標(biāo)題: Titlebook: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity; Frederick C. Kauffman (Director) Book 1994 Springer-Verlag Berlin Hei [打印本頁] 作者: sustained 時間: 2025-3-21 19:17
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書目名稱Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity讀者反饋學(xué)科排名
作者: Adjourn 時間: 2025-3-21 20:57
https://doi.org/10.1007/978-3-642-78429-3Drug conjugates; Konjugation; Stoffwechsel; Transferasen; acyl-linked conjugates; conjugate; enzymes; hydro作者: Anthem 時間: 2025-3-22 03:44
978-3-642-78431-6Springer-Verlag Berlin Heidelberg 1994作者: Exclaim 時間: 2025-3-22 07:16
Finanzielle UnternehmensführungGlucuronidation is a major detoxication pathway in all vertebrates examined, from the most primitive (fish; C. et al. 1991) to the most evolved (man; D. 1980) and accounts for most of the detoxified material in bile and urine (D. 1980).作者: 流動性 時間: 2025-3-22 10:47
The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and RegulationGlucuronidation is a major detoxication pathway in all vertebrates examined, from the most primitive (fish; C. et al. 1991) to the most evolved (man; D. 1980) and accounts for most of the detoxified material in bile and urine (D. 1980).作者: 不可侵犯 時間: 2025-3-22 14:59 作者: 不可侵犯 時間: 2025-3-22 17:12 作者: Soliloquy 時間: 2025-3-22 23:32 作者: 通情達理 時間: 2025-3-23 04:29
Die Kapitalflussrechnung nach IFRSug (reviewed in W. 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite its effectiveness, a high proportion (3.5%–17%) of treated patients developed a devastating, progressive nerve toxicity. Pharmacokinetic studies of isoniazid elimination in twins and in families revealed s作者: 地殼 時間: 2025-3-23 06:43
Der Geldkreislauf des Unternehmensng experimental results have appeared in these areas within the past 3 years. This review includes recent studies on the genetics and molecular mechanisms of glucuronidase subcellular localization, induction of glucuronidase by hormones, a new glucuronidase with unusual catalytic activity and inheri作者: ostensible 時間: 2025-3-23 13:45 作者: Solace 時間: 2025-3-23 17:11 作者: 驕傲 時間: 2025-3-23 19:58 作者: Diaphragm 時間: 2025-3-24 01:28 作者: 阻塞 時間: 2025-3-24 03:05
History of the Personal Involvement Taboos role as a highly specialized and heterogeneous organ (N. 1959; M. et al. 1979; . L. and K. 1984; G. et al. 1978; J. and K. 1982), and an accurate physiological description of hepatic drug conjugation and conjugate processing by the liver necessitates consideration of the structure of the liver and作者: 航海太平洋 時間: 2025-3-24 09:48
Disciplined Personal Involvementhe basolateral domain between the plasma and the hepatocyte and across the canalicular domain between the hepatocyte and the bile canaliculus. Since most drug conjugates are anions, i.e., sulfate, glucuronide, or glutathione conjugates, this review will focus on the transport properties of organic a作者: Chronic 時間: 2025-3-24 12:00
Treating the Chronically Depressed Patientserve to convert drug metabolites either to compounds that are biologically active per se or to prodrugs that serve as carriers of biological activity to various tissues. This chapter reviews important examples of the role of phase II reactions in generating biologically active compounds. Among the 作者: tackle 時間: 2025-3-24 15:35
Treating the Chronically Depressed Patientently undergo phase II conjugation with glucuronic acid. Often such a conjugate constitutes the major metabolite. Many examples are found among the hypolipidemic agents, diuretic agents, and nonsteroidal anti-inflammatory drugs. Most herbicides are metabolized in this manner by fish, birds and mamma作者: contrast-medium 時間: 2025-3-24 21:58
Health Anxiety and Somatization in Childrens of carcinogenesis. Glucuronides may be transport forms of carcinogens that play a major role in determining the target of carcinogenicity, for example, in urinary bladder or colon epithelium. Roles of UGT isozymes can be best appreciated in the context of overall xenobiotic metabolism. In addition作者: 溺愛 時間: 2025-3-25 02:46
Treatment: What Are the Choices?the sulfo group ( -SO.H , -SO.; B. and H. 1970) from the cofactor 3’-phospho-adenosine-5’-phosphosulfate (PAPS; R. and L. 1957) to the oxygen and nitrogen atoms of -C-OH, -N-OH, and -NH groups in physiological and foreign substrates (M. and J. 1990). The products of these transfers are sulfuric acid作者: 四牛在彎曲 時間: 2025-3-25 05:06
Health Anxiety and Somatization in Children GSH plays an integral role in a large number of biologically important reactions (S. and K. 1988; T. et al. 1989; V. 1990). The numerous reactions that GSH participates in can be divided into those involving the γ-glutamyl moiety of the tripeptide and those of the sulfhydryl moiety. Those reactions作者: Arthropathy 時間: 2025-3-25 09:52 作者: 喚起 時間: 2025-3-25 13:16 作者: 充滿人 時間: 2025-3-25 19:47
https://doi.org/10.1007/978-3-8349-9875-0 electrophiles, the GSTs bind with high affinity a variety of hydrophobic compounds such as heme, bilirubin, polycyclic hydrocarbons, and dexamethazone (L. et al. 1971; A. et al. 1976; B. et al. 1980; H. a n d L. 1985).作者: CHIP 時間: 2025-3-25 20:45 作者: alliance 時間: 2025-3-26 01:01 作者: 羽毛長成 時間: 2025-3-26 08:03 作者: superfluous 時間: 2025-3-26 08:28 作者: Finasteride 時間: 2025-3-26 14:36 作者: 妨礙議事 時間: 2025-3-26 20:10 作者: 不遵守 時間: 2025-3-26 22:58 作者: Gyrate 時間: 2025-3-27 01:19 作者: 比賽用背帶 時間: 2025-3-27 06:57
Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Inducti electrophiles, the GSTs bind with high affinity a variety of hydrophobic compounds such as heme, bilirubin, polycyclic hydrocarbons, and dexamethazone (L. et al. 1971; A. et al. 1976; B. et al. 1980; H. a n d L. 1985).作者: Congestion 時間: 2025-3-27 11:15
Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactionsin Chaps. 13 and 16 of this volume). Because of the important role of transferases in catalyzing conjugation reactions, these enzymes have been studied extensively, and the properties of the important conjugating enzymes are described in Chaps. 1–7.作者: 嘲笑 時間: 2025-3-27 14:05
Regulation of Drug Conjugate Production by Futile Cycling in Intact Cellsates across various cellular membranes, and the formation and release of conjugated products (D.V. et al. 1985) as well as the activities of transferases and hydrolases (D.V. et al. 1985; E. M. and K. 1986; S. et al. 1975).作者: perpetual 時間: 2025-3-27 19:31 作者: Dysarthria 時間: 2025-3-27 22:40
Health Anxiety and Somatization in Children to preventing accumulation of lipid-soluble compounds, “xenobiotic” or drugmetabolizing enzymes may also fulfill important roles in controlling endogenous signal compounds such as hormones (N. 1991).作者: Missile 時間: 2025-3-28 05:39
Treatment: What Are the Choices? esters (also variously called sulfates, or sulfooxy or sulfonyloxy derivatives) or sulfamides (sulfamates). Sulfate transfer is apparently unknown in biology. Were it to occur, the products in most cases would be peroxysulfates. We suggest that “sulfonation” be used to describe the conjugation of substrates by sulfotransferases and PAPS.作者: FLUSH 時間: 2025-3-28 08:24
0171-2004 logy and toxicology. This volume is an up-to-date source of information on this topic and will be of broad interest to pharmacologists and toxicologists.978-3-642-78431-6978-3-642-78429-3Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: LAVA 時間: 2025-3-28 12:11 作者: 專心 時間: 2025-3-28 18:03
Sulfotransferase Enzymestalyzed by those enzymes in tissue preparations. Simultaneously, attempts were made to separate and purify ST enzymes to make it possible to characterize the molecular species that catalyzed specific reactions. Unfortunately, overlap in substrate specificities of these enzymes has led to confusion w作者: 懶鬼才會衰弱 時間: 2025-3-28 20:21 作者: Interstellar 時間: 2025-3-29 02:09
Microsomal Amidases and Carboxylesterases they hydrolyze the esters of fatty acids, such as palmitoyl-Lcarnitine, 1-palmitoyl glycerol, and oleoyl cholesterol, the physiological role of amidases/carboxylesterases is not yet clear (M. et al. 1988).作者: 不可侵犯 時間: 2025-3-29 05:48
-, ,- and ,-Methyltransferasesy all these enzymes, i.e., .-adenosyl-.-methionine (AdoMet). The .-methylation (T. and C. 1990; B. et al. 1990; C. 1993; K. et al. 1992), .-methylation (A. and J. 1990), and S-methylation (S. and B. 1990; H. 1993) reactions have been discussed in recent comprehensive reviews.作者: 他一致 時間: 2025-3-29 07:49 作者: 投票 時間: 2025-3-29 15:15
Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems the basolateral domain to be excreted in the urine? Is this determined by the presence and substrate specificity of transporters in each membrane domain? How are drug conjugates which are formed in other tissues, such as the intestine, taken up by the liver? Recent advances have provided answers to作者: 猛然一拉 時間: 2025-3-29 18:57 作者: pulse-pressure 時間: 2025-3-29 21:27 作者: conscribe 時間: 2025-3-30 00:08 作者: 別名 時間: 2025-3-30 05:22
Die Kapitalflussrechnung nach IFRS961; J. 1965; E. and W. 1964), the term “inactivator” was supplanted by “acetylator.” Since then, the two genetically distinct major phenotypes have usually been referred to as rapid and slow acetylators.作者: Favorable 時間: 2025-3-30 11:10 作者: BARB 時間: 2025-3-30 14:00
https://doi.org/10.1007/978-3-8349-9875-0y all these enzymes, i.e., .-adenosyl-.-methionine (AdoMet). The .-methylation (T. and C. 1990; B. et al. 1990; C. 1993; K. et al. 1992), .-methylation (A. and J. 1990), and S-methylation (S. and B. 1990; H. 1993) reactions have been discussed in recent comprehensive reviews.作者: predict 時間: 2025-3-30 19:57
History of the Personal Involvement Taboo87, 1989; B. et al. 1989) and transport (B. et al. 1989; M. et al. 1990), together with clearance modifiers, such as organ blood flow, drug and conjugate binding to vascular proteins, transmembrane clearance, and the .. and .. of the saturable eliminatory pathways (for reviews, see G. and G. 1984; P作者: 搖曳的微光 時間: 2025-3-30 22:24
Disciplined Personal Involvement the basolateral domain to be excreted in the urine? Is this determined by the presence and substrate specificity of transporters in each membrane domain? How are drug conjugates which are formed in other tissues, such as the intestine, taken up by the liver? Recent advances have provided answers to作者: 不可侵犯 時間: 2025-3-31 03:36 作者: AROMA 時間: 2025-3-31 06:32
Health Anxiety and Somatization in Childrenin urine as the corresponding mercapturic acid, which are S-conjugates of .-acetylcysteine. Conjugation with GSH has usually been considered a detoxication reaction. The increased water solubility and the active secretion of organic acids by renal tubules greatly facilitates mercapturic acid excreti作者: Enliven 時間: 2025-3-31 09:30
Sulfotransferase Enzymesncreases the water solubility of most compounds and, therefore, their renal excretion. It also usually results in a decrease in biological activity, but, in some cases, sulfate conjugation is required to “activate” drugs such as the antihypertensive medication minoxidil (J. et al. 1982; M. et al. 19作者: interrogate 時間: 2025-3-31 13:53 作者: ingrate 時間: 2025-3-31 18:55
Human ,-Acetyltransferasesug (reviewed in W. 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite its effectiveness, a high proportion (3.5%–17%) of treated patients developed a devastating, progressive nerve toxicity. Pharmacokinetic studies of isoniazid elimination in twins and in families revealed s
