標題: Titlebook: Crystallographic and Modeling Methods in Molecular Design; Charles E. Bugg,Steven E. Ealick Book 1990 Springer-Verlag New York, Inc. 1990 [打印本頁] 作者: 矜持 時間: 2025-3-21 17:46
書目名稱Crystallographic and Modeling Methods in Molecular Design影響因子(影響力)
書目名稱Crystallographic and Modeling Methods in Molecular Design影響因子(影響力)學(xué)科排名
書目名稱Crystallographic and Modeling Methods in Molecular Design網(wǎng)絡(luò)公開度
書目名稱Crystallographic and Modeling Methods in Molecular Design網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Crystallographic and Modeling Methods in Molecular Design被引頻次
書目名稱Crystallographic and Modeling Methods in Molecular Design被引頻次學(xué)科排名
書目名稱Crystallographic and Modeling Methods in Molecular Design年度引用
書目名稱Crystallographic and Modeling Methods in Molecular Design年度引用學(xué)科排名
書目名稱Crystallographic and Modeling Methods in Molecular Design讀者反饋
書目名稱Crystallographic and Modeling Methods in Molecular Design讀者反饋學(xué)科排名
作者: 食草 時間: 2025-3-21 21:34
he DNA minor groove. In the latter case, two of the four AT base pairs in the ATAT stretch have low propeller twist angles, even though the DNA has a narrow minor groove. In the netropsind(CGCGATATCGCG) structure, the drug is found to occupy in two orientations equally well, suggesting a disordered 作者: aerial 時間: 2025-3-22 03:32 作者: Hemodialysis 時間: 2025-3-22 06:39 作者: 溫和女孩 時間: 2025-3-22 11:45 作者: 咽下 時間: 2025-3-22 15:39
Crystallographic and Modeling Methods in Molecular Design978-1-4612-3374-9作者: 咽下 時間: 2025-3-22 19:10
,Structural Studies of Elastase-Inhibitor Complexes with ?-Lactams,phil after the azurophilic granules entraining the enzyme are discharged into phagosomes containing engulfed debris (Parmley ., 1986). Tissue damage results when enzyme inevitably leaks out of the neutrophil (and into the extracellular space) by regurgitation during phagocytosis or by cell death, fo作者: Finasteride 時間: 2025-3-22 21:25 作者: Inertia 時間: 2025-3-23 02:36
The Cambridge Structural Database in Molecular Modeling: Systematic Conformational Analysis from Crn chemical substructure may well occur in several hundred of these crystal structures. It is therefore necessary to develop rapid automatic techniques by which such large datasets may be sorted into conformational subgroups. These subgroups may then be ranked in order of their population; if two or 作者: Processes 時間: 2025-3-23 09:31 作者: 熱情贊揚 時間: 2025-3-23 13:34
Book 1990r aiding in the design of enzyme inhibitors and other compounds that bind to selected biological targets. This book is therefore of interest not only to molecular biologists and biochem- ists, but is stimulating reading for anyone involved in structural biol- ogy, pharmaceutical chemistry, enzymolog作者: CORD 時間: 2025-3-23 15:46 作者: 束縛 時間: 2025-3-23 21:01
Take All My Wealth and Let My Body Go,omolecules. Molecular motion is modeled with classical mechanics, using a simple forcefield in which the potential energy is calculated as a sum of terms each of which depends on the coordinates of only a few atoms. Solvation is represented most accurately by including in the sample sufficient solvent molecules to entirely envelop the solute.作者: 縮影 時間: 2025-3-23 23:55 作者: Incise 時間: 2025-3-24 05:14 作者: FECT 時間: 2025-3-24 08:48 作者: Instrumental 時間: 2025-3-24 12:35 作者: HEW 時間: 2025-3-24 16:32
978-1-4612-7987-7Springer-Verlag New York, Inc. 1990作者: BAIT 時間: 2025-3-24 19:34
Take All My Wealth and Let My Body Go,The advent of directed mutagenesis has made it possible to alter protein structures at will. For the first time it is possible to design and to introduce modifications into a protein that are intended to change its behavior in predictable ways.作者: 原始 時間: 2025-3-24 23:12
Crystallographic and Genetic Approaches Toward the Design of Proteins of Enhanced Thermostability,The advent of directed mutagenesis has made it possible to alter protein structures at will. For the first time it is possible to design and to introduce modifications into a protein that are intended to change its behavior in predictable ways.作者: coddle 時間: 2025-3-25 05:34 作者: Cytology 時間: 2025-3-25 07:43 作者: semiskilled 時間: 2025-3-25 15:17 作者: 征服 時間: 2025-3-25 18:23 作者: Apogee 時間: 2025-3-25 21:32 作者: 繁殖 時間: 2025-3-26 02:54 作者: mosque 時間: 2025-3-26 08:21
of molecular dynamics in NMR structural refinement, in understanding loop motion and catalytic activity of mutants in triose phosphate isomerase and in the application of free energy perturbation methods in protein design, site-specific mutagenesis and in thermal stability.作者: Emasculate 時間: 2025-3-26 09:30
A dodecamers has been solved and refined by single crystal X-ray diffraction analysis. In these complexes, the drug molecules bind to the central AT segment (4–6 base pairs long) in the narrow minor groove of the dodecamer B-DNA double helix. The stabilizing forces between the drugs and DNAs are pro作者: 低能兒 時間: 2025-3-26 13:38
tient may suffer from more than one form of epilepsy. In addition, not all anticonvulsant drugs are effective against all types of seizure. There are two main classes of epileptic seizure, partial and generalized. These two classes of seizure are initiated differently: partial seizures begin at a lo作者: 合唱隊 時間: 2025-3-26 19:39 作者: 脫落 時間: 2025-3-26 22:59
teractive computer program that allows the graphical construction of protein models using fragments extracted from known x-ray crystal structures. An initial α-Carbon conformational template is used to screen and retrieve matching polypeptide fragments from a library of known protein structures. Fra作者: 失誤 時間: 2025-3-27 02:49 作者: 責(zé)任 時間: 2025-3-27 07:12 作者: pester 時間: 2025-3-27 12:34
ional procedures exist for this purpose, but suffer from some operational or scientific limitations. These primarily concern the size of molecules that can be processed, availability of relevant and reliable force-field parameters, or on the need to postulate a number of starting geometries so as to作者: Expediency 時間: 2025-3-27 14:58 作者: Phenothiazines 時間: 2025-3-27 21:40
synthetic organic chemists who are eager to have our input but who will move on without looking back if we are too slow to answer their questions. They expect computational chemists to either suggest for synthesis novel and patentable compounds that will possess the desired biological profile or to作者: Narrative 時間: 2025-3-27 23:39
Stability of Folded Conformations by Computer Simulation: Methods and Some Applications,omolecules. Molecular motion is modeled with classical mechanics, using a simple forcefield in which the potential energy is calculated as a sum of terms each of which depends on the coordinates of only a few atoms. Solvation is represented most accurately by including in the sample sufficient solvent molecules to entirely envelop the solute.作者: 袋鼠 時間: 2025-3-28 03:55
The Use of Molecular Dynamics and Free Energy Perturbation Approaches in Simulating the Properties of molecular dynamics in NMR structural refinement, in understanding loop motion and catalytic activity of mutants in triose phosphate isomerase and in the application of free energy perturbation methods in protein design, site-specific mutagenesis and in thermal stability.作者: Madrigal 時間: 2025-3-28 07:02 作者: BAIL 時間: 2025-3-28 11:50
Inhibitor Binding to Thymidylate Synthase Is Mediated by Different Structural Determinants than Thoofolate(CH.-H.PteGlu) as both the single carbon donor and reductant. Because the folate cofactor is utilized stoichiometrically rather than catalytically, cells must have a mechanism for regenerating CH.-H.PteGlu in order to ensure a continuing supply of dTMP for DNA synthesis. This requirement is m作者: 歸功于 時間: 2025-3-28 17:14 作者: 委屈 時間: 2025-3-28 19:07
,Structural Studies of Elastase-Inhibitor Complexes with ?-Lactams,It is a progressively degenerative disease for which there is no effective therapy at present. Human neutrophil elastase (HNE) is a serine protease which is stored in the azurophilic granules of neutrophils, and which has broad specificity for small aliphatic groups at the P. position of substrates 作者: 伴隨而來 時間: 2025-3-29 01:18
Design of Purine Nucleoside Phosphorylase Inhibitors Using X-Ray Crystallography,se-1-phosphate (1–4). Although equilibrium favors the synthesis of nucleosides, the biological function of PNP is to liberate purine bases through the purine salvage pathway. PNP has been isolated from a variety of sources including human erythrocytes, bovine spleen, chicken liver, rabbit erythrocyt作者: 斷言 時間: 2025-3-29 07:00
The Potential Role of Solvation in the Dihydrofolate Reductase Species Selectivity of Trimethoprim,folate reductase (DHFR) (Hitchings, 1983). DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate. The latter substance is important to the biosynthesis of purines, pyrimidines and several of the amino acids and is therefore necessary for normal cell function (Blakley, 198作者: 其他 時間: 2025-3-29 08:31
Stability of Folded Conformations by Computer Simulation: Methods and Some Applications,omolecules. Molecular motion is modeled with classical mechanics, using a simple forcefield in which the potential energy is calculated as a sum of terms each of which depends on the coordinates of only a few atoms. Solvation is represented most accurately by including in the sample sufficient solve作者: semble 時間: 2025-3-29 13:16
The Use of Molecular Dynamics and Free Energy Perturbation Approaches in Simulating the Properties of molecular dynamics in NMR structural refinement, in understanding loop motion and catalytic activity of mutants in triose phosphate isomerase and in the application of free energy perturbation methods in protein design, site-specific mutagenesis and in thermal stability.作者: 一再遛 時間: 2025-3-29 19:04
Molecular Recognition of DNA Minor Groove Binding Drugs,A dodecamers has been solved and refined by single crystal X-ray diffraction analysis. In these complexes, the drug molecules bind to the central AT segment (4–6 base pairs long) in the narrow minor groove of the dodecamer B-DNA double helix. The stabilizing forces between the drugs and DNAs are pro作者: AWL 時間: 2025-3-29 22:16
Structural and Computational Studies of Anticonvulsants: A Search for Correlation Between Moleculartient may suffer from more than one form of epilepsy. In addition, not all anticonvulsant drugs are effective against all types of seizure. There are two main classes of epileptic seizure, partial and generalized. These two classes of seizure are initiated differently: partial seizures begin at a lo作者: 神圣將軍 時間: 2025-3-30 01:00 作者: RENAL 時間: 2025-3-30 07:55 作者: FEAS 時間: 2025-3-30 10:23 作者: 漂泊 時間: 2025-3-30 13:41
Inhibitor Design from Known Structures, cell membrane. As knowledge of both drugs and disease states has grown, specific receptors have been identified for certain drugs, and target receptors have been identified for some disease states. Any effort to design drugs rationally depends on understanding the intermolecular interactions involv作者: 擴大 時間: 2025-3-30 17:28 作者: 含糊 時間: 2025-3-30 23:47 作者: noxious 時間: 2025-3-31 03:41 作者: inculpate 時間: 2025-3-31 06:10 作者: 強化 時間: 2025-3-31 12:15 作者: Synchronism 時間: 2025-3-31 13:40 作者: 美學(xué) 時間: 2025-3-31 19:08
Woman-as-Spectacle in Love-Story Films,still susceptible to infection by another. For this reason, vaccines have been developed to prevent poliovirus infection, but the great number of rhinovirus serotypes has thwarted the development of a rhinovirus vaccine. Therefore, in the case of rhinovirus, the only hope for a “cure” seems to lie in a pharmaceutical approach.作者: FRAUD 時間: 2025-3-31 23:19
Take All My Wealth and Let My Body Go,es, . and avian malarial parasite (5–15). In general, it appears that the mammalian enzyme is a trimer of identical subunits (16–20) while the bacterial enzyme is a hexamer of identical subunits (21). Both the human erythrocytic PNP and the . PNP have been crystallized (22, 23).作者: 不在灌木叢中 時間: 2025-4-1 03:21
Take All My Wealth and Let My Body Go,4). DHFR is a ubiquitous protein, found not only in bacteria but also man, and one of the unique properties of TMP is its ability to inhibit selectively the bacterial species of the enzyme (Roth, 1983; Hitchings et. al., 1988). That remarkable selectivity is illustrated in Table 1.作者: lipoatrophy 時間: 2025-4-1 07:23 作者: 鋪子 時間: 2025-4-1 12:46
ification of target geometry enables identification of substructures that conform to a variety of structural or amino acid sequence contexts. The method has been used to aid model building from crystallographic electron density maps, for homology model building, and in structure analysis applications relevant to protein engineering.作者: Choreography 時間: 2025-4-1 15:21 作者: 失誤 時間: 2025-4-1 20:05
