標(biāo)題: Titlebook: Computational Vaccine Design; Pedro A. Reche Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springe [打印本頁] 作者: hearken 時間: 2025-3-21 16:58
書目名稱Computational Vaccine Design影響因子(影響力)
作者: 結(jié)束 時間: 2025-3-21 21:51
Intermezzo – von der Klassik zur Modernef candidate peptides is validated ex vivo using PBMCs from HLA-typed individuals. This protocol compiles the essential information for executing the whole pipeline while focusing on the candidate epitope prioritizing scheme.作者: impaction 時間: 2025-3-22 02:00 作者: 鍍金 時間: 2025-3-22 07:48
Wer soll die St?dtebahnen bauen ?based vaccination strategies. In this chapter, we provide a pipeline to exploit the full capabilities of NetCleave, an open-source and retrainable algorithm for predicting the C-terminal antigen processing for the MHC-I and MHC-II pathways.作者: 講個故事逗他 時間: 2025-3-22 11:01
Clustering and Annotation of T Cell Receptor Repertoireshniques to analyze and annotate full TCR repertoire data. The method is explained using data from a published yellow fever virus (YFV) vaccination study in healthy individuals. The TCR repertoire of one individual is studied before and 2 weeks after vaccination, using an efficient clustering method and identification of YFV-specific TCRs.作者: CON 時間: 2025-3-22 15:39
CD4+ T Cell Epitope Identification from Complex Parasite Antigen Mixturesf candidate peptides is validated ex vivo using PBMCs from HLA-typed individuals. This protocol compiles the essential information for executing the whole pipeline while focusing on the candidate epitope prioritizing scheme.作者: CON 時間: 2025-3-22 18:04
Updates on Databases of Allergens and Allergen-Epitopesumber of databases have therefore been developed that serve as repositories of molecular information of allergens. In this chapter, we discuss the five most important widely used allergen databases that might be helpful for the research community working on molecular allergology.作者: absorbed 時間: 2025-3-23 01:09 作者: 公司 時間: 2025-3-23 02:35
Book 2023e Design: Methods and Protocols .aims to?reflect on the rigorous and imaginative use of computational technologies to help catalyze future efforts and to improve global public health through the development of a broad range of novel vaccines..作者: 航海太平洋 時間: 2025-3-23 09:25
Bericht der Universit?t G?ttingenrena and there is an increasing interest in designing vaccines to treat human ailments like cancer and chronic inflammatory diseases. In this chapter, we focus on prophylactic vaccines against infectious diseases, providing an overview on immunology principles underlying immunization and on how vaccines work and are designed.作者: 放牧 時間: 2025-3-23 11:38 作者: oxidize 時間: 2025-3-23 17:35 作者: calorie 時間: 2025-3-23 19:29 作者: Ligneous 時間: 2025-3-24 00:18
EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxvirusesional design of T cell epitope-based vaccines. In this chapter, we describe the main features of EPIPOX and exemplify its use, retrieving orthopoxvirus-specific T cell epitopes with features set to enhance their immunogenicity. EPIPOX is available for free public use at ..作者: Cumbersome 時間: 2025-3-24 04:18
Design of Linear B Cell Epitopes and Evaluation of Their Antigenicity, Allergenicity, and Toxicity: n an antigen constitutes one of the important steps in the design of multi-epitope-based vaccines. This chapter explains the prediction of linear B cell epitopes in an antigen as well as their allergenicity, antigenicity, and toxicity by using online tools.作者: Invigorate 時間: 2025-3-24 07:15
Book 2023cs and system immunology, databases, prediction of antigenicity and immunogenicity, and computational vaccinology. Written in the format of the highly successful?.Methods in Molecular Biology?.series, each chapter includes an introduction to the topic, lists necessary materials and reagents, include作者: maroon 時間: 2025-3-24 10:47
1064-3745 ation advice from the expertsThis volume explores computational vaccine design and the technologies that support it.? Chapters have been divided into four parts detailing immunonics and system immunology, databases, prediction of antigenicity and immunogenicity, and computational vaccinology. Writte作者: 華而不實(shí) 時間: 2025-3-24 16:14 作者: 著名 時間: 2025-3-24 21:03
https://doi.org/10.1007/978-3-642-50786-1 methods, which are currently available as user-friendly . servers, to predict B cell epitopes in proteins. A final assessment to validate these predictions is done by recurring to the Immune Epitope Database (IEDB).作者: plasma 時間: 2025-3-25 00:37
TSNAD and TSNAdb: The Useful Toolkit for Clinical Application of Tumor-Specific Neoantigensoantigens based on pan-cancer immunogenomics analyses. In this chapter, we describe the usage of TSNAD and TSNAdb for the clinical application of neoantigens. The latest version of TSNAD is available at ., and the latest version of TSNAdb is available at ..作者: Intersect 時間: 2025-3-25 04:14 作者: 傻 時間: 2025-3-25 08:28 作者: 抑制 時間: 2025-3-25 15:16 作者: 詼諧 時間: 2025-3-25 19:10 作者: 沒花的是打擾 時間: 2025-3-25 20:50 作者: angina-pectoris 時間: 2025-3-26 01:57
Prediction of TAP Transport of Peptides with Variable Length Using TAPREGhis chapter, we describe the use of TAPREG, a tool for predicting TAP binding affinity that has been enhanced to identify potential CD8 T cell epitope precursors transported by TAP. TAPREG is available for free public use at ..作者: Goblet-Cells 時間: 2025-3-26 05:48
https://doi.org/10.1007/978-3-662-49476-9tion of epitopes for the influenza hemagglutinin (HA) is shown for isolated human mAbs and pooled serum from HA-immunized mice. This method is versatile, high-throughput, and can be adapted to several antigens.作者: 投票 時間: 2025-3-26 12:05
https://doi.org/10.1007/978-3-8274-3018-2have provided sufficient details to enable the wet experimentalist to employ this computational methodology in their research objective. Scripts/programs are extensively described in this chapter and freely accessible through the provided link.作者: Iniquitous 時間: 2025-3-26 15:50 作者: 釘牢 時間: 2025-3-26 16:50
Der St?dteverkehr und die Ferneisenbahnenr the development of specific vaccines and diagnostics. In this chapter, we describe the methodology utilized to derive two sibling resources, the Immune Epitope Database (IEDB) and Cancer Epitope Database and Analysis Resource (CEDAR), to specifically host this data, and make them freely available to the scientific community.作者: FOLD 時間: 2025-3-26 22:42
https://doi.org/10.1007/978-3-642-50786-1his chapter, we describe the use of TAPREG, a tool for predicting TAP binding affinity that has been enhanced to identify potential CD8 T cell epitope precursors transported by TAP. TAPREG is available for free public use at ..作者: 一大塊 時間: 2025-3-27 03:52 作者: 得罪人 時間: 2025-3-27 05:34
Unbiased, High-Throughput Identification of T Cell Epitopes by ELISPOTting of all peptides that constitute the potential epitope space in that person. The goal of comprehensive, high-throughput epitope mapping can be readily established by the methods described in this chapter.作者: 步兵 時間: 2025-3-27 11:33 作者: Mucosa 時間: 2025-3-27 17:10
https://doi.org/10.1007/978-3-662-49476-9ical states. This protocol has three parts: (1) data preprocessing, (2) labeling of reference PBMC SCT datasets and training supervised ML models, and (3) labeling new PBMC datasets from disease samples. This protocol enables building classification models that are of high accuracy and efficiency. O作者: 亞麻制品 時間: 2025-3-27 19:56 作者: Neutropenia 時間: 2025-3-28 01:55 作者: Painstaking 時間: 2025-3-28 02:44
https://doi.org/10.1007/978-3-662-49476-9yer interferometry (BLI)-based methods to evaluate such epitopes and permit simultaneous analysis of antibodies from several sources, including monoclonal antibodies (mAbs) and polyclonal serum antibodies (pAbs). Using previously characterized antibodies with known epitopes as controls, the distribu作者: Ingrained 時間: 2025-3-28 10:21 作者: Ptosis 時間: 2025-3-28 11:36
https://doi.org/10.1007/978-3-662-49476-9e immune system, infectious diseases, cancer, and vaccine development. Single-cell transcriptomics (SCT) allows the labeling of cell types by gene expression patterns from biological samples. Classifying cells into cell types and states is essential for single-cell analyses, especially in the classi作者: 幼稚 時間: 2025-3-28 15:12 作者: 迎合 時間: 2025-3-28 18:54
Intermezzo – von der Klassik zur Moderne vaccine development. In this chapter, we provide a comprehensive picture of a pipeline that can be applied to virtually any complex antigen to overcome different limitations. Antigens are characterized by Mass Spectrometry to determine the available protein sources and their abundances. A reconstit作者: 笨拙的我 時間: 2025-3-29 01:35 作者: 自然環(huán)境 時間: 2025-3-29 06:30 作者: 確定方向 時間: 2025-3-29 08:32 作者: GRILL 時間: 2025-3-29 14:57
https://doi.org/10.1007/978-3-642-50786-1diseases via respiratory or gastrointestinal routes, respectively. A major setback in the clinical management of allergies is the unavailability of purified allergens required for diagnostic purposes. Furthermore, manipulation of allergen sequences and structures by employing protein-engineering app作者: 一起平行 時間: 2025-3-29 18:03
Der St?dteverkehr und die Ferneisenbahnention. TSNAD is the first one-stop neoantigen prediction tool from next-generation sequencing data, and TSNAdb provides both predicted and validated neoantigens based on pan-cancer immunogenomics analyses. In this chapter, we describe the usage of TSNAD and TSNAdb for the clinical application of neoa作者: HOWL 時間: 2025-3-29 22:13
https://doi.org/10.1007/978-3-642-50786-1llection of T cell epitopes that are shared by eight pathogenic orthopoxviruses, including variola minor and major?strains, monkeypox, cowpox, and vaccinia viruses. In EPIPOX, users can select T cell epitopes attending to the predicted binding to distinct major histocompatibility molecules (MHC) and作者: DENT 時間: 2025-3-30 03:50
https://doi.org/10.1007/978-3-642-50786-1ic diseases. Preventive vaccines are mainly based on the induction of highly specific neutralizing antibodies. This chapter deals with some prediction methods, which are currently available as user-friendly . servers, to predict B cell epitopes in proteins. A final assessment to validate these predi作者: Instrumental 時間: 2025-3-30 04:16 作者: Peak-Bone-Mass 時間: 2025-3-30 11:13 作者: 現(xiàn)任者 時間: 2025-3-30 13:15 作者: Hyperopia 時間: 2025-3-30 20:12 作者: 平庸的人或物 時間: 2025-3-30 23:43 作者: Incise 時間: 2025-3-31 02:54
https://doi.org/10.1007/978-1-0716-3239-0Immune system; Vaccine development; Immunomics; Databases; Systems vaccinology作者: 厚臉皮 時間: 2025-3-31 06:01
978-1-0716-3241-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: ALIEN 時間: 2025-3-31 10:45 作者: Invertebrate 時間: 2025-3-31 17:12
Vaccine Design: An Introduction,ons that are capable of stimulating the immune system to confer protective immunity against a particular harmful pathogen/agent. Vaccine design and development have evolved through the years. Early vaccines were obtained with little implementation of technology and in the absence of fundamental know作者: STENT 時間: 2025-3-31 19:29
Epitope Binning of Monoclonal and Polyclonal Antibodies by Biolayer Interferometryyer interferometry (BLI)-based methods to evaluate such epitopes and permit simultaneous analysis of antibodies from several sources, including monoclonal antibodies (mAbs) and polyclonal serum antibodies (pAbs). Using previously characterized antibodies with known epitopes as controls, the distribu
