標(biāo)題: Titlebook: Computational Methods in Protein Evolution; Tobias Sikosek Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 ph [打印本頁] 作者: Guffaw 時間: 2025-3-21 19:22
書目名稱Computational Methods in Protein Evolution影響因子(影響力)
書目名稱Computational Methods in Protein Evolution影響因子(影響力)學(xué)科排名
書目名稱Computational Methods in Protein Evolution網(wǎng)絡(luò)公開度
書目名稱Computational Methods in Protein Evolution網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Computational Methods in Protein Evolution被引頻次
書目名稱Computational Methods in Protein Evolution被引頻次學(xué)科排名
書目名稱Computational Methods in Protein Evolution年度引用
書目名稱Computational Methods in Protein Evolution年度引用學(xué)科排名
書目名稱Computational Methods in Protein Evolution讀者反饋
書目名稱Computational Methods in Protein Evolution讀者反饋學(xué)科排名
作者: 微枝末節(jié) 時間: 2025-3-21 20:26
2.3.2.5 Presentation of results,ns. In this chapter we cover the basic theoretical concepts important for the use of calculations utilizing the non-equilibrium alchemical switching methodology. We further provide a detailed step-by-step protocol for estimating the effect of a single amino acid mutation on protein thermostability. 作者: BABY 時間: 2025-3-22 04:11
2.2.1.2.3 Continental heat flow literature,ecular functions to genomes through molecular adaptation is one important goal in comparative genomics. In large gene families, however, characterizing adaptation and neofunctionalization across species is challenging, as models have traditionally quantified the timing of duplications without consid作者: Meditative 時間: 2025-3-22 07:06 作者: 哺乳動物 時間: 2025-3-22 09:59
2.2.1.2.6-7 References for 2.2.1.2,mation about unique intramolecular interactions and, therefore, can assist in the elucidation of biomolecular conformations. It is based on the idea that compensatory mutations at specific residue positions in a sequence help preserve stability of protein architecture and function and leave a statis作者: municipality 時間: 2025-3-22 15:09 作者: municipality 時間: 2025-3-22 18:50
2.2.1.2.4 Continental heat flow results,e, and fitness in biological systems. The applications cover many areas of biological research, including biochemistry, genomics, protein and systems engineering, medicine, and evolutionary biology. However, the quantitative definitions of epistasis vary among fields, and the analysis beyond just pa作者: 杠桿支點 時間: 2025-3-22 22:23 作者: Enteropathic 時間: 2025-3-23 03:33
2.2.1.2.4 Continental heat flow results, ASR is the computation of a phylogenetic tree whose leaves are the chosen extant sequences. Most often, the reconstructed sequence related to the root of this tree is of greatest interest: It represents the common ancestor (CA) of the sequences under study. If this sequence encodes a protein, one c作者: Processes 時間: 2025-3-23 06:43
2.2.1.2.6-7 References for 2.2.1.2,re may be strongly conserved despite large divergences in sequence, structural information can be used to help identify homology in such cases..While there exist well-studied models of sequence evolution, structurally informed alignment methods have typically made use of geometric measures of deviat作者: 翻動 時間: 2025-3-23 12:38
2.2.1.2.6-7 References for 2.2.1.2,dependently of each other and under the same substitution process. However, it is well known that the structural properties of a protein site in the native state affect its evolution, in particular the sequence entropy and the substitution rate. Starting from the seminal proposal by Halpern and Brun作者: Antarctic 時間: 2025-3-23 14:40 作者: Visual-Field 時間: 2025-3-23 18:40 作者: parsimony 時間: 2025-3-23 23:22 作者: A保存的 時間: 2025-3-24 02:28
2.2.1.2.6-7 References for 2.2.1.2,et of domains into unique arrangements, a large number of distinct?proteins can be generated. Since domains often have specific functions, changes in their arrangement usually affect the overall protein function. Furthermore, domains are well amenable to computational representations, e.g., by Hidde作者: 暴發(fā)戶 時間: 2025-3-24 07:12
2.3.2.5 Presentation of results,ucture of a protein is therefore instrumental to gain information about the molecular basis of its function. However, experimental structure determination is inherently time consuming and expensive, making it impossible to follow the explosion of sequence data deriving from genome-scale projects. As作者: 最高峰 時間: 2025-3-24 13:14 作者: GLEAN 時間: 2025-3-24 16:36
2.2.1.2.6-7 References for 2.2.1.2,ns. Molecular recognition features (MoRFs) are segments of intrinsically disordered regions that bind to partner proteins, where binding is concomitant with a transition to a structured conformation. MoRFs facilitate translation, transport, signaling, and regulatory processes and are found across al作者: Conflagration 時間: 2025-3-24 22:04
https://doi.org/10.1007/978-1-4939-8736-8phylogenetic trees; sequence reconstruction; co-evolution; Epistasis; allostery作者: 施魔法 時間: 2025-3-25 01:32
978-1-4939-9378-9Springer Science+Business Media, LLC, part of Springer Nature 2019作者: In-Situ 時間: 2025-3-25 07:24
Tobias SikosekIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts作者: Fracture 時間: 2025-3-25 08:19 作者: AWE 時間: 2025-3-25 12:12
Computational Methods in Protein Evolution978-1-4939-8736-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Cupidity 時間: 2025-3-25 17:28 作者: Stress 時間: 2025-3-25 22:17 作者: addition 時間: 2025-3-26 02:35 作者: 存心 時間: 2025-3-26 06:36
Context-Dependent Mutation Effects in Proteins,igher-order mutational dataset. We discuss general considerations regarding the null hypothesis for independent mutational effects, which then allows a quantitative identification of epistasis in an experimental dataset.作者: 蟄伏 時間: 2025-3-26 09:13 作者: 燈泡 時間: 2025-3-26 12:52 作者: 胎兒 時間: 2025-3-26 17:23 作者: 進步 時間: 2025-3-26 21:49
2.2.1.2.6-7 References for 2.2.1.2,web server that is freely available at .. We describe this predictor, explain how to run the web server, and show how to interpret the results it generates. We also demonstrate the utility of this web server based on two case studies, focusing on the relevance of evolutionary conservation of MoRF regions.作者: Minatory 時間: 2025-3-27 04:02 作者: senile-dementia 時間: 2025-3-27 07:39 作者: 直覺好 時間: 2025-3-27 10:58
2.2.1.2.6-7 References for 2.2.1.2,ng the protein-coding sequences. Here we describe a machine learning method (Bayesian graphical models) implemented in the open-source phylogenetic software package ., ., for extracting a network of coevolving residues from a sequence alignment.作者: laceration 時間: 2025-3-27 14:40 作者: 善于騙人 時間: 2025-3-27 18:05
Book 2019reproducible computational protocols (using command line or graphical user interfaces, sometimes including computer code), and tips on troubleshooting and avoiding known pitfalls..Cutting-edge and authoritative, .Computational Methods in Protein Evolution. is a valuable resource that offers useful w作者: 騷動 時間: 2025-3-28 00:34 作者: 細(xì)節(jié) 時間: 2025-3-28 05:23 作者: 衰弱的心 時間: 2025-3-28 07:49 作者: handle 時間: 2025-3-28 12:59
Coevolutionary Signals and Structure-Based Models for the Prediction of Protein Native Conformationnctional amino acid chain. In this chapter, we introduce a general and efficient methodology to perform coevolutionary analysis on protein sequences and to use this information in combination with computational physical models to predict the native 3D conformation of functional polypeptides. We pres作者: 不斷的變動 時間: 2025-3-28 15:20 作者: 無政府主義者 時間: 2025-3-28 22:40
Ancestral Sequence Reconstruction as a Tool for the Elucidation of a Stepwise Evolutionary Adaptatiring properties of extant proteins. As an illustrative example, we describe the protocol for the rapid identification of hotspots determining the binding of the two subunits within the heteromeric complex imidazole glycerol phosphate synthase.作者: 痛得哭了 時間: 2025-3-28 23:33
Enhancing Statistical Multiple Sequence Alignment and Tree Inference Using Structural Information,g how the inclusion of structural information can be used to inform joint estimation of alignments and trees. StructAlign can also be used to infer branch-specific rates of structural evolution, and analysis of an example globin dataset highlights strong variation in the inferred rate across the tre作者: 越自我 時間: 2025-3-29 03:18
The Influence of Protein Stability on Sequence Evolution: Applications to Phylogenetic Inference,sites approximation that can be readily incorporated in maximum likelihood methods of phylogenetic inference, including ancestral sequence reconstruction. Next, we describe its validation with simulated and real proteins and its limitations and advantages with respect to empirical models that lack s作者: CEDE 時間: 2025-3-29 08:38
Navigating Among Known Structures in Protein Space, The entities can be, for example, protein chains, domains, supra-domains, or smaller protein sub-parts denoted themes. The measures of similarity between the entities can be based on sequence, structure, function, or any combination of these. The representation can be global, encompassing the whole作者: oracle 時間: 2025-3-29 12:08 作者: 一窩小鳥 時間: 2025-3-29 19:00 作者: CLEFT 時間: 2025-3-29 23:24 作者: 植物茂盛 時間: 2025-3-30 01:26
Interface-Based Structural Prediction of Novel Host-Pathogen Interactions,ed for efficient and robust computational approaches to predict HPIs and their complex (bound) structures. In this chapter, we review the first and currently only interface-based computational approach to identify novel HPIs. The concept of interface mimicry promises to identify more HPIs than compl作者: 欺騙世家 時間: 2025-3-30 04:14
Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function,作者: 教唆 時間: 2025-3-30 10:24 作者: Coordinate 時間: 2025-3-30 13:21
2.2.1.2.3 Continental heat flow literature, to predict the change in the Gibbs free energy for protein folding and protein-protein interactions. It can be used both through a web server and as a stand-alone application. Since ELASPIC was trained using homology models and not crystal structures, it can be applied to a much broader range of pr作者: indoctrinate 時間: 2025-3-30 17:03 作者: cringe 時間: 2025-3-31 00:16 作者: 雀斑 時間: 2025-3-31 02:44 作者: Chronic 時間: 2025-3-31 07:37
2.3.2.5 Presentation of results,studies to examining a relatively small number of specific hypotheses. For this reason, we have little detailed, unbiased information about how molecular function evolves across large protein family phylogenies. Here we describe a generalized protocol that integrates ancestral sequence reconstructio作者: gusher 時間: 2025-3-31 10:57 作者: Keratin 時間: 2025-3-31 15:55 作者: 繁榮中國 時間: 2025-3-31 18:20
2.2.1.2.6-7 References for 2.2.1.2,sites approximation that can be readily incorporated in maximum likelihood methods of phylogenetic inference, including ancestral sequence reconstruction. Next, we describe its validation with simulated and real proteins and its limitations and advantages with respect to empirical models that lack s
