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標(biāo)題: Titlebook: Clinically Relevant Resistance in Cancer Chemotherapy; Borje Andersson,David Murray Book 2002 Springer Science+Business Media New York 200 [打印本頁(yè)]

作者: Iodine    時(shí)間: 2025-3-21 18:01
書目名稱Clinically Relevant Resistance in Cancer Chemotherapy影響因子(影響力)




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書目名稱Clinically Relevant Resistance in Cancer Chemotherapy讀者反饋學(xué)科排名





作者: Bumptious    時(shí)間: 2025-3-21 21:02
The Role of Membrane Transporters in Cellular Resistance to Anticancer Nucleoside Drugs, in lipid bilayers, and their cellular uptake is mediated by integral membrane proteins. Nucleoside transporters serve as the cellular entry point for nucleoside salvage pathways. Some cell types use these pathways exclusively because they lack the ability to synthesize purine and pyrimidine nucleot
作者: degradation    時(shí)間: 2025-3-22 01:08

作者: Simulate    時(shí)間: 2025-3-22 05:42
The Glutathione System in Alkylator Resistance, can be intrinsically resistant to chemotherapy or, in other cases, develop resistance during the course of antineoplastic treatment. This acquired resistance is thought to occur through the selection of a subpopulation of resistant tumor cells as the tumor is exposed to chemotherapy. To complicate
作者: 得意人    時(shí)間: 2025-3-22 11:44

作者: 夸張    時(shí)間: 2025-3-22 14:11
Mechanisms of Repair of Interstrand Crosslinks in DNA,d War, making these agents among the oldest, and yet still most effective, anticancer drugs available in the clinic. The alkylation chemistry of these drugs was elucidated shortly after the War, and their cellular pharmacology was studied extensively during the 1970s and 1980s.. In contemporary chem
作者: 夸張    時(shí)間: 2025-3-22 18:40
DNA Repair in Resistance to Bifunctional Alkylating and Platinating Agents,eutic agents. This rationale naturally extends to understanding the properties of tumor cells that make them responsive versus resistant to anticancer drugs. Many factors can contribute to the drug-resistant phenotype of individual tumor cells, and indeed, clinically relevant resistance in a given t
作者: characteristic    時(shí)間: 2025-3-22 23:57
Leukemic Cell Insensitivity to Cyclophosphamide and other Oxazaphosphorines Mediated by Aldehyde Deeroxyifosfamide, on the part of the leukemias for which these agents are used is encountered all too often clinically. Increased detoxification of the oxazaphosphorines catalyzed by relatively elevated levels of any of several aldehyde dehydrogenases (ALDHs) present in target (malignant) cells could
作者: 不朽中國(guó)    時(shí)間: 2025-3-23 02:11
Mechanisms of Resistance against Cyclophosphamide and Ifosfamide: Can they be Overcome without Sacrrst synthesized as an anticancer drug four decades ago, it continues to be widely used because of its unique efficacy against a broad range of human cancers.. To date, the structural isomer ifosfamide (IF, Ifos) is the most clinically useful CP analog, although its current applications in chemothera
作者: 淡紫色花    時(shí)間: 2025-3-23 07:18
Cellular Mechanisms of Cyclophosphamide Resistance: Model Studies in Human Medulloblastoma Cell Linldren’. Phase 2 trials in children with recurrent and newly diagnosed medulloblastoma have confirmed both clinical and radiographic responses to this alkylating agent.and a current Children’s Oncology Group international Phase 3 trial is comparing a cyclophosphamide-based regimen to a CCNU-based reg
作者: 陶醉    時(shí)間: 2025-3-23 10:49

作者: Ibd810    時(shí)間: 2025-3-23 16:47

作者: 的是兄弟    時(shí)間: 2025-3-23 19:57
Biochemical and Molecular Mechanisms of Cisplatin Resistance,ro-platinum(II); Figure 1) and its analogs fall into at least 13 clustered regions, each reflecting a distinct mechanism of action.. Many of these analogs have not been investigated in depth to unravel their fundamental mechanism of action. Indeed, almost 30 years after its clinical acceptance as a
作者: 極大痛苦    時(shí)間: 2025-3-24 00:27

作者: ellagic-acid    時(shí)間: 2025-3-24 05:13
Clinical Pharmacology of Melphalan and Its Implications for Clinical Resistance to Anticancer Agentwas reported by Bergel and Stock.. Its design was an outgrowth of studies performed during and following World War II on the mechanisms of mustard gas effects on biological systems. A summary of these early studies by Philips Philips. is of historical interest; it also serves as a model description
作者: SNEER    時(shí)間: 2025-3-24 10:09

作者: 懸崖    時(shí)間: 2025-3-24 11:01
Genomic Approaches to Clinical Drug Resistance,vances in methodologies, such as microarray analysis for gene expression profiling, and the even larger choice ofmethods now developed for scoring genetic variations among populations, will have a profound impact on the way we understand health and disease. The drug resistance phenotype in human tum
作者: 青少年    時(shí)間: 2025-3-24 18:06
Christopher Doherty,Ruby Grewal(P-gp) that are encoded by the MDR gene family. The second mechanism is exemplified by the multidrug resistance protein (MRP). Both P-gp and MRP contain ATP-binding cassettes and therefore belong to the ABC superfamily of membrane transporters
作者: 親屬    時(shí)間: 2025-3-24 19:06

作者: Femish    時(shí)間: 2025-3-24 23:20

作者: 抱怨    時(shí)間: 2025-3-25 07:14

作者: LANCE    時(shí)間: 2025-3-25 11:28

作者: dissent    時(shí)間: 2025-3-25 15:10
The Role of Signal Transduction Pathways in Drug and Radiation Resistance,vated protein (MAP) kinase. In the following years, additional studies demonstrated that the p42/p44 MAPKs regulated another protein kinase activity (p90.).and that they were themselves regulated by a protein kinase activity originally designated MKK (MAPK kinase).’.
作者: Aprope    時(shí)間: 2025-3-25 18:54

作者: 太空    時(shí)間: 2025-3-25 20:02

作者: 豪華    時(shí)間: 2025-3-26 00:51
Book 2002es in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For t
作者: 旅行路線    時(shí)間: 2025-3-26 04:18
The Romany Minority in the Czech Lands,ides. Other cell types use salvage pathways in addition to their . synthesis pathways. Nucleotides are key activated intermediates for many essential cellular biosynthetic pathways, including the synthesis of DNA and RNA
作者: pulmonary    時(shí)間: 2025-3-26 10:46

作者: 領(lǐng)導(dǎo)權(quán)    時(shí)間: 2025-3-26 12:54

作者: 漸強(qiáng)    時(shí)間: 2025-3-26 20:25
https://doi.org/10.1007/978-3-658-12055-9s a part with [.] cellular levels of relevant ALDH activity) to support that notion. By the same token, there is little direct evidence disputing it. Herein summarized is the indirect evidence consistent, as well as inconsistent, with the aforementioned possibility
作者: Armory    時(shí)間: 2025-3-26 21:16

作者: faucet    時(shí)間: 2025-3-27 03:00
Scarcity’s Ways: The Origins of Capital level, based on the ability of CD34.38.leukemic cells to repopulate NOD/scid mice. with the exception of acute promyelocytic leukemias (APL) that probably originate in CD34.33.cells. However, leukemic cells were recently reported to reside in the pre-CD34 “side-population” (SP) cell population,. suggesting an even more primitive cell of origin
作者: Overdose    時(shí)間: 2025-3-27 05:28

作者: aquatic    時(shí)間: 2025-3-27 09:45
Cellular Mechanisms of Cyclophosphamide Resistance: Model Studies in Human Medulloblastoma Cell Linthe only option currently available, definition of the mechanism(s) responsible for cyclophosphamide resistance might provide new therapeutic strategies to reverse or even prevent resistance to this alkylator
作者: armistice    時(shí)間: 2025-3-27 16:16
Mechanisms of Drug Resistance in AML, level, based on the ability of CD34.38.leukemic cells to repopulate NOD/scid mice. with the exception of acute promyelocytic leukemias (APL) that probably originate in CD34.33.cells. However, leukemic cells were recently reported to reside in the pre-CD34 “side-population” (SP) cell population,. suggesting an even more primitive cell of origin
作者: commensurate    時(shí)間: 2025-3-27 18:29

作者: GLEAN    時(shí)間: 2025-3-27 23:26
The Glutathione System in Alkylator Resistance,chemotherapeutic drug selection, it has been found that once a tumor demonstrates resistance to one class of drugs, it will often be resistant to other classes that share structural or functional homology
作者: 現(xiàn)實(shí)    時(shí)間: 2025-3-28 04:26

作者: 有其法作用    時(shí)間: 2025-3-28 10:04
0927-3042 ission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even furt
作者: 首創(chuàng)精神    時(shí)間: 2025-3-28 13:07
Scarcity’s Ways: The Origins of Capitalor breast tumors, salvage chemotherapy for a variety of solid tumors, and high-dose conditioning therapy of patients undergoing hematopoietic stem cell transplantation., .. In the latter context, these drugs are widely used for the treatment of myeloid leukemias, which represent the focus of this chapter
作者: 額外的事    時(shí)間: 2025-3-28 15:12
Introduction: The Present State of Affairs effects on biological systems. A summary of these early studies by Philips Philips. is of historical interest; it also serves as a model description of cancer drug development based upon evaluation of molecules observed to have antitumor effects as a result of empiric observation and congener synthesis
作者: agnostic    時(shí)間: 2025-3-28 20:49

作者: 不適    時(shí)間: 2025-3-29 02:21

作者: CAMP    時(shí)間: 2025-3-29 06:09
0927-3042 as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.978-1-4613-5428-4978-1-4615-1173-1Series ISSN 0927-3042 Series E-ISSN 2509-8497
作者: 上下倒置    時(shí)間: 2025-3-29 09:43
https://doi.org/10.1007/978-1-349-26446-9le. The relative cell survival after a six month course of adjuvant chemotherapy for breast cancer has been estimated to be as high as 10. or even greater.. This failure to eradicate all tumor cells has commonly been attributed to the intrinsic resistance of tumor cells to chemotherapy, and the vast
作者: 瑪瑙    時(shí)間: 2025-3-29 13:15

作者: 搖曳的微光    時(shí)間: 2025-3-29 17:40
Recycling as a Source of Regeneration,istant to bis-chloroethyl nitrosourea (BCNU) display a high incidence of increased activity of the protein 0.- alkylguanine DNA alkyltransferase (AGT) which removes mono-alkylated adducts from the 0.position of guanine (section 7). With cisplatin and melphalan, the ability of the tumor cells to repa
作者: 遭受    時(shí)間: 2025-3-29 21:29

作者: lipoatrophy    時(shí)間: 2025-3-30 03:01

作者: FLAGR    時(shí)間: 2025-3-30 04:05
Book 2002llular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.
作者: FIN    時(shí)間: 2025-3-30 10:22
Tumor Physiology and Resistance to Chemotherapy: Repopulation and Drug Penetration,le. The relative cell survival after a six month course of adjuvant chemotherapy for breast cancer has been estimated to be as high as 10. or even greater.. This failure to eradicate all tumor cells has commonly been attributed to the intrinsic resistance of tumor cells to chemotherapy, and the vast
作者: 里程碑    時(shí)間: 2025-3-30 14:30

作者: 剝皮    時(shí)間: 2025-3-30 19:03

作者: 紳士    時(shí)間: 2025-3-30 23:28

作者: maroon    時(shí)間: 2025-3-31 01:38

作者: 牢騷    時(shí)間: 2025-3-31 08:39

作者: mitral-valve    時(shí)間: 2025-3-31 09:32
https://doi.org/10.1007/978-1-349-26446-9 disease and other lymphomas, testicular cancer, and leukemia in children, cure is a realistic and frequently attainable goal, even in the advanced setting. However, for the majority of solid tumors the impact of chemotherapy on survival is at best modest. For tumors that have already metastasized,
作者: surrogate    時(shí)間: 2025-3-31 16:59

作者: otic-capsule    時(shí)間: 2025-3-31 18:40





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