標(biāo)題: Titlebook: Clostridial Neurotoxins; The Molecular Pathog Cesare Montecucco Book 1995 The Editor(s) (if applicable) and The Author(s), under exclusive [打印本頁(yè)] 作者: ominous 時(shí)間: 2025-3-21 17:19
書(shū)目名稱Clostridial Neurotoxins影響因子(影響力)
作者: 自負(fù)的人 時(shí)間: 2025-3-22 00:08 作者: 無(wú)能性 時(shí)間: 2025-3-22 03:28
Book 199524 centuries it was considered a neuro- logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon- strated that作者: 觀察 時(shí)間: 2025-3-22 05:21 作者: 柱廊 時(shí)間: 2025-3-22 09:27 作者: pericardium 時(shí)間: 2025-3-22 16:14 作者: pericardium 時(shí)間: 2025-3-22 21:00
Growth of Clostridia and Preparation of Their Neurotoxins,nd convultions of tetanospasm. Although symptomatically very different, the mechanisms of action of botulinum and tetanus toxins are very similar; both are presynaptically acting neurotoxins which inhibit the calcium-mediated secretion of various neurotransmitter substances (. et al. 1981).作者: 表示向下 時(shí)間: 2025-3-22 22:07
0070-217X B.C. For 24 centuries it was considered a neuro- logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon- st作者: Accord 時(shí)間: 2025-3-23 03:52 作者: 爭(zhēng)吵加 時(shí)間: 2025-3-23 06:01
https://doi.org/10.1007/978-3-319-73993-9immunogens. This review deals with two related aspects of TeNT as an antigen: (a) immunological responses at the T and B cell level to tetanus in humans and the possibility of exploiting tetanus in the wider context of immunotherapy, and (b) some aspects of the cell biology and biochemistry of TeNT processing in human B lymphoblastoid cells.作者: legacy 時(shí)間: 2025-3-23 11:18
Botulism: The Present Status of the Disease,otulism is the result of ingestion of food containing neurotoxin produced by .. The disease may also result from toxin produced in vivo by organisms growing in an infected wound (wound botulism) or colonizing the intestinal tract (infant botulism).作者: 免除責(zé)任 時(shí)間: 2025-3-23 16:31
Cellular Immunology of Tetanus Toxoid,immunogens. This review deals with two related aspects of TeNT as an antigen: (a) immunological responses at the T and B cell level to tetanus in humans and the possibility of exploiting tetanus in the wider context of immunotherapy, and (b) some aspects of the cell biology and biochemistry of TeNT processing in human B lymphoblastoid cells.作者: Pantry 時(shí)間: 2025-3-23 21:04 作者: 同謀 時(shí)間: 2025-3-24 01:37 作者: 輕推 時(shí)間: 2025-3-24 04:41 作者: forebear 時(shí)間: 2025-3-24 08:21
Schizophrenia Treatment Outcomestion with consumption of sausages, and thus the name botulism (derived from ., Latin for sausage) was given to the disease (. and . 1988). Foodborne botulism is the result of ingestion of food containing neurotoxin produced by .. The disease may also result from toxin produced in vivo by organisms g作者: Galactogogue 時(shí)間: 2025-3-24 14:35
https://doi.org/10.1007/978-3-319-73993-9effective immunogen, and how we might be able to exploit the biochemistry and physiology of antigen-presenting cells (APC) to make yet more effective immunogens. This review deals with two related aspects of TeNT as an antigen: (a) immunological responses at the T and B cell level to tetanus in huma作者: infarct 時(shí)間: 2025-3-24 15:50
https://doi.org/10.1007/978-3-319-73993-9 command attention and concern by those around the victim. In earlier times help might have been sought from the shaman or witch doctor, whose spells or potions provided little comfort from the symptoms and eventual death. As modern medicine developed in the last two centuries even well-trained phys作者: Tartar 時(shí)間: 2025-3-24 19:35
Why Are Delusions Pathological?nineteenth century, when . (1897) related botulism to a toxin produced by ., an anaerobic bacterium. The analysis of botulism outbreaks has led to the recognition that human intoxication may be caused by BoNT types A, B, E, and F (. et al. 1983; . 1983). There are three other antigenically distinct 作者: 土產(chǎn) 時(shí)間: 2025-3-25 01:33
https://doi.org/10.1007/978-3-319-73993-9nguished on the basis of their reactions with specific antibodies and are the causative agents of the disease botulism. These toxins act on the peripheral nervous system where they block neuromuscular transmission and induce widespread flaccid paralysis (. 1986; . 1991). Tetanus toxin, on the other 作者: 同謀 時(shí)間: 2025-3-25 07:19
Why Are Delusions Pathological?otency to man and his animals has ensured their extensive analysis by the scientific community. In recent years these studies have been strengthened by the application of recombinant procedures. As a result the genes encoding TeNT and all seven BoNT serotypes have been cloned and their entire nucleo作者: –scent 時(shí)間: 2025-3-25 10:02 作者: 舊石器時(shí)代 時(shí)間: 2025-3-25 12:36
https://doi.org/10.1007/978-3-662-02684-7 exert their effects on a cytosolic substrate (. and . 1978). Although many of the details remain to be determined, generally it is accepted that the clostridial neurotoxins (CNTs) interact with membrane receptors and are translocated into the cytosol where they act to block release of neurotransmit作者: municipality 時(shí)間: 2025-3-25 15:59 作者: intuition 時(shí)間: 2025-3-25 22:20
https://doi.org/10.1007/978-3-662-02684-7ified preparations is between 0.1 and 1 ng/kg. They block the release of neuro- transmitters either at the peripheral (BoNT) or central (TeNT) nervous system. This tremendous potency derives from two essential features of these bacterial toxins: (a) their absolute neurospecificity and (b) their intr作者: BILE 時(shí)間: 2025-3-26 01:42 作者: Entreaty 時(shí)間: 2025-3-26 05:03 作者: ARIA 時(shí)間: 2025-3-26 11:47 作者: recession 時(shí)間: 2025-3-26 14:15
Amresh Shrivastava,Avinash De SousaBotulism and tetanus are diseases of humans and animals which are characterized by specific neurological disorders. These diseases have been known since antiquity. The first clinical descriptions are from Greek and Roman authors several centuries . The bacterial origin, however, was established only in last century.作者: Cirrhosis 時(shí)間: 2025-3-26 16:56 作者: FIG 時(shí)間: 2025-3-26 23:19
Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/c/image/228382.jpg作者: VEIL 時(shí)間: 2025-3-27 04:44
The Present Status of Tetanus and Tetanus Vaccination,re the disease is called by various local names (Bytchenko 1967). The belief that neonatal tetanus (NT) is linked with divine intervention is reflected in the Biblical story of the death of the son of King David and Bathsheba (2 Samuel, 11 and 12).作者: limber 時(shí)間: 2025-3-27 06:59
,Quantal Neurotransmitter Release and the Clostridial Neurotoxins’ Targets,nly because they are responsible for the clinical manifestations of tetanus and botulism, but also because they have the unique ability to effectively block neurotransmitter release from nerve terminals in a long-lasting manner (for reviews see . and . 1981; . 1986; . and . 1986; . 1987; . 1989; . 1991; . and . 1992; . 1992; . 1992).作者: Mawkish 時(shí)間: 2025-3-27 10:03
The Present Status of Tetanus and Tetanus Vaccination,re the disease is called by various local names (Bytchenko 1967). The belief that neonatal tetanus (NT) is linked with divine intervention is reflected in the Biblical story of the death of the son of King David and Bathsheba (2 Samuel, 11 and 12).作者: MILK 時(shí)間: 2025-3-27 15:02
Botulism: The Present Status of the Disease,tion with consumption of sausages, and thus the name botulism (derived from ., Latin for sausage) was given to the disease (. and . 1988). Foodborne botulism is the result of ingestion of food containing neurotoxin produced by .. The disease may also result from toxin produced in vivo by organisms g作者: hieroglyphic 時(shí)間: 2025-3-27 20:46 作者: Anthology 時(shí)間: 2025-3-27 22:05 作者: 有機(jī)體 時(shí)間: 2025-3-28 05:42 作者: synovial-joint 時(shí)間: 2025-3-28 07:32
Growth of Clostridia and Preparation of Their Neurotoxins,nguished on the basis of their reactions with specific antibodies and are the causative agents of the disease botulism. These toxins act on the peripheral nervous system where they block neuromuscular transmission and induce widespread flaccid paralysis (. 1986; . 1991). Tetanus toxin, on the other 作者: 昆蟲(chóng) 時(shí)間: 2025-3-28 11:07 作者: calorie 時(shí)間: 2025-3-28 15:00
Neuroexocytosis,transfer is achieved by exocytotic release of chemical messengers, the neurotransmitters, into the extracellular space upon stimulation. Two major classes of chemical messengers exist: small molecules such as amino acids or amines (the so-called classical neurotransmitters) and neuropeptides. The tw作者: ATP861 時(shí)間: 2025-3-28 19:46
Neurospecific Binding, Internalization, and Retrograde Axonal Transport, exert their effects on a cytosolic substrate (. and . 1978). Although many of the details remain to be determined, generally it is accepted that the clostridial neurotoxins (CNTs) interact with membrane receptors and are translocated into the cytosol where they act to block release of neurotransmit作者: 睨視 時(shí)間: 2025-3-28 23:05 作者: 結(jié)束 時(shí)間: 2025-3-29 05:17 作者: Fsh238 時(shí)間: 2025-3-29 09:28
Immunodiagnosis and Immunotherapy of Tetanus and Botulinum Neurotoxins,apter reviews the past and current literature on vaccines and various antibody-based products for treatment or prevention of poisonings by both botulinum and tetanus neurotoxins. We also review the techniques employed for their detection and identification.作者: ARBOR 時(shí)間: 2025-3-29 13:24
Clinical Use of Botulinum Neurotoxins,ence with this toxin to correct strabismus in humans (. 1981). Since then BoNT injections have been demonstrated to be a safe and efficient therapy for a large number of neurologic and nonneurologic diseases (. and . 1991). In December 1989 the United States Food and Drug Administration approved BoN作者: Restenosis 時(shí)間: 2025-3-29 19:26
Neurospecific Binding, Internalization, and Retrograde Axonal Transport,ne domain, and the L chain is the catalytic domain (reviewed by . 1991; . 1992). This chapter summarizes current data on the binding of CNTs to sensitive cells and the mechanism whereby the toxins are thought to gain access to their cytoplasmic targets.作者: Androgen 時(shí)間: 2025-3-29 20:39
Intracellular Targets and Metalloprotease Activity of Tetanus and Botulism Neurotoxins,t was not unexpected that clostridial neurotoxins are enzymes, acting in the neuron cytosol (. et al. 1993a). In fact, an enzyme can modify one after another all the target molecules present in the system and hence one single molecule of an enzymic toxin is able to intoxicate a synapse. TeNT and the作者: 冷漠 時(shí)間: 2025-3-30 02:22 作者: 一再煩擾 時(shí)間: 2025-3-30 06:22 作者: 嘮叨 時(shí)間: 2025-3-30 11:07 作者: 客觀 時(shí)間: 2025-3-30 12:27
Why Are Delusions Pathological?ence with this toxin to correct strabismus in humans (. 1981). Since then BoNT injections have been demonstrated to be a safe and efficient therapy for a large number of neurologic and nonneurologic diseases (. and . 1991). In December 1989 the United States Food and Drug Administration approved BoN作者: 步兵 時(shí)間: 2025-3-30 19:54
https://doi.org/10.1007/978-3-662-02684-7ne domain, and the L chain is the catalytic domain (reviewed by . 1991; . 1992). This chapter summarizes current data on the binding of CNTs to sensitive cells and the mechanism whereby the toxins are thought to gain access to their cytoplasmic targets.
