標(biāo)題: Titlebook: Computational Methods in Synthetic Biology; Mario Andrea Marchisio Book 2015 Springer Science+Business Media New York 2015 CAD programs.DN [打印本頁] 作者: BREED 時間: 2025-3-21 17:36
書目名稱Computational Methods in Synthetic Biology影響因子(影響力)
書目名稱Computational Methods in Synthetic Biology影響因子(影響力)學(xué)科排名
書目名稱Computational Methods in Synthetic Biology網(wǎng)絡(luò)公開度
書目名稱Computational Methods in Synthetic Biology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Computational Methods in Synthetic Biology被引頻次
書目名稱Computational Methods in Synthetic Biology被引頻次學(xué)科排名
書目名稱Computational Methods in Synthetic Biology年度引用
書目名稱Computational Methods in Synthetic Biology年度引用學(xué)科排名
書目名稱Computational Methods in Synthetic Biology讀者反饋
書目名稱Computational Methods in Synthetic Biology讀者反饋學(xué)科排名
作者: enumaerate 時間: 2025-3-21 22:05
Computer-Aided Design of DNA Origami Structuresurable mechanical devices. Of relevance to synthetic biology, DNA origami structures can be delivered to cells where they can perform complicated sense-and-act tasks, and can be used as scaffolds to organize enzymes for enhanced synthesis. The design of DNA origami structures is a complicated matter作者: backdrop 時間: 2025-3-22 01:34
Computational Design of RNA Parts, Devices, and Transcripts with Kinetic Folding Algorithms Implemendevices with predictable behaviors continues to increase. By combining engineered transcript components, such as ribosome binding sites, transcriptional terminators, ligand-binding aptamers, catalytic ribozymes, and aptamer-controlled ribozymes (aptazymes), gene expression in bacteria can be fine-tu作者: 攤位 時間: 2025-3-22 08:28 作者: 豐滿中國 時間: 2025-3-22 09:26
Programming Languages for Circuit Designh level of abstraction through constraints on otherwise unspecified DNA parts. The GEC compiler then selects parts which satisfy the constraints from a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC lang作者: Inertia 時間: 2025-3-22 13:27
Kappa Rule-Based Modeling in Synthetic Biology from the underlying combinatorial complexity. One such rule-based modeling formalism is Kappa, which we introduce to readers in this chapter. We discuss the application of Kappa to three modeling scenarios in synthetic biology: a unidirectional switch based on nitrosylase induction in ., the repres作者: Inertia 時間: 2025-3-22 17:48
Modular Design of Synthetic Gene Circuits with Biological Parts and Pools—on the computer screen and connecting them with hypothetical wires. This procedure, achieved by our add-on for the software ProMoT, was successfully applied to bacterial circuits. Recently, we have extended this design-methodology to eukaryotic cells. Here, highly complex components such as promote作者: 中和 時間: 2025-3-23 00:14
Computationally Guided Design of Robust Gene Circuitsc biology. While systems modeling can aid this process and help reduce the space of design strategies, the unavailability and dynamic variability of kinetic parameters limits the utility of such models. Here, we present a general approach that employs an exhaustive enumeration of network architectur作者: Patrimony 時間: 2025-3-23 03:30 作者: gusher 時間: 2025-3-23 08:17
Feedback Loops in Biological Networkseveral examples, focusing in particular on the mitogen-activated protein kinase (MAPK) pathway, to illustrate the concept that feedback loops are fundamental in determining the overall dynamic behavior of a system. Often, these loops have a structural function and unequivocally define the system beh作者: certain 時間: 2025-3-23 13:29 作者: 撫慰 時間: 2025-3-23 16:45 作者: 阻擋 時間: 2025-3-23 20:45
In Silico Control of Biomolecular Processesrolling precisely the level of a protein of interest will be useful to probe quantitatively the dynamical properties of cellular processes and to drive complex, synthetically-engineered networks. In this chapter we describe a platform for real-time closed-loop control of gene expression in yeast tha作者: squander 時間: 2025-3-23 22:58 作者: Gobble 時間: 2025-3-24 02:51 作者: mosque 時間: 2025-3-24 08:38 作者: 哪有黃油 時間: 2025-3-24 12:51
Modular Design of Synthetic Gene Circuits with Biological Parts and Poolsomplex modules via the joint employment of the software BioNetGen (rule-based modeling) and ProMoT (modularization). In this chapter, we illustrate how to utilize our computational tool for synthetic biology with the in silico implementation of a simple eukaryotic gene circuit that performs the logic AND operation.作者: confederacy 時間: 2025-3-24 17:03 作者: 使厭惡 時間: 2025-3-24 20:09 作者: fidelity 時間: 2025-3-25 01:47
https://doi.org/10.1007/978-1-4842-6461-4ia. Herein, we present our method to carry out such evolutionary design and how to use it to create various types of riboregulators, allowing the systematic de novo design of genetic control systems in synthetic biology.作者: 草率女 時間: 2025-3-25 07:00 作者: Accessible 時間: 2025-3-25 07:33
Computer-Aided Design of DNA Origami Structuresrd crossover patterns for flat, square, and honeycomb DNA origami lattices. Second, we provide a step-by-step tutorial for the design of a simple DNA origami biosensor device, from schematic idea to blueprint creation and to 3D modeling and animation, and explain how careful modeling can facilitate later experimentation in the laboratory.作者: aptitude 時間: 2025-3-25 15:03
Regulatory RNA Design Through Evolutionary Computation and Strand Displacementia. Herein, we present our method to carry out such evolutionary design and how to use it to create various types of riboregulators, allowing the systematic de novo design of genetic control systems in synthetic biology.作者: Foregery 時間: 2025-3-25 16:24 作者: deforestation 時間: 2025-3-25 20:06
Book 2015and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful .Methods in Molecular Biology. series format, the chapters include the kind of detailed description and implementation advice that is crucial for g作者: 知道 時間: 2025-3-26 02:20
Feedback Loops in Biological Networksavior. We conclude with numerical simulations highlighting the potential for bistability and oscillations of the MAPK pathway re-engineered through synthetic promoters and RNA transducers to include positive and negative feedback loops.作者: 出血 時間: 2025-3-26 08:06
Book 2015etting optimal results in the laboratory..?.Authoritative and practical, .Computational Methods in Synthetic Biology. serves as a guide to plan .in silico. the .in vivo. or .in vitro. construction of a variety of synthetic bio-circuits..作者: 軍械庫 時間: 2025-3-26 12:16 作者: HAUNT 時間: 2025-3-26 15:17 作者: 改變立場 時間: 2025-3-26 20:09 作者: Anticoagulants 時間: 2025-3-26 23:18
https://doi.org/10.1007/978-3-658-29889-0a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC language and compiler is available through a Web tool which also provides functionality, e.g., for simulation of designed circuits.作者: 會犯錯誤 時間: 2025-3-27 03:59 作者: 夾克怕包裹 時間: 2025-3-27 08:28
Computational Protein Design Methods for Synthetic Biologyis described here consisting of (a) searching in the sequence, structure or chemical spaces for the desired function and associated protein templates; (b) finding the list of potential hot regions to mutate in the parent proteins; and (c) performing in silico screening of mutants with predicted improved properties.作者: Collected 時間: 2025-3-27 09:34 作者: Fraudulent 時間: 2025-3-27 15:30
Computationally Guided Design of Robust Gene Circuitsinetic parameters limits the utility of such models. Here, we present a general approach that employs an exhaustive enumeration of network architectures to suggest topologies that robustly enable a desired behavior.作者: 攝取 時間: 2025-3-27 20:05 作者: overhaul 時間: 2025-3-28 01:45 作者: 不可比擬 時間: 2025-3-28 03:32
https://doi.org/10.1007/978-3-658-29889-0can model biological interactions both at the genetic and the protein–protein interaction level, resulting in detailed stochastic models accounting naturally for transcriptional and translational resource usage. We also hope to impart the intuitively modular nature of the modeling processes involved作者: 制造 時間: 2025-3-28 06:46
https://doi.org/10.1007/978-3-658-29889-0 over 70 years. With the first complete solution of chemical master equations, a wide range of experimental observations of biomolecular interactions may be mathematically conceptualized. We anticipate that models based on the closure scheme described herein may assist in rationally designing synthe作者: 消極詞匯 時間: 2025-3-28 12:14
Evi Hartmann,Alexander de Grahlsed in concert to give a researcher the likelihood that the system exhibits its most typical behavior, as well as, non-typical behaviors. This methodology is applied to several genetic circuits leading to new understanding of the effects of various parameters on the behavior of these circuits.作者: 輕打 時間: 2025-3-28 17:07
Computational Design of RNA Parts, Devices, and Transcripts with Kinetic Folding Algorithms Implemenme- and dynamic aptazyme-regulated expression devices with quantitatively predictable functions (rREDs and aREDs, respectively) have been described (Carothers et al., Science 334:1716–1719, 2011). Here, we provide a detailed practical procedure for computational transcript design by illustrating a h作者: ECG769 時間: 2025-3-28 19:06
Kappa Rule-Based Modeling in Synthetic Biologycan model biological interactions both at the genetic and the protein–protein interaction level, resulting in detailed stochastic models accounting naturally for transcriptional and translational resource usage. We also hope to impart the intuitively modular nature of the modeling processes involved作者: Compatriot 時間: 2025-3-28 22:57
Chemical Master Equation Closure for Computer-Aided Synthetic Biology over 70 years. With the first complete solution of chemical master equations, a wide range of experimental observations of biomolecular interactions may be mathematically conceptualized. We anticipate that models based on the closure scheme described herein may assist in rationally designing synthe作者: commensurate 時間: 2025-3-29 04:16 作者: CT-angiography 時間: 2025-3-29 07:54
https://doi.org/10.1007/978-1-4842-6461-4thetic biology devices including biosensors, bioproduction, or regulation circuits. To that end, a rational workflow for computational protein design is described here consisting of (a) searching in the sequence, structure or chemical spaces for the desired function and associated protein templates;作者: GRUEL 時間: 2025-3-29 12:27
https://doi.org/10.1007/978-1-4842-6461-4urable mechanical devices. Of relevance to synthetic biology, DNA origami structures can be delivered to cells where they can perform complicated sense-and-act tasks, and can be used as scaffolds to organize enzymes for enhanced synthesis. The design of DNA origami structures is a complicated matter作者: 嗎啡 時間: 2025-3-29 19:01
https://doi.org/10.1007/978-1-4842-6461-4devices with predictable behaviors continues to increase. By combining engineered transcript components, such as ribosome binding sites, transcriptional terminators, ligand-binding aptamers, catalytic ribozymes, and aptamer-controlled ribozymes (aptazymes), gene expression in bacteria can be fine-tu作者: AWL 時間: 2025-3-29 22:25 作者: figurine 時間: 2025-3-30 02:01
https://doi.org/10.1007/978-3-658-29889-0h level of abstraction through constraints on otherwise unspecified DNA parts. The GEC compiler then selects parts which satisfy the constraints from a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC lang作者: instulate 時間: 2025-3-30 06:00 作者: 保守黨 時間: 2025-3-30 09:08 作者: 有組織 時間: 2025-3-30 14:27
Literature and Research Review,c biology. While systems modeling can aid this process and help reduce the space of design strategies, the unavailability and dynamic variability of kinetic parameters limits the utility of such models. Here, we present a general approach that employs an exhaustive enumeration of network architectur
