標(biāo)題: Titlebook: DNA Binders and Related Subjects; Michael J. Waring,Jonathan B. Chaires Book 2005 Springer-Verlag Berlin Heidelberg 2005 DNA.Isomer.Nucleo [打印本頁(yè)] 作者: 對(duì)將來(lái)事件 時(shí)間: 2025-3-21 16:55
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作者: Facet-Joints 時(shí)間: 2025-3-21 23:46
Telekooperation im Top-Managementod is based on firm thermodynamic principles and is simple to implement. In the competition dialysis experiment, an array of nucleic acid structures and sequences is dialyzed against a common test ligand solution. After equilibration, the amount of ligand bound to each structure or sequence is deter作者: 來(lái)這真柔軟 時(shí)間: 2025-3-22 02:00 作者: Cabg318 時(shí)間: 2025-3-22 06:47
Finanzmarktkapitalismus und Arbeitecules, monovalent and divalent cations, and polyamines compete for similar or adjacent sites. Many of these species give identical electron distributions (electron density maps). Such scattering iso-types allow one to construct different models that give similar fits of model to data. Even models w作者: 真實(shí)的人 時(shí)間: 2025-3-22 11:33
Thomas Haipeter,Christine Slomkaisomerases. These enzymes that resolve DNA topological constraints in cells are the primary targets for a large diversity of natural products extracted from plants, microorganisms or, as reviewed here, from marine organisms. Marine products capable of stabilizing topoisomerase II-DNA covalent comple作者: coltish 時(shí)間: 2025-3-22 13:26
Thomas Haipeter,Christine Slomkaimportant signals for regulating gene expression, and for maintaining genome integrity and stability. The design of tailor-made molecules that recognize specific sequences in the DNA double helix would provide interesting tools to interfere with DNA information processing and to target genome modifi作者: coltish 時(shí)間: 2025-3-22 18:46
Der Gestaltwandel des Mittelstandes990–2000) saw a resurgence in aminoglycoside-based drug development as their chemistry/mechanism of action became better understood. This work, however, had almost exclusively focused on targeting RNA. This review summarizes new developments (past 4–5 years) in aminoglycoside–nucleic acid interactio作者: Host142 時(shí)間: 2025-3-22 22:21
Der Gestaltwandel des Mittelstandesntibiotic activities are ascribed to their abilities to bind a highly conserved sequence (termed the A site) in the 16S rRNA of the 30S ribosomal subunit and interfere with protein synthesis. The aminoglycosides represent a paradigm for both drug–RNA and drug–ribosome interactions, and information g作者: 極小 時(shí)間: 2025-3-23 01:46
https://doi.org/10.1007/b99428DNA; Isomer; Nucleotide; RNA; biochemistry; gene expression; glycosides; nucleotides作者: 清楚說(shuō)話 時(shí)間: 2025-3-23 09:10 作者: effrontery 時(shí)間: 2025-3-23 09:49 作者: 控制 時(shí)間: 2025-3-23 16:06 作者: 的事物 時(shí)間: 2025-3-23 21:35 作者: BLUSH 時(shí)間: 2025-3-23 22:54 作者: BLUSH 時(shí)間: 2025-3-24 02:34 作者: travail 時(shí)間: 2025-3-24 06:50 作者: 休閑 時(shí)間: 2025-3-24 12:29
Der Gestaltwandel des Mittelstandesnderstanding of the molecular forces that govern aminoglycoside recognition of the rRNA A site, and underlie the mechanism and specificity of action of these drugs. Such knowledge provides the type of predictive capabilities that are essential for the devlopment of a rational basis for future drug design strategies.作者: pulse-pressure 時(shí)間: 2025-3-24 16:21 作者: 虛弱的神經(jīng) 時(shí)間: 2025-3-24 21:57 作者: overweight 時(shí)間: 2025-3-25 01:58
Der Gestaltwandel des Mittelstandesdevelopment of novel conjugates for major-minor groove recognition of B-form DNA. Neomycin is chosen as the representative aminoglycoside and is revealed here to be an underutilized scaffold in nucleic acid recognition.作者: 牌帶來(lái) 時(shí)間: 2025-3-25 05:52 作者: Incorporate 時(shí)間: 2025-3-25 07:32 作者: 不能仁慈 時(shí)間: 2025-3-25 13:10 作者: 斷言 時(shí)間: 2025-3-25 18:22 作者: Odyssey 時(shí)間: 2025-3-25 21:16 作者: tic-douloureux 時(shí)間: 2025-3-26 01:53 作者: 洞穴 時(shí)間: 2025-3-26 05:42 作者: Aviary 時(shí)間: 2025-3-26 09:06 作者: entitle 時(shí)間: 2025-3-26 14:05
,Aminoglycoside–Nucleic Acid Interactions: The Case for Neomycin,990–2000) saw a resurgence in aminoglycoside-based drug development as their chemistry/mechanism of action became better understood. This work, however, had almost exclusively focused on targeting RNA. This review summarizes new developments (past 4–5 years) in aminoglycoside–nucleic acid interactio作者: 重疊 時(shí)間: 2025-3-26 18:44 作者: forebear 時(shí)間: 2025-3-26 22:52 作者: carotid-bruit 時(shí)間: 2025-3-27 04:37
Finanzmarktkapitalismus und Arbeitannot be unambiguously extracted from conventional X-ray diffraction experiments. We give several examples where incorrect atom-type assignments have been revealed by anomalous scattering experiments. Published structures and the database that contains them do not provide realistic representations o作者: 厭惡 時(shí)間: 2025-3-27 06:10 作者: Bravura 時(shí)間: 2025-3-27 11:24 作者: 新陳代謝 時(shí)間: 2025-3-27 16:40
Structural Selectivity of Drug-Nucleic Acid Interactions Probed by Competition Dialysis,od, competition dialysis has been used worldwide to probe a variety of ligand-nucleic acid interactions. This chapter will focus on new analytical approaches for extracting information from the database that resulted from the first-generation competition dialysis assay, in which binding data were ga作者: Exhilarate 時(shí)間: 2025-3-27 17:52
Between Objectivity and Whim: Nucleic Acid Structural Biology,annot be unambiguously extracted from conventional X-ray diffraction experiments. We give several examples where incorrect atom-type assignments have been revealed by anomalous scattering experiments. Published structures and the database that contains them do not provide realistic representations o作者: synovial-joint 時(shí)間: 2025-3-27 22:15
Topoisomerase Inhibitors of Marine Origin and Their Potential Use as Anticancer Agents,somerase I have also been discovered such as wakayin, kalihinol F, and the cyclic peptide sansalvamide A, which inhibits the type I topoisomerase from the . virus. But the leading topoisomerase I poison is the marine alkaloid lamellarin D, recently characterized as a potent pro-apoptotic cytotoxic a作者: consolidate 時(shí)間: 2025-3-28 05:42
DNA Major Groove Binders: Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands velopment of triple helix-forming oligonucleotides as highly sequence-specific DNA major groove binders, the related triple helix structures, examples of triple helix-specific ligands and DNA cleaving agents, as well as their biological relevance, during the last 10–15 years.作者: Geyser 時(shí)間: 2025-3-28 09:34 作者: 感染 時(shí)間: 2025-3-28 13:32 作者: 啟發(fā) 時(shí)間: 2025-3-28 18:36 作者: nettle 時(shí)間: 2025-3-28 19:48 作者: Neonatal 時(shí)間: 2025-3-29 00:03
https://doi.org/10.1007/978-3-642-14171-3Gateway; LA; Routing; Scheduling; System; ad hoc networks; algorithms; cloud computing; cognition; communicat作者: ATP861 時(shí)間: 2025-3-29 05:02
Einleitung, sich die Notwendigkeit, stets auf die Beziehungen zu den immunisatorisch erzeugten Antik?rpern zurückzukommen, mit welchen die natürlichen Antik?rper die spezifische Affinit?t zu den als Antigene bezeichneten Substanzen und die Art ihrer Reaktionen mit diesen gemein haben.