defective DNA repair (reviewed in Robbins et al, 1974; Kraemer and Slor, 1985; Kraemer, 1987; Cleaver and Kraemer, 1989).
