標(biāo)題: Titlebook: Clinical Xenotransplantation; Pathways and Progres David K. C. Cooper,Guerard Byrne Book 2020 Springer Nature Switzerland AG 2020 surgery.t [打印本頁(yè)] 作者: urinary-tract 時(shí)間: 2025-3-21 17:25
書(shū)目名稱Clinical Xenotransplantation影響因子(影響力)
作者: CORE 時(shí)間: 2025-3-21 23:30
The Pathobiology of Pig-to-Primate Xeno.: A Historical Reviewthat bind to antigens expressed on the transplanted pig organ (the most important of which is galactose-α1,3-galactose [Gal]) and activate the complement cascade, which results in rapid destruction of the graft, a process known as hyperacute rejection. High levels of elicited anti-pig IgG may develo作者: regale 時(shí)間: 2025-3-22 02:29
Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?nograft. To answer this question, we have searched the literature. We primarily limited our review to the clinically relevant pig-to-nonhuman primate (NHP) model, and found five studies that explored this topic. No NHP that had received a pig graft developed antibodies to alloantigens, and in vitro 作者: 話 時(shí)間: 2025-3-22 07:58
Sensitization to Human Leukocyte Antigens and Xenotransplantationso the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, and reduced allograft survival, and they often experience prolonged waiting times prior to transplant作者: 誘使 時(shí)間: 2025-3-22 10:48 作者: 褪色 時(shí)間: 2025-3-22 13:30
Cardiac Xenotransplantation in Nonhuman Primates.g., in the neck or abdomen, of the recipient. This allowed observations to be made of rejection and of how this could be prevented by immunosuppressive therapy and/or immunomodulation procedures, e.g., anti-pig antibody adsorption. With the development of genetic engineering techniques, and the ava作者: 褪色 時(shí)間: 2025-3-22 17:16 作者: 節(jié)省 時(shí)間: 2025-3-22 23:31
Addressing Regulatory Requirements for the Organ-Source Pig?– A Pragmatic Approach to Facility Desigssigned regulatory responsibility for Xenotransplantation to the Center for Biologics Evaluation and Research. As a novel therapeutic, the Investigational New Drug Application will likely be subjected to review by a review committee assembled by the Office of Cellular, Tissue, and Gene Therapies. Th作者: NOTCH 時(shí)間: 2025-3-23 04:28 作者: 貪婪地吃 時(shí)間: 2025-3-23 06:34
Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejectionplant. Patients who are sensitized to allo-human leukocyte antigen (HLA) have a primed humoral and cellular immune response, and many will have preformed donor-specific antibody (DSA). Desensitization protocols and treatment of antibody-mediated rejection in allotransplantation have made great progr作者: extemporaneous 時(shí)間: 2025-3-23 12:14
Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejection these diseases. They have also rejuvenated interest in how B cells mediate multiple effector functions including antibody production, antigen presentation to T cells, costimulation, and the production of immune modulatory cytokines. Considerable experience in repurposing these drugs from autoimmuni作者: Initiative 時(shí)間: 2025-3-23 17:51
Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newborn transplantation of organs and tissues from animals into man, that is, xenotransplantation. For example, the scarcity of hearts of suitable size and condition for transplantation in newborn infants with severe cardiac failure, which motivated the use of ABO-incompatible hearts, also motivates consid作者: Diaphragm 時(shí)間: 2025-3-23 20:44 作者: canvass 時(shí)間: 2025-3-24 00:26 作者: 尖牙 時(shí)間: 2025-3-24 06:16
e mapping of a concrete pathway to clinical xenotransplantation.??.The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following thi978-3-030-49129-1978-3-030-49127-7作者: 狂熱文化 時(shí)間: 2025-3-24 10:29 作者: 小樣他閑聊 時(shí)間: 2025-3-24 11:58
Scalable Multi-core Architecturesed immunosuppressive regimen, prevents early antibody-mediated and cellular rejection. However, low levels of anti-nonGal antibody and innate immune cells and/or platelets may initiate the development of a thrombotic microangiopathy in the graft that may be associated with a consumptive coagulopathy作者: Corral 時(shí)間: 2025-3-24 15:02 作者: 邊緣 時(shí)間: 2025-3-24 22:42
Inter-Domain AOM and Incremental Deployment,d continued improvements in donor pig genetic modification. Genetically engineered pig cells, devoid of the known xenogeneic glycans, minimize human antibody reactivity in 90% of human serum samples. For wait-listed patients, early comparisons of patient PRA and anti-pig antibody reactivity found no作者: deadlock 時(shí)間: 2025-3-25 02:47 作者: 圓木可阻礙 時(shí)間: 2025-3-25 06:35
https://doi.org/10.1007/978-1-4614-0119-3methods of protection of the myocardium from ischemic insult during transplantation. Graft and recipient survival after orthotopic heart transplantation have now increased to 6?months. Nevertheless, ventricular hypertrophy has been observed and may be related to a higher systemic vascular resistance作者: DUCE 時(shí)間: 2025-3-25 09:20 作者: FADE 時(shí)間: 2025-3-25 12:43
Scalable Pattern Recognition Algorithmsmpliance are discussed. Additionally, UAB has proposed a nucleic acid testing approach to pathogen screening for a streamlined list of pathogens of interest. UAB believes that the four principles of designated pathogen-free pig production for xenotransplantation include all-in/all-out production, mo作者: 灰心喪氣 時(shí)間: 2025-3-25 16:24
Scalable Pattern Recognition Algorithmsnsitization strategies, kidney paired donation, and deceased donor allocation changes are improving the landscape..There are two standard-of-care methods of desensitization: (i) high-dose IVIg and (ii) plasmapheresis combined with low-dose IVIg. Rituximab is utilized widely for antibody reduction de作者: 嘲弄 時(shí)間: 2025-3-25 20:21 作者: 使成核 時(shí)間: 2025-3-26 00:39 作者: angiography 時(shí)間: 2025-3-26 04:32
Synthesis Lectures on Data Management significantly longer waiting period (>7?years). Many of these patients will not remain alive long enough to receive a deceased human donor organ and therefore may welcome the opportunity of entering the first clinical trial of genetically engineered pig kidney transplantation. The current (limited)作者: HAWK 時(shí)間: 2025-3-26 10:22 作者: agnostic 時(shí)間: 2025-3-26 16:09
A Brief History of Clinical Cross-Species Organ Xenotransplantationanastomosis, numerous attempts at nonhuman primate organ transplantation in patients were carried out in the early twentieth century..In 1963–1964, when human organs were not available and chronic dialysis was not yet in common use, Reemtsma transplanted chimpanzee kidneys into six patients, one of 作者: Lyme-disease 時(shí)間: 2025-3-26 18:50 作者: Astigmatism 時(shí)間: 2025-3-26 21:16
Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?ver) allografts were successful (except possibly in one case). In addition, pig fetal islets were transplanted into patients with kidney allografts; there was no increase in panel-reactive alloantibodies and the kidney grafts continued to function satisfactorily. In conclusion, the limited data sugg作者: 類型 時(shí)間: 2025-3-27 03:31 作者: Jingoism 時(shí)間: 2025-3-27 05:25
Kidney Xenotransplantation in Nonhuman Primatesidney transplanted from one of these pigs..Conventional pharmacologic immunosuppressive therapy (as used in allotransplantation) is inadequate to prevent an adaptive immune response to a transplanted pig kidney. However, when novel agents that block the CD40/CD154 costimulation pathway, e.g., an ant作者: expository 時(shí)間: 2025-3-27 10:57 作者: 令人悲傷 時(shí)間: 2025-3-27 16:35 作者: Optimum 時(shí)間: 2025-3-27 21:29
Addressing Regulatory Requirements for the Organ-Source Pig?– A Pragmatic Approach to Facility Desigmpliance are discussed. Additionally, UAB has proposed a nucleic acid testing approach to pathogen screening for a streamlined list of pathogens of interest. UAB believes that the four principles of designated pathogen-free pig production for xenotransplantation include all-in/all-out production, mo作者: 性行為放縱者 時(shí)間: 2025-3-27 22:36
Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejectionnsitization strategies, kidney paired donation, and deceased donor allocation changes are improving the landscape..There are two standard-of-care methods of desensitization: (i) high-dose IVIg and (ii) plasmapheresis combined with low-dose IVIg. Rituximab is utilized widely for antibody reduction de作者: 是他笨 時(shí)間: 2025-3-28 03:38
Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejections, clinical investigators, industry, National Institutes of Health (NIH), our academic societies, and the U.S. Food and Drug Administration (FDA) to continue support of these important objectives. Modification of alloimmunity and alloantibodies will also have relevance to xenotransplantation where t作者: MERIT 時(shí)間: 2025-3-28 06:53
Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newbornsful transplantation of ABO-incompatible hearts in newborn infants might be pertinent to the application of xenotransplantation in infants or, indeed, in all human recipients. Here, we review those insights and discuss the potential relevance for xenotransplantation.作者: Mechanics 時(shí)間: 2025-3-28 13:48 作者: ASSAY 時(shí)間: 2025-3-28 17:24 作者: 引導(dǎo) 時(shí)間: 2025-3-28 20:24
Scalable Multi-core Architecturesthat bind to antigens expressed on the transplanted pig organ (the most important of which is galactose-α1,3-galactose [Gal]) and activate the complement cascade, which results in rapid destruction of the graft, a process known as hyperacute rejection. High levels of elicited anti-pig IgG may develo作者: output 時(shí)間: 2025-3-29 01:51 作者: 緊張過(guò)度 時(shí)間: 2025-3-29 05:07
Inter-Domain AOM and Incremental Deployment,so the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, and reduced allograft survival, and they often experience prolonged waiting times prior to transplant作者: buoyant 時(shí)間: 2025-3-29 10:07
https://doi.org/10.1007/978-1-4614-0119-3could be resolved if kidneys from genetically engineered pigs offered an alternative with an acceptable clinical outcome..Genetic engineering has followed two major paths: (i) deletion of pig xenoantigens, against which all humans have ‘natural’ antibodies and (ii) insertion of ‘protective’ human tr作者: ABASH 時(shí)間: 2025-3-29 14:54
https://doi.org/10.1007/978-1-4614-0119-3.g., in the neck or abdomen, of the recipient. This allowed observations to be made of rejection and of how this could be prevented by immunosuppressive therapy and/or immunomodulation procedures, e.g., anti-pig antibody adsorption. With the development of genetic engineering techniques, and the ava作者: 放肆的我 時(shí)間: 2025-3-29 17:30 作者: FAR 時(shí)間: 2025-3-29 22:28 作者: 驚奇 時(shí)間: 2025-3-30 02:00 作者: Bridle 時(shí)間: 2025-3-30 05:17 作者: 惡意 時(shí)間: 2025-3-30 11:38
https://doi.org/10.1007/978-3-319-05630-2 these diseases. They have also rejuvenated interest in how B cells mediate multiple effector functions including antibody production, antigen presentation to T cells, costimulation, and the production of immune modulatory cytokines. Considerable experience in repurposing these drugs from autoimmuni作者: Cervical-Spine 時(shí)間: 2025-3-30 14:50 作者: 詞根詞綴法 時(shí)間: 2025-3-30 19:46
Synthesis Lectures on Data Managementical feat requires a source of donor kidneys for transplantation. Despite global efforts to increase the number of donors, and therefore kidneys for transplant, deceased donation supplies less than 10% of the need and thousands die each year waiting. Early data suggest xenotransplantation, in which
