標(biāo)題: Titlebook: Computational Methods for SNPs and Haplotype Inference; DIMACS/RECOMB Satell Sorin Istrail,Michael Waterman,Andrew Clark Conference proceed [打印本頁] 作者: Baleful 時間: 2025-3-21 16:33
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書目名稱Computational Methods for SNPs and Haplotype Inference被引頻次
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書目名稱Computational Methods for SNPs and Haplotype Inference讀者反饋
書目名稱Computational Methods for SNPs and Haplotype Inference讀者反饋學(xué)科排名
作者: 榮幸 時間: 2025-3-21 20:57
Kyoko Okino,Kentaro Nakamura,Hiroshi Sato21 confounded. A variety of methods including EM and Bayesian analysis have provided useful solutions for haplotype phasing of disomic genotypes. Here we provide an extension to the Bayesian approach for inferring linkage phase in trisomic samples.作者: 平常 時間: 2025-3-22 03:43 作者: Condyle 時間: 2025-3-22 05:25
Springer Series in Materials Sciencen chromosomes from a current population. In a small population, patterns of growth and population subdivision may have a substantial impact on observed patterns of chromosome segments, and the length distributions have high variance and are heavy-tailed.作者: 阻礙 時間: 2025-3-22 11:57 作者: CLAIM 時間: 2025-3-22 13:51
Conference proceedings 2004Piscataway, NJ, USA, in November 2002...The book presents ten revised full papers?as well as?abstracts of the remaining workshop papers. All relevant current issues in computational methods for SNP and haplotype analysis and their applications to disease associations are addressed..作者: CLAIM 時間: 2025-3-22 18:38 作者: 有惡臭 時間: 2025-3-23 00:19 作者: 平庸的人或物 時間: 2025-3-23 04:16
https://doi.org/10.1057/9781137012104be highly accurate over regions with high linkage disequilibrium (LD). If only polymorphisms with aminor allele frequency 10.2 are analyzed and scored according to the fraction of neighbor relations correctly called, reconstructions are 95.2% accurate over entire 100-kb stretches and are 98.6% accurate within blocks of high LD.作者: Tartar 時間: 2025-3-23 08:37
Code of Coordination for Corporate Taxation, each block. Our method partitions the SNPs into blocks and for each block, we predict the common haplotypes and each individual’s haplotype. We evaluate our method over biological data. Our method predicts the common haplotypes perfectly and has a very low error rate (0.47%) when taking into account the predictions for the uncommon haplotypes.作者: FER 時間: 2025-3-23 10:59
Simulating a Coalescent Process with Recombination and Ascertainmentr, or more prevalent, disease mutations, as expected. The marker polymorphism cutoff level also has an important influence on LD. Potential applications of the method for predicting the power of genome-wide marker-disease association studies are discussed.作者: miscreant 時間: 2025-3-23 14:57 作者: Valves 時間: 2025-3-23 19:14 作者: Interlocking 時間: 2025-3-23 22:44 作者: 憂傷 時間: 2025-3-24 05:44
https://doi.org/10.1007/978-3-662-54937-7 considerations. Extensions of the algorithms for analysis of genotype data from unrelated individuals as well as genotype data from general pedigrees are considered. Finally, we discuss the implications of haplotype blocks and tag SNPs in association studies to search for complex disease genes.作者: monopoly 時間: 2025-3-24 09:49
Otto Ernst Kempen,Gotlind Ulsh?ferdition to the pairwise association terms of the single marker tests, marker haplotype associations depend on the weighted sum of multi-locus disequilibria and genotypic susceptibilities. Several tests of haplotype association are presented here, along with a comparison of these tests within different LD contexts.作者: etiquette 時間: 2025-3-24 11:01 作者: Habituate 時間: 2025-3-24 15:17 作者: antenna 時間: 2025-3-24 22:33
Trisomic Phase Inference21 confounded. A variety of methods including EM and Bayesian analysis have provided useful solutions for haplotype phasing of disomic genotypes. Here we provide an extension to the Bayesian approach for inferring linkage phase in trisomic samples.作者: 欺騙世家 時間: 2025-3-25 02:57
An Overview of Combinatorial Methods for Haplotype Inference2002. It reviews several combinatorial approaches to the haplotype inference problem that we have investigated over the last several years. In addition, it updates some of the work presented earlier, and discusses the current state of our work.作者: 會議 時間: 2025-3-25 04:19 作者: 沒收 時間: 2025-3-25 10:50
A Coalescent-Based Approach for Complex Disease Mappingthis process, linkage mapping, have been addressed, but data analysis for LD-mapping remains extremely challenging. In this article we describe our work on developing a full statistical framework for LD mapping based on a population genetics model known as the coalescent.作者: GENUS 時間: 2025-3-25 14:49 作者: 輕快帶來危險 時間: 2025-3-25 19:28 作者: 善于 時間: 2025-3-25 22:53
Haplotyping as Perfect Phylogenyes established results from matroid and graph theory. In this work, we present an O(nm.) algorithm for this problem using elementary techniques. We also describe a linear space representation for representing all possible solutions, and provide a formula for counting the number of possible solutions.作者: 替代品 時間: 2025-3-26 02:22 作者: 招待 時間: 2025-3-26 05:08
Wolfgang Skorupa,Heidemarie Schmidt the information content of the full set of sequences. We develop methods for these approaches based on a prior method we developed for predicting piece-wise shared ancestry of haploid sequences. We apply these methods to a case study of two genetic regions with very different levels of sequence div作者: 催眠 時間: 2025-3-26 12:19 作者: oracle 時間: 2025-3-26 15:10 作者: acrimony 時間: 2025-3-26 20:35 作者: sacrum 時間: 2025-3-26 22:07 作者: 迫擊炮 時間: 2025-3-27 01:07 作者: Hiatus 時間: 2025-3-27 06:10
How Does Choice of Polymorphism Influence Estimation of LD and Mapping? on studies of the NIDDM1 region of 2qter and a region on chromosome 15 including CYP19 in which we have made a systematic examination of the effects of this type of polymorphism choice. While our conclusions are clearly limited because we have studied only these two regions, our results suggest tha作者: 酷熱 時間: 2025-3-27 10:39
Haplotype Inference and Haplotype Informationpe information contributes to linkage disequilibrium (LD) mapping and whether an in silico haplotype construction preceding the LD analysis can help. For simple disease gene mapping our conclusions are as follows: (a) if a proper statistical model is employed, the loss of haplotype information for e作者: 分期付款 時間: 2025-3-27 13:47 作者: 圓桶 時間: 2025-3-27 21:19 作者: 有常識 時間: 2025-3-28 00:25 作者: 衰老 時間: 2025-3-28 03:47
Haplotype Inference and Its Application in Linkage Disequilibrium Mappingto its potential value in disease gene identification and in pharmacogenomics. Because molecular haplotyping methods remain too costly to be used on a regular basis, statistical techniques for haplotype inference have emerged as the most time- and cost-efficient approach. This chapter explains the s作者: 東西 時間: 2025-3-28 08:06
Inferring Piecewise Ancestral History from Haploid Sequencesarching for genetic predictors of human disease. The use of haplotype structure is based on the premise that genetic variations that are physically close on the genome will often be predictive of one another due to their frequent descent intact through recent evolution. Understanding these correlati作者: 散布 時間: 2025-3-28 12:17
Haplotype Blocks in Small Populationsof recombination, it is first necessary to understand the effects of population history and demography on the survival of ancestral chromosome segments in the absence of these phenomena. In this paper, we present results on the mean and variance of lengths of ancestral segments and shared segments i作者: 音的強弱 時間: 2025-3-28 17:21
Simulating a Coalescent Process with Recombination and Ascertainmentl of mutation, genetic drift, and recombination. The method accounts for the potential effects of investigator sampling bias by allowing for ascertainment of chromosomes according to disease status and of markers according to a pre-specified polymorphism cutoff level. The method was implemented in a作者: Feedback 時間: 2025-3-28 20:33
Dynamic Programming Algorithms for Haplotype Block Partitioning and Tag SNP Selection Using Haplotypplotype diversity, separated by short regions of low LD. One of the practical implications of this observation is that only a small number of tag SNPs are needed for mapping genes responsible for human complex diseases, which can significantly reduce genotyping effort without much loss of power. In 作者: anagen 時間: 2025-3-29 01:51
Parametric Bootstrap for Assessment of Goodness of Fit of Models for Block?Haplotype?Structureds for linkage disequilibrium (LD) mapping. Some steps in that direction have been taken by Daly et al.(2001) who describe a block structure of haplotypes. They outline a hidden Markov model (HMM) that allows for common haplotypes in each block. We propose somewhat different models that also use HMM作者: Endometrium 時間: 2025-3-29 06:57
A Coalescent-Based Approach for Complex Disease Mappingard approach uses family-based ”linkage” methods to identify regions of the genome that harbor susceptibility genes, and then population-based ”linkage-disequilibrium” (LD) methods to search more narrowly for the culprit genes. Many of the important statistical issues involved in the first phase of 作者: Migratory 時間: 2025-3-29 07:55 作者: 勤勉 時間: 2025-3-29 13:57
How Does Choice of Polymorphism Influence Estimation of LD and Mapping?-off between information and economics. For example, for many of the genetic analytic approaches commonly used in fine-mapping and positional cloning, there is little value in typing polymorphisms that are in near-perfect linkage disequilibrium (LD) with each other. Consequently, investigators may f作者: cutlery 時間: 2025-3-29 18:50 作者: 現(xiàn)實 時間: 2025-3-29 21:30 作者: OVERT 時間: 2025-3-30 00:22 作者: 豐富 時間: 2025-3-30 06:38 作者: Analogy 時間: 2025-3-30 10:54 作者: Lumbar-Stenosis 時間: 2025-3-30 15:00
Computational Methods for SNPs and Haplotype Inference978-3-540-24719-7Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: Medicare 時間: 2025-3-30 18:38
Hiromi Watanabe,Girish Beedesseegle nucleotide polymorphisms (SNPs) are the most common form of genomic variation. Haplotypes have been suggested as one means for reducing the complexity of studying SNPs. In this paper we review some of the computational approaches that have been taking for determining haplotypes and suggest new approaches.作者: 發(fā)芽 時間: 2025-3-30 21:43 作者: Aromatic 時間: 2025-3-31 04:22 作者: 是他笨 時間: 2025-3-31 06:30
Lecture Notes in Computer Sciencehttp://image.papertrans.cn/c/image/232743.jpg作者: Circumscribe 時間: 2025-3-31 13:00 作者: exigent 時間: 2025-3-31 16:51
Bayesian Methods for Statistical Reconstruction of Haplotypesbution, and the computational methods used to approximate posterior distributions. We describe recent improvements to the software PHASE, including handling missing data and improved computational methods, and compare its behaviour to some other published methods.
