作者: 熱烈的歡迎 時間: 2025-3-21 20:15
Mary Judith Tevethia,Harvey L. Ozerhown that aspirin-like drugs inhibit prostaglandin biosynthesis (Vane, 1971; Ferreira, Moncada & Vane, 1971; Smith & Willis, 1971) and as a result the general theory was proposed (Vane, 1971) that this enzyme inhibition accounts for the anti-inflammatory effects (and perhaps the side effects) of asp作者: 向下五度才偏 時間: 2025-3-22 02:09 作者: Antagonist 時間: 2025-3-22 08:01
SystemVerilog Language Overviewions are important problems in clinical pharmacology. Indeed, variability in the responsiveness of all living organisms to toxic chemicals has general importance in biology. Individuality in the responsiveness of humans to drugs and environmental chemicals is caused, in part, by differences in rates作者: intellect 時間: 2025-3-22 09:34
https://doi.org/10.1007/978-3-319-07139-8limination are often discussed as though such factors were entirely separate, unrelated entities without interaction or interdependence. However, genetic and environmental factors that control these large variations in rates of drug elimination interact dynamically at multiple levels. In fact, to ac作者: Discrete 時間: 2025-3-22 16:39 作者: Discrete 時間: 2025-3-22 19:04
https://doi.org/10.1007/978-1-4302-0840-2lized before they are excreted. The traditional concept about metabolic reactions is that of a deactivation process but an increasing number of drugs are now known to be metabolized to active or even toxic products (Drayer, 1976).作者: Humble 時間: 2025-3-23 00:25
https://doi.org/10.1007/978-1-4302-0840-2that in most developed countries the elderly constitute 10% or more of the population, but spend 25 to 30% of total expenditures for drugs and drug products (Crooks, O’Malley & Stevenson, 1976; Vestal, 1978). These figures are likely to increase during the next several decades. In addition, the rate作者: 是貪求 時間: 2025-3-23 02:44 作者: Enervate 時間: 2025-3-23 09:27 作者: 隱藏 時間: 2025-3-23 10:06 作者: 舊式步槍 時間: 2025-3-23 14:02 作者: Introvert 時間: 2025-3-23 18:43
http://image.papertrans.cn/c/image/228161.jpg作者: 熄滅 時間: 2025-3-23 22:28 作者: 魔鬼在游行 時間: 2025-3-24 05:49 作者: thyroid-hormone 時間: 2025-3-24 08:21
K. Pitilakis,P. Franchin,H. WenzelMost drug pharmacology is done by acute experiment, but the drugs are then often given to man for months or years. Sometimes unwanted effects appear only on chronic treatment, as is the case for tardive dyskinesias produced by chronic neuroleptic therapy of schizophrenia.作者: CRP743 時間: 2025-3-24 12:35
The Ethical and Scientific Basis of RegulationA cynic has described regulation as the substitution of error for chance. Be that as it may, modern regulation unquestionably is based, to some degree at least, on scientific and ethical considerations.作者: 命令變成大炮 時間: 2025-3-24 18:35 作者: 縫紉 時間: 2025-3-24 22:05
Reversal of Pharmacological and Biochemical Effects of Neuroleptic Drugs on Chronic AdministrationMost drug pharmacology is done by acute experiment, but the drugs are then often given to man for months or years. Sometimes unwanted effects appear only on chronic treatment, as is the case for tardive dyskinesias produced by chronic neuroleptic therapy of schizophrenia.作者: Mortar 時間: 2025-3-25 02:17 作者: somnambulism 時間: 2025-3-25 05:08 作者: Conjuction 時間: 2025-3-25 07:42
https://doi.org/10.1007/978-1-349-05952-2medicine; pharmacology; research作者: GOAT 時間: 2025-3-25 12:08 作者: 阻塞 時間: 2025-3-25 18:57 作者: Individual 時間: 2025-3-25 21:07 作者: 產(chǎn)生 時間: 2025-3-26 00:21 作者: 不成比例 時間: 2025-3-26 07:00 作者: LATE 時間: 2025-3-26 12:10 作者: ORBIT 時間: 2025-3-26 13:18
Gene-Environment Interactions in Drug Metabolismthe presence of an environmental agent: a drug. Toxicity then develops only in those subjects whose genetic constitutions render them sensitive. The genetic factor may be a metabolic block that leads to drug accumulation or it may consist of a structurally altered receptor site that fails to bind the parent drug or its metabolites in a normal way.作者: archaeology 時間: 2025-3-26 18:49 作者: glowing 時間: 2025-3-27 00:44
Predictive Value of Pre-Clinical Drug Safety Evaluationation of new drugs. This applies mostly to the general format of toxicity testing. But there remain still many annoying discrepancies between the exigencies of various drug regulatory agencies (Griffin, 1979).作者: Obstreperous 時間: 2025-3-27 04:02
The Pharmacology and Clinical Potential of Prostacyclinirin-like drugs. Since then, substantial evidence to support this theory has accumulated and it is now widely accepted that the analgesic, anti-pyretic and anti-inflammatory effects of aspirin-like drugs are mediated via inhibition of prostaglandin biosynthesis (Vane, 1976; Moncada & Vane, 1979a).作者: Infant 時間: 2025-3-27 08:11
Possible Physiological Roles of the Enkephalins and Endorphins, 1980, 1981). For this reason, it is intended to deal in this paper mainly with those concepts that are important for an understanding of the principles governing the possible physiological functions of the enkephalins and endorphins.作者: 創(chuàng)新 時間: 2025-3-27 12:15 作者: cocoon 時間: 2025-3-27 16:03 作者: 難理解 時間: 2025-3-27 19:25 作者: FOIL 時間: 2025-3-27 23:31 作者: Peculate 時間: 2025-3-28 03:33
SystemVerilog Language Overview of chemical biotransformations in different individuals. In the present report, some studies on interindividual and intra-individual differences in the metabolism of foreign chemicals in humans and the effects of dietary factors on the metabolism of these substances in man are described.作者: 最初 時間: 2025-3-28 06:17 作者: infelicitous 時間: 2025-3-28 10:28
The Pharmacology and Clinical Potential of Prostacyclinhown that aspirin-like drugs inhibit prostaglandin biosynthesis (Vane, 1971; Ferreira, Moncada & Vane, 1971; Smith & Willis, 1971) and as a result the general theory was proposed (Vane, 1971) that this enzyme inhibition accounts for the anti-inflammatory effects (and perhaps the side effects) of asp作者: innate 時間: 2025-3-28 17:03 作者: 吵鬧 時間: 2025-3-28 21:46 作者: 遍及 時間: 2025-3-28 23:09
Gene-Environment Interactions in Drug Metabolismlimination are often discussed as though such factors were entirely separate, unrelated entities without interaction or interdependence. However, genetic and environmental factors that control these large variations in rates of drug elimination interact dynamically at multiple levels. In fact, to ac作者: 熱心 時間: 2025-3-29 05:10 作者: 聯(lián)邦 時間: 2025-3-29 11:11
Drug Metabolism at Various Ages — Younglized before they are excreted. The traditional concept about metabolic reactions is that of a deactivation process but an increasing number of drugs are now known to be metabolized to active or even toxic products (Drayer, 1976).作者: theta-waves 時間: 2025-3-29 11:49 作者: 噴出 時間: 2025-3-29 15:48
Renal Elimination of Drugs at Various Ages secretion, and/or active or passive tubular reabsorption (Weiner, 1971). Hydrophilic compounds, like the polycationic aminoglycosides, experience little passive reabsorption; their urine/plasma concentration ratios approximate 100, and their clearance is similar to that of inulin or creatinine. Lip作者: 追逐 時間: 2025-3-29 20:02 作者: COMMA 時間: 2025-3-30 00:47
The Effects of Digoxin on Red Cell Digitalis Receptor Function in Man). Bedside observation still holds prime place as a method for monitoring drug effects but more recently biochemical and pharmacological methods have been developed in attempts to provide information which might extend the interpretation of knowledge gained at the bedside. Principal among these has 作者: Aphorism 時間: 2025-3-30 05:27
Mechanisms for Regulation of β-Adrenergic Receptor Function in Desensitizationle of receptor alterations in mediating a variety of physiological changes in drug responsiveness. Among the more interesting properties of many biologically active agonist drugs is the fact that they not only stimulate target tissues but they also desensitize them. This means that after a period of作者: aesthetician 時間: 2025-3-30 09:23
John R. Gilbert,Hjálmtyr Hafsteinssone various processes of renal excretion and age. There is no doubt that the impairment of the renal excretion of drugs at the two extremes of age has therapeutic and toxicological implications (Morselli, 1976; Kampmann & Molholm Hansen, 1979; Schmucker, 1979). My purpose is not to present original re作者: CLEFT 時間: 2025-3-30 13:42
John R. Gilbert,Hjálmtyr Hafsteinsson adequate blood samples. As a result there is a relative abundance of pharmacokinetic studies in the elderly. However, even in infants and children increasingly complex pharmacokinetic studies can be attempted as more sophisticated methodology allows the use of small samples of blood.作者: pessimism 時間: 2025-3-30 17:09
https://doi.org/10.1007/978-1-4899-6048-1measuring those pharmacological effects were available such measurements might yield more useful information than the measurement of plasma drug concentrations, in terms of the final outcome. This notion is illustrated for the case of the cardiac glycosides (for example, digoxin) in Figure 1.作者: 圖畫文字 時間: 2025-3-31 00:33
https://doi.org/10.1007/978-1-4899-6048-1 basis for desensitization it might be possible to design therapeutic strategies to alter it. However, since only agonists desensitize tissues (antagonists do not), it seems likely that the activating and desensitizing properties of various agonists are very intimately linked. Thus, a very detailed
