標(biāo)題: Titlebook: Cytochrome P450; Structure, Mechanism Paul R. Ortiz Montellano Book 1995Latest edition Springer-Verlag US 1995 NADPH.Oxidation.biochemistry [打印本頁] 作者: deep-sleep 時間: 2025-3-21 16:14
書目名稱Cytochrome P450影響因子(影響力)
書目名稱Cytochrome P450影響因子(影響力)學(xué)科排名
書目名稱Cytochrome P450網(wǎng)絡(luò)公開度
書目名稱Cytochrome P450網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cytochrome P450被引頻次
書目名稱Cytochrome P450被引頻次學(xué)科排名
書目名稱Cytochrome P450年度引用
書目名稱Cytochrome P450年度引用學(xué)科排名
書目名稱Cytochrome P450讀者反饋
書目名稱Cytochrome P450讀者反饋學(xué)科排名
作者: 狂熱文化 時間: 2025-3-21 20:41 作者: A精確的 時間: 2025-3-22 02:46 作者: 神圣將軍 時間: 2025-3-22 06:21 作者: Liability 時間: 2025-3-22 10:34 作者: exceed 時間: 2025-3-22 16:13
NADPH Cytochrome P450 Reductase and Its Structural and Functional Domainsnd transfer of electrons from the flavin centers to oxygen and/or the redox partners of cytochrome P450 reductase. This present review, therefore, will not cover mechanism in any more than a cursory fashion, but will attempt to focus on a summary of the salient features of the study of structural/fu作者: exceed 時間: 2025-3-22 19:35 作者: TEM 時間: 2025-3-22 22:24
Induction of Cytochrome P450 Enzymes That Metabolize Xenobioticsetoxification, particularly when low to moderate concentrations of substrate are present; thus, under most conditions, induction is a protective mechanism, whereby the cell can detoxify lipophilic compounds that might otherwise accumulate. Both characteristics are likely to facilitate the survival o作者: amygdala 時間: 2025-3-23 05:01 作者: BLAND 時間: 2025-3-23 08:05 作者: 定點 時間: 2025-3-23 12:17 作者: 遷移 時間: 2025-3-23 14:27
S. Blot,D. Koulenti,G. Dimopoulos. Cytochrome P450 is known to catalyze hydroxylations, epoxidations, .-, .-, and .-dealkylations, .-oxidations, sulfoxidations, dehalogenations, and other reactions.. The reactive site of all of these enzymes is extraordinarily simple, containing only an iron protoporphyrin IX (.) (Fig. 1) with cyst作者: 言行自由 時間: 2025-3-23 20:09
M. Carlier,V. Stove,J. J. De Waele between peroxidases and P450s include the ability of P450s to accept electrons from a reductase; the redox potentials of the higher oxidation states; and the ability of P450s to generate the equivalent of a metal-bound peroxide by reduction of O. at the heme center during catalytic turnover.作者: 燕麥 時間: 2025-3-24 02:00
P. M. Honoré,R. Jacobs,H.D. Spapen is well documented.) Thus, scientists have become interested in the mechanisms of disease states resulting from mutations in P450s, and in alternative substrates metabolized and new products formed by the engineering of known P450 proteins. Only through an understanding of the structures of these p作者: 薄荷醇 時間: 2025-3-24 04:53
C. Chiurazzi,A. Motos-Galera,A. Torresnd transfer of electrons from the flavin centers to oxygen and/or the redox partners of cytochrome P450 reductase. This present review, therefore, will not cover mechanism in any more than a cursory fashion, but will attempt to focus on a summary of the salient features of the study of structural/fu作者: SEVER 時間: 2025-3-24 08:43 作者: 加入 時間: 2025-3-24 12:58
Light and Shade of New Antibioticsetoxification, particularly when low to moderate concentrations of substrate are present; thus, under most conditions, induction is a protective mechanism, whereby the cell can detoxify lipophilic compounds that might otherwise accumulate. Both characteristics are likely to facilitate the survival o作者: Inculcate 時間: 2025-3-24 16:55
M. Chan,M. Varrier,M. Ostermannenation reactions, and (3) the decoding of that chemical information either by receptor-mediated processes or, alternatively, by the direct effects of these oxygenated metabolites on metabolic pathways. (Fig. 1). As a net result, these processes provide cells with a rapid and versatile on/off molecu作者: BLINK 時間: 2025-3-24 22:00 作者: 向下 時間: 2025-3-24 23:52
J. Izawa,A. Zarbock,J. A. Kellumme-thiolate proteins, the cytochromes P450 responsible for monooxygenation reactions (which will be called “classical P450s” in this chapter) have been extensively studied. and their mechanisms of dioxygen activation and substrate hydroxylation are now well established.. During these last years, som作者: ONYM 時間: 2025-3-25 06:42 作者: MAZE 時間: 2025-3-25 10:43
https://doi.org/10.1007/978-3-642-35109-9ion studies of this important class of hemoproteins. Through the research efforts of numerous laboratories over the last 25 years we have reached a point where essentially every spectroscopy currently known has been applied to the first of these bacterial P450s, cytochrome P450..作者: Collar 時間: 2025-3-25 13:18 作者: Harbor 時間: 2025-3-25 16:47 作者: ALERT 時間: 2025-3-25 20:16 作者: 道學(xué)氣 時間: 2025-3-26 03:23 作者: 肥料 時間: 2025-3-26 07:13 作者: PAN 時間: 2025-3-26 12:10
Inhibition of Cytochrome P450 Enzymeslly oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as agents that interfere with the electron supply to the hemoprotein by accepting electrons directly from cytochrome P450 reductase,. are not discussed here.作者: 拋射物 時間: 2025-3-26 13:51
S. Suzuki,G. M. Eastwood,R. Bellomoopment of recombinant expression systems for P450., it has been possible to use site-directed mutagenesis. with reference to the crystal structure to probe questions of how structure relates to function.作者: 殘暴 時間: 2025-3-26 18:56
Structural Studies on Prokaryotic Cytochromes P450opment of recombinant expression systems for P450., it has been possible to use site-directed mutagenesis. with reference to the crystal structure to probe questions of how structure relates to function.作者: neuron 時間: 2025-3-26 23:18
n to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem st作者: 業(yè)余愛好者 時間: 2025-3-27 05:03
P. M. Honoré,R. Jacobs,H. D. Spapenlly oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as agents that interfere with the electron supply to the hemoprotein by accepting electrons directly from cytochrome P450 reductase,. are not discussed here.作者: Cursory 時間: 2025-3-27 06:12
Models and Mechanisms of Cytochrome P450 Actionn and olefin epoxidation, particularly, have attracted a sustained worldwide effort, the allure deriving from both a desire to understand the details of biological oxygen activation and transfer and, as well, the sense that catalysts for the practical application of these principles to organic synth作者: 金哥占卜者 時間: 2025-3-27 12:39 作者: 不安 時間: 2025-3-27 16:04
Twenty-five Years of P450cam Research, seminal breakthroughs have been made in mammalian P450s through work with microsomal fractions. and the astounding tour de force accomplishments in the purification of membrane-bound P450 systems originally initiated by Coon and his colleagues.. However, it was generally realized by the early 1980作者: 可用 時間: 2025-3-27 20:57
Structural Studies on Prokaryotic Cytochromes P450wealth of biochemical and biophysical studies on P450., the high-resolution crystal structure became available in 1987.. This was followed by a series of structures on various inhibitor/substrate complexes which revealed some key structure-function relationships in P450s. In addition, with the devel作者: 軍火 時間: 2025-3-27 22:27 作者: Aviary 時間: 2025-3-28 05:22 作者: Obsequious 時間: 2025-3-28 07:54
NADPH Cytochrome P450 Reductase and Its Structural and Functional Domainsction and trypsin treatment of a protein that catalyzed the reduction of cytochromes .. Since that initial report, much information has been revealed and reported about the nature, reactivities, structure, and regulation of the reductase that we have come to recognize as a component of the cytochrom作者: 臭名昭著 時間: 2025-3-28 10:39 作者: Lignans 時間: 2025-3-28 17:11
Inhibition of Cytochrome P450 Enzymes substrates, (2) the binding of molecular oxygen subsequent to the first electron transfer, and (3) the catalytic step in which the substrate is actually oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such作者: Stress-Fracture 時間: 2025-3-28 18:51 作者: 小鹿 時間: 2025-3-29 00:33
Hormonal Regulation of Liver Cytochrome P450 Enzymes and other tissues,. including the primary steroidogenic tissues (Kagawa and Waterman, this volume). Steroid hormones are metabolized by liver P450 enzymes with a higher degree of regio-and stereoselectivity than many foreign compound substrates,. suggesting that these endogenous lipophiles serve as作者: 補角 時間: 2025-3-29 03:25
Regulation of Steroidogenic and Related P450sogenous substrates (xenobiotics). Those forms that metabolize endogenous substrates generally convert less active compounds into more active ones. This is particularly true of the P450s that participate in steroid hormone biosynthesis, where the less active steroid cholesterol is converted into more作者: –scent 時間: 2025-3-29 09:19 作者: 線 時間: 2025-3-29 12:10 作者: connoisseur 時間: 2025-3-29 17:46
Heme-Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenationse been found in living organisms.. On the contrary, only a limited number of hemoprotein families where the heme iron is bound to a cysteinate proximal ligand have been discovered so far. The Fe(II)-CO complex of these hemoproteins is most often characterized by a visible spectrum exhibiting a redsh作者: 縮短 時間: 2025-3-29 20:02
Structures of Eukaryotic Cytochrome P450 Enzymesferent eukaryotic members of the cytochrome P450 superfamily. Such information would provide insights into the structural arrangement of these proteins that would assist in the rational design of therapeutic enzyme inhibitors or in the engineering of P450s as biotechnological tools.作者: GULLY 時間: 2025-3-30 02:19
http://image.papertrans.cn/d/image/242613.jpg作者: evaculate 時間: 2025-3-30 06:17 作者: EXUDE 時間: 2025-3-30 10:40
https://doi.org/10.1007/978-1-4757-2391-5NADPH; Oxidation; biochemistry; cytochrome P450; enzymes; metabolism; proteins作者: anesthesia 時間: 2025-3-30 13:06
Springer-Verlag US 1995作者: QUAIL 時間: 2025-3-30 20:11 作者: sultry 時間: 2025-3-31 00:31
M. Carlier,V. Stove,J. J. De Waeleo an effective mechanism for studying related proteins to better understand the structural basis of their functions. Indeed, there are many similarities between peroxidases and cytochromes P450 (P450s) in terms of prosthetic group and catalytic mechanism. However, there are also important difference作者: pantomime 時間: 2025-3-31 03:12 作者: 使人煩燥 時間: 2025-3-31 06:12
