標(biāo)題: Titlebook: Concepts and Principles of Pharmacology; 100 Years of the Han James E. Barrett,Clive P. Page,Martin C. Michel Book 2019 Springer Nature Swi [打印本頁(yè)] 作者: 可樂(lè) 時(shí)間: 2025-3-21 19:22
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書(shū)目名稱Concepts and Principles of Pharmacology讀者反饋
書(shū)目名稱Concepts and Principles of Pharmacology讀者反饋學(xué)科排名
作者: 通情達(dá)理 時(shí)間: 2025-3-21 23:58 作者: 墻壁 時(shí)間: 2025-3-22 01:20
Monoclonal Antibodies: Past, Present and Future,study population, route/s of administration, starting dose, study design and the potential difference in pharmacokinetics in healthy subjects compared to patients expressing the target antigen..Of the ever-increasing diversity of therapeutic indications for mAbs, we have concentrated on two that hav作者: VICT 時(shí)間: 2025-3-22 06:20 作者: 有惡意 時(shí)間: 2025-3-22 10:01
Ion Channel Pharmacology for Pain Modulation, study of ASIC or PIEZO channels in pain signaling is in an early stage, whereas antagonism of the purinergic P2X. channels has been reported to provide beneficial effects in chronic intractable cough. The present chapter covers these intriguing channels in great detail, highlighting their diverse m作者: photophobia 時(shí)間: 2025-3-22 13:03
Mechanistic Image-Based Modelling: Concepts and Applications,mage-based modelling in pharmaceutical industry holds promise to further advance model-informed drug discovery and development and aids substantially in our understanding of drug pharmacokinetic, pharmacodynamic and ultimately de-risk drug development.作者: photophobia 時(shí)間: 2025-3-22 21:02
The Microbiome and Its Potential for Pharmacology,iew we briefly discuss the nature of human microbial ecosystems and with pathologies and biological processes linked to the microbiome. We then review emerging computational metagenomic, metabolomic, and wet lab techniques researchers are using today to learn about the roles host-microbial interacti作者: anatomical 時(shí)間: 2025-3-22 22:40
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems PharmaME-Tox. Human MPS experimental models have been developed to address the relatively low concordance of human disease and ADME-Tox with engineered, experimental animal models of disease. The integration of the QSP paradigm with the use of human MPS has the potential to enhance the process of drug dis作者: 使成整體 時(shí)間: 2025-3-23 01:45
The Future of Clinical Trial Design: The Transition from Hard Endpoints to Value-Based Endpoints,disease at home or at work. Furthermore, they will measure the subjective experience of subjects in relation to other objective measurements. Ideally, the endpoints are suitable for individual assessment of the effect of an intervention. The value-based clinical trial of the future will have a low b作者: 不發(fā)音 時(shí)間: 2025-3-23 06:04
Pharmacoepidemiology,The methods can be exposure or disease-based cohorts or event-driven case-based studies, tailored to the specific questions to be answered. They rely on scrupulous analysis and execution of impeccable methodology, to ensure the most reliable results possible..Pharmacoepidemiology requires knowledge 作者: amyloid 時(shí)間: 2025-3-23 12:36
Formation of Surface Compounds on Electrodesh pharmacology as a viable and valuable contributor to the medical sciences met with considerable resistance and challenges. However, the persistence and dedication of these early pharmacologists placed pharmacology on a firm foundation from which to spread this discipline globally, leading ultimate作者: Neonatal 時(shí)間: 2025-3-23 17:38
Modifications of Bayes Procedures,wide array of functional assay technologies that can measure the effects of molecules on drug targets. In addition, the introduction of molecular dynamics, the appreciation of the allosteric nature of receptors, protein X-ray crystal structures, genetic manipulations in the form of knock-out and kno作者: Projection 時(shí)間: 2025-3-23 18:13
Hossein Boomari,Soheila Farokhistudy population, route/s of administration, starting dose, study design and the potential difference in pharmacokinetics in healthy subjects compared to patients expressing the target antigen..Of the ever-increasing diversity of therapeutic indications for mAbs, we have concentrated on two that hav作者: happiness 時(shí)間: 2025-3-23 22:13
https://doi.org/10.1007/978-3-030-57852-7at resulted in the diversification of inhaler technologies with significantly enhanced delivery efficiency, including modern pMDIs, dry powder inhalers and nebuliser systems. There is also great interest in tailoring particle size to deliver drugs to treat specific areas of the respiratory tract. On作者: 血統(tǒng) 時(shí)間: 2025-3-24 04:34 作者: Initial 時(shí)間: 2025-3-24 09:15
Unification of Hypergraph ,-Termsmage-based modelling in pharmaceutical industry holds promise to further advance model-informed drug discovery and development and aids substantially in our understanding of drug pharmacokinetic, pharmacodynamic and ultimately de-risk drug development.作者: 支形吊燈 時(shí)間: 2025-3-24 13:32
Mohammad Reza Mousavi,Ji?í Sgalliew we briefly discuss the nature of human microbial ecosystems and with pathologies and biological processes linked to the microbiome. We then review emerging computational metagenomic, metabolomic, and wet lab techniques researchers are using today to learn about the roles host-microbial interacti作者: MAUVE 時(shí)間: 2025-3-24 16:47 作者: OVER 時(shí)間: 2025-3-24 19:28 作者: depreciate 時(shí)間: 2025-3-25 00:46 作者: infringe 時(shí)間: 2025-3-25 04:23 作者: 等待 時(shí)間: 2025-3-25 07:56
Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications,eases, immunological diseases, nephrological diseases, gastrointestinal diseases, pulmonary/respiratory diseases, and many cancers. With more ion channel structures are being solved and functional robust assays are being developed, there are tremendous opportunities for identifying specific modulators targeting ion channels for new therapy.作者: 敲竹杠 時(shí)間: 2025-3-25 15:29 作者: Entirety 時(shí)間: 2025-3-25 18:14 作者: INERT 時(shí)間: 2025-3-25 21:39
Saeid Hanifehnezhad,Ardeshir Dolatiacokinetics, prior to drug administration, via an analysis of pre-dose metabolite profiles. This article will review the development of pharmacometabonomics as a new field of science that has much promise in helping to deliver more effective personalised medicine, a major goal of twenty-first century healthcare.作者: 起來(lái)了 時(shí)間: 2025-3-26 04:12 作者: 珍奇 時(shí)間: 2025-3-26 08:04 作者: 確定 時(shí)間: 2025-3-26 12:17 作者: 跟隨 時(shí)間: 2025-3-26 13:56
Some Properties of Continuous Yao Graph,eases, immunological diseases, nephrological diseases, gastrointestinal diseases, pulmonary/respiratory diseases, and many cancers. With more ion channel structures are being solved and functional robust assays are being developed, there are tremendous opportunities for identifying specific modulators targeting ion channels for new therapy.作者: 侵略主義 時(shí)間: 2025-3-26 20:01
Barbara Cafarelli,Corrado Crocettaared to another drug in comparator trials, is reached. Ignorance towards the placebo effect, which was common in the past, is no longer acceptable; instead, it should be the goal of all therapeutic trials to minimize the placebo effect in clinical trials, while utilizing and maximizing it in clinical routine.作者: 詞匯 時(shí)間: 2025-3-26 21:06 作者: GRATE 時(shí)間: 2025-3-27 05:03
Placebos and the Placebo Effect in Drug Trials,ared to another drug in comparator trials, is reached. Ignorance towards the placebo effect, which was common in the past, is no longer acceptable; instead, it should be the goal of all therapeutic trials to minimize the placebo effect in clinical trials, while utilizing and maximizing it in clinical routine.作者: 表示向下 時(shí)間: 2025-3-27 07:21
Why Are New Drugs Expensive and How Can They Stay Affordable?,t 90% attrition rate after start of clinical development. While many factors will be required in concert to keep innovative medicines affordable, reducing attrition appears to be the factor with the greatest potential to contain escalating drug development costs and thereby medication expenditures.作者: 讓空氣進(jìn)入 時(shí)間: 2025-3-27 12:23
Genetically Encoded Fluorescent Calcium and Voltage Indicators,nces. During recent years, limitations of small molecule-based indicators have been overcome by the development of genetically encoded indicators. Here we focus on fluorescent calcium and voltage indicators and point to their applications mainly in neurosciences.作者: electrolyte 時(shí)間: 2025-3-27 17:10
Book 2019atically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.作者: liposuction 時(shí)間: 2025-3-27 20:10 作者: 支柱 時(shí)間: 2025-3-28 00:36
Modifications of Bayes Procedures,ystems became more interested in the probes than the systems. Pharmacologists were always, and in many ways still are, bound to study drugs in systems they do not fully understand. Under these circumstances, null methods were the main ways in which conclusions about biologically active molecules wer作者: 臭名昭著 時(shí)間: 2025-3-28 03:05
https://doi.org/10.1007/978-1-4612-2088-6lonal antibodies have also been found to provide valuable therapeutic approaches for modulating tumour pathophysiology. As our knowledge of cancer biology improves, the specificity of this new generation of drugs is generally delivering an improved therapeutic ratio compared to traditional cytotoxic作者: ATRIA 時(shí)間: 2025-3-28 07:44
Hossein Boomari,Soheila Farokhi were originally produced by hybridomas grown in culture and, subsequently, by recombinant DNA technology using mammalian cell expression systems. The antigen-binding region of the mAb is formed by the variable domains of the heavy and light chains and contains the complementarity-determining region作者: 完成才會(huì)征服 時(shí)間: 2025-3-28 11:21
https://doi.org/10.1007/978-3-030-57852-7ctive and safe means of treating the lungs is to deliver drugs directly to the airways. Surprisingly, the delivery of therapeutic aerosols has a rich history dating back more than 2,000?years to Ayurvedic medicine in India, but in many respects, the introduction of the first pressurised metered-dose作者: 小淡水魚(yú) 時(shí)間: 2025-3-28 16:56 作者: 明智的人 時(shí)間: 2025-3-28 21:38 作者: 敲詐 時(shí)間: 2025-3-28 23:21 作者: Allowance 時(shí)間: 2025-3-29 03:36
Unification of Hypergraph ,-Termsally, physiologically and/or medically relevant information, however, remains challenging. In contrast, mechanistic computational modelling provides a means to formalise and dissect mechanisms governing the behaviour of complex systems. However, its application often is limited due to the lack of re作者: 本土 時(shí)間: 2025-3-29 09:48
Saeid Hanifehnezhad,Ardeshir Dolatiassess their health or other status and their responses to experimental interventions. Metabonomics is thus widely used in disease diagnosis and in understanding responses to therapies such as drug administration. Pharmacometabonomics, also known as pharmacometabolomics, is a related methodology but作者: 鞠躬 時(shí)間: 2025-3-29 15:16
Mohammad Reza Mousavi,Ji?í Sgalll practice. Recent advances in multi-“omics” techniques have dramatically improved our understanding of the constituents of the microbiome and their functions. The implications of this research for human health, including microbiome links to obesity, drug metabolism, neurological diseases, cancer, a作者: 考古學(xué) 時(shí)間: 2025-3-29 16:27 作者: miscreant 時(shí)間: 2025-3-29 20:54
Topics in Theoretical and Applied Statisticsby Austin Bradford Hill. This standard has produced enormous amounts of high-quality evidence, resulting in evidence-based clinical guidelines for physicians. However, the current trial paradigm needs to evolve because of the ongoing decrease of the incidence of hard endpoints and spiraling trial co作者: biosphere 時(shí)間: 2025-3-30 00:23
Barbara Cafarelli,Corrado Crocettaase the placebo effect in randomized placebo-controlled trials. These factors can be subdivided into four groups, and while not all factors are effective in every study and under all clinical conditions, they show on the whole that – even under the ideal condition of drug therapy, where blinded plac作者: 勛章 時(shí)間: 2025-3-30 06:10
Lidia Rivoli,Rosanna Verde,Antonio Irpinonical trials (RCT), comparing them to placebo or to existing drugs. However, RCT are by nature limited in their extent, and the often stringent inclusion and exclusion criteria destined to provide for homogeneous study populations reduce the generalizability of RCT results..The post-authorization ev作者: 人類(lèi) 時(shí)間: 2025-3-30 09:03
Topics in Theoretical and Applied Statisticsvalence of preventable diseases such as type 2 diabetes. This includes increasing expenditures for medicines, although these increases when expressed as a share of overall societal wealth are more moderate than often claimed. An increasing use of generic medicines (currently about 90% of all prescri作者: fetter 時(shí)間: 2025-3-30 15:39
https://doi.org/10.1007/978-3-030-35362-9History; Nobel prize; biased agonism; allosteric modulation; immunopharmacology; monoclonal antibodies; si作者: 玩笑 時(shí)間: 2025-3-30 20:25 作者: 沒(méi)有希望 時(shí)間: 2025-3-30 22:38
James E. Barrett,Clive P. Page,Martin C. MichelBroadens the understanding of past and present pharmacology as basis of future treatments.Reinforces basic principles of pharmacology as the foundation of modern drug discovery.Enriches understanding 作者: CREST 時(shí)間: 2025-3-31 04:38
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/c/image/234906.jpg作者: concise 時(shí)間: 2025-3-31 08:07 作者: Herd-Immunity 時(shí)間: 2025-3-31 10:11 作者: 確定 時(shí)間: 2025-3-31 15:14 作者: Esophagitis 時(shí)間: 2025-3-31 18:32
Emergent Concepts of Receptor Pharmacology,ystems became more interested in the probes than the systems. Pharmacologists were always, and in many ways still are, bound to study drugs in systems they do not fully understand. Under these circumstances, null methods were the main ways in which conclusions about biologically active molecules wer作者: 浸軟 時(shí)間: 2025-3-31 22:01
The Evolving Landscape of Cancer Therapeutics,lonal antibodies have also been found to provide valuable therapeutic approaches for modulating tumour pathophysiology. As our knowledge of cancer biology improves, the specificity of this new generation of drugs is generally delivering an improved therapeutic ratio compared to traditional cytotoxic作者: MUT 時(shí)間: 2025-4-1 02:58
