標(biāo)題: Titlebook: Cytotoxic Drug Resistance Mechanisms; Robert Brown,Uta B?ger-Brown Book 1999 Humana Press 1999 [打印本頁(yè)] 作者: Negate 時(shí)間: 2025-3-21 17:35
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms影響因子(影響力)
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms被引頻次
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms被引頻次學(xué)科排名
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms年度引用
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms年度引用學(xué)科排名
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms讀者反饋
書(shū)目名稱(chēng)Cytotoxic Drug Resistance Mechanisms讀者反饋學(xué)科排名
作者: 我悲傷 時(shí)間: 2025-3-21 22:21 作者: 飛鏢 時(shí)間: 2025-3-22 04:19 作者: engrossed 時(shí)間: 2025-3-22 07:13 作者: Interdict 時(shí)間: 2025-3-22 11:18
Analysis of Apoptosis in Tissue Sections,has been well-reviewed (.–.). In addition there is increasing recognition that many of the effects of chemo- and radiotherapeutic agents are mediated by apoptosis (.–.). The seminal work of Kerr, Wyllie, and Currie (.), building upon the earlier observations of Glucksmann (.) and Saunders (.), shoul作者: abolish 時(shí)間: 2025-3-22 13:21
Measurement of P-glycoprotein Function,his phenomenon is called multidrug resistance (MDR). The finding that this gene was expressed in many types of human cancers has stimulated many studies into the relevance of this protein for clinical chemotherapy resistance (.). Pgp is a protein that causes a net transport of substrate drug molecul作者: abolish 時(shí)間: 2025-3-22 19:26 作者: Arrhythmia 時(shí)間: 2025-3-22 22:48
Microtiter Plate Technique for the Measurement of Glutathione in Fresh and Cryopreserved Lymphoblas been implicated in the control of cell cycling (.,.) and apoptosis (.,.). It can exist in an oxidized (disulfide, [GSSG]) and a reduced (sulphydryl, [GSH]) form. In general, GSSG comprises less than 1% of the total intracellular glutathione. In circumstances of oxidative stress, GSH dimerizes to fo作者: Substance-Abuse 時(shí)間: 2025-3-23 01:25
Measurement of Reduced Glutathione Using High-Pressure Liquid Chromatography,lysis can lead to rapid oxidation to the oxidized form, GSSG, and degradation by γ-glutamyl transpeptidase. In order to obtain a true measurement of the amount of reduced glutathione (GSH) in living cells we have utilized the method of Cotgreave and Moldeus (.) in which GSH is derivatized using mono作者: fodlder 時(shí)間: 2025-3-23 08:15 作者: 卡死偷電 時(shí)間: 2025-3-23 12:22
5-Fluorouracil Metabolizing Enzymes,es, and has single-agent activity in colorectal cancer. 5-FU itself is inactive and requires intracellular conversion to form cytotoxic nucleotides (.). Several cellular targets for fluoropyrimidines have been well-characterized, including inhibition of thymidylate synthase (TS) by fluorodeoxyuridin作者: LUMEN 時(shí)間: 2025-3-23 16:45 作者: Offbeat 時(shí)間: 2025-3-23 19:15 作者: 哀求 時(shí)間: 2025-3-24 01:58
Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single-Cell Gel Electrophoresis aematological malignancies. Many commonly used clinical agents, such as members of the nitrogen mustard, chloroethylnitrosourea, dimethane-sulphonate and platinum classes, are bifunctional. DNA interstrand crosslinks (ISC) formed in cells are clearly critical cytotoxic lesions and the formation of D作者: 同義聯(lián)想法 時(shí)間: 2025-3-24 03:27
PCR Analysis of Microsatellite Instability,phic nature have been widely utilized as genetic markers (.). They consist of a repeating unit of 1–5 base pairs, averaging 25–60 bases in length, and are commonly found in the form d(CA)n:d(GT)n (.). It has been estimated that there are approximately 100,000 CA/GT repeat sequences in the human geno作者: BUOY 時(shí)間: 2025-3-24 09:04
,,-Alkylguanine-DNA Alkyltransferase Assay,diated . alkylation at the ..position of guanine in DNA (.–.). Repair of such adducts can be mediated by ..-alkylguanine-DNA alkyltransferase (ATase) (.,.). Both pro- and eukaryote ATases transfer alkyl groups from the ..-position of guanine in alkylated DNA (or from other low molecular weight subst作者: 助記 時(shí)間: 2025-3-24 14:17 作者: AXIOM 時(shí)間: 2025-3-24 15:02 作者: GULLY 時(shí)間: 2025-3-24 20:06 作者: Redundant 時(shí)間: 2025-3-25 00:06 作者: Fibroid 時(shí)間: 2025-3-25 07:16 作者: 很是迷惑 時(shí)間: 2025-3-25 09:32 作者: Spongy-Bone 時(shí)間: 2025-3-25 13:33
https://doi.org/10.1007/978-1-4842-2424-3ance. Reversal studies are best performed in diseases in which this mechanism represents the major component of drug resistance. The clearest approach to identifying these is to measure .-1 mRNA or P-glycoprotein in tumors at diagnosis, at the time of disease recurrence, and before and after treatment with P-glycoprotein reversal agents.作者: 細(xì)絲 時(shí)間: 2025-3-25 16:27
Scripting Languages & Server Side Includes, This is important, because despite considerable progress in the understanding of the mechanistic basis of apoptosis, morphological analysis remains unquestionably the “gold standard” for its assessment and quantitation.作者: 輕打 時(shí)間: 2025-3-25 23:42
https://doi.org/10.1007/978-1-4842-2424-3odimer and forms a covalent bond with the 5′-terminus of the DNA double-strand break with a four base-pairs overhang (.) (.–.). No energy cofactor is required for top1 activity, whereas top2 hydrolyzes adenosine triphosphate (ATP) during its catalytic cycle.作者: 小卷發(fā) 時(shí)間: 2025-3-26 03:28 作者: 小淡水魚(yú) 時(shí)間: 2025-3-26 05:54 作者: Trigger-Point 時(shí)間: 2025-3-26 10:42
Topoisomerase I and II Activity Assays,odimer and forms a covalent bond with the 5′-terminus of the DNA double-strand break with a four base-pairs overhang (.) (.–.). No energy cofactor is required for top1 activity, whereas top2 hydrolyzes adenosine triphosphate (ATP) during its catalytic cycle.作者: considerable 時(shí)間: 2025-3-26 12:43
Measuring Drug-DNA Adducts in Individual Cells, methods, to determine the extent of drug-DNA interaction in cells. These techniques however, rely on the measurement of adducts on DNA isolated from millions of cells (described by Tilby in . and .. and .).作者: 眼界 時(shí)間: 2025-3-26 20:11
Drug Resistance,d in the discovery of numerous mechanisms present within tumor cells that act to reduce their cytotoxic effects. However, the failure to translate this basic laboratory research into improved clinical outcome for patients remains one of the most pressing problems in contemporary cancer research.作者: Nonflammable 時(shí)間: 2025-3-26 22:11 作者: 焦慮 時(shí)間: 2025-3-27 02:34 作者: 嚴(yán)厲譴責(zé) 時(shí)間: 2025-3-27 07:13 作者: 裝入膠囊 時(shí)間: 2025-3-27 10:52
https://doi.org/10.1007/978-1-4842-2424-3rm glutathione disulfide (GSSG), making protons available to neutralize reactive oxygen species (.). In vivo, reduction of GSSG is catalysed by glutathione reductase, efficiently regenerating high intracellular GSH levels (.) 作者: carotid-bruit 時(shí)間: 2025-3-27 17:32 作者: 平淡而無(wú)味 時(shí)間: 2025-3-27 17:49
https://doi.org/10.1007/978-3-319-62773-1gnition as the first of a new class of oncogene able to prolong survival by inhibiting programmed cell death (apoptosis) and (b) the discovery of many additional related genes/proteins some of which, like Bcl-2, inhibit apoptosis, whereas others, such as Bax, conversely promote cell death (.) (.).作者: MOT 時(shí)間: 2025-3-27 23:40 作者: 預(yù)兆好 時(shí)間: 2025-3-28 04:37 作者: CANON 時(shí)間: 2025-3-28 06:57 作者: 單獨(dú) 時(shí)間: 2025-3-28 12:12 作者: 額外的事 時(shí)間: 2025-3-28 18:38 作者: 軍械庫(kù) 時(shí)間: 2025-3-28 22:20
Cell Sensitivity Assays, important consideration when making comparisons between cell lines, between cytotoxic agents, or when evaluating combinations of drugs. No one cytotoxicity assay is ideal and it is always advisable to support results with those from alternative assays where possible.作者: SIT 時(shí)間: 2025-3-29 01:57 作者: 陳腐的人 時(shí)間: 2025-3-29 05:59 作者: 不能平靜 時(shí)間: 2025-3-29 09:08 作者: 類(lèi)型 時(shí)間: 2025-3-29 12:10 作者: Pert敏捷 時(shí)間: 2025-3-29 16:17 作者: bibliophile 時(shí)間: 2025-3-29 20:28 作者: lesion 時(shí)間: 2025-3-30 02:42 作者: 西瓜 時(shí)間: 2025-3-30 05:28
Duncan McConnell B. S., M. S., Ph.D.nhanced repair of ISC has been suggested to play a role in the acquired resistance of some cancers, e.g., chronic lymphocytic leukaemia to nitrogen mustards (.). In addition, the inherent sensitivity (and curability) of some tumors, e.g., testicular cancer, to DNA damaging agents may result in part 作者: 沒(méi)收 時(shí)間: 2025-3-30 08:20
Flat Corrugated and Bull’s-Eye AntennasSomatic mutations in the p53 gene is the most common genetic abnormality so far described in human cancer (.). Patients with germ-line p53 mutation’s are part of the Li-Fraumeni syndrome. These patients have an increased risk of developing adrenocortical, breast, gastrointestinal tract, and lung car作者: 圓錐體 時(shí)間: 2025-3-30 15:51
https://doi.org/10.1007/978-1-4899-3434-5ll culture to produce metaphase spreads. Fluorescence . hybridization (FISH) is a powerful method for the analysis of genetic change in solid tumors (.,.–.). In particular, it allows the visualization of the genetic makeup of individual cells within their histological context (.). In general, FISH u作者: urethritis 時(shí)間: 2025-3-30 19:03
1543-1894 toxic Drug Resistance Mechanisms is to provide pro- cols that are appropriate for examining the mechanisms of cellular resistance to anticancer cytotoxics in hu978-1-61737-093-9978-1-59259-687-4Series ISSN 1543-1894 Series E-ISSN 1940-6037 作者: Ordeal 時(shí)間: 2025-3-30 21:28
Cell Sensitivity Assays, of individual cells to form colonies. However, cytotoxicity assays can also measure the ability of cells to proliferate if the cells are allowed a period of growth following drug exposure. This recovery time is comparable to the time taken for formation of colonies in a clonogenic assay.作者: 哪有黃油 時(shí)間: 2025-3-31 02:39 作者: flaunt 時(shí)間: 2025-3-31 05:12
5-Fluorouracil Metabolizing Enzymes,hydropyrimidine dehydrogenase (DPD; EC 1.3.1.2). Following a bolus injection of 5-FU, 80% is degraded via DPD after 24 h after administration (.). Studies of .F nuclear magnetic resonance (NMR) spectroscopy in mice bearing colon tumors found catabolites made up 51% of labeled drug in the tumor, comp作者: 哄騙 時(shí)間: 2025-3-31 12:46
Measuring DNA Adducts by Immunoassay (ELISA),Finally, a knowledge of the DNA adducts levels formed in patients during therapy permits direct assessment of the clinical relevance of the levels of DNA modification employed in in vitro experiments. This could be important because the nature and significance of the various types of cellular respon作者: 歌唱隊(duì) 時(shí)間: 2025-3-31 14:03 作者: 啟發(fā) 時(shí)間: 2025-3-31 21:12
Analysis of the p53 Status of Tumors,Somatic mutations in the p53 gene is the most common genetic abnormality so far described in human cancer (.). Patients with germ-line p53 mutation’s are part of the Li-Fraumeni syndrome. These patients have an increased risk of developing adrenocortical, breast, gastrointestinal tract, and lung car作者: 取消 時(shí)間: 2025-3-31 22:24 作者: 小樣他閑聊 時(shí)間: 2025-4-1 05:54
