標(biāo)題: Titlebook: Concepts, Mechanisms, and New Targets for Chemotherapy; F. M. Muggia Book 1995 Springer Science+Business Media New York 1995 DNA.breast ca [打印本頁] 作者: 表范圍 時(shí)間: 2025-3-21 16:10
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作者: 冬眠 時(shí)間: 2025-3-21 22:01
Recent clinical advances with camptothecin analoguesn, demonstrated encouraging activity in early clinical testing but was abandoned due to unpredictable toxicity. In 1985, Hsaing and Liu observed that the cytotoxic effect of camptothecin requires the nuclear enzyme topoisomerase I [2]. This finding coincided with the development of the semisynthetic作者: Delude 時(shí)間: 2025-3-22 02:35
The reversal of multidrug resistanceaboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug. The selected cells often display crossresistance to a number of functionally and structurally distinct drugs. This drug-resistant phenotype is referred to as . (MDR). Currently, the bes作者: Implicit 時(shí)間: 2025-3-22 04:35
Fluoropyrimidine catabolismtes for important enzymatic reactions required in vital cell biologic processes, e.g., synthesis of DNA and RNA. Several reviews on the metabolism of antimetabolite drugs have recently been published, providing a general background on these drugs [1–5]. The pyrimidine antimetabolite drugs consist of作者: 使人入神 時(shí)間: 2025-3-22 09:11 作者: 無價(jià)值 時(shí)間: 2025-3-22 14:19
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapyxyuridylate (FdUMP) inhibition of thymidylate synthase (TS) occurs by the ordered, sequential binding of TS, FdUMP, and then 5-10-methylenetetrahydrofolate (CH.FH.) [.–.]. In cell-free kinetic systems, CH.FH. must be in excess for maximal TS-FdUMP-CH.FH. ternary complex formation and complete inhibi作者: 無價(jià)值 時(shí)間: 2025-3-22 20:16 作者: 多產(chǎn)子 時(shí)間: 2025-3-22 22:38 作者: 吸引力 時(shí)間: 2025-3-23 03:43 作者: predict 時(shí)間: 2025-3-23 08:46
High-dose chemotherapy with peripheral blood progenitor autograftinglinic, this strategy also results in increased toxicity to normal tissues. For those cytotoxics that are primarily dose-limited by myelosuppression (e.g., alkylating agents, carboplain, and etoposide), the use of autologous bone marrow transplantation (ABMT) has facilitated substantial dose escalati作者: 水槽 時(shí)間: 2025-3-23 12:19 作者: Hallmark 時(shí)間: 2025-3-23 17:38 作者: 狗舍 時(shí)間: 2025-3-23 21:10
Das Konzept der Entwicklungsaufgaben then result in improved specificity for the target cells, and at the same time, reduce bone marrow and liver toxicity [3]. The concept leading to synthesis of estramustine phosphate was also based on the beneficial effect observed in prostate cancer of a polyestrodiol phosphate (Estradurin) [4].作者: Madrigal 時(shí)間: 2025-3-24 02:13 作者: 冷峻 時(shí)間: 2025-3-24 05:13
Fluoropyrimidine catabolism these endogenous nucleic acid precursors, with structural differences including substitutions at one of the carbons in the pyrimidine ring or one of the hydrogens attached to the ring of the pyrimidine or sugar (ribose or deoxyribose).作者: Encapsulate 時(shí)間: 2025-3-24 10:04
Estramustine revisited then result in improved specificity for the target cells, and at the same time, reduce bone marrow and liver toxicity [3]. The concept leading to synthesis of estramustine phosphate was also based on the beneficial effect observed in prostate cancer of a polyestrodiol phosphate (Estradurin) [4].作者: 外表讀作 時(shí)間: 2025-3-24 13:13 作者: 內(nèi)向者 時(shí)間: 2025-3-24 17:12
Das Konzept der Entwicklungsaufgabenr specimens are infrequently studied directly. Most of our knowledge has been obtained from in vitro studies with tumor cell lines, with a limited number of variables affecting the outcome. Using tumor cell lines, information has been acquired to formulate mechanisms whereby cells may survive chemotherapeutic interventions.作者: 易受刺激 時(shí)間: 2025-3-24 22:49
Use of hydroxyurea to alter drug resistance of human tumor cellsr specimens are infrequently studied directly. Most of our knowledge has been obtained from in vitro studies with tumor cell lines, with a limited number of variables affecting the outcome. Using tumor cell lines, information has been acquired to formulate mechanisms whereby cells may survive chemotherapeutic interventions.作者: Hypopnea 時(shí)間: 2025-3-25 00:55 作者: Limousine 時(shí)間: 2025-3-25 03:51
Book 1995. One route that has not beentravelled previously is that of protein kinase C inhibition. Thispathway may be exploited to give potent inhibitors, such as thebryostatins, now in clinical trial. A summary is given of the currentstatus of topoisomerase, focusing on recent clinical advances withcamptoth作者: 繁殖 時(shí)間: 2025-3-25 10:51
Ein Aufwachsen mit zahlreichen Anforderungenising preclinical activity has stimulated tremendous excitement about these agents. The remainder of this chapter reviews the mechanism of action, clinical pharmacology, toxicity profiles, and antitumor activities of these drugs used either as single agents or in combination chemotherapy.作者: 向外 時(shí)間: 2025-3-25 12:45 作者: 拍翅 時(shí)間: 2025-3-25 15:53 作者: 雀斑 時(shí)間: 2025-3-25 21:20
0927-3042 rapy usingvarious skin malignancies. In prostate cancer, estramustine phosphatewill likely play an expanding role. Taxanes are restructuringtreatment regimens i978-1-4613-5829-9978-1-4615-2007-8Series ISSN 0927-3042 Series E-ISSN 2509-8497 作者: chandel 時(shí)間: 2025-3-26 03:22 作者: 著名 時(shí)間: 2025-3-26 08:23 作者: 領(lǐng)巾 時(shí)間: 2025-3-26 12:16
Die Suche nach der eigenen Identit?tsed following treatment with, more conventional doses of the same agents. Some patients achieve prolonged disease-free survival and are possibly cured. This modality has been associated with substantial morbidity and morality, however, principally due to the relatively prolonged period of pancytopen作者: 掃興 時(shí)間: 2025-3-26 12:52 作者: ASSAY 時(shí)間: 2025-3-26 19:06 作者: harrow 時(shí)間: 2025-3-26 23:27 作者: cuticle 時(shí)間: 2025-3-27 02:54 作者: 為現(xiàn)場 時(shí)間: 2025-3-27 06:29 作者: 單調(diào)性 時(shí)間: 2025-3-27 10:05
Concepts, Mechanisms, and New Targets for Chemotherapy978-1-4615-2007-8Series ISSN 0927-3042 Series E-ISSN 2509-8497 作者: 返老還童 時(shí)間: 2025-3-27 17:30
Ein Blick zurück auf die ?Jugend von heute“. After failure of hormonal manipulation, the outlook for these patients remains dismal, in spite of the wide use of combination chemotherapy and the introduction of anthracyclines, currently considered to be the most active drugs for this disease.作者: Bumptious 時(shí)間: 2025-3-27 17:46 作者: 攤位 時(shí)間: 2025-3-28 00:51 作者: fringe 時(shí)間: 2025-3-28 02:54
https://doi.org/10.1007/978-1-4615-2007-8DNA; breast cancer; cancer; carcinoma; chemotherapy; clinical trial; diseases; neoplasm; prostate cancer; sys作者: 老巫婆 時(shí)間: 2025-3-28 09:12
978-1-4613-5829-9Springer Science+Business Media New York 1995作者: modish 時(shí)間: 2025-3-28 11:31 作者: 描繪 時(shí)間: 2025-3-28 16:57
Ein Aufwachsen mit zahlreichen Anforderungenn, demonstrated encouraging activity in early clinical testing but was abandoned due to unpredictable toxicity. In 1985, Hsaing and Liu observed that the cytotoxic effect of camptothecin requires the nuclear enzyme topoisomerase I [2]. This finding coincided with the development of the semisynthetic作者: Munificent 時(shí)間: 2025-3-28 19:18
Ein Aufwachsen mit zahlreichen Anforderungenaboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug. The selected cells often display crossresistance to a number of functionally and structurally distinct drugs. This drug-resistant phenotype is referred to as . (MDR). Currently, the bes作者: 花束 時(shí)間: 2025-3-29 00:39 作者: 無政府主義者 時(shí)間: 2025-3-29 05:12
Das Konzept der Entwicklungsaufgaben toxicity from drugs are poorly characterized. One of the most important factors for our lack of understanding of drug resistance is that patient tumor specimens are infrequently studied directly. Most of our knowledge has been obtained from in vitro studies with tumor cell lines, with a limited num作者: indenture 時(shí)間: 2025-3-29 10:06
https://doi.org/10.1007/978-3-531-91093-2xyuridylate (FdUMP) inhibition of thymidylate synthase (TS) occurs by the ordered, sequential binding of TS, FdUMP, and then 5-10-methylenetetrahydrofolate (CH.FH.) [.–.]. In cell-free kinetic systems, CH.FH. must be in excess for maximal TS-FdUMP-CH.FH. ternary complex formation and complete inhibi作者: 良心 時(shí)間: 2025-3-29 12:04
Die Suche nach der eigenen Identit?ts (SCCs) [1]. Most of these cancers are easily treated and cured via a primary resection by a surgeon or dermatologist. A small portion of these, however, become locally aggressive or even metastasize. This infrequent event (approximately 25,000 cases per year) presents a difficult challenge to the 作者: 商品 時(shí)間: 2025-3-29 16:06
Das Konzept der Entwicklungsaufgabenigned and developed for the treatment of breast cancer following the observation of the presence of estrogen receptors in normal breast tissue and tumors [2]. The design of the drug was based on the hypothesis that conjugation of 17-B estradiol with the alkylating agent nor-nitrogen mustard would al作者: 沙草紙 時(shí)間: 2025-3-29 23:11 作者: FIN 時(shí)間: 2025-3-30 01:48 作者: BOLT 時(shí)間: 2025-3-30 05:22
Markus Bestehornmiology, biology, and pathology of the disease.Examines the .This book is based on results of the 2010 International Symposium on Dupuytren‘s disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated conditi作者: Scintigraphy 時(shí)間: 2025-3-30 11:07
