標(biāo)題: Titlebook: Computational Methods for Estimating the Kinetic Parameters of Biological Systems; Quentin Vanhaelen Book 2022 Springer Science+Business M [打印本頁] 作者: 聲音會爆炸 時間: 2025-3-21 17:30
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems影響因子(影響力)
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems影響因子(影響力)學(xué)科排名
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems網(wǎng)絡(luò)公開度
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems被引頻次
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems被引頻次學(xué)科排名
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems年度引用
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems年度引用學(xué)科排名
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems讀者反饋
書目名稱Computational Methods for Estimating the Kinetic Parameters of Biological Systems讀者反饋學(xué)科排名
作者: 脫毛 時間: 2025-3-22 00:01
Relationship Between Dimensionality and Convergence of Optimization Algorithms: A Comparison Betweector-based methods. However, currently there is no parameter estimation software that directly supports DNS. In this chapter, we show how to apply DNS to dynamic models of systems and synthetic biology using PEPSSBI (Parameter Estimation Pipeline for Systems and Synthetic Biology). PEPSSBI is the fi作者: Osteons 時間: 2025-3-22 03:12 作者: Antioxidant 時間: 2025-3-22 06:02
Model Setup and Procedures for Prediction of Enzyme Reaction Kinetics with QM-Only and QM:MM Approastarts from the PDB structure of the enzyme, through MD simulation of enzyme: substrate complex and statistical analysis of MD trajectory, selection of a model of the?active site, and study of reaction pathways. We show how theoretical predictions basing on QM-only cluster models, QM:MM model, or mu作者: Generosity 時間: 2025-3-22 11:59 作者: Folklore 時間: 2025-3-22 15:47
Creating Maps of the Ligand Binding Landscape for Kinetics-Based Drug Discovery, describe the other steps in more detail. The end result of this protocol is a map of the ligand–protein binding landscape that identifies transition states of the ligand binding pathway, as well as alternative bound poses that could be stabilized with modifications to the ligand.作者: Folklore 時間: 2025-3-22 17:20 作者: 使人入神 時間: 2025-3-22 21:23 作者: 使人煩燥 時間: 2025-3-23 04:37
Subcellular Basis of Contractile Failure objectives had been defined appropriately. The methodology gives accurate identification results, as?it provides clear orientation on the effect of the parameter values over the system’s behavior even under different experimental scenarios. It is particularly useful for easily combining time-course作者: ADOPT 時間: 2025-3-23 08:13 作者: placebo 時間: 2025-3-23 12:27
Kiyotaka Hitomi,Norihiro Tsukagoshiox switches and probes, as well as the kinetic parameters that describe the reduction and oxidation of redox switches. The protocols are an analytical tool that helps to depict the cellular hydrogen peroxide signaling landscape, giving new insights on H.O. signaling mechanisms, and hold the potentia作者: NAVEN 時間: 2025-3-23 14:41
Hilton H. Mollenhauer,D. James Morréstarts from the PDB structure of the enzyme, through MD simulation of enzyme: substrate complex and statistical analysis of MD trajectory, selection of a model of the?active site, and study of reaction pathways. We show how theoretical predictions basing on QM-only cluster models, QM:MM model, or mu作者: 夜晚 時間: 2025-3-23 20:47 作者: NOT 時間: 2025-3-24 02:06 作者: CYN 時間: 2025-3-24 04:50 作者: Manifest 時間: 2025-3-24 06:50 作者: 慟哭 時間: 2025-3-24 14:15 作者: 很像弓] 時間: 2025-3-24 16:11 作者: Adrenaline 時間: 2025-3-24 19:07 作者: Senescent 時間: 2025-3-25 00:29
Ali N. Akansu,Richard A. Haddadbines a range of processes, such as turnover, protein binding, internalization, and non-specific elimination, and often serves as a nucleus of more complex pharmacokinetic models. It is simple enough to comprehend but complex enough to be able to describe a wide range of phenomena and data sets. How作者: 流動才波動 時間: 2025-3-25 03:59
Jean-Pierre Antoine,Romain Murenzi low enzyme concentration. Furthermore, even when this condition is satisfied, parameter estimation is often imprecise due to the parameter identifiability issue. To overcome these limitations of the canonical approach to enzyme kinetics, we developed a Bayesian approach based on a modified form of 作者: 充滿裝飾 時間: 2025-3-25 07:32
Subcellular Basis of Contractile Failureonal behavior that arises from varying concentrations of the cellular components over time. Here, we describe a computational tuning framework to facilitate both the selection of kinetic parameters for these models and its estimation from experimental data. On the one hand, the tuning framework uses作者: incubus 時間: 2025-3-25 11:51
Subcellular Basis of Contractile Failurelucidate intracellular regulation. To construct such quantitative and predictive models of intracellular interactions, unknown parameters need to be estimated. Most of biological data are expressed in relative or arbitrary units, raising the question of how to compare model simulations with data. It作者: –FER 時間: 2025-3-25 19:26 作者: crescendo 時間: 2025-3-25 23:21
Craig T. January,Harry A. Fozzardf enzymes today, as they are now largely produced using recombinant technology, or can even be synthesized from scratch. Studies of the three-dimensional structures of enzymes can provide answers to many questions, but the kinetics of enzymatic reactions is the only method that can lead to better un作者: FIS 時間: 2025-3-26 01:10
Kiyotaka Hitomi,Norihiro Tsukagoshi of the transient variations in localized H.O. pools during signaling events and how these variations impact redox switches present in the cell remain elusive. A canonical model with two chemical reactions comprising the oxidation/reduction cycle of a redox switch is described. The model is dimensio作者: 刪除 時間: 2025-3-26 04:55
The Mitochondrial Translation System,s in target-based systems. This technique has become a powerful tool in medicinal chemistry for the identification of hit molecules. The recent developments in target-based systems have played a major role in the creation of libraries of compounds, and it has also been widely applied for the design 作者: cultivated 時間: 2025-3-26 10:22
Hilton H. Mollenhauer,D. James Morrémentary way to investigate these catalytic reactions. Experimental assay frequently does not allow an unequivocal answer to the factors controlling the reaction mechanism. On the other hand, the theoretical experiments provide a precise understanding of the molecular-level steps involved in catalyti作者: heartburn 時間: 2025-3-26 15:49 作者: Medicaid 時間: 2025-3-26 19:34 作者: 憤怒事實 時間: 2025-3-26 23:32
Dehydrogenases of the Plasma Membrane,ptor (TCR), but it is still unclear how the TCR, peptide, and the major histocompatibility complex (MHC) act together to trigger celiac disease. For now, most of the analysis is based on static crystal structures. And the detailed information about these structures based on energetic interaction is 作者: 毗鄰 時間: 2025-3-27 04:59
https://doi.org/10.1007/978-1-4615-7945-8rms. The binding/unbinding pathways of these protein–inhibitor complexes can be rather straightforwardly sampled by using umbrella sampling (US) simulation methods. During a US simulation, the . atoms of the protein are restrained via a harmonic force. The potential of mean force (PMF) along the bin作者: obstinate 時間: 2025-3-27 05:54 作者: nugatory 時間: 2025-3-27 10:40
Immunological Studies of Tissue Proteinases,eractions between proteins that are both time and location specific. The strength, or binding affinity, of protein–protein interactions ranges between the micro- and the nanomolar association constant, often dictating the molecular mechanisms underlying the interaction and the longevity of the compl作者: affect 時間: 2025-3-27 13:46
A. A. Bogdanov,A. M. Kopylov,I. N. Shatskyng kinetics is not trivial when the mechanism is complex, and a large number of parameters must be extracted from data. Furthermore, the information contained in the data is often limited, and the model may not be fully determined. The solution is to reduce the number of parameters and to estimate t作者: 含鐵 時間: 2025-3-27 20:57
Quentin VanhaelenIncludes cutting-edge techniques.Provides step-by-step details for ease of use.Contains key implementation advice from the experts作者: 極小量 時間: 2025-3-28 01:22
Methods in Molecular Biologyhttp://image.papertrans.cn/c/image/232715.jpg作者: orient 時間: 2025-3-28 03:27
Computational Methods for Estimating the Kinetic Parameters of Biological Systems978-1-0716-1767-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 厚顏 時間: 2025-3-28 09:06 作者: exhilaration 時間: 2025-3-28 13:35
978-1-0716-1769-4Springer Science+Business Media, LLC, part of Springer Nature 2022作者: Ingredient 時間: 2025-3-28 15:59
,Current Approaches of Building Mechanistic Pharmacodynamic Drug–Target Binding Models,ngagement and the efficacy of a drug dose. However, guidelines on how to build and interpret mechanistic pharmacodynamic drug–target binding models considering both biological and computational factors are still missing in the literature. In this chapter, current approaches of building mechanistic P作者: Cryptic 時間: 2025-3-28 21:02 作者: expdient 時間: 2025-3-29 01:03
,Beyond the Michaelis–Menten: Bayesian Inference for Enzyme Kinetic Analysis, low enzyme concentration. Furthermore, even when this condition is satisfied, parameter estimation is often imprecise due to the parameter identifiability issue. To overcome these limitations of the canonical approach to enzyme kinetics, we developed a Bayesian approach based on a modified form of 作者: 橫條 時間: 2025-3-29 04:25 作者: BRIBE 時間: 2025-3-29 09:42 作者: 問到了燒瓶 時間: 2025-3-29 15:29
Dynamic Optimization Approach to Estimate Kinetic Parameters of Monod-Based Microalgae Growth Modelm specific growth rate and saturation constant of light intensity were evaluated by nonlinear least squares methods that focused on minimizing the sum of squares error (SSE). The importance of good initial guess for the nonlinear least squares method was also discussed. The optimal control problem o作者: 嘲弄 時間: 2025-3-29 16:44
Automatic Assembly and Calibration of Models of Enzymatic Reactions Based on Ordinary Differential f enzymes today, as they are now largely produced using recombinant technology, or can even be synthesized from scratch. Studies of the three-dimensional structures of enzymes can provide answers to many questions, but the kinetics of enzymatic reactions is the only method that can lead to better un作者: vector 時間: 2025-3-29 21:53
Data Processing to Probe the Cellular Hydrogen Peroxide Landscape, of the transient variations in localized H.O. pools during signaling events and how these variations impact redox switches present in the cell remain elusive. A canonical model with two chemical reactions comprising the oxidation/reduction cycle of a redox switch is described. The model is dimensio作者: 誘拐 時間: 2025-3-30 03:30 作者: MODE 時間: 2025-3-30 07:55 作者: 祖?zhèn)髫敭a(chǎn) 時間: 2025-3-30 10:08
The Role of Ligand Rebinding and Facilitated Dissociation on the Characterization of Dissociation R sites, and lies at the backbone of pharmaceutical, biosensing, and biomolecular research. The extraction of dissociation rates from SPR-response signals often relies on several commonly adopted assumptions, one of which is the exponential decay of the dissociation part of the response signal. Howev作者: 有發(fā)明天才 時間: 2025-3-30 12:37 作者: GRACE 時間: 2025-3-30 20:10 作者: Ophthalmologist 時間: 2025-3-30 21:20
Umbrella Sampling-Based Method to Compute Ligand-Binding Affinity,rms. The binding/unbinding pathways of these protein–inhibitor complexes can be rather straightforwardly sampled by using umbrella sampling (US) simulation methods. During a US simulation, the . atoms of the protein are restrained via a harmonic force. The potential of mean force (PMF) along the bin作者: 低位的人或事 時間: 2025-3-31 03:27
Creating Maps of the Ligand Binding Landscape for Kinetics-Based Drug Discovery,can be used to get information about ligand binding transition states, which form the rate-limiting step of the binding and release processes. However, these simulations are typically limited by the presence of large energy barriers that separate stable poses of interest. Here we describe a simulati作者: TAP 時間: 2025-3-31 07:12
,Prediction of Protein–Protein Binding Affinities from Unbound Protein Structures,eractions between proteins that are both time and location specific. The strength, or binding affinity, of protein–protein interactions ranges between the micro- and the nanomolar association constant, often dictating the molecular mechanisms underlying the interaction and the longevity of the compl作者: 協(xié)定 時間: 2025-3-31 11:41
Parameter Optimization for Ion Channel Models: Integrating New Data with Known Channel Properties,ng kinetics is not trivial when the mechanism is complex, and a large number of parameters must be extracted from data. Furthermore, the information contained in the data is often limited, and the model may not be fully determined. The solution is to reduce the number of parameters and to estimate t作者: 男生如果明白 時間: 2025-3-31 14:15 作者: Injunction 時間: 2025-3-31 17:59
Book 2022ating kinetic parameters of biological systems. Focusing on three distinct situations, the volume covers the prediction of the kinetics of enzymatic reactions, the prediction of the kinetics of protein-protein or protein-ligand interactions (binding rates, dissociation rates, binding affinities), an
