標(biāo)題: Titlebook: Cytochrome P450; John B. Schenkman,Helmut Greim Book 1993 Springer-Verlag Berlin Heidelberg 1993 biosynthesis.cytochrome P450.enzyme.enzym [打印本頁(yè)] 作者: Enkephalin 時(shí)間: 2025-3-21 18:38
書目名稱Cytochrome P450影響因子(影響力)
書目名稱Cytochrome P450影響因子(影響力)學(xué)科排名
書目名稱Cytochrome P450網(wǎng)絡(luò)公開(kāi)度
書目名稱Cytochrome P450網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Cytochrome P450被引頻次
書目名稱Cytochrome P450被引頻次學(xué)科排名
書目名稱Cytochrome P450年度引用
書目名稱Cytochrome P450年度引用學(xué)科排名
書目名稱Cytochrome P450讀者反饋
書目名稱Cytochrome P450讀者反饋學(xué)科排名
作者: Pruritus 時(shí)間: 2025-3-21 23:27
https://doi.org/10.1007/978-981-13-7693-1for this enzyme was prompted by the previous discovery of an NADPH-cytochrome . reductase in yeast (. et al. 1940). The yeast enzyme was shown to use NADPH as the source of reducing equivalents, and contained flavin mononucleotide (FMN) as a prosthetic group. This newly discovered enzyme was isolate作者: nuclear-tests 時(shí)間: 2025-3-22 03:58
https://doi.org/10.1007/978-981-16-1982-3ent of the microsomal mixed function oxidase system, functioning in the endoplasmic reticulum (. and . 1962; . and . 1962) and nuclear membrane (. 1971) to catalyze electron transfer from NADPH to cytochrome P450 (. and . 1968). This 78-kDa flavin mononucleotide (FMN)- and flavin adenine dinucleotid作者: 極大痛苦 時(shí)間: 2025-3-22 07:59 作者: 神圣在玷污 時(shí)間: 2025-3-22 11:36
Combinatorial chemistry: A perspectivenzymatically active system was established by the use of phosphatidylcholines by . et al. (1970). Among various acyl derivatives of glycerol-3-phosphorylcholine the dioleoyl-derivative was most effective. The most commonly used and convenient system for reconstitution in numerous studies over the ye作者: 眨眼 時(shí)間: 2025-3-22 14:57 作者: 眨眼 時(shí)間: 2025-3-22 17:12 作者: 創(chuàng)作 時(shí)間: 2025-3-23 00:11
Annual Review of Gerontology and Geriatricstes include both xenobiotics (drugs, carcinogens, environmental pollutants, and other chemicals) and endogenous metabolites (steroids, fatty acids, prostaglandins, etc.). As shown in Fig. 1, the major sites of cytochrome P450 action in mammalian metabolism are reactions connected to sterol metabolis作者: 啟發(fā) 時(shí)間: 2025-3-23 01:39
Depression in Late Life: An Updateated oxygen, representing oxygen metabolites, mainly reduction products of oxygen, released from the cytochrome P-450 enzyme system. Reactive oxygen formed during the metabolic reaction of the cytochrome P-450 enzyme at the active site of the heme moiety will not be discussed here; the reader is ref作者: 吊胃口 時(shí)間: 2025-3-23 05:57 作者: obtuse 時(shí)間: 2025-3-23 09:43
https://doi.org/10.1007/978-3-662-38443-5y acids, drugs, and xenobiotics. The catalytic diversity required to bind and oxidize the many substrates of this monooxygenase system is possible due to the expression of multiple isozymes, many of which have overlapping substrate specificities. Relatively little is known about the topologies of th作者: 平躺 時(shí)間: 2025-3-23 16:52
Annual Review of Gerontology and Geriatricsiplicity is to a major extent responsible for the extremely broad substrate specificity of the hepatic microsomal monooxygenase system, although many individual cytochromes P450 catalyze the metabolism of a number of substrates and frequently display overlapping substrate specificities (. et al. 198作者: Foolproof 時(shí)間: 2025-3-23 20:56
https://doi.org/10.1007/978-3-662-11155-0tematic attempts to explore substrate and inhibitor specificity of individual cytochrome P450 species have been occasional. An improved understanding of the specificity of individual cytochrome P450 enzymes, however, is desirable for several reasons. First, animal species differ from each other and 作者: 膽汁 時(shí)間: 2025-3-23 22:16
https://doi.org/10.1007/978-3-662-11152-9 proteins possess a non-covalently bound heme (protoporphyrin IX) and segment of 26 amino acids surrounding a cysteine that is highly conserved. This cysteine donates the thiolate fifth ligand to the heme iron. The amino acid environment surrounding the heme results in a typical cytochrome P450 Sore作者: 小木槌 時(shí)間: 2025-3-24 02:41 作者: 暫停,間歇 時(shí)間: 2025-3-24 07:04
Cytochrome P450978-3-642-77763-9Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 易彎曲 時(shí)間: 2025-3-24 12:40
Depression in Late Life: An Updateated oxygen, representing oxygen metabolites, mainly reduction products of oxygen, released from the cytochrome P-450 enzyme system. Reactive oxygen formed during the metabolic reaction of the cytochrome P-450 enzyme at the active site of the heme moiety will not be discussed here; the reader is referred to other chapters in this book.作者: obligation 時(shí)間: 2025-3-24 17:36 作者: Synapse 時(shí)間: 2025-3-24 22:13 作者: arthroscopy 時(shí)間: 2025-3-25 02:48
Metabolic Reactions: Role of Cytochrome P-450 in the Formation of Reactive Oxygen Speciesated oxygen, representing oxygen metabolites, mainly reduction products of oxygen, released from the cytochrome P-450 enzyme system. Reactive oxygen formed during the metabolic reaction of the cytochrome P-450 enzyme at the active site of the heme moiety will not be discussed here; the reader is referred to other chapters in this book.作者: Vulvodynia 時(shí)間: 2025-3-25 03:39
https://doi.org/10.1007/978-3-642-77763-9biosynthesis; cytochrome P450; enzyme; enzymes; hormone; hormones; steroid; synthesis作者: 粗糙濫制 時(shí)間: 2025-3-25 08:46
Springer-Verlag Berlin Heidelberg 1993作者: 增減字母法 時(shí)間: 2025-3-25 15:23 作者: Merited 時(shí)間: 2025-3-25 16:02
Fredric D. Wolinsky Ph.D.,Connie Lea Arnolds also been invested in research aimed at elucidation of primary, secondary, and tertiary structural features of the cytochromes. The collective aim of these studies has been to understand the connection between structure and function at a sophisticated molecular level.作者: patriarch 時(shí)間: 2025-3-25 23:50
https://doi.org/10.1007/978-3-662-11149-9. 1990). In this chapter, we describe the purification and catalytic properties of cytochrome P450 from the rat, rabbit, and mouse and then the changes in the levels of cytochromes P450 by treatment with chemical inducers or under pathophysiological conditions.作者: heterogeneous 時(shí)間: 2025-3-26 01:20
Cytochrome P450 Structure and Functions also been invested in research aimed at elucidation of primary, secondary, and tertiary structural features of the cytochromes. The collective aim of these studies has been to understand the connection between structure and function at a sophisticated molecular level.作者: Optometrist 時(shí)間: 2025-3-26 05:34
Cytochrome P450 in Rodents. 1990). In this chapter, we describe the purification and catalytic properties of cytochrome P450 from the rat, rabbit, and mouse and then the changes in the levels of cytochromes P450 by treatment with chemical inducers or under pathophysiological conditions.作者: 全部 時(shí)間: 2025-3-26 10:42
https://doi.org/10.1007/978-981-16-1982-30 in the mitochondria which participates in the biosynthesis of metamorphosis hormones (. and . 1984). However, the occurrence of cytochrome P450 in mitochondria has not been confirmed for plants and eukaryotic microbes including yeasts.作者: 郊外 時(shí)間: 2025-3-26 15:37 作者: Stress 時(shí)間: 2025-3-26 19:29
Localization of Cytochrome P450 in Membranes: Mitochondria0 in the mitochondria which participates in the biosynthesis of metamorphosis hormones (. and . 1984). However, the occurrence of cytochrome P450 in mitochondria has not been confirmed for plants and eukaryotic microbes including yeasts.作者: 撤退 時(shí)間: 2025-3-27 00:38
Structure of Cytochrome P450: Heme-Binding Site and Heme Reactivityave been determined. The exception to this is cytochrome P450., the only member of this family of enzymes for which a crystal structure is available (. et al. 1987). The structure of cytochrome P450. therefore serves as the template for all current efforts to model the active sites of cytochrome P450 enzymes.作者: Adrenaline 時(shí)間: 2025-3-27 01:59 作者: filicide 時(shí)間: 2025-3-27 08:39 作者: 細(xì)微的差異 時(shí)間: 2025-3-27 12:53
https://doi.org/10.1007/978-3-662-11152-9t absorption band at around 450 nm when the iron is reduced by electrons and complexed with carbon monoxide. Any enzyme having these properties would be a “card-holding” member of the cytochrome P450 superfamily.作者: 背書 時(shí)間: 2025-3-27 17:15 作者: 積云 時(shí)間: 2025-3-27 17:47
Cytochrome P450 Evolution and Nomenclaturet absorption band at around 450 nm when the iron is reduced by electrons and complexed with carbon monoxide. Any enzyme having these properties would be a “card-holding” member of the cytochrome P450 superfamily.作者: 拋物線 時(shí)間: 2025-3-28 00:27 作者: 品嘗你的人 時(shí)間: 2025-3-28 05:04
Depression in Late Life: An Updateoxygen activation, splitting and formation of a very reactive oxygen species suited to oxidizing such chemically inert compounds as alkanes. The catalytic power of cytochrome P450 can be demonstrated by the thermodynamic parameters of the oxygenation process (Eq. 1).作者: Libido 時(shí)間: 2025-3-28 07:02
Annual Review of Gerontology and Geriatricsindividual cytochromes P450 catalyze the metabolism of a number of substrates and frequently display overlapping substrate specificities (. et al. 1982; . and . 1987). In contrast to this broad substrate specificity of cytochrome P450 forms, some also display regio- and stereospecificities for selected substrates (. et al. 1982).作者: 猛烈責(zé)罵 時(shí)間: 2025-3-28 14:20 作者: 惰性氣體 時(shí)間: 2025-3-28 18:35
https://doi.org/10.1007/978-981-13-7693-1. The reductase was subsequently found to be located in the microsomal fraction (. and . 1962; . and . 1962). These earlier findings provided the setting for raising a number of questions concerning reductase function: Since cytochrome . is located in the mitochondria, what is the physiological subs作者: chronology 時(shí)間: 2025-3-28 20:10 作者: poliosis 時(shí)間: 2025-3-28 23:57
Combinatorial chemistry: A perspectiveenerating system. This simple reconstitution system has been found to be very reproducible, so that data from different laboratories can often be easily compared if the same incubation conditions have been used.作者: 不要嚴(yán)酷 時(shí)間: 2025-3-29 03:40
Brian K. Kay,Andrew D. Ellingtonendent upon the presence of a particular metal, ligand structure, or solvent. Indeed, much has been inferred about the catalytic mechanism of the enzyme from studies with these models (. et al. 1989) because some of the postulated enzyme intermediates are probably inaccessible for direct observation作者: 捐助 時(shí)間: 2025-3-29 08:42 作者: 飾帶 時(shí)間: 2025-3-29 12:52
https://doi.org/10.1007/978-3-662-11155-0ular cytochrome P450 enzyme and thus whether its plasma concentration and, consequently, its therapeutic effects may be subjected to interindividual variations of the activity of this enzyme. Likewise, more knowledge about structural features of compounds inhibitory for cytochrome P450 enzymes is re作者: Gesture 時(shí)間: 2025-3-29 18:31
Historical Background and Description of the Cytochrome P450 Monooxygenase System as well as work from Miller’s laboratory (. and . 1953), it became clear that liver microsomes were the source of NADPH-dependent, oxidative enzymes capable of metabolizing a number of xenobiotic compounds. Since the 1950s more than 800 different xenobiotics, ranging from drugs to organic chemicals作者: 閑逛 時(shí)間: 2025-3-29 22:14
NADPH-Cytochrome P450 Reductase: Function. The reductase was subsequently found to be located in the microsomal fraction (. and . 1962; . and . 1962). These earlier findings provided the setting for raising a number of questions concerning reductase function: Since cytochrome . is located in the mitochondria, what is the physiological subs作者: judiciousness 時(shí)間: 2025-3-30 00:58
Protein and Gene Structure and Regulation of NADPH-Cytochrome P450 Oxidoreductase toxicity of these compounds (. et al. 1978, 1979), while electron transfer to mitomycin C produces the active form of this antitumor compound (. et al. 1984). in conjunction with EDTA-Fe., cytochrome P450 or O.., the reductase can initiate microsomal lipid peroxidation (. et al. 1973; reviewed by .作者: 痛恨 時(shí)間: 2025-3-30 07:51
Localization of Cytochrome P450 in Membranes: Reconstituted Systemsenerating system. This simple reconstitution system has been found to be very reproducible, so that data from different laboratories can often be easily compared if the same incubation conditions have been used.作者: artless 時(shí)間: 2025-3-30 09:01
