作者: 悲痛 時(shí)間: 2025-3-21 23:13
978-1-4899-8774-7Springer-Verlag US 2008作者: Optic-Disk 時(shí)間: 2025-3-22 04:25 作者: Allergic 時(shí)間: 2025-3-22 07:13 作者: 無(wú)瑕疵 時(shí)間: 2025-3-22 10:14 作者: 陰郁 時(shí)間: 2025-3-22 16:08 作者: 陰郁 時(shí)間: 2025-3-22 20:37
https://doi.org/10.1007/978-981-13-3275-3on is critical in shaping the neural circuitry. Recently, accumulating evidence indicates that cyclin-dependent kinase 5 (Cdk5), a kinase implicated in the control of neuronal migration and survival, regulates multiple aspects of dendrite development and synaptic function. Here we summarize the exis作者: DRILL 時(shí)間: 2025-3-22 21:27 作者: vasculitis 時(shí)間: 2025-3-23 03:20 作者: Serenity 時(shí)間: 2025-3-23 09:18 作者: insert 時(shí)間: 2025-3-23 13:07
Storage Patterns for User Input but genetically distinct. Analysis of the Cdk5 knockout (or the double p35/p39 knockout) has led to the view that the primary function of Cdk5 is in the migration and maturation of embryonic post-mitotic neurons. The literature has no reference to a role of Cdk5 in normal cell cycle regulation. Rec作者: 強(qiáng)有力 時(shí)間: 2025-3-23 15:08
Peter F. Pelz,Thomas Keil,Gerhard LudwigLS), and Parkinson’s disease (PD). Overexpression of p25 in transgenic mice leads to enhanced cdk5 activity, together with aberrant phosphorylation of cytoskeletal components and the formation of hyperphosphorylated tau. Consistent with previous findings, we observed enhanced NRG-1/ErbB receptor sig作者: 先兆 時(shí)間: 2025-3-23 21:38 作者: 鉗子 時(shí)間: 2025-3-24 00:36
Yu-Qiu Long,Song Cen,Zhi-Fei Longrminus to form the protein p25. Although p25 is equally potent in activating Cdk5 as p35, it displays a number of differences from the latter, indicating an indispensable role of the N-terminal region for carrying out many of the Cdk5-p35 activities. A number of proteins have been identified that in作者: 吸引力 時(shí)間: 2025-3-24 04:43 作者: Repetitions 時(shí)間: 2025-3-24 08:02 作者: 嚴(yán)厲批評(píng) 時(shí)間: 2025-3-24 13:50 作者: Nefarious 時(shí)間: 2025-3-24 16:46 作者: 徹底檢查 時(shí)間: 2025-3-24 22:21 作者: 真繁榮 時(shí)間: 2025-3-25 02:55
Planes, Polyhedra, and Polytopesse. Since NFTs consist mainly of hyperphosphorylated tau, tau kinases have been suggested as drug targets to slow the progression of AD. This notion has further been supported by recent studies showing the importance of tau and its phosphorylation in neurodegeneration and cognitive deficits in anima作者: 魅力 時(shí)間: 2025-3-25 05:43
Cdk5 in Presynapses,vesicles are fused to the synaptic membrane and recycled to internal compartments via exocytosis and endocytosis, respectively. Cdk5 is involved in the regulation of the exocytosis and endocytosis of synaptic vesicles.作者: 枯萎將要 時(shí)間: 2025-3-25 09:02
Li-Huei Tsai,Nancy Y. IpWill appeal to researchers from various fields of neuroscience research, in light of the extensive involvement of Cdk5 in neuronal development, plasticity and neurological disorders.Written by leaders作者: 大范圍流行 時(shí)間: 2025-3-25 13:50 作者: Inelasticity 時(shí)間: 2025-3-25 18:09
https://doi.org/10.1007/978-981-13-3275-3vesicles are fused to the synaptic membrane and recycled to internal compartments via exocytosis and endocytosis, respectively. Cdk5 is involved in the regulation of the exocytosis and endocytosis of synaptic vesicles.作者: cancer 時(shí)間: 2025-3-25 22:42 作者: Influx 時(shí)間: 2025-3-26 01:03 作者: Enthralling 時(shí)間: 2025-3-26 04:52
Cdk5 in Presynapses,vesicles are fused to the synaptic membrane and recycled to internal compartments via exocytosis and endocytosis, respectively. Cdk5 is involved in the regulation of the exocytosis and endocytosis of synaptic vesicles.作者: BROW 時(shí)間: 2025-3-26 09:36 作者: 瘙癢 時(shí)間: 2025-3-26 16:42 作者: 地殼 時(shí)間: 2025-3-26 17:06
Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survivaegrates fluctuations in the activities of signaling cascades involved in nervous system growth, differentiation, and survival. In this review, we have focused primarily on Cdk5 cross talk and neuronal survival conducted in our laboratory. Cdk5 activity is tightly regulated in the nervous system, but作者: Calculus 時(shí)間: 2025-3-26 21:03
CDK5 and Mitochondrial Cell Death Pathways,multicellular organisms during development. The same apoptotic machinery can be reactivated in the adult organism under disease conditions. Mitochondria play a central role in many apoptotic cascades, both as a storage place for pro-apoptotic molecules and for the production of ATP that is required 作者: neutralize 時(shí)間: 2025-3-27 05:04
Regulation and Function of Cdk5 in the Nucleus,rocesses. This seems to distinct Cdk5 from other more traditional Cdks. However, recent discoveries have now extended the role of Cdk5 to the nucleus. This chapter summarizes these novel findings. These include the detection of Cdk5 and its regulators in the nucleus, identification of nuclear target作者: DOSE 時(shí)間: 2025-3-27 05:24
Cdk5 May Be an Atypical Kinase, but Not in the Way You Think, but genetically distinct. Analysis of the Cdk5 knockout (or the double p35/p39 knockout) has led to the view that the primary function of Cdk5 is in the migration and maturation of embryonic post-mitotic neurons. The literature has no reference to a role of Cdk5 in normal cell cycle regulation. Rec作者: AORTA 時(shí)間: 2025-3-27 12:22 作者: PRE 時(shí)間: 2025-3-27 13:55 作者: 羊齒 時(shí)間: 2025-3-27 19:56
,Protein–Protein Interactions Involving the N-Terminus of p35,rminus to form the protein p25. Although p25 is equally potent in activating Cdk5 as p35, it displays a number of differences from the latter, indicating an indispensable role of the N-terminal region for carrying out many of the Cdk5-p35 activities. A number of proteins have been identified that in作者: 果核 時(shí)間: 2025-3-28 00:25
The Kinase Activity of Cdk5 and Its Regulation,In this chapter we describe the enzymatic properties and the regulation mechanisms of Cdk5 activity in post-mitotic neurons in comparison to cell cycle Cdks. The regulation mechanisms are synthesis and degradation of p35, the interaction with p35- or Cdk5-binding proteins, phosphorylation of Cdk5 or作者: 效果 時(shí)間: 2025-3-28 03:02
The Structural Bases of CDK5 Activity,f protein kinases are usually structurally alike, a requirement imposed by the necessity to maintain the basic geometry of a highly conserved machinery required for good catalytic output. Conversely, the structures of the inactive states of kinase-family members can vary widely from each other, a pr作者: 館長(zhǎng) 時(shí)間: 2025-3-28 09:39
Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting,ires binding with its activator p35 and/or p39 to execute its kinase activity. Cdk5 was initially identified by purification from bovine brain extract and termed “Cdk5” because of its nucleotide sequence homology with human CDC2. Since the discovery of this kinase in 1992, it has been extensively st作者: Fibrin 時(shí)間: 2025-3-28 14:02
Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory,dk5 in synaptic plasticity, and learning and memory. In this chapter, we summarize the data that reveal the involvement of Cdk5 in mnemonic processes on molecular as well as cellular levels and relate these findings to its emerging function in learning and memory. From amongst the impressive range o作者: 輕打 時(shí)間: 2025-3-28 17:31
Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration,ward an important role of Cdk5 in regulating synaptic plasticity, learning, and memory in the adult brain. However, aberrant Cdk5 activity has been implicated in various neurodegenerative diseases such as Alzheimer’s disease. Deregulation of Cdk5 has been attributed to calpain-mediated cleavage of t作者: 門(mén)窗的側(cè)柱 時(shí)間: 2025-3-28 21:44
,Cdk5 as a Drug Target for Alzheimer’s Disease,se. Since NFTs consist mainly of hyperphosphorylated tau, tau kinases have been suggested as drug targets to slow the progression of AD. This notion has further been supported by recent studies showing the importance of tau and its phosphorylation in neurodegeneration and cognitive deficits in anima作者: 圓錐 時(shí)間: 2025-3-29 00:42 作者: colony 時(shí)間: 2025-3-29 06:19
Peter F. Pelz,Thomas Keil,Gerhard Ludwigspecific cdk5 inhibitor CP-681301 reduces ErbB2 receptor tyrosine phosphorylation. These results imply that cdk5 is involved in neuregulin-dependent activation of the PI3?K/Akt neuronal survival pathway and potentially other NRG-1-related signaling pathways by regulating the phosphorylation of ErbB2/ErbB3.作者: 形容詞 時(shí)間: 2025-3-29 08:10
Sub-Region Mixed Element II—V-Notch Problem35 to p25 by calpain, leading to hyperactivation and eventually neuronal cell death. The kinase activity and stability of Cdk5–p39, which still remains to be characterized, are also described here. The biochemical information will be useful in studying Cdk5 and elucidating its functions.作者: 教義 時(shí)間: 2025-3-29 15:08 作者: intertwine 時(shí)間: 2025-3-29 17:03 作者: 大猩猩 時(shí)間: 2025-3-29 22:46 作者: 征稅 時(shí)間: 2025-3-29 23:55
Cdk5 and Neuregulin-1 Signaling,specific cdk5 inhibitor CP-681301 reduces ErbB2 receptor tyrosine phosphorylation. These results imply that cdk5 is involved in neuregulin-dependent activation of the PI3?K/Akt neuronal survival pathway and potentially other NRG-1-related signaling pathways by regulating the phosphorylation of ErbB2/ErbB3.作者: Painstaking 時(shí)間: 2025-3-30 06:19
The Kinase Activity of Cdk5 and Its Regulation,35 to p25 by calpain, leading to hyperactivation and eventually neuronal cell death. The kinase activity and stability of Cdk5–p39, which still remains to be characterized, are also described here. The biochemical information will be useful in studying Cdk5 and elucidating its functions.作者: Meander 時(shí)間: 2025-3-30 08:42
The Structural Bases of CDK5 Activity, within the general frame of reference of kinase activation mechanisms, and in comparison to other members of the CDK family. We explain how CDK5, not unlike other kinases, has made its own capricious decisions to design an original activation mechanism and distinguish itself from CDK-family relatives.作者: Endemic 時(shí)間: 2025-3-30 15:27
Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory,oth, synaptic plasticity, and learning and memory, including NMDA receptor modulation, transcriptional regulation and organization of synaptic structures. We aim to show that Cdk5 is uniquely placed amongst kinases to orchestrate the multi-level processes inherent in learning and memory owing to its integral role in many neuronal functions.作者: Blanch 時(shí)間: 2025-3-30 16:53 作者: TRUST 時(shí)間: 2025-3-30 21:56 作者: inspiration 時(shí)間: 2025-3-31 03:08 作者: 橢圓 時(shí)間: 2025-3-31 07:39 作者: 產(chǎn)生 時(shí)間: 2025-3-31 11:43 作者: Absenteeism 時(shí)間: 2025-3-31 16:57 作者: 不透明 時(shí)間: 2025-3-31 21:34
Fluid Mechanics and Its Applicationsparatus that is similar to the presynaptic machinery mediating synaptic transmission in neuronal networks. We now summarize recent developments in the field of Cdk5 and regulated exocytosis and also present some novel findings regarding Cdk5’s effect on insulin secretion.作者: DEVIL 時(shí)間: 2025-3-31 21:44
https://doi.org/10.1007/978-981-13-3275-3ein kinase (MAPK), c-Jun N-terminal kinase (JNK3), and phosphoinositol-3-kinase/protein kinase B (PI3?K/Akt). In addition, it is shown that Cdk5 directly and indirectly mediates the Ras guanine nucleotide exchange factors-1/2 (RasGRF1/2) and glycogen synthase kinase 3β (GSK3β) signaling pathways, respectively.作者: Obverse 時(shí)間: 2025-4-1 04:06 作者: CLASP 時(shí)間: 2025-4-1 09:58
Planes, Polyhedra, and Polytopesls. In addition, inhibition of Cdk5 activities is neuroprotective and appears to enhance long-term potentiation and improve learning and memory—all are potential beneficial features for the treatment of AD.
