標(biāo)題: Titlebook: Critical Issues in Head and Neck Oncology; Key Concepts from th Jan B. Vermorken,Volker Budach,Brian O‘Sullivan Conference proceedings‘‘‘‘‘ [打印本頁(yè)] 作者: 叛亂分子 時(shí)間: 2025-3-21 16:39
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書目名稱Critical Issues in Head and Neck Oncology讀者反饋學(xué)科排名
作者: Amendment 時(shí)間: 2025-3-21 23:09 作者: Spina-Bifida 時(shí)間: 2025-3-22 04:27
,Das r?tselhafte Ph?nomen der Emergenz,uch example stems from the discovery that malignant melanomas with metastatic potential can downregulate autophagy in the overlying epidermis. Autophagy is essential for normal keratinocyte maturation. AMBRA1 is a key autophagy regulatory molecule and its expression in the epidermis is reduced in th作者: Coronary-Spasm 時(shí)間: 2025-3-22 04:54 作者: Ischemic-Stroke 時(shí)間: 2025-3-22 11:22
Administration und Gremienarbeit,n nuclear DNA above an unspecified threshold that exceeded the tumour cell’s capacity for repair. Greater understanding of the importance of non-tumour cell-autonomous, immunological aspects of radiation-induced cell death in the context of the tumour micro-environment (TME) has altered this rather 作者: 合并 時(shí)間: 2025-3-22 15:56 作者: 合并 時(shí)間: 2025-3-22 17:40
Administration und Gremienarbeit, (HNSCC) patients, both in the first and second recurrent and metastatic settings. However, not all patients respond to PD-1 blockade, nor derive prolonged benefit from these immunotherapies, requiring further development of immune-oncology strategies beyond PD-1/PD-L1 inhibitors. There has been an 作者: insert 時(shí)間: 2025-3-22 23:43 作者: 莊嚴(yán) 時(shí)間: 2025-3-23 04:46
https://doi.org/10.1007/978-3-662-56638-1 microscope (pathologic-ENE, pENE). As ENE progresses, it can eventually become visible on imaging (radiologic-ENE, rENE). When ENE further advances to invade skin and/or underlining structures causing fixation and neurovascular impairment, it becomes clinically evident (clinical-ENE, cENE). pENE is作者: CRAFT 時(shí)間: 2025-3-23 08:57 作者: ELUC 時(shí)間: 2025-3-23 11:53
Gregor Domes,Beate Ditzen,Jürgen Barth and trials on de-escalation of treatment, in an attempt to reduce morbidity of treatment. However, the results of recent trials show that de-escalation, especially the removal or replacement of cisplatin, may have detrimental effects on survival. We discuss the lessons learnt from the first de-esca作者: 杠桿支點(diǎn) 時(shí)間: 2025-3-23 16:50 作者: Insulin 時(shí)間: 2025-3-23 20:48
Gregor Domes,Beate Ditzen,Jürgen Barthts with inoperable recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). For curable HNSCC, the role of immunotherapy is under investigation. In this chapter, we briefly review the current use of immunotherapy with surgery or radio(chemo)therapy in the treatment of HNSCC w作者: 大方一點(diǎn) 時(shí)間: 2025-3-23 23:34
,Laios und die Komplexe der drei V?ter,HPV) related oropharyngeal squamous cell carcinoma (OPSCC) as well as the emerging role of transoral robotic surgery (TORS) has led to revision and evolution of diagnostic and treatment paradigms. The concept of tongue base mucosectomy (TBM) has gained its place in the diagnostic pathway. The most r作者: 向下五度才偏 時(shí)間: 2025-3-24 04:07
,Laios und die Komplexe der drei V?ter,mplete resection or full-dose radiotherapy, systemic treatment has seen important advances over the past several decades. In general, there are six major factors impacting on the decision-making process. Four of them belong to a class of continuous functions and include overall health status (from f作者: 大約冬季 時(shí)間: 2025-3-24 08:58
,Elektra: Des ?dipus geistige Schwester,nitially in melanoma trials and has been gradually incorporated in the treatment algorithm of a variety of malignancies in multiple settings. Immune checkpoint inhibitors (ICIs), the most widely used immunotherapy drugs, are monoclonal antibodies that target specific immune checkpoints such as Progr作者: Brain-Imaging 時(shí)間: 2025-3-24 10:49
delivering precisely targeted high doses of radiation in one or several fractions, the concept of SBRT has been rapidly adopted by many institutions. This chapter aims to summarize the available literature regarding the use of SBRT in the reirradiation setting of recurrent and second primary head an作者: Cognizance 時(shí)間: 2025-3-24 15:19
,Elektra: Des ?dipus geistige Schwester,asal sinuses, nasopharynx, and adjacent mesenchymal tissues translates into a proportionally vast spectrum of prognoses, with some histologies such as olfactory neuroblastoma being associated with rare disease-specific death to other histologies such as mucosal melanoma for which survival beyond 5?y作者: 毀壞 時(shí)間: 2025-3-24 22:28 作者: beta-carotene 時(shí)間: 2025-3-25 00:36 作者: 單片眼鏡 時(shí)間: 2025-3-25 06:23 作者: GLUE 時(shí)間: 2025-3-25 08:09 作者: Leisureliness 時(shí)間: 2025-3-25 11:48
http://image.papertrans.cn/d/image/240013.jpg作者: NORM 時(shí)間: 2025-3-25 17:26
Immune Checkpoint Inhibitors in the Curative Setting: Pre-clinical and Clinical Data,ts with inoperable recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). For curable HNSCC, the role of immunotherapy is under investigation. In this chapter, we briefly review the current use of immunotherapy with surgery or radio(chemo)therapy in the treatment of HNSCC with curative intent.作者: Angiogenesis 時(shí)間: 2025-3-25 21:04 作者: Painstaking 時(shí)間: 2025-3-26 02:03 作者: 舊石器 時(shí)間: 2025-3-26 08:04
ows surgeons to plan resection and reconstruction to a high degree of precision, with a number of associated benefits. This chapter discusses the indications and processes involved in three-dimensional planning and its application to surgical resection and reconstruction of the facial bones.作者: 大量殺死 時(shí)間: 2025-3-26 10:53
The Bi-Directional Communication Between Tumour Cells and Other Components of the Tumour Microenviruch example stems from the discovery that malignant melanomas with metastatic potential can downregulate autophagy in the overlying epidermis. Autophagy is essential for normal keratinocyte maturation. AMBRA1 is a key autophagy regulatory molecule and its expression in the epidermis is reduced in th作者: 就職 時(shí)間: 2025-3-26 15:53
Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms d/or metastatic stages. Clinical responses are impressive but remain limited to a minority of patients. Primary resistance of never-responders is considered to derive from host- and tumor-specific characteristics, the latter comprising tumor immune checkpoint activity, immune contexture, tumor mutat作者: entreat 時(shí)間: 2025-3-26 19:26 作者: 蚊子 時(shí)間: 2025-3-26 22:47 作者: Clinch 時(shí)間: 2025-3-27 03:59 作者: 印第安人 時(shí)間: 2025-3-27 07:06 作者: Mercurial 時(shí)間: 2025-3-27 10:01
Sensitivity and Specificity of Extranodal Extension: Unlocking One of the Strongest Prognostic Fact microscope (pathologic-ENE, pENE). As ENE progresses, it can eventually become visible on imaging (radiologic-ENE, rENE). When ENE further advances to invade skin and/or underlining structures causing fixation and neurovascular impairment, it becomes clinically evident (clinical-ENE, cENE). pENE is作者: glomeruli 時(shí)間: 2025-3-27 13:51
Proton Therapy for Head and Neck Cancer,se distribution properties with the so-called Bragg-peak enabling protons to stop after their maximum depth is reached within millimeters. PT allows sparing of normal tissues and organs to a much greater extent than photons, even when modern photon techniques like intensity-modulated radiotherapy (I作者: 慢跑鞋 時(shí)間: 2025-3-27 19:52 作者: 褻瀆 時(shí)間: 2025-3-28 01:36
Treatment Intensification in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: What Ar, including concurrent chemoradiotherapy (CCRT) or surgery followed by radiotherapy (RT), with/without chemotherapy (CT). Induction chemotherapy followed by (chemo)-RT has also level I evidence for larynx preservation procedures in patients with advanced laryngeal or hypopharyngeal cancer. The CT pa作者: 致詞 時(shí)間: 2025-3-28 03:05 作者: 放棄 時(shí)間: 2025-3-28 08:58 作者: antiandrogen 時(shí)間: 2025-3-28 13:30
Systemic Treatment Sequencing and Prediction of First-line Therapy Outcomes in Recurrent or Metastamplete resection or full-dose radiotherapy, systemic treatment has seen important advances over the past several decades. In general, there are six major factors impacting on the decision-making process. Four of them belong to a class of continuous functions and include overall health status (from f作者: ABASH 時(shí)間: 2025-3-28 15:15
Patterns of Response to Immune Oncology Drugs: How Relevant Are They in SCCHN?,nitially in melanoma trials and has been gradually incorporated in the treatment algorithm of a variety of malignancies in multiple settings. Immune checkpoint inhibitors (ICIs), the most widely used immunotherapy drugs, are monoclonal antibodies that target specific immune checkpoints such as Progr作者: Blasphemy 時(shí)間: 2025-3-28 19:31 作者: 牽連 時(shí)間: 2025-3-29 02:11
Precision Medicine in the Treatment of Malignancies Involving the Ventral Skull Base: Present and Fasal sinuses, nasopharynx, and adjacent mesenchymal tissues translates into a proportionally vast spectrum of prognoses, with some histologies such as olfactory neuroblastoma being associated with rare disease-specific death to other histologies such as mucosal melanoma for which survival beyond 5?y作者: theta-waves 時(shí)間: 2025-3-29 05:57 作者: 喚醒 時(shí)間: 2025-3-29 10:30
Targeting Molecular Residual Disease Using Novel Technologies and Clinical Trials Design in Head anave substantial risks of relapse despite definitive therapy, and thus represent conditions of unmet clinical need. The ability now exists to detect molecular residual disease (MRD) in these patients post-definitive treatment such as surgery or (chemo)radiotherapy using novel and highly sensitive and作者: TERRA 時(shí)間: 2025-3-29 14:54
New Developments in Surgery for Malignant Salivary Gland Tumors,tment of choice in most patients. In this respect, recently, interesting developments in ablative and reconstructive procedures have been proposed. Regarding the ablative part, transoral surgery, both with laser (transoral laser microsurgery or TLM) and robot (transoral robotic surgery or TORS) is i作者: 的是兄弟 時(shí)間: 2025-3-29 18:56 作者: Eulogy 時(shí)間: 2025-3-29 23:12
Administration und Gremienarbeit,al characteristics of the delivered radiation, can all influence the immunogenicity of radiotherapy. By understanding and modulating cross-talk between molecular responses to radiation-induced DNA damage, associated mechanisms of cell death and subsequent innate and adaptive immune responses, we may作者: 暫時(shí)過(guò)來(lái) 時(shí)間: 2025-3-30 01:52 作者: 懸崖 時(shí)間: 2025-3-30 05:53
https://doi.org/10.1007/978-3-662-56638-1ENE carries prognostic significance beyond traditional cN classification for both viral-related and unrelated head and neck cancer, and can serve an important role for clinical care and risk stratification. For clinical care, such as triaging HPV-positive oropharyngeal cancer to surgery vs radiother作者: bizarre 時(shí)間: 2025-3-30 09:50
Gregor Domes,Beate Ditzen,Jürgen Bartheal, nasopharyngeal, sinonasal, periorbital, and salivary gland cancer. The limited broad availability of this treatment method and its unknown cost-effectiveness need to be evaluated. In this chapter, we discuss the currently available evidence of PT for HNCs and viable options to generate further 作者: Comedienne 時(shí)間: 2025-3-30 13:04
Entscheidungen vor dem Schreiben,rboplatin with or without 5-fluorouracil, taxanes or cetuximab). However, none of these have shown superior results over the use of cisplatin in randomized trials. Late toxicity is a major downside of CCRT, and this is most worrying for those with the highest chance of cure, i.e. low-risk human papi作者: temperate 時(shí)間: 2025-3-30 18:08 作者: 虛構(gòu)的東西 時(shí)間: 2025-3-30 22:03
, overall survival following SBRT-based reirradiation remains moderate, which might be due to insufficient doses. There is thus a need for well-designed trials of SBRT-based reirradiation in terms of dose escalation and combination with systemic therapy. In HNC, the evidence for treatment of oligome作者: Bmd955 時(shí)間: 2025-3-31 02:15
,Elektra: Des ?dipus geistige Schwester,ent in most cases, along with radiotherapy and chemotherapy. Biotherapy and immunotherapy are only anecdotally and compassionately used. For each histology, a careful selection of modalities and their timing is paramount to ensure the best chance of cure. In keeping with the principles of precision 作者: explicit 時(shí)間: 2025-3-31 05:43
Zaher Jandali,Klaus Müller,Lucian Jigaonent in the multidisciplinary management of MiSGMTs, and its possible use should be considered. For selected naso-ethmoidal MiSGMTs, especially adenoid cystic carcinoma of the ethmoid, small case series have supported the use of endoscopic transnasal surgery. Similarly, it has been shown that MiSGM作者: 偏狂癥 時(shí)間: 2025-3-31 12:31 作者: 洞穴 時(shí)間: 2025-3-31 13:22
Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms l researchers currently aims at the development and evaluation of combined modality treatment approaches. Radiotherapy is a highly promising partner in this regard and represents a crucial treatment modality for patients with locally advanced HNSCC. Historically established as cytotoxic anti-cancer 作者: 防銹 時(shí)間: 2025-3-31 18:13 作者: critique 時(shí)間: 2025-4-1 00:14
How to Standardize Molecular Profiling Programs for Routine Patient Care,nical judgement. All steps described above are not standardized, resulting in relevant heterogeneity in treatment recommendations among MTBs in different institutions..In this chapter, contemporary challenges will be discussed, including intratumoral heterogeneity, use of diverse molecular diagnosti
