標(biāo)題: Titlebook: Current Directions in Insulin-Like Growth Factor Research; Derek Roith,Mohan K. Raizada Book 1993 The Editor(s) (if applicable) and The Au [打印本頁(yè)] 作者: commingle 時(shí)間: 2025-3-21 16:32
書目名稱Current Directions in Insulin-Like Growth Factor Research影響因子(影響力)
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書目名稱Current Directions in Insulin-Like Growth Factor Research被引頻次
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書目名稱Current Directions in Insulin-Like Growth Factor Research讀者反饋
書目名稱Current Directions in Insulin-Like Growth Factor Research讀者反饋學(xué)科排名
作者: Crayon 時(shí)間: 2025-3-21 21:35
Differential Regulation of IGF-I Leader Exon Transcription,cts of these stimuli, its circulating concentrations being sensitive to both GH (Zapf et al., 1981) and nutritional (Prewitt et al., 1982) status. Therefore, in addition to the ubiquitous autocrine/paracrine synthesis of IGF-I by tissues (D’Ercole et al., 1984), circulating IGF-I may exert an import作者: BRUNT 時(shí)間: 2025-3-22 04:07 作者: FLIT 時(shí)間: 2025-3-22 07:54
Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins,uble proteins with high affinity for both IGF-I and IGF-II. The type 1 IGF receptor and the IGFBPs appear to form a complex regulatory system for transducing and modulating the activity of IGF-I and IGF-II. The determination of the roles of these proteins in IGF action has been facilitated by the us作者: Mendicant 時(shí)間: 2025-3-22 09:18 作者: 交響樂 時(shí)間: 2025-3-22 16:42 作者: 交響樂 時(shí)間: 2025-3-22 18:29
Significant Species Differences in Local IGF-I and -II Gene Expression, rodents reflect IGF system function or regulation in other species. For example, IGF-II is usually regarded primarily as a fetal growth factor because its postnatal expression is highly restricted in the rodent. However, in the human and other species, IGF-II levels are equal to or greater than IGF作者: 解脫 時(shí)間: 2025-3-22 22:55
Transcriptional Regulation of the Insulin Receptor Gene Promoter,n receptor is a tyrosine kinase. The receptor is a heterotetramer composed of 2 alpha-and 2 beta-subunits. The alpha-subunit is located extracellularly where it binds insulin while the beta-subunit spans the membrane and contains the tyrosine kinase domain. The presence of this receptor is probably 作者: FACT 時(shí)間: 2025-3-23 02:29 作者: 推延 時(shí)間: 2025-3-23 07:44 作者: sacrum 時(shí)間: 2025-3-23 10:55 作者: 無(wú)力更進(jìn) 時(shí)間: 2025-3-23 17:36 作者: 涂掉 時(shí)間: 2025-3-23 21:12 作者: rectocele 時(shí)間: 2025-3-23 23:18
Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus,n ligand binding (Czech, 1989). It has striking homology to the insulin receptor; however, each receptor maintains a unique specificity for its own ligand (Schumacher et al., 1991). The mechanism by which the binding of IGF-1 to its receptor elicits a cellular effect has been the subject of consider作者: 勤勞 時(shí)間: 2025-3-24 04:03
Molecular Cloning of pp120/ ECTO-ATPase, An Endogenous Substrate of the Insulin Receptor Kinase, receptor kinase (1). Several laboratories have reported the identification of protein substrates of the insulin receptor tyrosine kinase (2). Here, we review our studies of pp120/ecto-ATPase, a liver-specific glycoprotein of Mr-120,000 which was originally identified by us as a substrate of the ins作者: 菊花 時(shí)間: 2025-3-24 08:16 作者: Obloquy 時(shí)間: 2025-3-24 10:40 作者: GIDDY 時(shí)間: 2025-3-24 16:26 作者: 積習(xí)已深 時(shí)間: 2025-3-24 22:17 作者: callous 時(shí)間: 2025-3-25 02:30 作者: 暖昧關(guān)系 時(shí)間: 2025-3-25 05:50 作者: HUMP 時(shí)間: 2025-3-25 08:32 作者: orient 時(shí)間: 2025-3-25 13:24 作者: Infirm 時(shí)間: 2025-3-25 16:50 作者: immunity 時(shí)間: 2025-3-25 21:18 作者: 字形刻痕 時(shí)間: 2025-3-26 02:07 作者: 就職 時(shí)間: 2025-3-26 07:56
https://doi.org/10.1007/978-3-031-18545-8evelopment and in the control of both normal and abnormal growth (for reviews, see Werner et al., 1991 and Lowe, 1991). The importance of the IGF-1 receptor in development is especially supported by the seminal experiments of Efstratiadis and co-workers (DeChiara et al., 1990, and personal communica作者: saphenous-vein 時(shí)間: 2025-3-26 10:07
and the Reconfiguration of Civil Societych and Schlessinger, 1990). The structure of the insulin receptor, defined using recombinant DNA techniques, exhibits a high degree of overall similarity with the receptor for the structurally related insulin-like growth factor (IGF), IGF-I (for review, see Czech, 1989). These heterotetrameric glyco作者: mortgage 時(shí)間: 2025-3-26 13:36
https://doi.org/10.1007/978-3-031-18888-6via binding to specific high affinity receptors on the plasma membrane of target cells. Similar to these growth factors, the receptors for insulin and IGF-1 share a high degree of structural and functional properties.. Both these receptors are classified as Type I receptors being composed of two a s作者: Spongy-Bone 時(shí)間: 2025-3-26 18:23
and the Reconfiguration of Civil Societyt cell types. The receptors show considerable similarity in primary sequence within a common disulphide linked (αβ)2 subunit structure. The insulin receptor-related receptor (IRR), a third member of this receptor family for which a ligand has yet to be identified, apparently has a much more restrict作者: 隨意 時(shí)間: 2025-3-27 00:35 作者: fatuity 時(shí)間: 2025-3-27 04:49
https://doi.org/10.1007/978-3-031-18888-6 receptor kinase (1). Several laboratories have reported the identification of protein substrates of the insulin receptor tyrosine kinase (2). Here, we review our studies of pp120/ecto-ATPase, a liver-specific glycoprotein of Mr-120,000 which was originally identified by us as a substrate of the ins作者: 有限 時(shí)間: 2025-3-27 07:46 作者: 察覺 時(shí)間: 2025-3-27 12:13
Arash Dahi Taleghani,Livio Santosmolecular corollary of this has also been demonstrated for the majority of the genes studied: Both copies of each autosomal gene are equivalently expressed at the mRNA level, regardless of the parent from which each was derived.作者: 進(jìn)入 時(shí)間: 2025-3-27 15:14 作者: 對(duì)待 時(shí)間: 2025-3-27 20:00 作者: Incommensurate 時(shí)間: 2025-3-28 00:56
Women, Ageing and the Screen IndustriesInsulin-like growth factor (IGF) -I and -II mediate mitogenesis, differentiation and insulin-like metabolic effects.1 Their amino acid sequence is divided into 4 domains designated B-C-A-D beginning from the amino terminus. The B-and A-domains of IGF-I and IGF-II share substantial homology with each other and with the B-and A-chains of insulin.作者: Defraud 時(shí)間: 2025-3-28 05:49
Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins,Insulin-like growth factor (IGF) -I and -II mediate mitogenesis, differentiation and insulin-like metabolic effects.1 Their amino acid sequence is divided into 4 domains designated B-C-A-D beginning from the amino terminus. The B-and A-domains of IGF-I and IGF-II share substantial homology with each other and with the B-and A-chains of insulin.作者: NORM 時(shí)間: 2025-3-28 09:40
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/d/image/241181.jpg作者: 思考才皺眉 時(shí)間: 2025-3-28 10:27
Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Fuligands (IGF-I, IGF-II and insulin),. three receptors (type 1 and type 2 IGF receptors and insulin receptors). and six distinct, but structurally related binding proteins (IGFBP-1 to IGFBP-6).. The physiological interactions among these components of the IGF system are not completely understood, although they have all been cloned and sequenced..作者: Assignment 時(shí)間: 2025-3-28 17:07 作者: Sleep-Paralysis 時(shí)間: 2025-3-28 22:36
Current Directions in Insulin-Like Growth Factor Research978-1-4615-2988-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 萬(wàn)花筒 時(shí)間: 2025-3-29 00:18
https://doi.org/10.1007/978-3-031-18258-7ligands (IGF-I, IGF-II and insulin),. three receptors (type 1 and type 2 IGF receptors and insulin receptors). and six distinct, but structurally related binding proteins (IGFBP-1 to IGFBP-6).. The physiological interactions among these components of the IGF system are not completely understood, although they have all been cloned and sequenced..作者: LIKEN 時(shí)間: 2025-3-29 07:02
Arash Dahi Taleghani,Livio Santosmolecular corollary of this has also been demonstrated for the majority of the genes studied: Both copies of each autosomal gene are equivalently expressed at the mRNA level, regardless of the parent from which each was derived.作者: Archipelago 時(shí)間: 2025-3-29 09:57 作者: 飾帶 時(shí)間: 2025-3-29 11:26
The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcriptiontative role of IGF-I as a progression factor in the cell cycle.. Recent studies have shown that overexpression of the IGF-I-R in a fibroblast cell line abrogates all requirements for exogenous growth factors, suggesting that this receptor does, in fact, mediate a central mechanism in the cell cycle..作者: 鑲嵌細(xì)工 時(shí)間: 2025-3-29 19:30 作者: 里程碑 時(shí)間: 2025-3-29 22:00 作者: 針葉樹 時(shí)間: 2025-3-30 02:36 作者: grenade 時(shí)間: 2025-3-30 05:42
0065-2598 igands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, ther作者: 憤世嫉俗者 時(shí)間: 2025-3-30 10:57 作者: 殖民地 時(shí)間: 2025-3-30 14:54 作者: gerontocracy 時(shí)間: 2025-3-30 19:06 作者: 胰島素 時(shí)間: 2025-3-30 20:57
Cell Cycle Control by the IGF-1 Receptor and Its Ligands,mutant embryos at birth have a body weight that is only 30% the weight of wild type litter mates. Thus, it can be stated that the activation of IGF-1 receptor by its ligands (IGF-1 or IGF-II) accounts for 70% of embryonal murine growth.作者: 迫擊炮 時(shí)間: 2025-3-31 01:34 作者: NOMAD 時(shí)間: 2025-3-31 07:06 作者: BAIL 時(shí)間: 2025-3-31 10:54
and the Reconfiguration of Civil Society a cytoplasmic tyrosine kinase activated by insulin binding (Ebina et al., 1985; Ullrich et al., 1985; Ullrich et al., 1986). The α-and β-subunits are derived by proteolytic cleavage of the proreceptor.作者: 許可 時(shí)間: 2025-3-31 15:48 作者: CHOP 時(shí)間: 2025-3-31 21:25 作者: 表被動(dòng) 時(shí)間: 2025-4-1 00:37 作者: 并置 時(shí)間: 2025-4-1 03:09 作者: 注入 時(shí)間: 2025-4-1 06:40
IRR: A Novel Member of the Insulin Receptor Family, a cytoplasmic tyrosine kinase activated by insulin binding (Ebina et al., 1985; Ullrich et al., 1985; Ullrich et al., 1986). The α-and β-subunits are derived by proteolytic cleavage of the proreceptor.作者: 受傷 時(shí)間: 2025-4-1 13:04
Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid andse activity of the receptors appears to be essential. These tyrosine kinases are highly homologous and differences in signalling capacities of the IR and IGFR in a given cell background have not been clearly defined.
