作者: 大漩渦 時(shí)間: 2025-3-21 23:40
Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance,y, and drug sensitivity. Thus, DJ-1 plays a critical role in cancer. Although DJ-1 has an important role within cancer cells, cancer cells secrete DJ-1 outside the cells. DJ-1 may serve as a tumor marker that can be detected from an early stage in the blood, secretory fluids, ascites, or pleural effusion.作者: 永久 時(shí)間: 2025-3-22 00:29 作者: Forehead-Lift 時(shí)間: 2025-3-22 06:50
Fish Lectins in Host–Pathogen Interactiony, and drug sensitivity. Thus, DJ-1 plays a critical role in cancer. Although DJ-1 has an important role within cancer cells, cancer cells secrete DJ-1 outside the cells. DJ-1 may serve as a tumor marker that can be detected from an early stage in the blood, secretory fluids, ascites, or pleural effusion.作者: 在前面 時(shí)間: 2025-3-22 09:29
https://doi.org/10.1007/1-4020-5368-1also plays a critical role in tumor development and progression. In this review, we provide an overview of current knowledge concerning the role and the mechanism of DJ-1 in cancer and also discuss the possibility of DJ-1 as a therapeutic target against cancer.作者: 固定某物 時(shí)間: 2025-3-22 14:49 作者: 固定某物 時(shí)間: 2025-3-22 18:41 作者: 機(jī)構(gòu) 時(shí)間: 2025-3-23 01:16
Introduction/Overview,ve rise to the common mechanism among these diseases. Furthermore, secreted DJ-1 levels in serum and DJ-1-binding compounds will be a diagnostic biomarker and therapeutic drug for neurodegenerative diseases, respectively.作者: 周年紀(jì)念日 時(shí)間: 2025-3-23 05:05 作者: 憤怒事實(shí) 時(shí)間: 2025-3-23 09:31
Sources and Age of Aquatic Humusnction primarily as a redox-responsive protein that may act as a sensor for imbalances in cellular redox state. Because mutations in human DJ-1 cause certain types of heritable Parkinson’s disease, the role of oxidative posttranslational modifications and pathogenic mutations in human DJ-1 is emphasized in the latter sections of this chapter.作者: morale 時(shí)間: 2025-3-23 11:51 作者: hedonic 時(shí)間: 2025-3-23 17:06 作者: CHAFE 時(shí)間: 2025-3-23 20:09 作者: GRE 時(shí)間: 2025-3-23 23:07
0065-2598 ity.Broadens the understanding of the various uses of DJ-1 sThis book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The?.DJ-1?.gene was first found to be a novel oncogene in 1997 and later, in 作者: 個(gè)人長(zhǎng)篇演說 時(shí)間: 2025-3-24 05:17
https://doi.org/10.1007/978-981-10-6583-5DJ-1; Parkinson’s disease; Cancer; Type 2 diabetes; Male infertility; Oxidative stress; Mitochondria; Signa作者: Detain 時(shí)間: 2025-3-24 08:11 作者: corporate 時(shí)間: 2025-3-24 14:27 作者: BROOK 時(shí)間: 2025-3-24 17:37 作者: intangibility 時(shí)間: 2025-3-24 22:55 作者: maudtin 時(shí)間: 2025-3-25 01:07 作者: deadlock 時(shí)間: 2025-3-25 05:16 作者: judicial 時(shí)間: 2025-3-25 09:44 作者: NIB 時(shí)間: 2025-3-25 13:37
Fish Lectins in Host–Pathogen Interactioncreatic duct adenocarcinoma, urinary transitional cell carcinoma, and gynecologic carcinoma. At the protein level, intensity and intracellular localization of DJ-1 expression is varied, and the DJ-1 protein regulates cancer progression, clinical aggressiveness, differentiation, cancer cell morpholog作者: 笨拙處理 時(shí)間: 2025-3-25 16:24 作者: Negotiate 時(shí)間: 2025-3-25 21:53
V. Ramasubramanian,V. Brindha Priyadarisinie at position 106 (C106) is crucial for determination of the activation level of DJ-1..DJ-1 binds to many proteins, including various transcription factors, and acts as a coactivator or corepressor for regulating their target genes without direct binding to DNA, thereby affecting various cell functi作者: HEW 時(shí)間: 2025-3-26 01:00 作者: 縮短 時(shí)間: 2025-3-26 06:34 作者: LATE 時(shí)間: 2025-3-26 11:48
Joaquim I. Goes,Helga do R. Gomess been identified as a causative gene of a familial form of Parkinson’s disease, ., and plays a significant role in antioxidative defense, protecting cells from oxidative stress. A cysteine residue of DJ-1 at position 106 (Cys-106) is preferentially oxidized under oxidative stress. This reactive Cys作者: calorie 時(shí)間: 2025-3-26 13:45
Tatiana A. Rynearson,Susanne Menden-Deuereta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokin作者: Counteract 時(shí)間: 2025-3-26 18:39
Joaquim I. Goes,Helga do R. Gomese nigrostriatal pathway. Loss-of-function mutations in the gene encoding PARK7/DJ-1 were identified in familial PD. Wild-type DJ-1 acts as an oxidative stress sensor in neural cells. Previously, we identified binding compounds of DJ-1, including UCP0045037/compound A, UCP0054278/compound B, and comp作者: galley 時(shí)間: 2025-3-26 23:55
https://doi.org/10.1007/1-4020-5368-1egulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1 作者: occult 時(shí)間: 2025-3-27 01:18 作者: 顯示 時(shí)間: 2025-3-27 06:54 作者: enterprise 時(shí)間: 2025-3-27 10:12 作者: idiopathic 時(shí)間: 2025-3-27 14:36
Structural Biology of the DJ-1 Superfamily,nt in most organisms. Many of these proteins remain poorly characterized at the biochemical level, but include some known chaperones, proteases, and various stress response proteins that remain mechanistically mysterious. This chapter outlines what is known from a structural perspective about the ce作者: Infuriate 時(shí)間: 2025-3-27 20:54
Expression of DJ-1 in Neurodegenerative Disorders, a conserved protein termed DJ-1. DJ-1 is a ubiquitous protein, and within the brain, it is present in the nucleus and cytoplasm of both neuronal and glial cells. DJ-1 is a multifunctional protein, and numerous studies have ascribed various roles, including antioxidative properties, chaperone functi作者: Fatten 時(shí)間: 2025-3-27 23:23 作者: 變量 時(shí)間: 2025-3-28 05:29
The Multifaceted Roles of DJ-1 as an Antioxidant,cysteine residues, which are involved in its dimerisation and functional properties. A mildly oxidised form of DJ-1 is the most active form and protects cells from oxidative stress conditions. DJ-1 functions as an antioxidant through a variety of mechanisms, including a weak direct antioxidant activ作者: 一再困擾 時(shí)間: 2025-3-28 09:03 作者: 名詞 時(shí)間: 2025-3-28 14:10
Regulation of Signal Transduction by DJ-1,ptosis, and autophagy to adapt to changing environmental stimuli and stresses. Perturbations of DJ-1 levels or function can disrupt the equilibrium of homeostatic signaling networks and set off cascades that play a role in the pathogenesis of conditions such as cancer and Parkinson’s disease..DJ-1 p作者: 削減 時(shí)間: 2025-3-28 18:08
Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases, their major glycating agents. Glycation is a non-enzymatic covalent reaction discovered by Louis Camille Maillard in 1912, between reactive carbonyls (reducing sugars and glyoxals) and amino acids (cysteine, arginine and lysine), which inactivates proteins. By degrading Maillard adducts formed betw作者: Hiatus 時(shí)間: 2025-3-28 22:46
,DJ-1 as a Biomarker of Parkinson’s Disease,s been identified as a causative gene of a familial form of Parkinson’s disease, ., and plays a significant role in antioxidative defense, protecting cells from oxidative stress. A cysteine residue of DJ-1 at position 106 (Cys-106) is preferentially oxidized under oxidative stress. This reactive Cys作者: Dorsal-Kyphosis 時(shí)間: 2025-3-29 02:27 作者: Spartan 時(shí)間: 2025-3-29 06:58 作者: 表被動(dòng) 時(shí)間: 2025-3-29 07:49
DJ-1 as a Therapeutic Target Against Cancer,egulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1 作者: 變異 時(shí)間: 2025-3-29 12:50 作者: backdrop 時(shí)間: 2025-3-29 18:24
P. Nisha,Manuel Thomas,T. K. Neelima thioredoxin and glutathione pathways, which in turn mediate an antioxidant protective function. Crosstalk between DJ-1 and both the thioredoxin and glutathione systems has also been identified. Thioredoxin reduces a cysteine residue on DJ-1 to modulate its activity, while glutaredoxin1 de-glutathio作者: Dorsal 時(shí)間: 2025-3-29 20:05 作者: 共同生活 時(shí)間: 2025-3-30 02:38
Aquatic Lectins: An Overview (A Paradigm). It also modulates autophagy through the ERK, Akt, or the JNK/Beclin1 pathways. In addition, DJ-1 regulates the transcription of genes essential for male reproductive function, such as spermatogenesis, by relaying nuclear receptor androgen receptor (AR) signaling. In this chapter, we summarize the 作者: fiction 時(shí)間: 2025-3-30 06:45 作者: 古老 時(shí)間: 2025-3-30 09:44 作者: 辭職 時(shí)間: 2025-3-30 12:45 作者: 螢火蟲 時(shí)間: 2025-3-30 17:35
0065-2598 at DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.?.978-981-13-4908-9978-981-10-6583-5Series ISSN 0065-2598 Series E-ISSN 2214-8019
