標(biāo)題: Titlebook: Conditional Mutagenesis: An Approach to Disease Models; Robert Feil,Daniel Metzger Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromo [打印本頁] 作者: 筆記 時間: 2025-3-21 18:15
書目名稱Conditional Mutagenesis: An Approach to Disease Models影響因子(影響力)
書目名稱Conditional Mutagenesis: An Approach to Disease Models影響因子(影響力)學(xué)科排名
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書目名稱Conditional Mutagenesis: An Approach to Disease Models網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Conditional Mutagenesis: An Approach to Disease Models被引頻次
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書目名稱Conditional Mutagenesis: An Approach to Disease Models讀者反饋
書目名稱Conditional Mutagenesis: An Approach to Disease Models讀者反饋學(xué)科排名
作者: 空中 時間: 2025-3-21 23:00 作者: 不真 時間: 2025-3-22 01:21
Tetracycline-Controlled Genetic Switchesse. Trancriptional activation can be induced by activators termed tTA (Tet-Off) or rtTA (Tet-On) in the absence and presence of Tet, respectively. The Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both sys作者: Servile 時間: 2025-3-22 04:36
Novel Gene Switchesery as well as fundamental and applied research. This chapter provides a comprehensive overview of the different approaches for regulating gene activity and product protein formation at different biosynthetic levels, from genomic rearrangements over transcription and translation control to strategie作者: 小說 時間: 2025-3-22 11:03
Improved Embryonic Stem Cell Technologiesadvances, including tetraploid aggregation, new site-specific recombinases and RNAi, have enabled more sophisticated manipulation of the ES cell genome. For instance, it is now possible to control gene expression in both a temporally and spatially restricted manner. Such new technologies are answeri作者: miniature 時間: 2025-3-22 14:32
Gene Trap Mutagenesiso a powerful tool for dissecting the genetic causes of human disease and identifying potential targets for pharmaceutical intervention. With the recent sequencing of the human and mouse genomes, a large number of novel genes have been identified whose function in normal and disease physiology remain作者: miniature 時間: 2025-3-22 17:34 作者: Amylase 時間: 2025-3-22 23:22 作者: 斥責(zé) 時間: 2025-3-23 04:10 作者: MAPLE 時間: 2025-3-23 08:08 作者: 不給啤 時間: 2025-3-23 12:52
Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Threshrm line gene inactivation are instrumental in establishing the importance of such genes in vivo, distortion of embryonic development or multiple body systems often preclude detailed functional studies. To overcome this limitation, DNA recombination systems such as Cre/loxP of bacteriophage P1, have 作者: 標(biāo)準(zhǔn) 時間: 2025-3-23 17:42
Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and contribution of specific genes to brain functions is difficult because the brain is a highly complex organ with multiple neuroanatomical structures, orchestrating virtually every function in the body. Further, higher-order brain functions such as learning and memory simultaneously recruit several s作者: Aerophagia 時間: 2025-3-23 21:51 作者: 小丑 時間: 2025-3-23 23:10
Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopand cardiomyopathy. It is caused by severely reduced levels of frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biosynthesis. Mouse models have been important tools in dissecting the steps of pathogenesis in FRDA. Furthermore, animal models that reproduce some of the key events作者: Flatter 時間: 2025-3-24 05:20 作者: Harridan 時間: 2025-3-24 10:27
Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disordersof human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprote作者: glucagon 時間: 2025-3-24 11:57 作者: 推測 時間: 2025-3-24 15:41
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/c/image/235210.jpg作者: DEFT 時間: 2025-3-24 20:16 作者: 瑪瑙 時間: 2025-3-25 02:37
QoS Preservation in Web Service Selection,malian genome. The technology, based on the Cre/. system, is used more and more in the scientific community in order to generate new chromosomes carrying deletions, duplications, inversions and translocations in targeted regions of interest. In this review, we will present the basic principle of the作者: 小步舞 時間: 2025-3-25 06:27
Bi-proportional Apportionments,se. Trancriptional activation can be induced by activators termed tTA (Tet-Off) or rtTA (Tet-On) in the absence and presence of Tet, respectively. The Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both sys作者: 原告 時間: 2025-3-25 10:23 作者: Juvenile 時間: 2025-3-25 12:11
An IoT Virtual eLearning Space,advances, including tetraploid aggregation, new site-specific recombinases and RNAi, have enabled more sophisticated manipulation of the ES cell genome. For instance, it is now possible to control gene expression in both a temporally and spatially restricted manner. Such new technologies are answeri作者: 異端邪說下 時間: 2025-3-25 16:32
https://doi.org/10.1007/978-3-662-62245-2o a powerful tool for dissecting the genetic causes of human disease and identifying potential targets for pharmaceutical intervention. With the recent sequencing of the human and mouse genomes, a large number of novel genes have been identified whose function in normal and disease physiology remain作者: intuition 時間: 2025-3-25 21:46
https://doi.org/10.1007/978-3-662-62245-2 promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach. This review provides an overview of the progress of RNAi in vivo, with emphasis on systemic/local siRNA delivery, viral shRNA vectors, shRNA vector transgenic mice 作者: DEMN 時間: 2025-3-26 01:47 作者: Grasping 時間: 2025-3-26 04:29
David M. Ramsey,Aleksander Mariańskigovern development and disease. In the last 15 years, these mechanisms have been analyzed with vastly greater precision and clarity with the advent of systems that allow the conditional control of gene expression. Typically, this control is achieved by silencing or activating the gene of interest wi作者: 磨坊 時間: 2025-3-26 12:32 作者: Iniquitous 時間: 2025-3-26 16:18
A Validity Criterion for Fuzzy Clusteringrm line gene inactivation are instrumental in establishing the importance of such genes in vivo, distortion of embryonic development or multiple body systems often preclude detailed functional studies. To overcome this limitation, DNA recombination systems such as Cre/loxP of bacteriophage P1, have 作者: Neutropenia 時間: 2025-3-26 19:13
Lecture Notes in Computer Science contribution of specific genes to brain functions is difficult because the brain is a highly complex organ with multiple neuroanatomical structures, orchestrating virtually every function in the body. Further, higher-order brain functions such as learning and memory simultaneously recruit several s作者: 猛烈責(zé)罵 時間: 2025-3-26 22:05 作者: 提煉 時間: 2025-3-27 02:37 作者: 慟哭 時間: 2025-3-27 07:34
On Reduct Construction Algorithmsaddressing a particular time point in animal life is certainly an important breakthrough allowed by conditional strategies with temporal control of either transgene expression or gene modifications. The purpose of this review is to present various mouse models for cardiovascular diseases based on co作者: 間接 時間: 2025-3-27 11:08
Yingxu Wang,Yiyu Yao,Guoyin Wangof human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprote作者: 歡笑 時間: 2025-3-27 15:41 作者: Blasphemy 時間: 2025-3-27 18:31 作者: Tdd526 時間: 2025-3-28 01:18
Animal Models in Cardiovascular Diseases: New Insights from Conditional Modelsaddressing a particular time point in animal life is certainly an important breakthrough allowed by conditional strategies with temporal control of either transgene expression or gene modifications. The purpose of this review is to present various mouse models for cardiovascular diseases based on conditional approaches.作者: 砍伐 時間: 2025-3-28 03:34 作者: 積習(xí)難改 時間: 2025-3-28 07:21 作者: cajole 時間: 2025-3-28 13:41
978-3-642-07121-8Springer-Verlag Berlin Heidelberg 2007作者: 墻壁 時間: 2025-3-28 17:40 作者: GEM 時間: 2025-3-28 22:14
Lecture Notes in Computer Scienceors, the stability of their transgenic expression, the tropism of the recombinant viruses, the likelihood of induction of immunotoxicity, and the ease (or difficulty) of the virus production. In the end, we discuss applications of these vectors for delivery of three molecular systems for conditional作者: gastritis 時間: 2025-3-29 02:09
A Validity Criterion for Fuzzy Clusteringuction have been identified. Inactivation of immunoregulatory receptors in leukocyte subsets can provide robust experimental systems revealing the conceptual simplicity underlying the modulation of complex signaling pathways during homeostatic responses. As illustrated for TGF-β receptor, such syste作者: acrobat 時間: 2025-3-29 06:31 作者: 皺痕 時間: 2025-3-29 10:52 作者: 軍械庫 時間: 2025-3-29 13:33
Yingxu Wang,Yiyu Yao,Guoyin Wangn Part I of this volume. Our aim is to provide an exemplary survey of the application of different conditional mutagenesis techniques in lipid research in order to illustrate their potential to unravel physiological functions of a broad range of genes involved in lipid homeostasis.作者: Intend 時間: 2025-3-29 19:19 作者: facilitate 時間: 2025-3-29 22:39 作者: Rebate 時間: 2025-3-30 02:34
Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinaseshe mouse by site-specific recombination can provide new solutions to old problems in the analysis of human physiology and pathophysiology and how it can be employed for drug discovery and development.作者: Functional 時間: 2025-3-30 04:39 作者: OASIS 時間: 2025-3-30 10:20
Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Threshuction have been identified. Inactivation of immunoregulatory receptors in leukocyte subsets can provide robust experimental systems revealing the conceptual simplicity underlying the modulation of complex signaling pathways during homeostatic responses. As illustrated for TGF-β receptor, such syste作者: 四指套 時間: 2025-3-30 15:27
Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity andNMDA receptor, the protein kinase CaMKIIα, the protein phosphatases calcineurin and PP1, or the transcription factor CREB, in the processes of learning and memory. This review illustrates the broad and innovative applicability of these methodologies to the study of brain plasticity and cognitive fun作者: 碌碌之人 時間: 2025-3-30 17:35 作者: Ballerina 時間: 2025-3-30 22:08 作者: blight 時間: 2025-3-31 04:56
Tetracycline-Controlled Genetic Switches Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both systems were optimized over the years and can now be used to develop mouse models.作者: happiness 時間: 2025-3-31 05:09
RNA Interference in Miceovides an overview of the progress of RNAi in vivo, with emphasis on systemic/local siRNA delivery, viral shRNA vectors, shRNA vector transgenic mice and conditional systems to control shRNA vectors. Taken together, the data from 80 in vivo studies show that RNAi is a useful tool that offers new opportunities for functional genomics in mice.作者: INCUR 時間: 2025-3-31 12:15
0171-2004 f the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them. .978-3-642-07121-8978-3-540-35109-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 藐視 時間: 2025-3-31 17:18
QoS Preservation in Web Service Selection, technique either in vivo or in vitro and we will briefly describe some applications to provide highly valuable genetic tools, to decipher the mammalian genome organisation and to analyze human diseases in the mouse.作者: 節(jié)約 時間: 2025-3-31 21:29 作者: 水土 時間: 2025-4-1 01:10 作者: 公理 時間: 2025-4-1 02:03 作者: ACTIN 時間: 2025-4-1 07:38
Book 2007del human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them. .作者: 誘導(dǎo) 時間: 2025-4-1 11:46
