標(biāo)題: Titlebook: Cytokine Knockouts; Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c [打印本頁] 作者: advocate 時(shí)間: 2025-3-21 19:12
書目名稱Cytokine Knockouts影響因子(影響力)
書目名稱Cytokine Knockouts影響因子(影響力)學(xué)科排名
書目名稱Cytokine Knockouts網(wǎng)絡(luò)公開度
書目名稱Cytokine Knockouts網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cytokine Knockouts被引頻次
書目名稱Cytokine Knockouts被引頻次學(xué)科排名
書目名稱Cytokine Knockouts年度引用
書目名稱Cytokine Knockouts年度引用學(xué)科排名
書目名稱Cytokine Knockouts讀者反饋
書目名稱Cytokine Knockouts讀者反饋學(xué)科排名
作者: GRACE 時(shí)間: 2025-3-21 22:28 作者: 虛弱 時(shí)間: 2025-3-22 03:50 作者: headlong 時(shí)間: 2025-3-22 04:40 作者: Carcinogen 時(shí)間: 2025-3-22 12:30
Russell L. Ciochon,Gregg F. Gunnells to TNF receptor-mediated effects tends to be obscured in single gene knockout mice, because the loss of one ligand may be compensated by the remaining one. Since both genes are very closely linked and map within the major histo compatibility complex (MHC), single mutations cannot be crossed togeth作者: CHART 時(shí)間: 2025-3-22 16:04 作者: CHART 時(shí)間: 2025-3-22 17:49
https://doi.org/10.1057/978-1-137-54786-6, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b作者: 夜晚 時(shí)間: 2025-3-23 00:20
https://doi.org/10.1007/978-3-030-26376-8e receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functions 作者: Spartan 時(shí)間: 2025-3-23 03:25 作者: cathartic 時(shí)間: 2025-3-23 06:59
The IL-2 Deficiency Syndrome,e excluded, and the different sources of the two lymphokines, i.e., mainly activated T-cells for IL-2 versus a wide variety of non-lymphocytic cells for IL-15 . predict that in vivo, the two cytokines will play quite distinct roles in the regulation of lymphocyte activation. Therefore, it will be im作者: 占卜者 時(shí)間: 2025-3-23 11:47 作者: Dorsal-Kyphosis 時(shí)間: 2025-3-23 14:53 作者: handle 時(shí)間: 2025-3-23 21:53 作者: COUCH 時(shí)間: 2025-3-23 22:28
IL-6 Gene Knockout Mice,, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b作者: 大門在匯總 時(shí)間: 2025-3-24 03:29
Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Commone receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functions 作者: Preamble 時(shí)間: 2025-3-24 07:56
,Phenotypes of TGF? Knockout Mice, amino acid precursor. It has the characteristics of a secretory polypeptide, contains a hydrophobic signal sequence for translocation across the endoplasmic reticulum, and is glycosylated. The precursor cleavage site is a sequence of four basic amino acids immediately preceding the bioactive domain作者: 易于 時(shí)間: 2025-3-24 11:27 作者: 發(fā)展 時(shí)間: 2025-3-24 17:15 作者: preeclampsia 時(shí)間: 2025-3-24 21:07
Contemporary Immunologyhttp://image.papertrans.cn/d/image/242629.jpg作者: fiscal 時(shí)間: 2025-3-25 02:40
https://doi.org/10.1057/9781137513441 IL-1Ra is a specific receptor antagonist. IL-1α and IL-1β are synthesized as precursor molecules, without leader sequences. The molecular weight of each precursor is 31 kDa. Processing of IL-1α or IL-1β to “mature” forms of 17 kDa requires specific cellular proteases.作者: forestry 時(shí)間: 2025-3-25 03:29 作者: 爭吵 時(shí)間: 2025-3-25 08:08
Kuniyasu Mokudai,Ryoji Soda,Takuma Watakabe this requires a cytokine-specific receptor subunit and a “common” receptor subunit. The common subunit is, by definition, shared among numerous cytokines. The result is a grouping of cytokines into families that all require a particular common subunit for high-affinity binding and signal transducti作者: 浮雕寶石 時(shí)間: 2025-3-25 14:17 作者: ARBOR 時(shí)間: 2025-3-25 17:39 作者: SHRIK 時(shí)間: 2025-3-25 21:10
https://doi.org/10.1007/978-1-4419-8873-7 observed a remission of inoperable tumors in some patients after infusion of bacterial toxins .. Unacceptable side effects, however, and a lack of understanding of how these toxins induced hemorrhages in tumors, prevented the further development and application of this treatment. It was more than 6作者: Immunotherapy 時(shí)間: 2025-3-26 03:55
Anthropoid Origins: A Phylogenetic Analysisf NF-κB, cytotoxicity, tumor necrosis as well as antiviral, inflammatory, and immunoregulatory responses. TNF has been implicated as a central mediator of septic shock as well as graft-vs-host disease, arthritis, and several autoimmune disorders. There are two related TNF molecules, TNFα (tumor necr作者: 投票 時(shí)間: 2025-3-26 07:04
Russell L. Ciochon,Gregg F. Gunnellds bind to TNF receptor 1 (TNFR1) and TNFR2, leading to receptor homotrimer formation . and consecutive triggering of various biological responses such as proliferation, cytotoxicity and apoptosis in target cells. Lyrnphotoxin-α (LTα), which like TNF belongs to the family of TNF-like ligands ., can 作者: recede 時(shí)間: 2025-3-26 12:19
https://doi.org/10.1057/9781137513441cally involved in the regulation of the immune system. To date, a large number of studies have focused on the structural and functional relationships of three cytokines in particular, tumor necrosis factor-α (TNFα), lymphotoxin-α (LTα), and lymphotoxin-β (LTβ). Whereas TNFα and LTα were one of the f作者: 放棄 時(shí)間: 2025-3-26 14:54
https://doi.org/10.1057/9781137513441 IL-1Ra is a specific receptor antagonist. IL-1α and IL-1β are synthesized as precursor molecules, without leader sequences. The molecular weight of each precursor is 31 kDa. Processing of IL-1α or IL-1β to “mature” forms of 17 kDa requires specific cellular proteases.作者: 脆弱吧 時(shí)間: 2025-3-26 20:07 作者: 高原 時(shí)間: 2025-3-27 00:55 作者: osteopath 時(shí)間: 2025-3-27 03:09
https://doi.org/10.1057/978-1-137-54786-6f, and is a major factor in acute inflammation, being responsible for the activation and chemotaxis of neutrophils to the site of acute injury .. Neutrophils provide the first line of defense in fighting infection by destroying bacteria with phagocytosis and the release of super oxides and peroxides作者: Recessive 時(shí)間: 2025-3-27 08:53
https://doi.org/10.1057/978-1-137-54786-6terferons was the inhibition of virus replication. Only much later did it become apparent that, as is characteristic of cytokines in general, interferons have many pleiotropic activities, including modulating effects on the rate of cell growth and a variety of actions on functions of the immune syst作者: 發(fā)怨言 時(shí)間: 2025-3-27 10:54 作者: deceive 時(shí)間: 2025-3-27 16:16
https://doi.org/10.1007/978-3-030-26376-8tion of B-lymphocytes into antibody-producing plasma cells and the activation of T-cells, and it stimulates proliferation and differentiation of hematopoietic stem cells and thymocytes (for review . ref. .). IL-6 is also a central mediator of several host responses to acute inflammation, including t作者: 惡臭 時(shí)間: 2025-3-27 20:00 作者: FADE 時(shí)間: 2025-3-27 23:39 作者: febrile 時(shí)間: 2025-3-28 02:19
, – Einheit und Vielfalt der Arbeitlular signal (for reviews . refs. . and 2). Leukemia inhibitory factor (LIFR) binds LW that is converted to high affinity binding by heterodimerization with gp130. Other ligands that use the LIFR are oncostatin M (OSM) and cardiotrophin-1 (CT-1). CT-1 utilizes LIFR although all the receptor componen作者: 攤位 時(shí)間: 2025-3-28 07:01
, – Einheit und Vielfalt der Arbeitnt advances have been made recently in understanding the functions of these molecules in vivo by the targeted ablation of various members of the super gene family. The family members include the TGF(is, activins, inhibins, bone morphogenetic proteins, Müllerian-inhibiting substance, nodal, dorsalin,作者: 特別容易碎 時(shí)間: 2025-3-28 13:16 作者: 浸軟 時(shí)間: 2025-3-28 16:43
The IL-2 Deficiency Syndrome,units (for review, . ref. 2): an IL-2 specific a-chain with low binding affinity and no signal-transducing capacity; a (3-chain that is shared with the IL-15 receptor (.) and participates in signaling through its cytoplasmic tail; and the “common” γ-chain (γc) shared by receptors for IL-4, -7, -9, a作者: Fantasy 時(shí)間: 2025-3-28 20:53 作者: MILK 時(shí)間: 2025-3-28 22:54
Lymphoid Development and Function in IL-7R-Deficient Mice,rearrangement, and cytokine responsiveness. For example, interleukin-7 (IL-7) was originally identified as a factor produced by bone marrow stromal cells that could support the proliferation of B-cell precursors .. The IL-7 responsive B-lineage cells were clearly defined in vitro using sorted B-cell作者: incite 時(shí)間: 2025-3-29 05:21
CD40 Ligand Knockout Mice,nomas (for review, . ref. .). Its counterstructure, CD40 ligand (CD40L), is a 33-kDa glycoprotein expressed primarily on activated CD4. T-cells, but also found on CD8. T-cells, mast cells, basophils (.), and eosinophils (.). CD40L belongs to the tumor necrosis factor (TNF) superfamily (.), members o作者: 邊緣 時(shí)間: 2025-3-29 07:45
Physiological, Immunological, and Pathological Functions of Tumor Necrosis Factor (TNF) Revealed by observed a remission of inoperable tumors in some patients after infusion of bacterial toxins .. Unacceptable side effects, however, and a lack of understanding of how these toxins induced hemorrhages in tumors, prevented the further development and application of this treatment. It was more than 6作者: 情感 時(shí)間: 2025-3-29 14:09
Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice,f NF-κB, cytotoxicity, tumor necrosis as well as antiviral, inflammatory, and immunoregulatory responses. TNF has been implicated as a central mediator of septic shock as well as graft-vs-host disease, arthritis, and several autoimmune disorders. There are two related TNF molecules, TNFα (tumor necr作者: 乳白光 時(shí)間: 2025-3-29 15:41 作者: DEBT 時(shí)間: 2025-3-29 19:52 作者: omnibus 時(shí)間: 2025-3-30 01:20 作者: 外向者 時(shí)間: 2025-3-30 07:55 作者: 直言不諱 時(shí)間: 2025-3-30 10:13
,Mice Deficient in Interleukin-1β Converting Enzyme,L-1α and IL-1β of which IL-1β is the predominant form released by human monocytes in culture. IL-1β is synthesized as a 31-kDa precursor devoid of a conventional signal sequence and is processed to its active 17-kDa form by an enzyme called IL-1β converting enzyme (ICE) which has an unique cleavage 作者: 路標(biāo) 時(shí)間: 2025-3-30 14:09 作者: 古老 時(shí)間: 2025-3-30 17:57 作者: Daily-Value 時(shí)間: 2025-3-30 22:42 作者: Figate 時(shí)間: 2025-3-31 01:20
IL-6 Unique Functions in Inflammation, Bone Metabolism, and B-Cell Neoplasias Revealed by Studies otion of B-lymphocytes into antibody-producing plasma cells and the activation of T-cells, and it stimulates proliferation and differentiation of hematopoietic stem cells and thymocytes (for review . ref. .). IL-6 is also a central mediator of several host responses to acute inflammation, including t作者: conjunctivitis 時(shí)間: 2025-3-31 08:59 作者: LIKEN 時(shí)間: 2025-3-31 10:21
NF-IL6 Knockout Mice,hin an interleukin (IL)-1 responsive element in the human IL-6 gene .. The cloning of the cDNA encoding human NF-IL6 revealed that it shows a high degree of homology with C/EBP in the carboxy-terminal basic and leucine zipper domains, responsible for DNA binding and dimerization, respectively .. NF-作者: tattle 時(shí)間: 2025-3-31 13:49
Disruption of the LIF Receptor,lular signal (for reviews . refs. . and 2). Leukemia inhibitory factor (LIFR) binds LW that is converted to high affinity binding by heterodimerization with gp130. Other ligands that use the LIFR are oncostatin M (OSM) and cardiotrophin-1 (CT-1). CT-1 utilizes LIFR although all the receptor componen作者: Bmd955 時(shí)間: 2025-3-31 19:54
,Phenotypes of TGF? Knockout Mice,nt advances have been made recently in understanding the functions of these molecules in vivo by the targeted ablation of various members of the super gene family. The family members include the TGF(is, activins, inhibins, bone morphogenetic proteins, Müllerian-inhibiting substance, nodal, dorsalin,作者: 聾子 時(shí)間: 2025-3-31 22:08 作者: 壯觀的游行 時(shí)間: 2025-4-1 04:03
https://doi.org/10.1057/978-1-137-54786-6tact organism. Specifically, the availability of these knockout mice has made it possible to determine the importance of the interferons in the resistance to infections and in some specific functions of the immune system. These investigations, to be briefly reviewed in this chapter, led to some unexpected findings.作者: 愛好 時(shí)間: 2025-4-1 06:10
Piety in the Pocket: An Introduction,in (LAP, equivalent to NF-IL6) and liver inhibitory protein (LIP) by alternative usage of two AUG initiation codons within the same open reading frame .. LIP contains the DNA binding and dimerization domains but is devoid of the N terminal transcriptional activation domain, and therefore behaves as an antagonist of LAP-induced transcription.作者: deface 時(shí)間: 2025-4-1 12:34 作者: circuit 時(shí)間: 2025-4-1 15:25
Lymphoid Development and Function in IL-7R-Deficient Mice,imilar fashion, it has been established that the CD44.CD25. fraction of CD4.CD8. thymocytes, comprising <1% of the total thymocyte population, is IL-7 responsive, whereas the predominant CD4.CD8. thymocyte subpopulation is not (.).作者: Heterodoxy 時(shí)間: 2025-4-1 19:09
Knockouts of Interferons, Interferon Receptors and Interferon Signaling Components,tact organism. Specifically, the availability of these knockout mice has made it possible to determine the importance of the interferons in the resistance to infections and in some specific functions of the immune system. These investigations, to be briefly reviewed in this chapter, led to some unexpected findings.作者: Observe 時(shí)間: 2025-4-2 00:17
NF-IL6 Knockout Mice,in (LAP, equivalent to NF-IL6) and liver inhibitory protein (LIP) by alternative usage of two AUG initiation codons within the same open reading frame .. LIP contains the DNA binding and dimerization domains but is devoid of the N terminal transcriptional activation domain, and therefore behaves as an antagonist of LAP-induced transcription.作者: Fracture 時(shí)間: 2025-4-2 04:23
Disruption of the LIF Receptor,irst binds CNTF receptor (CNTFR) and this complex then interacts with LIFR and gp130 .. Therefore, of the known ligands, the absence of LIFR would completely disrupt activity of LIF, CNTF, and CT-1, and would affect some OSM activity.
