標(biāo)題: Titlebook: Clinical Pharmacology in Psychiatry; Strategies in Psycho Lars F. Gram,Luc P. Balant,Svein G. Dahl Conference proceedings 1993 Springer-Ver [打印本頁(yè)] 作者: BID 時(shí)間: 2025-3-21 19:37
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry影響因子(影響力)
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry被引頻次
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry被引頻次學(xué)科排名
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry年度引用
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry年度引用學(xué)科排名
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry讀者反饋
書(shū)目名稱(chēng)Clinical Pharmacology in Psychiatry讀者反饋學(xué)科排名
作者: Feckless 時(shí)間: 2025-3-21 20:58 作者: 留戀 時(shí)間: 2025-3-22 03:08 作者: Interim 時(shí)間: 2025-3-22 05:14
Neuroleptics and Diagnostic Heterogeneity in Relation to Drug Evaluation,sting that quite different patient categories have been studied. Thus Brockington et al. (1978), using 10 diagnostic systems in the study of 119 psychotic patients, found that the number of patients with a diagnosis of schizophrenia ranged between 4% and 45%.作者: hereditary 時(shí)間: 2025-3-22 11:05
Residual and Negative Symptoms in Treatment with Neuroleptics, addition, increasing efforts to develop antipsychotic compounds either with a broader or novel spectrum of activity have focused more attention on residual and negative symptoms. Since these are the symptoms that may remain most salient after optimal neuroleptic treatment, they contribute enormousl作者: AMPLE 時(shí)間: 2025-3-22 16:58
Clinical Dosing of Neuroleptics,nical benefits and side effects of some antipsychotic agents has been carried out with acutely and chronically psychotic patients treated for periods ranging from several hours to several months (Baldessarini et al. 1988, 1990). In addition, there have been studies of relationships between plasma co作者: AMPLE 時(shí)間: 2025-3-22 17:51
Dose-Effect Relationships for Tricyclic Antidepressants: The Basis for Rational Clinical Testing of time, the demonstration of pronounced variations in steady state levels in patients on standard TCA (Sj?qvist et al. 1968) gave rise to a series of studies on concentration-effect relationships during the following two decades. For the introduction of new antidepressants, there is an increasing dem作者: 不溶解 時(shí)間: 2025-3-22 22:51
Reform and Transition in the Mediterraneaniple 5-HT receptor subtypes and their signal transduction mechanisms have dominated many recent investigations of this neurotransmitter system, there have also been substantial advances in the development of selective receptor subtype agonists and antagonists with therapeutic potentials in a variety作者: CREEK 時(shí)間: 2025-3-23 03:46 作者: 嚴(yán)厲批評(píng) 時(shí)間: 2025-3-23 08:55 作者: 摻和 時(shí)間: 2025-3-23 11:26
B. Grecu,G. Ad?r,V. Ad?r,V. G. Ad?rsting that quite different patient categories have been studied. Thus Brockington et al. (1978), using 10 diagnostic systems in the study of 119 psychotic patients, found that the number of patients with a diagnosis of schizophrenia ranged between 4% and 45%.作者: 木訥 時(shí)間: 2025-3-23 17:23
B. Grecu,G. Adir,A. Adir,V. Ad?r addition, increasing efforts to develop antipsychotic compounds either with a broader or novel spectrum of activity have focused more attention on residual and negative symptoms. Since these are the symptoms that may remain most salient after optimal neuroleptic treatment, they contribute enormousl作者: acrimony 時(shí)間: 2025-3-23 18:56
E. Mertens,R. Fiedler,W. Sinzignical benefits and side effects of some antipsychotic agents has been carried out with acutely and chronically psychotic patients treated for periods ranging from several hours to several months (Baldessarini et al. 1988, 1990). In addition, there have been studies of relationships between plasma co作者: 顛簸地移動(dòng) 時(shí)間: 2025-3-24 00:59 作者: 無(wú)節(jié)奏 時(shí)間: 2025-3-24 05:42
0931-6795 cations in this series, provides further evidence of the ongoing interaction between preclinical and clinical scientists, who only together can assure progress 978-3-642-78012-7978-3-642-78010-3Series ISSN 0931-6795 作者: 平常 時(shí)間: 2025-3-24 08:07 作者: 匍匐 時(shí)間: 2025-3-24 13:00
Dose-Effect and Concentration-Effect Relationships with New Antidepressants,作者: cloture 時(shí)間: 2025-3-24 14:58 作者: Odyssey 時(shí)間: 2025-3-24 23:03 作者: debunk 時(shí)間: 2025-3-25 00:15
Conference proceedings 1993logy in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basic theme of the previous meetings in this series (Chicago 1979, Troms0 1980, Odense 1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge the gap between experimental development and clini作者: Alveolar-Bone 時(shí)間: 2025-3-25 04:27 作者: 比賽用背帶 時(shí)間: 2025-3-25 08:29 作者: OPINE 時(shí)間: 2025-3-25 13:26
Evaluation of Existing Fragility Curves, with intra- and extracellular loops of various lengths, and (c) a COOH-terminal intracellular domain often containing several sites for phosphorylation by protein kinases (O’Dowd et al. 1989; Strosberg 1991; Strosberg and Leysen 1991).作者: canvass 時(shí)間: 2025-3-25 17:59
https://doi.org/10.1007/978-3-319-47479-3in linked receptors; the 5-HT. (DeVivo and Maayani 1985), 5-HT. (Ariani et al. 1989), and 5-HT. (Peroutka 1988) receptors are coupled to adenylyl cyclase inhibitory (G.) proteins, while the 5-HT. receptor is coupled to phospholipase C through a Gp protein (Conn et al. 1986).作者: Adulate 時(shí)間: 2025-3-25 22:23
About Liberal Democracy and Extremism,ts and antagonists directed at certain 5-HT receptor classes and subclasses. Some of these drugs are considered as potentially useful for the treatment of psychiatric disorders, for example, 5-HT. receptor agonists, which act as anxiolytics and antidepressants, and 5-HT. receptor antagonists, which appear to possess antipsychotic properties.作者: 偉大 時(shí)間: 2025-3-26 01:25 作者: 慌張 時(shí)間: 2025-3-26 05:53 作者: Flustered 時(shí)間: 2025-3-26 10:10 作者: 背帶 時(shí)間: 2025-3-26 16:00
https://doi.org/10.1007/978-94-007-7872-6 receptor (Sylte et al., to be published), and the 5-HT. receptor (Edvardsen et al. 1992), based on their amino acid sequence. The models were constructed by computer graphics and molecular modeling techniques, and used to examine the mechanisms of drug and neurotransmitter interactions with these receptors.作者: Maximize 時(shí)間: 2025-3-26 18:29
Reform and Transition in the Mediterraneann or suspected subtypes - 5-HT., 5-HT., 5-HT. and 5-HT. - still remain to be cloned. At least one of these, the 5-HT. receptor(s), is a member of the multisubunit ligand-gated ion channel superfamily and likely to be unrelated in structure to the 7TM receptors known at this time.作者: Bricklayer 時(shí)間: 2025-3-26 21:04 作者: alabaster 時(shí)間: 2025-3-27 02:16
Molecular Modeling of Neurotransmitter Receptors and Ligands, receptor (Sylte et al., to be published), and the 5-HT. receptor (Edvardsen et al. 1992), based on their amino acid sequence. The models were constructed by computer graphics and molecular modeling techniques, and used to examine the mechanisms of drug and neurotransmitter interactions with these receptors.作者: 思鄉(xiāng)病 時(shí)間: 2025-3-27 09:09
Serotonin Receptor Subtypes,n or suspected subtypes - 5-HT., 5-HT., 5-HT. and 5-HT. - still remain to be cloned. At least one of these, the 5-HT. receptor(s), is a member of the multisubunit ligand-gated ion channel superfamily and likely to be unrelated in structure to the 7TM receptors known at this time.作者: 斗爭(zhēng) 時(shí)間: 2025-3-27 12:11
Methods to Facilitate Early Exploratory Testing of Novel Psychopharmacologic Agents in Humans, latter point, it is well known that even marketed psychotropic drugs have had very misleading dose recommendations because what is required for marketing is to establish safe doses which on average have a positive effect rather than doses which produce the maximum possible benefit.作者: 不法行為 時(shí)間: 2025-3-27 17:11 作者: 艦旗 時(shí)間: 2025-3-27 18:25 作者: mighty 時(shí)間: 2025-3-27 23:03 作者: 細(xì)頸瓶 時(shí)間: 2025-3-28 02:41
Psychopharmacology Serieshttp://image.papertrans.cn/c/image/228162.jpg作者: inflate 時(shí)間: 2025-3-28 06:27 作者: 是剝皮 時(shí)間: 2025-3-28 12:43
Evaluation of Existing Fragility Curves,genes, two of which (β. and β.) are devoid of introns, have been isolated and sequenced. Structurally, the β-AR proteins display the typical hallmarks of all the other membrane R7G receptors coupled to GTP binding proteins, as represented in Fig. 1. They consist of: (a) a single polypeptide chain, 3作者: infantile 時(shí)間: 2025-3-28 17:53
Reform and Transition in the Mediterraneanceptor or 7TM superfamily) and that most are intronless genes has helped accelerate the cloning of this receptor family. The fact that the amino acid sequences of different serotonin receptors are among the least homologous of any single biogenic amine receptor family has had the opposite effect upo作者: GET 時(shí)間: 2025-3-28 21:59 作者: abstemious 時(shí)間: 2025-3-29 00:55 作者: 針葉類(lèi)的樹(shù) 時(shí)間: 2025-3-29 06:04
Reform and Transition in the Mediterraneanogical, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems; however, more definitive evidence of 5-HT receptor heterogeneity did not begin to emerge until th作者: 補(bǔ)充 時(shí)間: 2025-3-29 09:34
https://doi.org/10.1007/978-3-319-47479-3y, 5-HT has an inhibitory effect on dopaminergic output (see Meltzer and Nash 1991, for review). However, there is also evidence that 5-HT can enhance some aspects of dopaminergic function; thus, an over-simplistic one-way model should not be considered (Meltzer and Nash 1991). The effect of 5-HT in作者: liposuction 時(shí)間: 2025-3-29 13:11 作者: Countermand 時(shí)間: 2025-3-29 16:56
Challenges for Mechanism Design,e drugs were introduced in the 1950s, acute extrapyramidal syndromes have been associated with these neuroleptic agents. Indeed, the word “neuroleptic,” meaning “to take the neuron,” was intentionally created to encompass the concept that both antipsychotic benefits and motor side effects occurred a作者: Organization 時(shí)間: 2025-3-29 23:15 作者: 繁榮中國(guó) 時(shí)間: 2025-3-30 01:25 作者: Blatant 時(shí)間: 2025-3-30 04:15 作者: 不來(lái) 時(shí)間: 2025-3-30 10:20 作者: 廣告 時(shí)間: 2025-3-30 13:20 作者: 鳥(niǎo)籠 時(shí)間: 2025-3-30 17:53
https://doi.org/10.1007/978-3-642-48032-4ffect concept has usually been acknowledged, but the actual demonstration of dose-effect relationships in clinical drug research is often extremely difficult. In the early years after the introduction of imipramine and subsequently other tricyclic antidepressants (TCA), the dose-effect problems were作者: Melanocytes 時(shí)間: 2025-3-30 23:34
E. Mertens,R. Fiedler,W. Sinzigsm in drug metabolism has been an area of particular interest. A genetic polymorphism is a monogenic or mendelian trait that exists in the population in at least two phenotypes (and presumably in at least two genotypes), the rarest of whom exists in at least 1%–2% (Vogel and Motulsky 1982). Thus, tw作者: FIS 時(shí)間: 2025-3-31 03:37
https://doi.org/10.1007/978-3-642-78010-3pharmacology; psychiatry; research作者: constitute 時(shí)間: 2025-3-31 07:03 作者: 炸壞 時(shí)間: 2025-3-31 10:56
E. Mertens,R. Fiedler,W. SinzigAntidepressant drugs have not been classified very systematically and no commonly accepted nomenclature has been developed. Classification has been based upon criteria as different as the time of development of the drugs, their chemical structure, their biochemical properties, and their behavioral effects.作者: 自由職業(yè)者 時(shí)間: 2025-3-31 13:27 作者: NIB 時(shí)間: 2025-3-31 20:42
PET Examination of Central D2 Dopamine Receptor Occupancy in Relation to Extrapyramidal Syndromes its undergoing neuroleptic drug treatment. The dopamine hypothesis of antipsychotic drug action has been supported by consistent PET findings of a high D. dopamine receptor occupancy in patients treated with conventional clinical doses of chemically distinct classes of antipsychotic drugs (Farde et al. 1988; Smith et al. 1988; Baron et al. 1989).作者: MOTIF 時(shí)間: 2025-3-31 23:26 作者: 發(fā)電機(jī) 時(shí)間: 2025-4-1 05:45
Molecular Modeling of Neurotransmitter Receptors and Ligands,ural information which may be potentially useful in drug development. X-ray crystallographic diffraction techniques are the most widely used experimental methods for determining three-dimensional protein structures. However, while the amino acid sequences are known for a continuously increasing numb作者: scoliosis 時(shí)間: 2025-4-1 06:53
,Structure-Function Analysis of the Three β-Adrenergic Catecholamine Receptors,genes, two of which (β. and β.) are devoid of introns, have been isolated and sequenced. Structurally, the β-AR proteins display the typical hallmarks of all the other membrane R7G receptors coupled to GTP binding proteins, as represented in Fig. 1. They consist of: (a) a single polypeptide chain, 3作者: Platelet 時(shí)間: 2025-4-1 13:55 作者: refraction 時(shí)間: 2025-4-1 16:28 作者: Obvious 時(shí)間: 2025-4-1 21:19
Relevance of 5-HT Autoreceptors for Psychotropic Drug Action,n. Accordingly, drugs influencing this system either have been found to be of therapeutic value in these disorders or they are developed systematically as new classes of psychotropic agents. Evidence for the heterogeneity of serotonin (5-hydroxytryptamine; 5-HT) receptors and recent progress in thei作者: Altitude 時(shí)間: 2025-4-2 00:22 作者: grotto 時(shí)間: 2025-4-2 02:58
Serotonin Receptors and Antipsychotic Drug Action,y, 5-HT has an inhibitory effect on dopaminergic output (see Meltzer and Nash 1991, for review). However, there is also evidence that 5-HT can enhance some aspects of dopaminergic function; thus, an over-simplistic one-way model should not be considered (Meltzer and Nash 1991). The effect of 5-HT in作者: Tincture 時(shí)間: 2025-4-2 08:58
