標(biāo)題: Titlebook: Computational Methods in Systems Biology; 16th International C Milan ?e?ka,David ?afránek Conference proceedings 2018 Springer Nature Switz [打印本頁] 作者: Randomized 時間: 2025-3-21 16:50
書目名稱Computational Methods in Systems Biology影響因子(影響力)
書目名稱Computational Methods in Systems Biology影響因子(影響力)學(xué)科排名
書目名稱Computational Methods in Systems Biology網(wǎng)絡(luò)公開度
書目名稱Computational Methods in Systems Biology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Computational Methods in Systems Biology被引頻次
書目名稱Computational Methods in Systems Biology被引頻次學(xué)科排名
書目名稱Computational Methods in Systems Biology年度引用
書目名稱Computational Methods in Systems Biology年度引用學(xué)科排名
書目名稱Computational Methods in Systems Biology讀者反饋
書目名稱Computational Methods in Systems Biology讀者反饋學(xué)科排名
作者: Merited 時間: 2025-3-21 22:39 作者: Commentary 時間: 2025-3-22 03:49 作者: 欲望小妹 時間: 2025-3-22 07:06
Formal Analysis of Network Motifs, we extend this approach to allow reasoning about the requirement for specific network motifs as a way of explaining how these behaviors arise. We illustrate the approach by analyzing the motifs involved in sign-sensitive delay and pulse generation. We demonstrate the scalability and biological rel作者: 享樂主義者 時間: 2025-3-22 12:43
Buffering Gene Expression Noise by MicroRNA Based Feedforward Regulationble than the second. Finally, we identify a special parametric regime, supporting a broad range of behaviour, in which the distribution can be analytically described in terms of the confluent hypergeometric limit function. We verify our analysis against large-scale kinetic Monte Carlo simulations. O作者: 譏諷 時間: 2025-3-22 15:22 作者: 譏諷 時間: 2025-3-22 18:56 作者: opinionated 時間: 2025-3-22 21:51 作者: Expiration 時間: 2025-3-23 01:47
Composable Rate-Independent Computation in Continuous Chemical Reaction Networksiderata, permitting implementations that violate mass-action kinetics, or even “well-mixedness”, and allowing the systematic construction of complex computation via modular design. We show that to construct composable rate-independent CRNs, it is necessary and sufficient to ensure that the output sp作者: Cacophonous 時間: 2025-3-23 05:31
0302-9743 ices..Chapters 3, 9 and 10 are available open access under a CreativeCommons Attribution 4.0 International License via link.springer.com..978-3-319-99428-4978-3-319-99429-1Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: 虛情假意 時間: 2025-3-23 12:26
Characterization of the Experimentally Observed Clustering of VEGF Receptors作者: Supplement 時間: 2025-3-23 14:04 作者: 一再煩擾 時間: 2025-3-23 18:44 作者: LAIR 時間: 2025-3-23 22:43
https://doi.org/10.1007/978-1-4419-9120-1 implemented the encodings in a highly configurable tool and applied to a couple of found-in-nature VTSs and several synthetic graphs. Our results demonstrate that our method can scale up?to the graphs of interest.作者: inculpate 時間: 2025-3-24 04:48
https://doi.org/10.1007/978-1-4419-9120-1, we extend this approach to allow reasoning about the requirement for specific network motifs as a way of explaining how these behaviors arise. We illustrate the approach by analyzing the motifs involved in sign-sensitive delay and pulse generation. We demonstrate the scalability and biological rel作者: freight 時間: 2025-3-24 07:16
Denise Belchetz,Kenneth Leithwoodble than the second. Finally, we identify a special parametric regime, supporting a broad range of behaviour, in which the distribution can be analytically described in terms of the confluent hypergeometric limit function. We verify our analysis against large-scale kinetic Monte Carlo simulations. O作者: 抗生素 時間: 2025-3-24 14:22
https://doi.org/10.1007/978-3-658-38276-6ems being experimented on, together with the discrete events representing the liquid-handling steps of biological protocols. We present both a deterministic and a stochastic semantics to this language, both defined in terms of hybrid processes. In particular, the stochastic semantics captures uncert作者: Texture 時間: 2025-3-24 17:52 作者: 后退 時間: 2025-3-24 21:51
,How to Get Your Legislator’s Attention,rgy barriers. We apply this model to design catalytic systems with an arbitrarily large energy barrier to uncatalyzed reactions. Our results yield robust amplifiers using DNA strand displacement, a popular technology for engineering synthetic reaction pathways, and suggest design strategies for prev作者: enormous 時間: 2025-3-25 03:05
https://doi.org/10.1007/978-1-349-06192-1iderata, permitting implementations that violate mass-action kinetics, or even “well-mixedness”, and allowing the systematic construction of complex computation via modular design. We show that to construct composable rate-independent CRNs, it is necessary and sufficient to ensure that the output sp作者: OMIT 時間: 2025-3-25 06:25
0302-9743 held in BRNO, Czech Republic, in September 2018. .The 15 full and 7 short papers presented together with 5 invited talks were carefully reviewed and selected from 46 submissions. Topics of interest include formalisms for modeling ?biological processes; models?and their biological applications; fram作者: tangle 時間: 2025-3-25 08:50 作者: micturition 時間: 2025-3-25 15:09
Stochastic Rate Parameter Inference Using the Cross-Entropy Methodaping) with the cross-entropy method. Also, it can work with incomplete datasets missing some model species, and with multiple datasets originating from experiment repetitions. We evaluate our algorithm on a number of challenging case studies, including bistable systems (Schl?gl’s and toggle switch) and experimental data.作者: PLAYS 時間: 2025-3-25 19:11
A Trace Query Language for Rule-Based Models on a simple example, and then discuss its semantics and implementation for the Kappa language. Finally, we provide a detailed use case where we analyze the dynamics of .-catenin degradation in Wnt signaling from an agent-centric perspective.作者: aesthetic 時間: 2025-3-25 21:52 作者: Working-Memory 時間: 2025-3-26 00:22
https://doi.org/10.1007/978-3-319-66140-7of a CPBN. Thanks to its divide and conquer strategy, the implemented detection algorithm can deal with large and realistic biological networks under both synchronous and asynchronous updating schemes.作者: 炸壞 時間: 2025-3-26 06:54
Inferring Mechanism of Action of an Unknown Compound from Time Series Omics Datanscriptomics, proteomics, and metabolomics data..The work was performed as part of the DARPA Rapid Threat Assessment program, where the challenge was to identify the MoA of a potential threat agent in 30 days or less, using only project generated data, with no recourse to pre-existing databases or published literature.作者: adjacent 時間: 2025-3-26 08:31 作者: Irrepressible 時間: 2025-3-26 15:19
Deborah Ann Jensen,Jennifer A. Tuten on a simple example, and then discuss its semantics and implementation for the Kappa language. Finally, we provide a detailed use case where we analyze the dynamics of .-catenin degradation in Wnt signaling from an agent-centric perspective.作者: 搖晃 時間: 2025-3-26 18:13 作者: MORPH 時間: 2025-3-26 21:02
https://doi.org/10.1007/978-1-4419-9120-1 for finding diverse solutions and then we demonstrate the results of the proposed approach on two different benchmark scenarios in systems biology: (1) an artificial dataset to model . and (2) the . challenge dataset to model breast cancer cell lines.作者: asthma 時間: 2025-3-27 02:16 作者: CLAP 時間: 2025-3-27 07:36 作者: habitat 時間: 2025-3-27 09:54
Computing Diverse Boolean Networks from Phosphoproteomic Time Series Data for finding diverse solutions and then we demonstrate the results of the proposed approach on two different benchmark scenarios in systems biology: (1) an artificial dataset to model . and (2) the . challenge dataset to model breast cancer cell lines.作者: 蝕刻術(shù) 時間: 2025-3-27 14:48 作者: GENRE 時間: 2025-3-27 18:43
Conference proceedings 2018s methods; design, analysis, and verification methods for synthetic biology; methods for biomolecular computing and engineered molecular devices..Chapters 3, 9 and 10 are available open access under a CreativeCommons Attribution 4.0 International License via link.springer.com..作者: Laconic 時間: 2025-3-27 23:25 作者: 少量 時間: 2025-3-28 04:07
https://doi.org/10.1007/978-3-319-99429-1Agent / Discrete Models; Artificial intelligence; Computational Systems Biology; Continuous Models; Data作者: 祖先 時間: 2025-3-28 07:54
978-3-319-99428-4Springer Nature Switzerland AG 2018作者: Iniquitous 時間: 2025-3-28 12:18 作者: cathartic 時間: 2025-3-28 17:11 作者: 擴(kuò)大 時間: 2025-3-28 21:49
Programs to Improve Physical Health,e . dynamics of RNA production of . promoters at the single event level. This dynamics is mostly controlled at the promoter region, which can be engineered with single nucleotide precision. Based on these developments, we propose a new strategy to engineer genes with predefined transcription dynamic作者: 新陳代謝 時間: 2025-3-28 23:21
https://doi.org/10.1007/978-1-4899-0065-4 to High Performance Computing (HPC) facilities, particularly when each cell is described by a detailed model of some intra-cellular pathways and cells are coupled and interacting at the tissue level. Model abstraction can play a crucial role in this setting, by providing simpler models of intra-cel作者: CHOIR 時間: 2025-3-29 04:28
https://doi.org/10.1007/978-1-4419-9120-1an organism, based on information present in its genome. Such models have been designed so that flux balance analysis (FBA) can be applied in order to analyse metabolism under steady state. For this purpose, a biomass function is added to these models as an overall indicator of the model’s viability作者: Interstellar 時間: 2025-3-29 08:21
https://doi.org/10.1007/978-1-4419-9120-1. system has been proposed recently to learn logical models from time series data. It uses Answer Set Programming to enumerate Boolean Networks (BNs) given prior knowledge networks and phosphoproteomic time series data. In the resulting sequence of solutions, similar BNs are typically clustered toge作者: INCH 時間: 2025-3-29 14:49
https://doi.org/10.1007/978-1-4419-9120-1s nodes that are labeled with the containing chemicals and the transport channels are similarly viewed as labeled edges between the nodes. Understanding VTSs is an ongoing area of research and for many cells they are partially known. For example, there may be undiscovered edges, nodes, or their labe作者: 填滿 時間: 2025-3-29 17:20
https://doi.org/10.1007/978-1-4419-9120-1s have been associated with certain dynamical behaviors and define key modules that are important for understanding complex biological programs. Besides studying the properties of motifs in isolation, existing algorithms often evaluate the occurrence frequency of a specific motif in a given biologic作者: 參考書目 時間: 2025-3-29 22:17
Denise Belchetz,Kenneth Leithwoodere we study one such system, which is broadly inspired by the interaction between an mRNA molecule and an antagonistic microRNA molecule encoded by the same gene. The two reaction species are synchronously produced, individually degraded, and the second species (microRNA) exerts an antagonistic pre作者: GUILE 時間: 2025-3-30 00:34 作者: Custodian 時間: 2025-3-30 05:31
https://doi.org/10.1007/978-3-658-38276-6put machinery, while computational models are synthesized or inferred automatically from data. However, integration between automated tasks in the process of biological discovery is still lacking, largely due to incompatible or missing formal representations. While theories are expressed formally as作者: AMPLE 時間: 2025-3-30 11:44
SpringerBriefs in Public Healthe physiology from available patient data and using a mixed integer optimization approach to control blood glucose levels in real-time using the inferred models. First, our approach learns neural networks to predict the future blood glucose values from given data on insulin infusion and their resulti作者: 新鮮 時間: 2025-3-30 12:56 作者: considerable 時間: 2025-3-30 16:57
Deborah Ann Jensen,Jennifer A. Tuten. In our approach, a query consists in a trace pattern along with an expression that depends on the variables captured by this pattern. On a given trace, it evaluates to the multiset of all values of the expression for every possible matching of the pattern. We illustrate our proposed query language作者: 情感 時間: 2025-3-31 00:33
Deborah Ann Jensen,Jennifer A. Tutenists typically spend years working out the MoA for known compounds. MoA determination is especially challenging if there is no prior knowledge and if there is an urgent need to understand the mechanism for rapid treatment and/or prevention of global health emergencies. In this paper, we describe a d作者: Venules 時間: 2025-3-31 04:55 作者: Infirm 時間: 2025-3-31 05:12 作者: 按時間順序 時間: 2025-3-31 11:26
Courses for Non-science Studentscondly, KaSa may provide useful properties to check that what is implemented is what the modeler has in mind and to provide a quick overview of the model for the people who have not written it..The cornerstone of KaSa is a fix-point engine which detects some patterns that may never occur whatever th作者: Ethics 時間: 2025-3-31 13:55
Modeling and Engineering Promoters with Pre-defined RNA Production Dynamics in e . dynamics of RNA production of . promoters at the single event level. This dynamics is mostly controlled at the promoter region, which can be engineered with single nucleotide precision. Based on these developments, we propose a new strategy to engineer genes with predefined transcription dynamic作者: 惡臭 時間: 2025-3-31 19:33
Deep Abstractions of Chemical Reaction Networks to High Performance Computing (HPC) facilities, particularly when each cell is described by a detailed model of some intra-cellular pathways and cells are coupled and interacting at the tissue level. Model abstraction can play a crucial role in this setting, by providing simpler models of intra-cel作者: cuticle 時間: 2025-3-31 23:37
Derivation of a Biomass Proxy for Dynamic Analysis of Whole Genome Metabolic Modelsan organism, based on information present in its genome. Such models have been designed so that flux balance analysis (FBA) can be applied in order to analyse metabolism under steady state. For this purpose, a biomass function is added to these models as an overall indicator of the model’s viability作者: –scent 時間: 2025-4-1 04:19 作者: Fierce 時間: 2025-4-1 09:46
Synthesis for Vesicle Traffic Systemss nodes that are labeled with the containing chemicals and the transport channels are similarly viewed as labeled edges between the nodes. Understanding VTSs is an ongoing area of research and for many cells they are partially known. For example, there may be undiscovered edges, nodes, or their labe作者: 古董 時間: 2025-4-1 12:54
