作者: 防銹 時間: 2025-3-21 23:53 作者: BROTH 時間: 2025-3-22 02:07
Springer Series in Computational Neurosciencehttp://image.papertrans.cn/c/image/232339.jpg作者: 卜聞 時間: 2025-3-22 07:43 作者: wangle 時間: 2025-3-22 10:05
Simple Gaussian and Non-Gaussian SDEs,l role as a central regulator in calcium dynamics, several sources of relevant experimental data are introduced. Single ion channels are best studied by recording single-channel currents under different ligand concentrations via the patch-clamp technique. The particular relevance of modal gating, th作者: NIL 時間: 2025-3-22 15:29 作者: NIL 時間: 2025-3-22 18:49
Simple Gaussian and Non-Gaussian SDEs,es, from local puffs to global intra- and intercellular waves. Local Ca. puffs released from a cluster of IP.R s are strongly stochastic. The most obvious source of noise for puffs is the small number of channels within a cluster. In this chapter we discuss the simulation of stochastic Ca. signals. 作者: forager 時間: 2025-3-22 23:23 作者: exceed 時間: 2025-3-23 05:06
Data-Driven Low-Order Stochastic Models,l-stirred astrocyte model to first identify characteristic?IP. pathways whereby?Ca. and?IP. dynamics “bifurcate,” namely their dynamics changes from stable (constant) concentration levels, to oscillating ones. Then, we extend our analysis to the elemental case of two astrocytes, coupled by?IP. diffu作者: Junction 時間: 2025-3-23 08:18 作者: Suppository 時間: 2025-3-23 11:55
Fumio Oosawa,Masateru Tsuchiya,Tomoko Kuborif astrocyte processes facing synapses provides the proper structural and functional conditions for neuron-astrocyte communication giving rise to the concept of “tripartite synapse”. These synapses envisage an active role for astrocytes in their function whereby: (i) astrocytes sense neurotransmissio作者: 不給啤 時間: 2025-3-23 15:11
Fumio Oosawa,Masateru Tsuchiya,Tomoko Kuboriosine mediate astrocyte-neuron crosstalk through a plethora of ionotropic and metabotropic purinergic receptors and provide a unique framework that enables bidirectional modulation of neuronal excitability over a range of spatial and temporal scales. More recently dysregulation in purinergic signali作者: 護(hù)身符 時間: 2025-3-23 20:30
G. Kallianpur,Robert L. Wolpert, but its putative functional consequences remain elusive. Here we review and expand a mathematical modeling framework originally introduced by De Pittà et al. (.) to study how gliotransmission could affect synaptic coding and mechanisms of short-term plasticity. Consideration of analytical solution作者: 蝕刻 時間: 2025-3-24 00:11 作者: Itinerant 時間: 2025-3-24 02:37 作者: defile 時間: 2025-3-24 07:52 作者: CAGE 時間: 2025-3-24 10:59
Utility Maximisation in Incomplete Markets,m in the extracellular space (ECS) is transported away to prevent pathological neural spiking. The recently introduced Kirchhoff–Nernst–Planck (KNP) scheme for modelling ion dynamics in astrocytes (and brain tissue in general) is outlined and used to study such spatial buffering. We next describe ho作者: FLOUR 時間: 2025-3-24 18:34
Modeling and Valuation of Credit Risk,ial to deduce underlying molecular mechanisms and to monitor the effect of perturbations such as diseases. The constraint-based modeling approach to organism- and tissue-specific metabolic networks has therefore become a popular focus in the computational system’s biology field. The approach uses re作者: ABOUT 時間: 2025-3-24 19:58 作者: hair-bulb 時間: 2025-3-25 03:07
Lecture Notes in Biomathematicsronal cells in the limelight of CNS pathologies. The renewed interest in glial physiology and the advent of new experimental methods motivated the development of computational models of glial cells. In this contribution, we review the development and challenges of computational models of pathophysiological glial activation in CNS disorders.作者: Ingratiate 時間: 2025-3-25 04:53 作者: 無所不知 時間: 2025-3-25 08:31 作者: Culmination 時間: 2025-3-25 12:43
2197-1900 ng this gap, providing the first systematic computational approach to the complex, wide subject of neuron-glia interactions. The organization of the book is unique insofar as it considers a selection978-3-030-00817-8Series ISSN 2197-1900 Series E-ISSN 2197-1919 作者: etidronate 時間: 2025-3-25 19:06 作者: drusen 時間: 2025-3-25 21:31
https://doi.org/10.1007/978-3-031-22249-8 selection of arguments inspired by available experimental and modeling studies with the aim to computational neuroscience that no longer is a mere prerogative of neuronal signaling but rather it is the outcome of complex interaction between neurons and glial cells.作者: 作嘔 時間: 2025-3-26 03:34 作者: justify 時間: 2025-3-26 08:23
Basic Stochastic Computational Methods, this hypothesis because they do not allow to resolve the exact connectivity of astrocyte networks in the brain. With this aim, we present a general framework to model intercellular calcium wave propagation in astrocyte networks and use it to specifically investigate how different network topologies作者: Presbycusis 時間: 2025-3-26 12:23
Fumio Oosawa,Masateru Tsuchiya,Tomoko Kuborin the extracellular ion balance, neurotransmitter uptake from the extracellular space, and metabolic energy supply to neurons, astrocytes play active roles in synaptic transmission and plasticity, being involved in the coding information and cognitive processes by brain networks.作者: Obloquy 時間: 2025-3-26 12:41 作者: Landlocked 時間: 2025-3-26 19:42
Fumio Oosawa,Masateru Tsuchiya,Tomoko Kuboriisotropy could account for spatial segregation of transporter- versus receptor-mediated calcium signaling pathways. In the second case, we study how regulation of extracellular glutamate levels by astrocytic transporters could affect tuning responses of primary sensory areas, linking our analysis to作者: 水槽 時間: 2025-3-26 21:44 作者: 男生戴手銬 時間: 2025-3-27 01:40 作者: Latency 時間: 2025-3-27 08:07 作者: Dungeon 時間: 2025-3-27 11:14
Astrocyte Networks and Intercellular Calcium Propagation this hypothesis because they do not allow to resolve the exact connectivity of astrocyte networks in the brain. With this aim, we present a general framework to model intercellular calcium wave propagation in astrocyte networks and use it to specifically investigate how different network topologies作者: 脫水 時間: 2025-3-27 15:52 作者: 敲竹杠 時間: 2025-3-27 20:32
Purinergic Signaling at Tripartite Synapses of purinergic signaling and pinpoint the essential requirements for a modeling framework to study this signaling at tripartite synapses. The ultimate goal would be to quantify the diverse functions of purinergic transmission stemming from a large variety of receptor type and spatiotemporal landscap作者: MAL 時間: 2025-3-27 22:18 作者: allergen 時間: 2025-3-28 05:39
Constraint-Based Modeling of Metabolic Interactions in and Between Astrocytes and Neuronsbasics of constraint-based modeling via a toy metabolic network example and gives an overview of the application of the approach to couple neuronal and astrocytic metabolisms. It further utilizes a recently developed genome-scale metabolic network of the brain to calculate fluxes for the resting sta作者: 決定性 時間: 2025-3-28 06:20
Book 2019and release neuroactive agents, has been instrumental in the uncovering of many roles that these cells could play in brain processing and the storage of information. These findings initiated a conceptual revolution that leads to rethinking how brain communication works since they imply that informat作者: 情節(jié)劇 時間: 2025-3-28 13:47 作者: RENIN 時間: 2025-3-28 18:30
Data-Driven Low-Order Stochastic Models,al models susceptible to mathematical analysis. In this chapter, we provide an overview of a number of models for intracellular calcium dynamics belonging to both categories. Both types of models complement each other nicely and are vital for a better understanding of the complex mechanisms involved in cellular calcium signalling.作者: Carbon-Monoxide 時間: 2025-3-28 19:06
Simple Gaussian and Non-Gaussian SDEs,n introduced for use in the study of stochastic gating dynamics of IP.R channels. Combining the stochastic channel dynamics with the deterministic simulation the Ca. diffusion process, the fluctuating Ca. signals, including puffs and both intra- and intercellular waves, can be investigated by hybrid models.作者: ineptitude 時間: 2025-3-29 01:46
Data-Driven Low-Order Stochastic Models,ively describe GPCR-mediated astrocytic calcium signals. Our model is then used to study different mechanisms at play in stimulus encoding by shape and frequency of calcium oscillations in astrocytes.作者: Small-Intestine 時間: 2025-3-29 04:44 作者: BLA 時間: 2025-3-29 08:12 作者: Aids209 時間: 2025-3-29 12:08 作者: hypnotic 時間: 2025-3-29 17:38 作者: vascular 時間: 2025-3-29 22:10 作者: Mobile 時間: 2025-3-30 01:24
Emergence of Regular and Complex Calcium Oscillations by Inositol 1,4,5-Trisphosphate Signaling in Amics in a spatially extended astrocyte model, gaining insights on the possible physical mechanisms whereby random Ca.?generation could be orchestrated into robust, spatially confined intracellular?Ca. oscillations.作者: Analogy 時間: 2025-3-30 04:50
Gliotransmitter Exocytosis and Its Consequences on Synaptic Transmissionl modulations of synaptic transmission by gliotransmitters in experiments. At the same time, we present theoretical arguments that reveal how functional gliotransmission is a complex phenomenon that depends on the nature of structural and functional coupling between astrocytic and synaptic elements.作者: 有效 時間: 2025-3-30 09:54
Utility Maximisation in Incomplete Markets,w the ion dynamics of astrocytes may regulate microscopic liquid flow by osmotic effects and how such microscopic flow can be linked to whole-brain macroscopic flow. We thus describe key elements in a putative multiscale theory with astrocytes linking neural activity on a microscopic scale to macroscopic fluid flow.作者: 莎草 時間: 2025-3-30 12:44 作者: Organonitrile 時間: 2025-3-30 17:02
Lecture Notes in Biomathematicsd the biochemical pathways that supply energy to these cells. These findings indicate that astrocytes are crucial regulators of brain activity, due to their ability to shape synaptic transmission and control the energy budget of the entire brain.作者: 收到 時間: 2025-3-31 00:11